LOCUS       NM_025844               2205 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cysteine and histidine rich domain containing 1
            (Chordc1), mRNA.
ACCESSION   NM_025844
VERSION     NM_025844.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2205)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2205)
  AUTHORS   Fusella,F., Secli,L., Busso,E., Krepelova,A., Moiso,E., Rocca,S.,
            Conti,L., Annaratone,L., Rubinetto,C., Mello-Grand,M., Singh,V.,
            Chiorino,G., Silengo,L., Altruda,F., Turco,E., Morotti,A.,
            Oliviero,S., Castellano,I., Cavallo,F., Provero,P., Tarone,G. and
            Brancaccio,M.
  TITLE     The IKK/NF-kappaB signaling pathway requires Morgana to drive
            breast cancer metastasis
  JOURNAL   Nat Commun 8 (1), 1636 (2017)
   PUBMED   29158506
  REMARK    GeneRIF: Morgana silencing blocks metastasis formation in breast
            cancer mouse models and this phenotype is reverted by IkappaBalpha
            downregulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2205)
  AUTHORS   Di Savino,A., Panuzzo,C., Rocca,S., Familiari,U., Piazza,R.,
            Crivellaro,S., Carra,G., Ferretti,R., Fusella,F., Giugliano,E.,
            Camporeale,A., Franco,I., Miniscalco,B., Cutrin,J.C., Turco,E.,
            Silengo,L., Hirsch,E., Rege-Cambrin,G., Gambacorti-Passerini,C.,
            Pandolfi,P.P., Papotti,M., Saglio,G., Tarone,G., Morotti,A. and
            Brancaccio,M.
  TITLE     Morgana acts as an oncosuppressor in chronic myeloid leukemia
  JOURNAL   Blood 125 (14), 2245-2253 (2015)
   PUBMED   25678499
  REMARK    GeneRIF: Loss of Morgana expression is associated with drug
            resistance and chronic myeloid leukemia.
REFERENCE   4  (bases 1 to 2205)
  AUTHORS   Fusella,F., Ferretti,R., Recupero,D., Rocca,S., Di Savino,A.,
            Tornillo,G., Silengo,L., Turco,E., Cabodi,S., Provero,P.,
            Pandolfi,P.P., Sapino,A., Tarone,G. and Brancaccio,M.
  TITLE     Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN
            pathway
  JOURNAL   J Pathol 234 (2), 152-163 (2014)
   PUBMED   24615293
  REMARK    GeneRIF: morgana causes PTEN destabilization, by inhibiting ROCK
            activity
REFERENCE   5  (bases 1 to 2205)
  AUTHORS   Hong,T.J., Kim,S., Wi,A.R., Lee,P., Kang,M., Jeong,J.H. and
            Hahn,J.S.
  TITLE     Dynamic nucleotide-dependent interactions of cysteine- and
            histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1
            and melusin with cochaperones PP5 and Sgt1
  JOURNAL   J Biol Chem 288 (1), 215-222 (2013)
   PUBMED   23184943
  REMARK    GeneRIF: Chp-1 and melusin can interact with cochaperones PP5 and
            Sgt1 and with each other in an ATP-dependent manner
REFERENCE   6  (bases 1 to 2205)
  AUTHORS   Gerstner,J.R. and Landry,C.F.
  TITLE     The zinc-binding protein chordc1 undergoes complex diurnal changes
            in mRNA expression during mouse brain development
  JOURNAL   Neurochem Res 32 (2), 241-250 (2007)
   PUBMED   17253150
  REMARK    GeneRIF: results suggest that Chordc1 mRNA is under complex and
            widespread transcriptional regulation during development and
            implicate Chordc1 in circadian and/or homeostatic mechanisms in
            mammalian brain.
REFERENCE   7  (bases 1 to 2205)
  AUTHORS   Hahn,J.S.
  TITLE     Regulation of Nod1 by Hsp90 chaperone complex
  JOURNAL   FEBS Lett 579 (20), 4513-4519 (2005)
   PUBMED   16083881
REFERENCE   8  (bases 1 to 2205)
  AUTHORS   Wu,J., Luo,S., Jiang,H. and Li,H.
  TITLE     Mammalian CHORD-containing protein 1 is a novel heat shock protein
            90-interacting protein
  JOURNAL   FEBS Lett 579 (2), 421-426 (2005)
   PUBMED   15642353
  REMARK    GeneRIF: The first biochemical evidence demonstrating that
            mammalian Chp-1 is a novel Hsp90-interacting protein.
REFERENCE   9  (bases 1 to 2205)
  AUTHORS   Brancaccio,M., Menini,N., Bongioanni,D., Ferretti,R., De Acetis,M.,
            Silengo,L. and Tarone,G.
  TITLE     Chp-1 and melusin, two CHORD containing proteins in vertebrates
  JOURNAL   FEBS Lett 551 (1-3), 47-52 (2003)
   PUBMED   12965203
  REMARK    GeneRIF: Full length sequence, gene structure and expression of
            Chp-1.
REFERENCE   10 (bases 1 to 2205)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK003259.1.
            
            On Apr 6, 2007 this sequence version replaced NM_025844.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003259.1, AK132696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2205              AK003259.1         2-2206
FEATURES             Location/Qualifiers
     source          1..2205
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.01 cM"
     gene            1..2205
                     /gene="Chordc1"
                     /gene_synonym="1110001O09Rik; Chp-1; morgana"
                     /note="cysteine and histidine rich domain containing 1"
                     /db_xref="GeneID:66917"
                     /db_xref="MGI:MGI:1914167"
     exon            1..194
                     /gene="Chordc1"
                     /gene_synonym="1110001O09Rik; Chp-1; morgana"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1126
                     /gene="Chordc1"
                     /gene_synonym="1110001O09Rik; Chp-1; morgana"
                     /note="CHORD-containing protein 1; CHORD domain-containing
                     protein 1; protein morgana; cysteine and histidine-rich
                     domain (CHORD)-containing, zinc-binding protein 1"
                     /codon_start=1
                     /product="cysteine and histidine-rich domain-containing
                     protein 1"
                     /protein_id="NP_080120.1"
                     /db_xref="CCDS:CCDS22842.1"
                     /db_xref="GeneID:66917"
                     /db_xref="MGI:MGI:1914167"
                     /translation="MALLCYNRGCGQRFDPEANSDDACTYHPGVPVFHDALKGWSCCK
                     RRTTDFSDFLSIVGCTKGRHNSEKPPEPVKPEVKTTEKKELSELKPKFQEHIIQAPKP
                     VEAIKRPSPDEPMTNLELKISASLKQALDKLKLSSGSEEDKKEEDSDEIKIGTSCKNG
                     GCSKTYQGLQSLEEVCVYHSGVPIFHEGMKYWSCCRRKTSDFNTFLAQEGCTRGKHVW
                     TKKDAGKKVVPCRHDWHQTGGEVTISVYAKNSLPELSQVEANSTLLNVHIVFEGEKEF
                     HQNVKLWGVIDVKRSYVTMTATKIEITMRKAEPMQWASLELPTTKKQEKQKDIAD"
     exon            195..244
                     /gene="Chordc1"
                     /gene_synonym="1110001O09Rik; Chp-1; morgana"
                     /inference="alignment:Splign:2.1.0"
     exon            245..301
                     /gene="Chordc1"
                     /gene_synonym="1110001O09Rik; Chp-1; morgana"
                     /inference="alignment:Splign:2.1.0"
     exon            302..459
                     /gene="Chordc1"
                     /gene_synonym="1110001O09Rik; Chp-1; morgana"
                     /inference="alignment:Splign:2.1.0"
     exon            460..563
                     /gene="Chordc1"
                     /gene_synonym="1110001O09Rik; Chp-1; morgana"
                     /inference="alignment:Splign:2.1.0"
     exon            564..622
                     /gene="Chordc1"
                     /gene_synonym="1110001O09Rik; Chp-1; morgana"
                     /inference="alignment:Splign:2.1.0"
     exon            623..693
                     /gene="Chordc1"
                     /gene_synonym="1110001O09Rik; Chp-1; morgana"
                     /inference="alignment:Splign:2.1.0"
     exon            694..799
                     /gene="Chordc1"
                     /gene_synonym="1110001O09Rik; Chp-1; morgana"
                     /inference="alignment:Splign:2.1.0"
     exon            800..919
                     /gene="Chordc1"
                     /gene_synonym="1110001O09Rik; Chp-1; morgana"
                     /inference="alignment:Splign:2.1.0"
     exon            920..982
                     /gene="Chordc1"
                     /gene_synonym="1110001O09Rik; Chp-1; morgana"
                     /inference="alignment:Splign:2.1.0"
     exon            983..2205
                     /gene="Chordc1"
                     /gene_synonym="1110001O09Rik; Chp-1; morgana"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2205
                     /gene="Chordc1"
                     /gene_synonym="1110001O09Rik; Chp-1; morgana"
                     /note="putative"
ORIGIN      
        1 gttcgggaaa attcctgaag cagtaccggc ggcttccgga agctagctgc ggcctgaaca
       61 gtagtgctgg tgattgctgc ggtgattcac ttctagtccc gggtggtgtg gatttcgccg
      121 agaagacgga atggcgctct tgtgttacaa ccgcggctgt ggccagcgtt tcgacccaga
      181 ggccaactcg gacgatgctt gcacatacca cccaggtgtt cctgtctttc atgatgccct
      241 aaagggttgg tcttgctgta aaagaaggac aactgatttc tctgacttct taagcattgt
      301 aggctgtaca aaaggtaggc ataatagtga gaagccacct gaaccggtca agcctgaagt
      361 caagactact gagaagaagg aactatctga attaaaaccc aaatttcagg agcacatcat
      421 tcaagcccct aagccagtag aagcaataaa aaggccaagc ccagatgagc caatgacaaa
      481 cttggagtta aaaatatctg cttccctaaa acaagcactt gataaactta aactgtcatc
      541 tgggagtgaa gaagataaaa aagaagaaga cagtgatgaa attaagattg ggacttcctg
      601 taaaaatgga gggtgttcaa agacatacca gggtctacag agtctagaag aagtctgtgt
      661 atatcattct ggagtaccta ttttccacga ggggatgaaa tattggagct gttgtagaag
      721 aaaaacttca gattttaata cattcttagc ccaagagggc tgtacaagag ggaagcatgt
      781 atggactaaa aaagatgcag ggaaaaaagt tgttccgtgt agacacgact ggcatcagac
      841 tgggggtgaa gttaccatct cagtgtatgc taaaaattcc ctgccagaac tcagtcaagt
      901 agaagccaac agtactttgt taaatgtaca cattgtattt gaaggagaga aagaatttca
      961 tcaaaatgtg aaactgtggg gtgtaattga tgttaaacga agttatgtaa ctatgactgc
     1021 aacaaagatt gagatcacta tgagaaaggc ggaacccatg cagtgggcaa gtcttgaact
     1081 acctacaacc aaaaagcagg agaaacaaaa agatatagct gattgattag aagagaaatg
     1141 gaattcttaa tgtgtgtggt gaaatagttg cttgctgctg taatcttttt gttgttttta
     1201 gtctgtcgtt ttggggtcat catgaggttc ttcaaagcca aagtctgtta aatgtttgtg
     1261 cctctatctt cctttcgagt tgcataatat aattattcaa gtctcctcac tagaactata
     1321 gttgttgccc ttacacttga agggagggaa agaaaccata agtataattg cagtattttt
     1381 tagtataaat tattataagc aggaagtgaa agaagttttg ttttgttttg tttaatcctg
     1441 ataactcctt tttcccttaa atgggaaagc aaagtggtat ataaaaaact gagttggcct
     1501 ctccatgaac ttttgttatt ataattcttg aaaatcttta aggaaaagac tttttgtttc
     1561 ttcctatgca gtagttactt tttgtagtac taattctgaa gtggagtcaa accgtctgtg
     1621 tgtgctggct gagtttataa ttcatttgca gttaaattaa ttttagaaag ttgcttcaat
     1681 acttgcatta cctggcaagc agtataattt aagtctatag gaaataaact aagattatag
     1741 aattacaatt tggttaaaat tcatcataag agtaagcaat aatgttaaaa tctctttcct
     1801 gattatttaa agaactcttt atggtgtttt gacaaaatta tatctgattt atagtctaaa
     1861 cactcttatg ggtgatatct gtctccctga tgaaaaactg tatctgttaa attgtgaatg
     1921 tgtagcttcg ttgaaataca ttaaggtgtg tgttgcggct tgaatctgaa atgtacctgg
     1981 aggcttgttt tgagctgttg gtctttcaac ttagggctct attttgaagg ctgtgaaacc
     2041 tttagcatat tgaggggtga gcctttaagg attatacagt cttgctggtc tgatccagtc
     2101 aggacatatg aaccacctct gtcccatact cccactgctg cctcctcagc cattatagat
     2161 tgtatcctct gaaaccgtga gccaaaataa accttacctc ccttg
//
