LOCUS       NM_021350               6907 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus choroideremia-like (Chml), mRNA.
ACCESSION   NM_021350
VERSION     NM_021350.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6907)
  AUTHORS   Namiki,Y., Endoh,D. and Kon,Y.
  TITLE     Genetic mutation associated with meiotic metaphase-specific
            apoptosis in MRL/MpJ mice
  JOURNAL   Mol Reprod Dev 64 (2), 179-188 (2003)
   PUBMED   12506350
REFERENCE   2  (bases 1 to 6907)
  AUTHORS   Kasper,G., Taudien,S., Staub,E., Mennerich,D., Rieder,M.,
            Hinzmann,B., Dahl,E., Schwidetzky,U., Rosenthal,A. and Rump,A.
  TITLE     Different structural organization of the encephalopsin gene in man
            and mouse
  JOURNAL   Gene 295 (1), 27-32 (2002)
   PUBMED   12242008
REFERENCE   3  (bases 1 to 6907)
  AUTHORS   Barrat,F.J., Depetris,D., Certain,S., Mattei,M.G. and de Saint
            Basile,G.
  TITLE     Localization of the Rab escort protein-2 (REP2) and inositol
            1,4,5-trisphosphate 3-kinase (ITPKB) genes to mouse chromosome 1 by
            in situ hybridization and precision of the syntenic regions between
            mouse and human 1q42-q44
  JOURNAL   Genomics 43 (1), 111-113 (1997)
   PUBMED   9226383
REFERENCE   4  (bases 1 to 6907)
  AUTHORS   van den Hurk,J.A., Hendriks,W., van de Pol,D.J., Oerlemans,F.,
            Jaissle,G., Ruther,K., Kohler,K., Hartmann,J., Zrenner,E., van
            Bokhoven,H., Wieringa,B., Ropers,H.H. and Cremers,F.P.
  TITLE     Mouse choroideremia gene mutation causes photoreceptor cell
            degeneration and is not transmitted through the female germline
  JOURNAL   Hum Mol Genet 6 (6), 851-858 (1997)
   PUBMED   9175730
REFERENCE   5  (bases 1 to 6907)
  AUTHORS   Tchernev,V.T., Barbosa,M.D., Detter,J.C., Patel,T.D., Achey,K.,
            Wakeland,E.K., Gueorguieva,R.V., Yang,M.C., Gossler,A. and
            Kingsmore,S.F.
  TITLE     Genetic mapping of 20 novel expressed sequence tags from
            midgestation mouse embryos suggests chromosomal clustering
  JOURNAL   Genomics 40 (1), 170-174 (1997)
   PUBMED   9070936
REFERENCE   6  (bases 1 to 6907)
  AUTHORS   Barbosa,M.D., Johnson,S.A., Achey,K., Gutierrez,M.J., Wakeland,E.K.
            and Kingsmore,S.F.
  TITLE     Genetic mapping of the choroideremia-like, rab escort protein-2
            gene on mouse chromosome 1
  JOURNAL   Mamm Genome 6 (7), 488-489 (1995)
   PUBMED   7579897
REFERENCE   7  (bases 1 to 6907)
  AUTHORS   Cremers,F.P., Molloy,C.M., van de Pol,D.J., van den Hurk,J.A.,
            Bach,I., Geurts van Kessel,A.H. and Ropers,H.H.
  TITLE     An autosomal homologue of the choroideremia gene colocalizes with
            the Usher syndrome type II locus on the distal part of chromosome
            1q
  JOURNAL   Hum Mol Genet 1 (2), 71-75 (1992)
   PUBMED   1301160
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124366.4.
            
            On Oct 20, 2022 this sequence version replaced NM_021350.2.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.77700.1,
                                           SRR1660819.14904.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-463               AC124366.4         134190-134652       c
            464-6907            AC124366.4         124257-130700       c
FEATURES             Location/Qualifiers
     source          1..6907
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 81.7 cM"
     gene            1..6907
                     /gene="Chml"
                     /gene_synonym="E030003F13Rik; REP-2; Rep2"
                     /note="choroideremia-like"
                     /db_xref="GeneID:12663"
                     /db_xref="MGI:MGI:101913"
     exon            1..463
                     /gene="Chml"
                     /gene_synonym="E030003F13Rik; REP-2; Rep2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..6907
                     /gene="Chml"
                     /gene_synonym="E030003F13Rik; REP-2; Rep2"
                     /inference="alignment:Splign:2.1.0"
     CDS             791..2656
                     /gene="Chml"
                     /gene_synonym="E030003F13Rik; REP-2; Rep2"
                     /note="rab escort protein-2; choroideremia-like protein;
                     choroideraemia-like protein"
                     /codon_start=1
                     /product="rab proteins geranylgeranyltransferase component
                     A 2"
                     /protein_id="NP_067325.2"
                     /db_xref="CCDS:CCDS35796.1"
                     /db_xref="GeneID:12663"
                     /db_xref="MGI:MGI:101913"
                     /translation="MAEKLPTEFDVVIIGTGLPESILAAACSRSGQRVLHVDSRSYYG
                     GNWASFSFTGLQSWLKDYQQNHDSEEGVTATWQDLIHETEEAISLRKKDETIQHTEVF
                     CYASQDVEDSVQDTETLQRSSPLEASATPADSLDSASLPKERQSAYSTSYEVPSRHTE
                     ESDRELSLPSANVEDSLEKEKYCGDKTDMHTVSGEDKGEHKLVVQDSIEQPKRNRITY
                     SQMVKESRRFNIDLVSKPLYSQGSLIDLLIKSNVSRYAEFKNVTRILAFWEGKVEQVP
                     CSRADVFNSKELSMVEKRMLMKFLTFCLDYEQHSDEYQDFKQCSFSDYLKTKKLTPNL
                     QHFILHSIAMTSESSCTTLDGLQATKTFLQCLGRFGNTPFIFPLYGHGEIPQCFCRMC
                     AVFGGVYCLRHKVQCLVVDKDSGRCKGIIDAFGQRISANYFIVEDSYLPKETCSNVQY
                     KQISRAVLITDQSILKTDSDQQISILVVPPLEPGTTSVRVMELCSSTMTCMKDSYLVH
                     LTCSSSKTAREDLEPVVKQLFIPEAEAEAGKDELRKPRLLWALYFNMRDSSGVSRSSY
                     CGLPSNVYICSGPDWGLGSEHAVKQAETLFQEIFPSEEFCPPPPNPEDIIFEAEG"
     regulatory      6886..6891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chml"
                     /gene_synonym="E030003F13Rik; REP-2; Rep2"
                     /note="hexamer: AATAAA"
     polyA_site      6907
                     /gene="Chml"
                     /gene_synonym="E030003F13Rik; REP-2; Rep2"
                     /note="major polyA site"
ORIGIN      
        1 acaatggcct gagcggcccg cagagcgtga gatccaccct gttcgggccg cccggctcac
       61 cgagccctct ctctcacggc gcgccggcgt cgggccatgt actcggggaa ccgtagtggc
      121 gaccagggct actgggagga cggggcgggc gccgagggcg cagcaccggc gggcacgcgg
      181 agccccgcgc ctctcttcag ccccaccgcg tacgagcgcc tggcgctgct actcggctgc
      241 ctcgcgctgc tgggcgtcgg cggcaacctg ctggtgctgc ttctctactc caagttcccg
      301 agactgcgca cgcccaccca cctcttcctg gtcaacctga gcctgggcga cctgctggta
      361 tccctgttcg gagtcacctt caccttcgcg tcgtgcctgc ggaacggctg ggtgtgggac
      421 gccgtgggct gcgcgtggga cgggtttagc ggcagcctct ttgagaagag ttccagcaca
      481 cacgcatatg tgatgcatgg taacatttac cgctatggtg aaatgcagaa atggaaagga
      541 cacagccgtt tgcgtattct cagataatgg ttacatgcac tttgtcgtgt tttccaaact
      601 actgactttt tttttttaat gtttaaaaat tgtaacagtt aaaagcttag gacttaaaaa
      661 ctcagtgttt ccgaatgaac atcacaagtc gagattttat tacagcatca gtacctcaga
      721 agagccctca acctagatct atacggtgtt ctttcatcag ctgtggcccg aagcttcatc
      781 agctcctagg atggcggaga agcttcccac agagtttgat gtggtaataa tagggacagg
      841 cttgccggag tccatcctgg cagctgcatg ttcaagaagt ggacagagag ttctgcatgt
      901 tgactcaagg agttactatg gagggaattg ggcgagtttc agctttacag gtttgcagtc
      961 ctggctgaag gactatcaac agaaccatga cagcgaggaa ggcgtgaccg ccacatggca
     1021 agacctgatc catgaaacag aagaagccat ctctcttcgc aagaaggatg aaactattca
     1081 gcacacagaa gtcttctgtt atgctagtca agatgtggag gacagcgtgc aagacaccga
     1141 gactctgcag agaagttccc ccctagaggc atctgctact ccggctgact ctctggattc
     1201 tgcaagcttg cccaaagaaa ggcagtcagc ttactctaca agctatgaag tgccttctag
     1261 acatacagag gaaagtgata gagagctttc actaccctca gctaatgtgg aggactcact
     1321 ggagaaagaa aagtactgtg gcgataagac ggatatgcac acagtttcag gtgaagataa
     1381 aggtgaacac aaacttgttg tacaagacag cattgaacaa ccaaagagaa ataggattac
     1441 ttactctcaa atggttaagg agagccggag atttaatatt gacttggtat caaagccgct
     1501 gtattctcaa gggtcactga ttgatcttct aatcaaatca aatgttagtc gttatgcaga
     1561 atttaagaat gtcactagga tccttgcatt ttgggaaggg aaggtagaac aggtgccttg
     1621 ctccagagca gatgtcttta atagtaaaga gctcagtatg gttgaaaaga gaatgctaat
     1681 gaagtttctt acattctgtt tagactatga acaacattct gatgaatacc aagatttcaa
     1741 acagtgttca ttttctgact acttaaaaac taaaaaacta acacctaatc tccagcactt
     1801 catactacac tcaattgcaa tgacatcaga atcatcttgc actacattag atggccttca
     1861 agcaacaaaa acctttcttc agtgtcttgg acggtttggc aatactccct ttatatttcc
     1921 tttatacggc cacggagaaa ttccccagtg tttctgcagg atgtgtgcag tttttggtgg
     1981 agtctattgt cttcgccata aagtacaatg ccttgtagtt gacaaagact ctggaagatg
     2041 taaaggaatc atagatgcct ttggtcagag aataagtgcc aactacttta ttgtggagga
     2101 cagttatctt cctaaggaaa catgttcaaa cgtgcaatat aagcagatct caagggcagt
     2161 gctcatcaca gatcagtcca tcctgaagac agattcggac cagcagattt ccattttggt
     2221 agtgcctcct ctggagccag gaaccacttc tgttcgggtc atggaattat gttcgtcaac
     2281 catgacatgc atgaaggaca gctatctggt ccacctgacc tgttcctctt caaaaacagc
     2341 cagagaagac ttggaacctg tggtgaagca gttattcatt cctgaagcag aagcagaagc
     2401 aggcaaagat gaactccgaa aaccaagact cttgtgggct ctttatttta atatgagaga
     2461 ttcctcagga gtgagccgaa gctcatactg tggcttacct tccaatgtgt acatctgctc
     2521 tgggcctgac tggggactgg ggagtgagca tgcagtcaag caggcggaaa cactgttcca
     2581 agagattttt cccagtgaag agttctgccc tcctccacca aaccctgaag acatcatctt
     2641 tgaagctgag ggttagcaac cctccaaaca catatggaac tgactacgtt caaaacctta
     2701 atcttctggc aatcctggag ttagtaatac actcaccact aagctagaca ccccaaggac
     2761 agtaagaact tttaaatcct ataacacctt caaaaacaaa aggaaacact ggaaatgctt
     2821 catcctggct tcaaaacatt gccatatgaa agaataagca gcagtaactg tgtaagaaac
     2881 actgttcacg tgtcttcaac agtgagatac tgggtcccgc taacctttca gcaacagctc
     2941 tgttggtgac tcggctcttt tgtttcagaa ttggctccag gaattcagaa tctttgaatg
     3001 gtgttcactt ttattttact ttggggtccc tcattagcac ctttgtttac cttaagggaa
     3061 tatcacactt gctcctgtgt ttaggtttta ttattattat ttttttacac aatgcccaag
     3121 gactattata gctactgctg ccgctactgt tgttggtacc acctcagata catagaggga
     3181 cacataaatc ataaactgag aggttttttt ttttgtatat tacataacac atagagatgg
     3241 taggagtagc agctaattca agtgccatgt gataagttta gctgtgcatt ctgctgtgtc
     3301 ttcgggttga taattacatg tgaattcatt cacctgcttg accgttggaa ctcaggaggc
     3361 agtgagacta ccctagccgc ctactttata agacatacct tttagaagtc caagaaattc
     3421 atatttagga gattcatcac aatctgggca tggtggctca ctcgtgtaat cctgtcattc
     3481 aggagactga ggcaggagga ttgctgtaac ccaagccagt ctgggctaca gtgttgagac
     3541 aatttcaaaa caaaacaatc ctcctcccac caaaaagaag tacattataa agaaaactag
     3601 gaacaagatt tattcagaaa aaaatttata gacttgacaa tatttaactc ccaactcagg
     3661 ctaacataaa ttaataaatt accccagaaa aagatacttc aggacagaca ttaagaaatt
     3721 atcagaaagg aattcctggg gaggaacagt ggtacatctt aatgtgggat tataggtaac
     3781 tttacatttt agatagattt ccccatccag gcttctcagg tgaagcatgc cacctggttg
     3841 gctggaattt cataagcact ggtaatggac agagggtatg actactacat gtctgttacc
     3901 tggagacggg aggttttccc tctagaacta cctgctacac cccagcagtg aaaaccctct
     3961 gtactgtggg aaggggacta cagtatgctc tcagtatatt cttactcctc tttagtgagg
     4021 aaagcagggc cagccagcca ttcacatgaa tgacacatgc tgagagtaga cagccattga
     4081 ttggtcttag tgtttgcttt ttttaataca acaaagtgaa aacattgggt agatcttaag
     4141 gtttaaatct agcctaacaa ctgaaatacc tgaaatgacc taaaaatagc aattaagaaa
     4201 ataacaattc taagatcagc aaaatggatg gtaaaaagtg agagcaattc aagcccacta
     4261 tataaagtca gtcaggacga cagtctatta ttccacagac atttaaaaga ggtatagctg
     4321 taaaagataa acagacattt caaaagacag aactgaatgt aatggaacta aagattagac
     4381 taggccaaag tactgtttgt ttgtttgttt gtttgtttgt ttgttttaaa ctaaggaagt
     4441 gaatacatta ctttaaataa tcacaaaata ataagttgga agtgagacag accagtaaaa
     4501 agtattaaac cagtaaaacc tattaggagt attatctaat tttctaacaa gttagaatag
     4561 gcttattgta gtttctagat gtttaagaaa taaaatcata aatgctgctt ttcaccaatt
     4621 atattttaag tcaatgaggg ctccattcta aaaatcaaac aaaggtcctc attccgggta
     4681 ggtgggagct gcagaataca gtgttggcaa agagctaaca acaaacagaa agaattactt
     4741 acagtgactc aggagcagag ggctgtgtcc agtagaggag ccatacctcc gcaggaacag
     4801 gacagaaccc ttagtactaa ctgcactaac cagaacctta ctcacatttg ctttaattat
     4861 gtttgctaat gattttgtag gcttttcata atatgataag caactactta aaacttaact
     4921 caaatttata ttgggaaagc aggtatgaac catttctcaa gcagaaatga aaggccttgc
     4981 tactattttc atctgtatat ggctgaaaaa attgtcactg gaataaaaat gcaaagtaaa
     5041 gatgcagaaa gaaatcagtg taaatatatt ttatttctat ggctttataa tttataaaac
     5101 ctataacaaa catattacaa acagaagata atttcacaag ttgcaagata catagttact
     5161 taaaatctct agattccaac agtgatggaa atttaaaaag catccacaca cacatataga
     5221 tatatataca cacacataca tgtatatata tatttaaaat gttatataac tatattagaa
     5281 taatttaaga aatatactaa aatagaaggt ttaatgaagg agctaaattt aaaatatgag
     5341 tatgctccca tgagacctat cttgaagaaa atgctataaa cacagaaaga cctcacatca
     5401 ttcactactg gttgtgtgat ctcttagcaa tcactttcag cttccattca ccgtctataa
     5461 agtagctata atacttaaca gaattactgt gaagatcagg ttgaataata cataagaact
     5521 catatctaaa gtaatgccag catatggtat ttgtatgtaa atggttttat tataatatca
     5581 tttgtgatac caagcttatg ctttatgtaa tttgagagaa ttgtgataag ttatccagga
     5641 aagtaagcag ggaaagctac tgtaaatttt agaggggaaa atacagggct ttgcccttca
     5701 agtccttaag gcatgataac tgtgcaacct atctaaatct tctgtagtgc tgaattcaag
     5761 aaagttaaga ctagctaggt atctggatgg aagtatttag aagctgctca taggaagact
     5821 gcattagtat agagataggt actaggtcca cttttcatca agtaatgcag tttatttgta
     5881 aatgaaactg ttaagcataa acgtaataag actatgattt ttaccctagt catggtgcca
     5941 ggaatgttct ggcagtgaac attgacaagt tacattaacc aaacttaaac tgaaaaacca
     6001 taaaaataaa aataaacaag gacagaaggt ggaataaaaa agcagttgct atttcgtaga
     6061 gttttttgtt ttgtttttgt ttttaatttt tactttagtt tagtttttca agacggggtt
     6121 tctctgtgta accctggctg tcctggagct ctatagacca ggctggcctc aaactctagg
     6181 agagctgcct gcctctgcct cccaagtgct ggcattaaag gtgtgtgctt ggcttgtttt
     6241 tattaatatt tttaagtggg tgcaaaatct ttaggcttcc tgttcttctt gtgcatagaa
     6301 taaagtgata ggttgcaaaa gagaaaaaaa gaagtaaaaa taatttcctt gatcctcaaa
     6361 ttaatatgca ttaaaataga gtttggagca atgttgactg agttcctact attttgaaat
     6421 ctgcatgagt cttctcacag taacatcgtg tattcatggt cattttgaag aactacttta
     6481 ggagattaac cagactgcta taacagtatt tttgacatca ctttgagtag cacatgccca
     6541 ggaaaatact tagaatgaac taatgaataa ataaagctac ttttaaacag ctattctagc
     6601 aattccattt atacaacttt ttaaaaacgc cagctaagag atggataaat tttgctgtgt
     6661 tgctagtgtt attataggct tacagagagt taaatggcac atatatgatt atatggaaac
     6721 atgtctgagg atcagaacaa tgttagttta caccagaaat tattgcgtgc tgattacatt
     6781 tgtgtaaaac tttagacctc tacactgaaa ggaatcagaa ggcatgtaac tacaggctaa
     6841 tatatgatct ttttgtttct gtaagatatt aatgtgtaga actaaaataa acgattaatt
     6901 ggtgaaa
//
