LOCUS       NM_145606               2188 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus charged multivesicular body protein 1A (Chmp1a), mRNA.
ACCESSION   NM_145606 NM_181487
VERSION     NM_145606.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2188)
  AUTHORS   Hermosilla Aguayo,V., Martin,P., Tian,N., Zheng,J., Aho,R., Losa,M.
            and Selleri,L.
  TITLE     ESCRT-dependent control of craniofacial morphogenesis with
            concomitant perturbation of NOTCH signaling
  JOURNAL   Dev Biol 503, 25-42 (2023)
   PUBMED   37573008
REFERENCE   2  (bases 1 to 2188)
  AUTHORS   Szakats,S., McAtamney,A., Cross,H. and Wilson,M.J.
  TITLE     Sex-biased gene and microRNA expression in the developing mouse
            brain is associated with neurodevelopmental functions and
            neurological phenotypes
  JOURNAL   Biol Sex Differ 14 (1), 57 (2023)
   PUBMED   37679839
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2188)
  AUTHORS   Guan,Y., Liang,X., Ma,Z., Hu,H., Liu,H., Miao,Z., Linkermann,A.,
            Hellwege,J.N., Voight,B.F. and Susztak,K.
  TITLE     A single genetic locus controls both expression of DPEP1/CHMP1A and
            kidney disease development via ferroptosis
  JOURNAL   Nat Commun 12 (1), 5078 (2021)
   PUBMED   34426578
  REMARK    GeneRIF: A single genetic locus controls both expression of
            DPEP1/CHMP1A and kidney disease development via ferroptosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2188)
  AUTHORS   Sun,N., Zhang,D., Ni,N., Tang,Z., Gao,H., Ju,Y., Dai,X., Wang,J.,
            Gu,P. and Ji,J.
  TITLE     miR-17 regulates the proliferation and differentiation of retinal
            progenitor cells by targeting CHMP1A
  JOURNAL   Biochem Biophys Res Commun 523 (2), 493-499 (2020)
   PUBMED   31894018
  REMARK    GeneRIF: miR-17 regulates the proliferation and differentiation of
            retinal progenitor cells by targeting CHMP1A.
REFERENCE   5  (bases 1 to 2188)
  AUTHORS   Coulter,M.E., Dorobantu,C.M., Lodewijk,G.A., Delalande,F.,
            Cianferani,S., Ganesh,V.S., Smith,R.S., Lim,E.T., Xu,C.S., Pang,S.,
            Wong,E.T., Lidov,H.G.W., Calicchio,M.L., Yang,E., Gonzalez,D.M.,
            Schlaeger,T.M., Mochida,G.H., Hess,H., Lee,W.A., Lehtinen,M.K.,
            Kirchhausen,T., Haussler,D., Jacobs,F.M.J., Gaudin,R. and
            Walsh,C.A.
  TITLE     The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog
            on a Distinctive Subtype of Extracellular Vesicles
  JOURNAL   Cell Rep 24 (4), 973-986 (2018)
   PUBMED   30044992
  REMARK    GeneRIF: Findings show CHMP1A loss impairs secretion of SHH on
            ART-EVs, providing molecular mechanistic insights into the role of
            ESCRT proteins and EVs in the brain.
REFERENCE   6  (bases 1 to 2188)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 2188)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2188)
  AUTHORS   Stauffer,D.R., Howard,T.L., Nyun,T. and Hollenberg,S.M.
  TITLE     CHMP1 is a novel nuclear matrix protein affecting chromatin
            structure and cell-cycle progression
  JOURNAL   J Cell Sci 114 (Pt 13), 2383-2393 (2001)
   PUBMED   11559747
REFERENCE   9  (bases 1 to 2188)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 2188)
  AUTHORS   Sasaki,N., Nagaoka,S., Itoh,M., Izawa,M., Konno,H., Carninci,P.,
            Yoshiki,A., Kusakabe,M., Moriuchi,T., Muramatsu,M., Okazaki,Y. and
            Hayashizaki,Y.
  TITLE     Characterization of gene expression in mouse blastocyst using
            single-pass sequencing of 3995 clones
  JOURNAL   Genomics 49 (2), 167-179 (1998)
   PUBMED   9598303
  REMARK    Erratum:[Genomics 1998 Dec 15;54(3):583]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY112937.1, AK159830.1 and CJ325786.1.
            
            On Apr 16, 2009 this sequence version replaced NM_145606.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036152.1, SRR1660819.8669.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN02415130
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BY112937.1         1-28
            29-2163             AK159830.1         2-2136
            2164-2188           CJ325786.1         453-477
FEATURES             Location/Qualifiers
     source          1..2188
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.08 cM"
     gene            1..2188
                     /gene="Chmp1a"
                     /gene_synonym="2900018H07Rik; Pcoln3"
                     /note="charged multivesicular body protein 1A"
                     /db_xref="GeneID:234852"
                     /db_xref="MGI:MGI:1920159"
     exon            1..123
                     /gene="Chmp1a"
                     /gene_synonym="2900018H07Rik; Pcoln3"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..707
                     /gene="Chmp1a"
                     /gene_synonym="2900018H07Rik; Pcoln3"
                     /note="procollagen (type III) N-endopeptidase;
                     chromatin-modifying protein 1a; chromatin modifying
                     protein 1A"
                     /codon_start=1
                     /product="charged multivesicular body protein 1a"
                     /protein_id="NP_663581.1"
                     /db_xref="CCDS:CCDS40509.1"
                     /db_xref="GeneID:234852"
                     /db_xref="MGI:MGI:1920159"
                     /translation="MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALQQKNVEC
                     ARVYAENAIRKKNEGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSA
                     MDLQKVSAVMDRFEQQVQNLDVHTSVMEDSVSSATTLTTPQEQVDSLIVQIAEENGLE
                     VLDQLSQLPEGASAVGESSVRSQEDQLSRRLAALRN"
     exon            124..143
                     /gene="Chmp1a"
                     /gene_synonym="2900018H07Rik; Pcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            144..221
                     /gene="Chmp1a"
                     /gene_synonym="2900018H07Rik; Pcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            222..368
                     /gene="Chmp1a"
                     /gene_synonym="2900018H07Rik; Pcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            369..497
                     /gene="Chmp1a"
                     /gene_synonym="2900018H07Rik; Pcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            498..685
                     /gene="Chmp1a"
                     /gene_synonym="2900018H07Rik; Pcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..2171
                     /gene="Chmp1a"
                     /gene_synonym="2900018H07Rik; Pcoln3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2148..2153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chmp1a"
                     /gene_synonym="2900018H07Rik; Pcoln3"
                     /note="hexamer: AATAAA"
     polyA_site      2168
                     /gene="Chmp1a"
                     /gene_synonym="2900018H07Rik; Pcoln3"
                     /note="major polyA site"
ORIGIN      
        1 gacagccggc cgcgcgaccg gaagcggtgg cgaccccgga agccctcgcg gagacagcgg
       61 gtccgtaaca tcgcgtcccc tgcgccgccc cgagggctgt gctagcccga ccggccatgg
      121 acgataccct gttccagttg aagttcacag cgaagcagct ggagaaactg gccaagaagg
      181 ccgagaagga ctccaaggct gagcaggcca aagtgaagaa ggcccttcag cagaaaaatg
      241 tggagtgtgc ccgggtgtat gctgaaaatg ccatccgcaa gaagaatgaa ggtgtaaatt
      301 ggctccgaat ggcctcccgt gtggacgcag tggcctccaa ggtgcagaca gctgtgacca
      361 tgaagggggt gaccaagaat atggcccagg tgaccaaggc tctggacaag gccctgagcg
      421 ccatggacct tcagaaggtg tctgcagtga tggacaggtt tgagcagcag gtgcagaacc
      481 tggatgtgca cacatcggta atggaggatt ccgtgagctc tgccaccacg ctgaccacgc
      541 ctcaggagca ggtcgacagc ctcattgtcc agatagctga ggaaaacggc ctggaggtcc
      601 tagaccagct cagccagctg ccagagggag cgtctgctgt gggcgagagc tctgtgcgca
      661 gccaggagga ccagctgtcc cggaggttgg ctgccctgag gaattagcac gtccgtggca
      721 gctgctgcct cccttgtcct gtgattgttc tggaggcttc tgcccaactg cttcactttc
      781 tccaaccctt cgtagctgcc tgggctcttt tccaacctgt caggctggcg ccttagaact
      841 gagccttagg ttgggcagcg ggtctctgtc ctggtattga atttgcacaa gtgtgtggtg
      901 acatatgtgc ttgtgggcca cagctggagg atggcaagct ttctgttgtc ctctgcctat
      961 gtggagttga cagggtttgg cctgcagatg tgtctggact tgagcccagt gctttggggc
     1021 cttgagactc cagcgactgc acacccgctc tgtgctgcgg ccagggaggg tgagaaccat
     1081 cgctcctttg ccaggtaact cttgggagcc tctccccctt ctgcatagag gaaatcccag
     1141 tgtgtgacag cccttaaggt tcctgtggac tttgtgtacc aaggtgtcca gtgccaccaa
     1201 cactgacctg gggcctttac aaatggttgc tctcctccat cttcccaggg ctgcggtcct
     1261 ggtgtctact gccggccggc tgagtctgcg tgggctttct gtctctcagc tccctttccc
     1321 agcccacagg gacagaagta ccatccactt tcaagtccag ctccttccta agagattctt
     1381 ccaccttact ctgcagctgc ctctggaaga actttgggct gctggggctg agctgtctgc
     1441 ttgatgctga cagactccta gtgtcagctc ccaggccgcc ttagagctgc tcattcctga
     1501 atgactggct cccctgccct tttagacaaa ggctgctgct ttcagccttc tccaagggag
     1561 agcctggctg gctaacagag ggagcctgag tcagtcacat ctggcagctg gcagcaagct
     1621 cttcatccct ccacagtgag gaagctggca gcgagcaggt agacctggag actgcacggc
     1681 tgctgattgg tcttctatct cctgaagttt actcatgttc ttaaaactcc tggtgacttt
     1741 gttcttttgc caacgtagaa agcacagtgg acgggttgtg tttgtcccag ccctctctgt
     1801 aggctgagca gtgcagcggc gcccacaggt ttacacacaa gtttggtttg gtttcttctg
     1861 ttctgcactt tggagtccct gggtattcca cattacaagt tgatgttata ggtgggggct
     1921 ggaattgttg ccctggatgt ggggaccaag gtacaatcta accatgggcc cccacaaggc
     1981 ttcctgaaat caaatgttag gtgttgagag tagctgcagt ctcgggataa cttgtgagtt
     2041 ccctgggtcc tggagggtgc agggtttgtg gaacagtagt agggatgggg agctgggctg
     2101 ggttcatcag aatgggcgtg tctgccttca cagtgctgtc ctaagtaaat aaagggattg
     2161 gtgaagaacg taaaaaaaaa aaaaaaaa
//
