LOCUS       NM_029362               1603 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus charged multivesicular body protein 4B (Chmp4b), mRNA.
ACCESSION   NM_029362 XM_906248
VERSION     NM_029362.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1603)
  AUTHORS   Yang,Y., Chen,H.L., Wu,S.F. and Bao,W.
  TITLE     CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane
            remodeling in endometrial carcinoma
  JOURNAL   Biochim Biophys Acta Gen Subj 1868 (1), 130497 (2024)
   PUBMED   37931722
  REMARK    GeneRIF: CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell
            membrane remodeling in endometrial carcinoma.
REFERENCE   2  (bases 1 to 1603)
  AUTHORS   Hermosilla Aguayo,V., Martin,P., Tian,N., Zheng,J., Aho,R., Losa,M.
            and Selleri,L.
  TITLE     ESCRT-dependent control of craniofacial morphogenesis with
            concomitant perturbation of NOTCH signaling
  JOURNAL   Dev Biol 503, 25-42 (2023)
   PUBMED   37573008
REFERENCE   3  (bases 1 to 1603)
  AUTHORS   Fu,J.L., Zheng,S.Y., Wang,Y., Hu,X.B., Xiao,Y., Wang,J.M.,
            Zhang,L., Wang,L., Nie,Q., Hou,M., Bai,Y.Y., Gan,Y.W., Liang,X.M.,
            Xie,L.L. and Li,D.W.
  TITLE     HSP90beta prevents aging-related cataract formation through
            regulation of the charged multivesicular body protein (CHMP4B) and
            p53
  JOURNAL   Proc Natl Acad Sci U S A 120 (31), e2221522120 (2023)
   PUBMED   37487085
  REMARK    GeneRIF: HSP90beta prevents aging-related cataract formation
            through regulation of the charged multivesicular body protein
            (CHMP4B) and p53.
REFERENCE   4  (bases 1 to 1603)
  AUTHORS   Zhou,Y., Bennett,T.M., White,T.W. and Shiels,A.
  TITLE     Charged multivesicular body protein 4b forms complexes with gap
            junction proteins during lens fiber cell differentiation
  JOURNAL   FASEB J 37 (4), e22801 (2023)
   PUBMED   36880430
REFERENCE   5  (bases 1 to 1603)
  AUTHORS   Lu,W., Li,D., Wei,S., Yang,J., Tang,C., Ma,X. and Zou,Y.
  TITLE     Long noncoding RNA Sh2d3c promotes manganese-induced neuronal
            apoptosis through the mmu-miR-675-5p/Chmp4b/Bax axis
  JOURNAL   Toxicol Lett 365, 24-35 (2022)
   PUBMED   35690225
  REMARK    GeneRIF: Long noncoding RNA Sh2d3c promotes manganese-induced
            neuronal apoptosis through the mmu-miR-675-5p/Chmp4b/Bax axis.
REFERENCE   6  (bases 1 to 1603)
  AUTHORS   Lee,J.A. and Gao,F.B.
  TITLE     Inhibition of autophagy induction delays neuronal cell loss caused
            by dysfunctional ESCRT-III in frontotemporal dementia
  JOURNAL   J Neurosci 29 (26), 8506-8511 (2009)
   PUBMED   19571141
REFERENCE   7  (bases 1 to 1603)
  AUTHORS   Wollert,T., Wunder,C., Lippincott-Schwartz,J. and Hurley,J.H.
  TITLE     Membrane scission by the ESCRT-III complex
  JOURNAL   Nature 458 (7235), 172-177 (2009)
   PUBMED   19234443
REFERENCE   8  (bases 1 to 1603)
  AUTHORS   Lee,J.A., Beigneux,A., Ahmad,S.T., Young,S.G. and Gao,F.B.
  TITLE     ESCRT-III dysfunction causes autophagosome accumulation and
            neurodegeneration
  JOURNAL   Curr Biol 17 (18), 1561-1567 (2007)
   PUBMED   17683935
  REMARK    Erratum:[Curr Biol. 2007 Sep 18;17(18):1622]
REFERENCE   9  (bases 1 to 1603)
  AUTHORS   Azmi,I., Davies,B., Dimaano,C., Payne,J., Eckert,D., Babst,M. and
            Katzmann,D.J.
  TITLE     Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a
            conserved VSL region in Vta1
  JOURNAL   J Cell Biol 172 (5), 705-717 (2006)
   PUBMED   16505166
REFERENCE   10 (bases 1 to 1603)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929557.15.
            
            On Jan 12, 2022 this sequence version replaced NM_029362.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059279.1, AK159193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               AL929557.15        60528-60870
            344-521             AL929557.15        93017-93194
            522-636             AL929557.15        94709-94823
            637-763             AL929557.15        96048-96174
            764-1603            AL929557.15        97443-98282
FEATURES             Location/Qualifiers
     source          1..1603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 76.79 cM"
     gene            1..1603
                     /gene="Chmp4b"
                     /gene_synonym="2010012F05Rik; Snf7-2"
                     /note="charged multivesicular body protein 4B"
                     /db_xref="GeneID:75608"
                     /db_xref="MGI:MGI:1922858"
     exon            1..343
                     /gene="Chmp4b"
                     /gene_synonym="2010012F05Rik; Snf7-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..828
                     /gene="Chmp4b"
                     /gene_synonym="2010012F05Rik; Snf7-2"
                     /note="chromatin-modifying protein 4b; chromatin modifying
                     protein 4B"
                     /codon_start=1
                     /product="charged multivesicular body protein 4b"
                     /protein_id="NP_083638.1"
                     /db_xref="CCDS:CCDS16938.1"
                     /db_xref="GeneID:75608"
                     /db_xref="MGI:MGI:1922858"
                     /translation="MSVFGKLFGAGGGKAGKGGPTPQEAIQRLRDTEEMLSKKQEFLE
                     KKIEQELTAAKKHGTKNKRAALQALKRKKRYEKQLAQIDGTLSTIEFQREALENANTN
                     TEVLKNMGYAAKAMKAAHDNMDIDKVDELMQDIADQQELAEEISTAISKPVGFGEEFD
                     EDELMAELEELEQEELDKNLLEISGPETVPLPNVPSVALPSKPAKKKEEEDDDMKELE
                     NWAGSM"
     exon            344..521
                     /gene="Chmp4b"
                     /gene_synonym="2010012F05Rik; Snf7-2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..636
                     /gene="Chmp4b"
                     /gene_synonym="2010012F05Rik; Snf7-2"
                     /inference="alignment:Splign:2.1.0"
     exon            637..763
                     /gene="Chmp4b"
                     /gene_synonym="2010012F05Rik; Snf7-2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..1603
                     /gene="Chmp4b"
                     /gene_synonym="2010012F05Rik; Snf7-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1064..1069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chmp4b"
                     /gene_synonym="2010012F05Rik; Snf7-2"
                     /note="hexamer: AATAAA"
     polyA_site      1087
                     /gene="Chmp4b"
                     /gene_synonym="2010012F05Rik; Snf7-2"
                     /note="major polyA site"
     regulatory      1579..1584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chmp4b"
                     /gene_synonym="2010012F05Rik; Snf7-2"
                     /note="hexamer: ATTAAA"
     polyA_site      1603
                     /gene="Chmp4b"
                     /gene_synonym="2010012F05Rik; Snf7-2"
                     /note="major polyA site"
ORIGIN      
        1 ggtggcgcgg ccgggcccag ctgcggggcg gaggtggagg cgaggcctgc ggctgcgggg
       61 agcggcaggc cgggagtggg cgcgggagcc gagccgagcc gagccgagcc gagccggagt
      121 gggcgccgga ggccggcgcg gcgagcagca accatgtcgg tgttcgggaa gctgttcggg
      181 gctggagggg gtaaggcggg caagggcggc ccgacccccc aggaggccat ccagcggctt
      241 cgggacacgg aggagatgtt aagcaagaag caggagttcc tggagaagaa aatcgaacag
      301 gagctgacgg ctgccaagaa gcacggcacc aaaaataaac gcgccgccct gcaggctctg
      361 aagcgcaaga agaggtatga gaagcagctg gcacaaattg atggcaccct gtcaaccatc
      421 gagttccagc gggaggccct agagaacgcc aacaccaaca cggaggtgct caagaacatg
      481 ggctatgccg ccaaggccat gaaggctgcc cacgacaaca tggacattga taaggtggat
      541 gagttaatgc aggacattgc tgaccagcaa gaacttgcag aggagatttc cacagctatc
      601 tccaaacctg tgggctttgg agaagagttc gacgaggatg agctcatggc agagttggag
      661 gaacttgaac aagaggagtt ggacaagaat ttgttggaga tcagtgggcc cgaaacagtc
      721 cctctaccaa atgtcccctc cgtagcccta ccatccaaac ccgccaagaa gaaggaagag
      781 gaagatgacg acatgaagga attggagaac tgggccggat ccatgtaact gttccagcag
      841 aggctgggcc cagacggact ctggtggcct gtgcatcggg caggcatgtg cgtgcgcagg
      901 gcaggcagga cgcggtgcag gcagcctcca tcgctcagct ctcacccaaa gcagtagccg
      961 caccactgct cactctcgca tagcatggtc tgtgcccagg ggtgggtggg gggagggggg
     1021 cgggggggag gtgcctgctg tttataatgt tgaatttctg taaaataaac tgtatttgca
     1081 aatccaacac tgagttgctg ggctgcgcta agcccactgc tgcgtcctct gtggagggtc
     1141 ggccgtttgc agttgaagcg aactggaaat gtagccctgc agctgacgtg tctcactctg
     1201 taagatgtgt acggtactgg cagaaaagtc gttttttaaa agccatagat aggcttttcc
     1261 ttgttcttag ctgtaataac acatctagtt ttggttccct caagagctgt gtttctgtct
     1321 gtcacctgtg tactggcccc atgtctacca tcctggccct tgtcactcct gtcccccctg
     1381 gtcttttgga gtttgtgaca cggatctgaa atggatgtgt tctcttgcaa gcgaataaga
     1441 ttgttagagt taattccagc tatccagttt tctaacgtag ctctaaggtc ctcattgctg
     1501 ttgtgataat tgatacatag ctcattggaa acgtgtgcat acatttatat tcagatgaaa
     1561 ttatggtttg caccgtctat taaatatctc gatttaattt tca
//
