LOCUS       NM_001085498            1561 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus charged multivesicular body protein 6 (Chmp6), mRNA.
ACCESSION   NM_001085498 XM_126613 XM_917071
VERSION     NM_001085498.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1561)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1561)
  AUTHORS   Hermosilla Aguayo,V., Martin,P., Tian,N., Zheng,J., Aho,R., Losa,M.
            and Selleri,L.
  TITLE     ESCRT-dependent control of craniofacial morphogenesis with
            concomitant perturbation of NOTCH signaling
  JOURNAL   Dev Biol 503, 25-42 (2023)
   PUBMED   37573008
REFERENCE   3  (bases 1 to 1561)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1561)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1561)
  AUTHORS   Wollert,T., Wunder,C., Lippincott-Schwartz,J. and Hurley,J.H.
  TITLE     Membrane scission by the ESCRT-III complex
  JOURNAL   Nature 458 (7235), 172-177 (2009)
   PUBMED   19234443
REFERENCE   6  (bases 1 to 1561)
  AUTHORS   Azmi,I., Davies,B., Dimaano,C., Payne,J., Eckert,D., Babst,M. and
            Katzmann,D.J.
  TITLE     Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a
            conserved VSL region in Vta1
  JOURNAL   J Cell Biol 172 (5), 705-717 (2006)
   PUBMED   16505166
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB870252.1, BG078687.2, BC027085.1 and BY463843.1.
            
            On Feb 14, 2008 this sequence version replaced NM_001085498.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147754.1, BQ891491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                BB870252.1         2-86
            86-678              BG078687.2         1-593
            679-1540            BC027085.1         794-1655
            1541-1561           BY463843.1         416-436
FEATURES             Location/Qualifiers
     source          1..1561
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.96 cM"
     gene            1..1561
                     /gene="Chmp6"
                     /gene_synonym="2400004G01Rik"
                     /note="charged multivesicular body protein 6"
                     /db_xref="GeneID:208092"
                     /db_xref="MGI:MGI:3583942"
     exon            1..128
                     /gene="Chmp6"
                     /gene_synonym="2400004G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            129..238
                     /gene="Chmp6"
                     /gene_synonym="2400004G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            239..326
                     /gene="Chmp6"
                     /gene_synonym="2400004G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            327..413
                     /gene="Chmp6"
                     /gene_synonym="2400004G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            414..479
                     /gene="Chmp6"
                     /gene_synonym="2400004G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            480..560
                     /gene="Chmp6"
                     /gene_synonym="2400004G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            561..615
                     /gene="Chmp6"
                     /gene_synonym="2400004G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            616..1561
                     /gene="Chmp6"
                     /gene_synonym="2400004G01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1520..1525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chmp6"
                     /gene_synonym="2400004G01Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1555
                     /gene="Chmp6"
                     /gene_synonym="2400004G01Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggcggagta cggtggccgc agagcggcgg ctgcgacggg ttcggccggc cggcgcgggg
       61 ccgccatggg caacctgttc ggccgcaaga agcagagccg agtcaccgaa caggacaggg
      121 ccatcctgca actgaagcag cagagggaca aactgaggca gtaccagaag agggtcacgc
      181 agcagctgga gagggagcgg gccctggcca ggcagctgct gcgggatggc aggaaagaac
      241 gagccaagct gctgctcaag aagaagaggt accgggagca actgctcgat aggacagaaa
      301 accagatcag cagcctggaa gccatggttc agagcatcga gttcacgcag atcgagatga
      361 aggtgatgga ggggctacag gtggggaacg aatgtctgaa taagatgcac caggtgatgt
      421 ccatagagga ggtggagagg atcctggacg agacccagga ggcagtggag taccagcggc
      481 aaattgatga gctgctggcc ggaaacttca cccaggagga tgaggacgcc atcctggaag
      541 agctgaatgc aatcactcag gaacaaatgg agttaccaga ggttccgtca gagccgctcc
      601 ctgaccgaaa cccagaagcc cctgccaagg ccagatccag gcaggcagag ctggtggcgg
      661 cttcataacc tggtctctcc aggcactcat agggattctc tgaggactgg cccacagagc
      721 ctttggctgc gagtcaaccc tgagggctcc cgggaggcct ggagggctgg actggccagt
      781 gcaggtgctg atggctggag cagcagctta catggaagct gacatcaggg cgccttgaag
      841 tttagtctgg atgcaccttt gtctctttct ccttctggac taagtggatc cccggccagc
      901 caggcccagc tttaggcagc tgtggacccc atgctggccg cagcccacta ctcctggtgc
      961 tgttctcatg ctgccccagc ccatgtgagc tgcgctcaga cctcggggtc cctgtgctcc
     1021 cctctcgtgt ctctgctgct cacatgagct ggtgggggct tcagctgagc agttctcgcc
     1081 ttgcctggca tcctgacacc cctcagttac cctgcaggct agtggcagaa accctagtgt
     1141 tctccaaatc tgttggagca tctttgcacc tcagatcacc ttgagcctct tctgttgggg
     1201 gaggtgggcc aggggccatc ccacagaatg gacaaatcta ggagcccggc ttggggtctg
     1261 ttcgcagaag aaaaacatgt tgaaggtggt aacaagaccc tgttttaatg ggcatgtacc
     1321 ccatggagtc ctggacacac taagccacca acgcccagga ggcacggaac tctgaactga
     1381 cctccagagc cctatgcttg tttcatcacg gacaatctct ggtcctcggg tctttgagga
     1441 acaaagggtc ttatgtaccc ttagggccta ccaggaaagg agggcatttc ttccttaccc
     1501 aaaacaggtc aacctcagta ttaaagttga cccctgcatg gtctttggcc tcttggactt
     1561 g
//
