LOCUS       NM_029814               1372 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus charged multivesicular body protein 5 (Chmp5), mRNA.
ACCESSION   NM_029814
VERSION     NM_029814.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1372)
  AUTHORS   Gao,W., Liu,R., Huang,K., Fu,W., Wang,A., Du,G., Tang,H., Yin,L.
            and Yin,Z.S.
  TITLE     CHMP5 attenuates osteoarthritis via inhibiting chondrocyte
            apoptosis and extracellular matrix degradation: involvement of
            NF-kappaB pathway
  JOURNAL   Mol Med 30 (1), 55 (2024)
   PUBMED   38664616
  REMARK    GeneRIF: CHMP5 attenuates osteoarthritis via inhibiting chondrocyte
            apoptosis and extracellular matrix degradation: involvement of
            NF-kappaB pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1372)
  AUTHORS   Chen,D., He,F., Lu,T., Huang,J., Li,M., Cai,D., Huang,C., Chen,D.
            and Xiong,F.
  TITLE     VPS4B deficiency causes early embryonic lethality and induces
            signal transduction disorders of cell endocytosis
  JOURNAL   Genesis 59 (4), e23415 (2021)
   PUBMED   33682352
REFERENCE   3  (bases 1 to 1372)
  AUTHORS   Liu,Y., Mei,Y., Han,X., Korobova,F.V., Prado,M.A., Yang,J.,
            Peng,Z., Paulo,J.A., Gygi,S.P., Finley,D. and Ji,P.
  TITLE     Membrane skeleton modulates erythroid proteome remodeling and
            organelle clearance
  JOURNAL   Blood 137 (3), 398-409 (2021)
   PUBMED   33036023
REFERENCE   4  (bases 1 to 1372)
  AUTHORS   Mo,J.S., Han,S.H., Yun,K.J. and Chae,S.C.
  TITLE     MicroRNA 429 regulates the expression of CHMP5 in the inflammatory
            colitis and colorectal cancer cells
  JOURNAL   Inflamm Res 67 (11-12), 985-996 (2018)
   PUBMED   30334065
  REMARK    GeneRIF: Our findings show that CHMP5 is a direct target of MIR429
            in human colon cancer cell lines and suggest that CHMP5
            up-regulation as a result of reduced MIR429 expression in
            DSS-induced mice colitis tissues and human UC tissues may restrict
            apoptosis and promote cell proliferation.
REFERENCE   5  (bases 1 to 1372)
  AUTHORS   Adoro,S., Park,K.H., Bettigole,S.E., Lis,R., Shin,H.R., Seo,H.,
            Kim,J.H., Knobeloch,K.P., Shim,J.H. and Glimcher,L.H.
  TITLE     Post-translational control of T cell development by the ESCRT
            protein CHMP5
  JOURNAL   Nat Immunol 18 (7), 780-790 (2017)
   PUBMED   28553951
  REMARK    GeneRIF: CHMP5 is a key sensor of thresholds for signaling via the
            T cell antigen receptor (TCR) that is essential for T cell
            development. CHMP5 enabled positive selection by promoting
            post-selection thymocyte survival in part through stabilization of
            the pro-survival protein Bcl-2.
REFERENCE   6  (bases 1 to 1372)
  AUTHORS   Wollert,T., Wunder,C., Lippincott-Schwartz,J. and Hurley,J.H.
  TITLE     Membrane scission by the ESCRT-III complex
  JOURNAL   Nature 458 (7235), 172-177 (2009)
   PUBMED   19234443
REFERENCE   7  (bases 1 to 1372)
  AUTHORS   Shim,J.H., Xiao,C., Hayden,M.S., Lee,K.Y., Trombetta,E.S.,
            Pypaert,M., Nara,A., Yoshimori,T., Wilm,B., Erdjument-Bromage,H.,
            Tempst,P., Hogan,B.L., Mellman,I. and Ghosh,S.
  TITLE     CHMP5 is essential for late endosome function and down-regulation
            of receptor signaling during mouse embryogenesis
  JOURNAL   J Cell Biol 172 (7), 1045-1056 (2006)
   PUBMED   16567502
  REMARK    GeneRIF: CHMP5 regulates late endosome function downstream of MVB
            formation, and the loss of CHMP5 enhances signal transduction by
            inhibiting lysosomal degradation of activated receptors.
REFERENCE   8  (bases 1 to 1372)
  AUTHORS   Azmi,I., Davies,B., Dimaano,C., Payne,J., Eckert,D., Babst,M. and
            Katzmann,D.J.
  TITLE     Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a
            conserved VSL region in Vta1
  JOURNAL   J Cell Biol 172 (5), 705-717 (2006)
   PUBMED   16505166
REFERENCE   9  (bases 1 to 1372)
  AUTHORS   Easterday,M.C., Dougherty,J.D., Jackson,R.L., Ou,J., Nakano,I.,
            Paucar,A.A., Roobini,B., Dianati,M., Irvin,D.K., Weissman,I.L.,
            Terskikh,A.V., Geschwind,D.H. and Kornblum,H.I.
  TITLE     Neural progenitor genes. Germinal zone expression and analysis of
            genetic overlap in stem cell populations
  JOURNAL   Dev Biol 264 (2), 309-322 (2003)
   PUBMED   14651920
REFERENCE   10 (bases 1 to 1372)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK008911.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008911.1, AK147058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1372
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 20.69 cM"
     gene            1..1372
                     /gene="Chmp5"
                     /gene_synonym="2210412K09Rik"
                     /note="charged multivesicular body protein 5"
                     /db_xref="GeneID:76959"
                     /db_xref="MGI:MGI:1924209"
     exon            1..124
                     /gene="Chmp5"
                     /gene_synonym="2210412K09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..715
                     /gene="Chmp5"
                     /gene_synonym="2210412K09Rik"
                     /note="likely ortholog of H. sapiens SNF7 domain
                     containing 2; SNF7 domain-containing protein 2; chromatin
                     modifying protein 5"
                     /codon_start=1
                     /product="charged multivesicular body protein 5"
                     /protein_id="NP_084090.1"
                     /db_xref="CCDS:CCDS18053.1"
                     /db_xref="GeneID:76959"
                     /db_xref="MGI:MGI:1924209"
                     /translation="MNRFFGKAKPKAPPPSLTDCIGTVDSRAESIDKKISRLDAELVK
                     YKDQIKKMREGPAKNMVKQKALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDT
                     KTTVDAMKLGVKEMKKAYKEVKIDQIEDLQDQLEDMMEDANEIQEALGRSYGTPELDE
                     DDLEAELDALGDELLADEDSSYLDEAASAPAIPEGVPTDTKNKDGVLVDEFGLPQIPA
                     S"
     exon            125..229
                     /gene="Chmp5"
                     /gene_synonym="2210412K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            230..276
                     /gene="Chmp5"
                     /gene_synonym="2210412K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            277..370
                     /gene="Chmp5"
                     /gene_synonym="2210412K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            371..442
                     /gene="Chmp5"
                     /gene_synonym="2210412K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            443..551
                     /gene="Chmp5"
                     /gene_synonym="2210412K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            552..664
                     /gene="Chmp5"
                     /gene_synonym="2210412K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            665..1372
                     /gene="Chmp5"
                     /gene_synonym="2210412K09Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1372
                     /gene="Chmp5"
                     /gene_synonym="2210412K09Rik"
                     /note="putative"
ORIGIN      
        1 acgcttccgt ttctggtttt cctccagtgt ttgggtttcc tcgcagccgg ccaagatgaa
       61 ccgattcttc ggaaaagcga aacccaaggc tccgccacct agcttgacgg actgcattgg
      121 gacggtggat agcagggcag aatccattga caaaaagatt tcccggctgg atgctgaact
      181 agtgaaatat aaggatcaaa tcaagaagat gagagagggt cctgctaaga acatggtcaa
      241 acagaaagcc ctgagagttt taaagcaaaa gcggatgtat gagcaacagc gagacaacct
      301 ggcccaacag tcctttaaca tggagcaagc taattacacc atccagtcac taaaggacac
      361 caagaccacg gttgatgcca tgaagttggg agtaaaggaa atgaagaagg catataagga
      421 agtaaaaatt gaccagattg aggacttaca agaccagctg gaggatatga tggaagatgc
      481 aaatgagatc caggaagccc tgggccgcag ctacggcacc ccagagttag atgaggacga
      541 cctggaagca gagttagatg cgctgggcga tgagcttctg gctgatgaag atagctccta
      601 cttggatgag gcagcttccg ctcctgcaat tccggaaggt gttcccactg acacaaaaaa
      661 caaggatggc gtgctggtgg atgaatttgg actgccgcag attcccgctt cgtagactta
      721 caacattcca gcacgtgatg tgaaacaaca agagaagtat tctgggacta ggaaatagtt
      781 cccgatctgc caaccagatt taggtttctt tcctttcttt gaaggaaaag ctatctacac
      841 tgctcctgta tttttatttt ttccgttaag gaattcattg cttttgggaa gctgtcttta
      901 ctaaaacttg attctttttt ttttttttct cttaggaaag actaattgaa aagtaccctt
      961 gactttgtat gacttgtttt cattcattaa caataatctg aaattaaacc aaggagatga
     1021 gactctgaat tctatggtag tgtaagtaca gtctcagtgt gctgatacat tgataagata
     1081 aaagtgattg atgagattgg gactgctgat agtatgcttc agaacccttg tctgttgtgg
     1141 tattgtagat gggtttaagt catggcctct tttgatagat tttgttgtgt catgtgagca
     1201 agtcattaca cgatctactg ttggaatgaa ctgtctctac ggtatcatga gttactattt
     1261 tgattccatg gttccctcag tatactagcc tgacttgtaa tgaataatga atatttcttg
     1321 atatttaatg tataggacat ttatttatac tcaataaata tttttcaaaa gg
//
