LOCUS       NM_026885                927 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Mus musculus charged multivesicular body protein 2A (Chmp2a),
            transcript variant 2, mRNA.
ACCESSION   NM_026885
VERSION     NM_026885.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 927)
  AUTHORS   Yun,J., Saddawi-Konefka,R., Goldenson,B., Al-Msari,R.,
            Bernareggi,D., Thangaraj,J.L., Tang,S., Patel,S.H., Luna,S.M.,
            Gutkind,J.S. and Kaufman,D.
  TITLE     CHMP2A regulates broad immune cell-mediated antitumor activity in
            an immunocompetent in vivo head and neck squamous cell carcinoma
            model
  JOURNAL   J Immunother Cancer 12 (5), e007187 (2024)
   PUBMED   38702144
  REMARK    GeneRIF: CHMP2A regulates broad immune cell-mediated antitumor
            activity in an immunocompetent in vivo head and neck squamous cell
            carcinoma model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 927)
  AUTHORS   Hermosilla Aguayo,V., Martin,P., Tian,N., Zheng,J., Aho,R., Losa,M.
            and Selleri,L.
  TITLE     ESCRT-dependent control of craniofacial morphogenesis with
            concomitant perturbation of NOTCH signaling
  JOURNAL   Dev Biol 503, 25-42 (2023)
   PUBMED   37573008
REFERENCE   3  (bases 1 to 927)
  AUTHORS   Wang,H., Wang,Y., Wang,X., Huang,H., Bao,J., Zhong,W. and Li,A.
  TITLE     PTEN alleviates maladaptive repair of renal tubular epithelial
            cells by restoring CHMP2A-mediated phagosome closure
  JOURNAL   Cell Death Dis 12 (12), 1087 (2021)
   PUBMED   34789720
  REMARK    GeneRIF: PTEN alleviates maladaptive repair of renal tubular
            epithelial cells by restoring CHMP2A-mediated phagosome closure.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 927)
  AUTHORS   Gompers,A.L., Su-Feher,L., Ellegood,J., Copping,N.A., Riyadh,M.A.,
            Stradleigh,T.W., Pride,M.C., Schaffler,M.D., Wade,A.A.,
            Catta-Preta,R., Zdilar,I., Louis,S., Kaushik,G., Mannion,B.J.,
            Plajzer-Frick,I., Afzal,V., Visel,A., Pennacchio,L.A., Dickel,D.E.,
            Lerch,J.P., Crawley,J.N., Zarbalis,K.S., Silverman,J.L. and
            Nord,A.S.
  TITLE     Germline Chd8 haploinsufficiency alters brain development in mouse
  JOURNAL   Nat Neurosci 20 (8), 1062-1073 (2017)
   PUBMED   28671691
REFERENCE   5  (bases 1 to 927)
  AUTHORS   Wollert,T., Wunder,C., Lippincott-Schwartz,J. and Hurley,J.H.
  TITLE     Membrane scission by the ESCRT-III complex
  JOURNAL   Nature 458 (7235), 172-177 (2009)
   PUBMED   19234443
REFERENCE   6  (bases 1 to 927)
  AUTHORS   Azmi,I., Davies,B., Dimaano,C., Payne,J., Eckert,D., Babst,M. and
            Katzmann,D.J.
  TITLE     Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a
            conserved VSL region in Vta1
  JOURNAL   J Cell Biol 172 (5), 705-717 (2006)
   PUBMED   16505166
REFERENCE   7  (bases 1 to 927)
  AUTHORS   Fujita,H., Umezuki,Y., Imamura,K., Ishikawa,D., Uchimura,S.,
            Nara,A., Yoshimori,T., Hayashizaki,Y., Kawai,J., Ishidoh,K.,
            Tanaka,Y. and Himeno,M.
  TITLE     Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact
            with and regulate the function of an AAA-ATPase SKD1/Vps4B
  JOURNAL   J Cell Sci 117 (Pt 14), 2997-3009 (2004)
   PUBMED   15173323
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY157363.1, AK005267.1 and AC121301.8.
            
            On Jul 29, 2009 this sequence version replaced NM_026885.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012230.1, AK005267.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BY157363.1         2-34
            34-909              AK005267.1         2-877
            910-927             AC121301.8         107536-107553       c
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 7.73 cM"
     gene            1..927
                     /gene="Chmp2a"
                     /gene_synonym="1500016L11Rik; mVps2"
                     /note="charged multivesicular body protein 2A"
                     /db_xref="GeneID:68953"
                     /db_xref="MGI:MGI:1916203"
     exon            1..143
                     /gene="Chmp2a"
                     /gene_synonym="1500016L11Rik; mVps2"
                     /inference="alignment:Splign:2.1.0"
     exon            144..357
                     /gene="Chmp2a"
                     /gene_synonym="1500016L11Rik; mVps2"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..858
                     /gene="Chmp2a"
                     /gene_synonym="1500016L11Rik; mVps2"
                     /note="isoform a is encoded by transcript variant 2;
                     chromatin modifying protein 2A; chromatin-modifying
                     protein 2a; vacuolar protein sorting-associated protein 2"
                     /codon_start=1
                     /product="charged multivesicular body protein 2a isoform
                     a"
                     /protein_id="NP_081161.1"
                     /db_xref="CCDS:CCDS20824.1"
                     /db_xref="GeneID:68953"
                     /db_xref="MGI:MGI:1916203"
                     /translation="MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKII
                     ADIKKMAKQGQMDAVRIMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQA
                     MKGVTKAMGTMNRQLKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEES
                     DAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGGKKAEATASALADADADLEERLKN
                     LRRD"
     exon            358..537
                     /gene="Chmp2a"
                     /gene_synonym="1500016L11Rik; mVps2"
                     /inference="alignment:Splign:2.1.0"
     exon            538..668
                     /gene="Chmp2a"
                     /gene_synonym="1500016L11Rik; mVps2"
                     /inference="alignment:Splign:2.1.0"
     exon            669..730
                     /gene="Chmp2a"
                     /gene_synonym="1500016L11Rik; mVps2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..927
                     /gene="Chmp2a"
                     /gene_synonym="1500016L11Rik; mVps2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      902..907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chmp2a"
                     /gene_synonym="1500016L11Rik; mVps2"
                     /note="hexamer: AAGAAA"
     polyA_site      919
                     /gene="Chmp2a"
                     /gene_synonym="1500016L11Rik; mVps2"
                     /note="major polyA site"
ORIGIN      
        1 gtgtgacgtc aggtcgctta atccggaaac ggcggccgca gcaggggcta ccgaaccgag
       61 gggttgtcgt tggtggagtc tcaaggcttc ggaggggtag aggcgtgacc cggaagcgga
      121 aacccatcgt tctctcggct ccgctagttc tgacggttgt cccagacctg ctggtggagt
      181 cttaccacca tggacctgtt gtttgggcgc cggaagacgc cagaggaact acttcggcaa
      241 aaccagaggg ccctgaaccg agccatgaga gaactggaca gggaacgaca gaaactagaa
      301 acccaggaaa agaaaatcat tgcggacatc aaaaagatgg caaagcaagg ccagatggat
      361 gctgttcgaa tcatggcaaa agacctggtg cgtacccgga gatatgtacg caagtttgtg
      421 ttgatgcggg ccaacatcca agctgtgtcc ctcaagatac agactctaaa atccaacaac
      481 tcaatggcac aagccatgaa gggtgttact aaggccatgg gcactatgaa cagacagctg
      541 aaattacccc agatccagaa gatcatgatg gagtttgaac ggcaggcaga gatcatggac
      601 atgaaggaag aaatgatgaa tgacgcaatt gatgatgcca tgggtgatga ggaagatgaa
      661 gaggagagtg atgctgttgt gtcccaggtc ctggatgagc tgggactgag cctcacagat
      721 gagctgtcaa accttccctc cactggaggc tcactcagtg tggcagctgg tgggaagaaa
      781 gcagaggcca cagcctcagc cctggctgat gctgatgcag acctggaaga gaggctcaag
      841 aaccttcgca gggactgaaa acaccccacc ccaactcagt gcatcctgtc cccctgtaat
      901 aaagaaattt ggacactaat ttaccaa
//
