LOCUS       NM_025519               1790 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus charged multivesicular body protein 4C (Chmp4c), mRNA.
ACCESSION   NM_025519
VERSION     NM_025519.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1790)
  AUTHORS   Kim,H., Jang,J.W., Sim,S.E., Lee,J., Jeong,J.H., Park,S., Lee,Y.K.,
            Ham,H.J., Yu,N.K., Lim,C.S., Gao,F.B., Lee,J.A. and Kaang,B.K.
  TITLE     Crucial role of Snf7-3 in synaptic function and cognitive behavior
            revealed by conventional and conditional knockout mouse models
  JOURNAL   Neuroscience 560, 347-356 (2024)
   PUBMED   39369944
  REMARK    GeneRIF: Crucial role of Snf7-3 in synaptic function and cognitive
            behavior revealed by conventional and conditional knockout mouse
            models.
REFERENCE   2  (bases 1 to 1790)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1790)
  AUTHORS   Liu,A., Xie,H., Tian,F., Bai,P., Weng,H., Liu,Y., Liu,W., Tang,L.,
            You,H., Zhou,N. and Shu,X.
  TITLE     ESCRT-III Component CHMP4C Attenuates Cardiac Hypertrophy by
            Targeting the Endo-Lysosomal Degradation of EGFR
  JOURNAL   Hypertension 80 (12), 2674-2686 (2023)
   PUBMED   37846580
  REMARK    GeneRIF: ESCRT-III Component CHMP4C Attenuates Cardiac Hypertrophy
            by Targeting the Endo-Lysosomal Degradation of EGFR.
REFERENCE   4  (bases 1 to 1790)
  AUTHORS   Tedeschi,A., Almagro,J., Renshaw,M.J., Messal,H.A., Behrens,A. and
            Petronczki,M.
  TITLE     Cep55 promotes cytokinesis of neural progenitors but is dispensable
            for most mammalian cell divisions
  JOURNAL   Nat Commun 11 (1), 1746 (2020)
   PUBMED   32269212
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1790)
  AUTHORS   Scavuzzo,M.A., Chmielowiec,J., Yang,D., Wamble,K., Chaboub,L.S.,
            Duraine,L., Tepe,B., Glasgow,S.M., Arenkiel,B.R., Brou,C.,
            Deneen,B. and Borowiak,M.
  TITLE     Pancreatic Cell Fate Determination Relies on Notch Ligand
            Trafficking by NFIA
  JOURNAL   Cell Rep 25 (13), 3811-3827 (2018)
   PUBMED   30590051
REFERENCE   6  (bases 1 to 1790)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 1790)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1790)
  AUTHORS   Wollert,T., Wunder,C., Lippincott-Schwartz,J. and Hurley,J.H.
  TITLE     Membrane scission by the ESCRT-III complex
  JOURNAL   Nature 458 (7235), 172-177 (2009)
   PUBMED   19234443
REFERENCE   9  (bases 1 to 1790)
  AUTHORS   Lee,J.A., Beigneux,A., Ahmad,S.T., Young,S.G. and Gao,F.B.
  TITLE     ESCRT-III dysfunction causes autophagosome accumulation and
            neurodegeneration
  JOURNAL   Curr Biol 17 (18), 1561-1567 (2007)
   PUBMED   17683935
  REMARK    Erratum:[Curr Biol. 2007 Sep 18;17(18):1622]
REFERENCE   10 (bases 1 to 1790)
  AUTHORS   Azmi,I., Davies,B., Dimaano,C., Payne,J., Eckert,D., Babst,M. and
            Katzmann,D.J.
  TITLE     Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a
            conserved VSL region in Vta1
  JOURNAL   J Cell Biol 172 (5), 705-717 (2006)
   PUBMED   16505166
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC123726.11.
            
            On Mar 21, 2007 this sequence version replaced NM_025519.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009273.1, BC117538.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               AC123726.11        47477-47725         c
            250-427             AC123726.11        28969-29146         c
            428-542             AC123726.11        27547-27661         c
            543-696             AC123726.11        24996-25149         c
            697-1790            AC123726.11        23693-24786         c
FEATURES             Location/Qualifiers
     source          1..1790
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 2.63 cM"
     gene            1..1790
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
                     /note="charged multivesicular body protein 4C"
                     /db_xref="GeneID:66371"
                     /db_xref="MGI:MGI:1913621"
     exon            1..249
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..758
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
                     /note="chromatin-modifying protein 4c; Snf7 homologue
                     associated with Alix 3; chromatin modifying protein 4C"
                     /codon_start=1
                     /product="charged multivesicular body protein 4c"
                     /protein_id="NP_079795.1"
                     /db_xref="CCDS:CCDS17243.1"
                     /db_xref="GeneID:66371"
                     /db_xref="MGI:MGI:1913621"
                     /translation="MSKLGKFFKGTRSSRARAAPSAQEALARLRETEEMLAKKQEYLE
                     NRIQRELALAKKHGSQNKRAALQALKRKKRFEKQLTQVDGTLSTIEFQREALENSHTN
                     TEVLRNMGFAAKAMKAVHDNMDLNKIDDLMQDITEQQDIAQEISEAFSQRVQFADGFD
                     EAELLAELEELEQEELNKKMTSLELPNVPSSSLPAQPSRKASMPSSVHRSRAASSRRA
                     EEDDDFKQLAAWAT"
     exon            250..427
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            428..542
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            543..696
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            697..1790
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      810..815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
                     /note="hexamer: CATAAA"
     polyA_site      832
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
                     /note="major polyA site"
     regulatory      1156..1161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
                     /note="hexamer: AGTAAA"
     regulatory      1162..1167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
                     /note="hexamer: AATAAA"
     regulatory      1166..1171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
                     /note="hexamer: AATACA"
     polyA_site      1177
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
     polyA_site      1184
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
     polyA_site      1206
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
     regulatory      1702..1707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
                     /note="hexamer: ATTAAA"
     polyA_site      1726
                     /gene="Chmp4c"
                     /gene_synonym="2010012P02Rik; 2210015K02Rik;
                     2310010I16Rik; Shax3; Snf7-3"
ORIGIN      
        1 tccgactgtg gcttacctgt ctccagagcg ctgggacgct cgtcccccac tgctcagcca
       61 tgagcaagtt gggtaagttc tttaaaggga cccgctcctc ccgggcccgg gcggctccca
      121 gcgcccagga agccctggct cgcctccggg agacggagga gatgctggcc aagaagcaag
      181 agtacctgga gaaccgaatc cagagggagc tcgccttagc caagaagcac ggctcccaga
      241 acaagcgagc tgccttgcag gcactgaaaa gaaagaagag gtttgagaag cagctcactc
      301 aggtggatgg caccctttcc accatcgagt tccagcgaga agcgctggag aactcgcaca
      361 ccaacacgga ggtcttacgg aacatgggct tcgcagccaa ggccatgaaa gcggttcatg
      421 acaacatgga cctcaacaaa attgatgact tgatgcaaga tatcacagag cagcaggaca
      481 ttgcccagga aatctcagaa gcattttctc aaagggttca gtttgccgat ggcttcgatg
      541 aggctgagct tctggcagag cttgaggaat tggagcagga ggaattaaat aagaagatga
      601 caagcctgga gcttccaaat gtgccgtcct cgtccctccc agcacagccc agtaggaaag
      661 ccagcatgcc ctcctccgtg caccggtctc gagcagcatc ttccaggagg gcagaggaag
      721 atgatgactt caaacaacta gcagcttggg ccacttaaaa gctacaatgg aaaacacttg
      781 acacctaaat tattgaacta catataagac ataaatgctt ttgcaaagct tagaaattag
      841 cagagacctg ttttatatga attattgtct tttaagtaac agttaaggga tagtcagaga
      901 tggaaagggg cccgtagcat tataggagac ccttccggat tgatgttggt ggggctcgtc
      961 tgcctgcttt gttactgtgt ttctagatgt agttgttgtt ttttgtatat atacattgaa
     1021 agcaaagtga attttactga catttcatac atattccagt ttatacacca tcccgaggaa
     1081 tacctgggta actggggggg ggggggggaa tgtctatgca aatacgaggc agctgtgtgc
     1141 atccaggtca tgcagagtaa aaataaatac atggctagaa cagacttgtt ctagtgagtc
     1201 tatgtattca gagtttcagt tgagtttcac agctgagaat ctttagggag ctttactcta
     1261 attgatgttt attatgccgg ttgagctttg agtggagcaa tggatgaatc tcccgaaata
     1321 cctgaaagca gtaacagcgt agtgtgctga gcggtgctcc cgggggtgtg gttagccact
     1381 cagggagctg agtgagcact tgtgggcggt gctccccagg gtgtggtcag gaagctgagt
     1441 gagcacttgg gggcggtgct ccagggggtg tggtcaggaa gctgagtgag cacttgggag
     1501 tggtgctccc gggggtgtgg tcaggaagct gagtgagctc ttgggggcgg tgttcccggg
     1561 ggtgtggtca ggaagctgag tgaacacttg ggggctgttc ccaacactgc ttattctctt
     1621 ctgctttctg ttctcttgca ctttaaaaga aacaaaacaa aacaaaatcc aaacacttca
     1681 cagcttgcac tttgtaagta tattaaaata ctggcaatta gaaatatatc ttgagtaaaa
     1741 ttttgcccat gattatcttt aaatgaaaat aaatgataaa attaggtgtc
//
