LOCUS       NM_001284525            1851 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus chitinase 1 (Chit1), transcript variant 1, mRNA.
ACCESSION   NM_001284525
VERSION     NM_001284525.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1851)
  AUTHORS   Sklepkiewicz,P., Dymek,B.A., Mlacki,M., Koralewski,R., Mazur,M.,
            Nejman-Gryz,P., Korur,S., Zagozdzon,A., Rymaszewska,A., von der
            Thusen,J.H., Siwinska,A.M., Guner,N.C., Cheda,L.,
            Paplinska-Goryca,M., Proboszcz,M., van den Bosch,T.P.P., Gorska,K.,
            Golab,J., Kaminski,R.M., Krenke,R., Golebiowski,A., Dzwonek,K. and
            Dobrzanski,P.
  TITLE     Inhibition of CHIT1 as a novel therapeutic approach in idiopathic
            pulmonary fibrosis
  JOURNAL   Eur J Pharmacol 919, 174792 (2022)
   PUBMED   35122869
REFERENCE   2  (bases 1 to 1851)
  AUTHORS   Kimura,M., Watanabe,T., Sekine,K., Ishizuka,H., Ikejiri,A.,
            Sakaguchi,M., Kamaya,M., Yamanaka,D., Matoska,V., Bauer,P.O. and
            Oyama,F.
  TITLE     Comparative functional analysis between human and mouse
            chitotriosidase: Substitution at amino acid 218 modulates the
            chitinolytic and transglycosylation activity
  JOURNAL   Int J Biol Macromol 164, 2895-2902 (2020)
   PUBMED   32853624
  REMARK    GeneRIF: Comparative functional analysis between human and mouse
            chitotriosidase: Substitution at amino acid 218 modulates the
            chitinolytic and transglycosylation activity.
REFERENCE   3  (bases 1 to 1851)
  AUTHORS   Sharma,L., Amick,A.K., Vasudevan,S., Lee,S.W., Marion,C.R., Liu,W.,
            Brady,V., Losier,A., Bermejo,S.D., Britto,C.J., Lee,C.G.,
            Elias,J.A. and Dela Cruz,C.S.
  TITLE     Regulation and Role of Chitotriosidase during Lung Infection with
            Klebsiella pneumoniae
  JOURNAL   J Immunol 201 (2), 615-626 (2018)
   PUBMED   29891554
  REMARK    GeneRIF: these data show a detrimental role of chit1 in Klebsiella
            pneumoniae lung infections
REFERENCE   4  (bases 1 to 1851)
  AUTHORS   Van Dyken,S.J., Liang,H.E., Naikawadi,R.P., Woodruff,P.G.,
            Wolters,P.J., Erle,D.J. and Locksley,R.M.
  TITLE     Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic
            Lung Disease
  JOURNAL   Cell 169 (3), 497-509 (2017)
   PUBMED   28431248
REFERENCE   5  (bases 1 to 1851)
  AUTHORS   Canto,E., Espejo,C., Costa,C., Montalban,X. and Comabella,M.
  TITLE     Breast regression protein-39 is not required for experimental
            autoimmune encephalomyelitis induction
  JOURNAL   Clin Immunol 160 (2), 133-141 (2015)
   PUBMED   26079949
  REMARK    GeneRIF: No significant differences were observed between
            experimental autoimmune encephalitis and control groups for CHIT-1
            expression.
REFERENCE   6  (bases 1 to 1851)
  AUTHORS   Wiesner,D.L., Specht,C.A., Lee,C.K., Smith,K.D., Mukaremera,L.,
            Lee,S.T., Lee,C.G., Elias,J.A., Nielsen,J.N., Boulware,D.R.,
            Bohjanen,P.R., Jenkins,M.K., Levitz,S.M. and Nielsen,K.
  TITLE     Chitin recognition via chitotriosidase promotes pathologic type-2
            helper T cell responses to cryptococcal infection
  JOURNAL   PLoS Pathog 11 (3), e1004701 (2015)
   PUBMED   25764512
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1851)
  AUTHORS   Kitamoto,S., Egashira,K., Ichiki,T., Han,X., McCurdy,S., Sakuda,S.,
            Sunagawa,K. and Boisvert,W.A.
  TITLE     Chitinase inhibition promotes atherosclerosis in hyperlipidemic
            mice
  JOURNAL   Am J Pathol 183 (1), 313-325 (2013)
   PUBMED   23685110
  REMARK    GeneRIF: CHIT1 exerts protective effects against atherosclerosis by
            suppressing inflammatory responses and polarizing macrophages
            toward an M2 phenotype, and promoting lipid uptake and cholesterol
            efflux in macrophages.
REFERENCE   8  (bases 1 to 1851)
  AUTHORS   Lee,C.G., Herzog,E.L., Ahangari,F., Zhou,Y., Gulati,M., Lee,C.M.,
            Peng,X., Feghali-Bostwick,C., Jimenez,S.A., Varga,J. and Elias,J.A.
  TITLE     Chitinase 1 is a biomarker for and therapeutic target in
            scleroderma-associated interstitial lung disease that augments
            TGF-beta1 signaling
  JOURNAL   J Immunol 189 (5), 2635-2644 (2012)
   PUBMED   22826322
REFERENCE   9  (bases 1 to 1851)
  AUTHORS   Boot,R.G., Bussink,A.P., Verhoek,M., de Boer,P.A., Moorman,A.F. and
            Aerts,J.M.
  TITLE     Marked differences in tissue-specific expression of chitinases in
            mouse and man
  JOURNAL   J Histochem Cytochem 53 (10), 1283-1292 (2005)
   PUBMED   15923370
REFERENCE   10 (bases 1 to 1851)
  AUTHORS   Zheng,T., Rabach,M., Chen,N.Y., Rabach,L., Hu,X., Elias,J.A. and
            Zhu,Z.
  TITLE     Molecular cloning and functional characterization of mouse
            chitotriosidase
  JOURNAL   Gene 357 (1), 37-46 (2005)
   PUBMED   16005164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009012.1, BC138765.1 and AY536287.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer protein (isoform 1). Variants 1
            and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138765.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AK009012.1         2-35
            35-1733             BC138765.1         1-1699
            1734-1800           AY536287.1         1572-1638
            1801-1851           AK009012.1         1531-1581
FEATURES             Location/Qualifiers
     source          1..1851
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.12 cM"
     gene            1..1851
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /note="chitinase 1"
                     /db_xref="GeneID:71884"
                     /db_xref="MGI:MGI:1919134"
     exon            1..121
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            122..289
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1659
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /EC_number="3.2.1.14"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; chitotriosidase-1; chitinase 1
                     (chitotriosidase)"
                     /codon_start=1
                     /product="chitotriosidase-1 isoform 1 precursor"
                     /protein_id="NP_001271454.1"
                     /db_xref="CCDS:CCDS15304.1"
                     /db_xref="GeneID:71884"
                     /db_xref="MGI:MGI:1919134"
                     /translation="MVQSLAWAGVMTLLMVQWGSAAKLVCYLTNWSQYRTEAVRFFPR
                     DVDPNLCTHVIFAFAGMDNHQLSTVEHNDELLYQELNSLKTKNPKLKTLLAVGGWTFG
                     TQKFTDMVATASNRQTFVKSALSFLRTQGFDGLDLDWEFPGGRGSPTVDKERFTALIQ
                     DLAKAFQEEAQSSGKERLLLTAAVPSDRGLVDAGYEVDKIAQSLDFINLMAYDFHSSL
                     EKTTGHNSPLYKRQGESGAAAEQNVDAAVTLWLQKGTPASKLILGMPTYGRSFTLASS
                     SDNGVGAPATGPGAPGPYTKDKGVLAYYEACSWKERHRIEDQKVPYAFQDNQWVSFDD
                     VESFKAKAAYLKQKGLGGAMVWVLDLDDFKGSFCNQGPYPLIRTLRQELNLPSETPRS
                     PEQIIPEPRPSSMPEQGPSPGLDNFCQGKADGVYPNPGDESTYYNCGGGRLFQQSCPP
                     GLVFRASCKCCTWS"
     exon            290..319
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            320..521
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            522..578
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            579..744
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            745..869
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            870..993
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1179
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1287
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1414
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1851
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtttctcct gactgcagtt ggaacaagtt gtagagctct cggctccttc tccagcacca
       61 agtcggccta gacagtgcca tgcttctcac catgatgatg atggattaaa ccgctgaaac
      121 tgcatcgatt tcaacatttc tggttgtact gctgcaggcc cgtcagagga gagcagatca
      181 ggacctgtgg agccagtcac aggagagcac ggcaggacct gtggagcggg tactcacaga
      241 gctgatatcc ccagagcctt catcatggtg cagtccctgg cctgggcagg tgtgatgact
      301 ctgctgatgg tccagtgggg ctctgctgca aaactggtct gctacctcac caactggtcc
      361 cagtaccgga cggaggcagt tcggttcttt cccagggatg tggatcccaa cctgtgtacc
      421 cacgtcatct ttgcttttgc tggaatggac aaccatcagc tcagcactgt ggagcacaat
      481 gacgaacttc tctaccagga gctgaacagc ctaaagacta agaaccccaa gctcaagacc
      541 ctgttagccg ttggaggctg gacctttggt acccagaagt tcacagacat ggtggccacc
      601 gccagcaacc ggcagacctt tgtgaagtca gccctaagtt tcctgcgcac tcaaggtttt
      661 gatggccttg accttgactg ggagttccca ggtggacgtg ggagccccac agtagacaaa
      721 gagagattca cagccctgat acaggacttg gccaaagcct tccaggagga agcccagtcc
      781 tcagggaagg aacgcctcct tctgactgca gctgtaccga gtgatcgagg cctggtggat
      841 gctggctacg aggtggacaa gattgcccag agcttggatt tcatcaacct tatggcctac
      901 gacttccaca gctccttgga aaagaccaca gggcataaca gccccctcta caaaaggcaa
      961 ggagaaagtg gggcagccgc tgagcaaaac gtggatgctg ctgtgacgct ctggctgcag
     1021 aaggggaccc cagccagcaa actgatcctt ggcatgccta cctatggacg ctctttcacc
     1081 ttggcctcct cgtcagacaa tggagttggg gccccagcca cagggcctgg tgccccaggc
     1141 ccctatacga aggacaaagg ggtcctggct tactatgagg cctgctcctg gaaggaaaga
     1201 cacagaatcg aggaccagaa ggtgccttac gccttccagg acaaccagtg ggtgagcttt
     1261 gacgacgtgg aaagcttcaa agccaaggct gcctacctga aacagaaggg gctgggagga
     1321 gccatggtct gggtcctgga cttggatgac ttcaagggtt ccttctgcaa ccagggcccg
     1381 taccctctca tccggacact acggcaggaa ctaaatcttc catccgagac tccaaggagc
     1441 ccagaacaga taatacctga gccacgccca tcttctatgc cagagcaggg acccagccca
     1501 gggctagata acttctgcca aggcaaagct gatggggtct accccaaccc tggagacgag
     1561 tccacttact acaactgtgg aggagggcgg ctgttccagc agagctgtcc tccaggcctg
     1621 gtgtttagag cctcttgcaa atgttgtacc tggagctaag ttcctggaac cccatccaac
     1681 tccagtctga ggccaggctt ggggtccccc accacctgcc tctgctttcc ctggggcctg
     1741 caggcctctc tgttccttcc atgcccccac ctctgatcag cttcttggtt tcctttttgt
     1801 ctcttttagg cttcctcttt atctgaaaaa taaacatatt tttcacccct g
//
