LOCUS       NP_001271454             464 aa            linear   ROD 02-APR-2024
DEFINITION  chitotriosidase-1 isoform 1 precursor [Mus musculus].
ACCESSION   NP_001271454
VERSION     NP_001271454.1
DBSOURCE    REFSEQ: accession NM_001284525.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 464)
  AUTHORS   Sklepkiewicz,P., Dymek,B.A., Mlacki,M., Koralewski,R., Mazur,M.,
            Nejman-Gryz,P., Korur,S., Zagozdzon,A., Rymaszewska,A., von der
            Thusen,J.H., Siwinska,A.M., Guner,N.C., Cheda,L.,
            Paplinska-Goryca,M., Proboszcz,M., van den Bosch,T.P.P., Gorska,K.,
            Golab,J., Kaminski,R.M., Krenke,R., Golebiowski,A., Dzwonek,K. and
            Dobrzanski,P.
  TITLE     Inhibition of CHIT1 as a novel therapeutic approach in idiopathic
            pulmonary fibrosis
  JOURNAL   Eur J Pharmacol 919, 174792 (2022)
   PUBMED   35122869
REFERENCE   2  (residues 1 to 464)
  AUTHORS   Kimura,M., Watanabe,T., Sekine,K., Ishizuka,H., Ikejiri,A.,
            Sakaguchi,M., Kamaya,M., Yamanaka,D., Matoska,V., Bauer,P.O. and
            Oyama,F.
  TITLE     Comparative functional analysis between human and mouse
            chitotriosidase: Substitution at amino acid 218 modulates the
            chitinolytic and transglycosylation activity
  JOURNAL   Int J Biol Macromol 164, 2895-2902 (2020)
   PUBMED   32853624
  REMARK    GeneRIF: Comparative functional analysis between human and mouse
            chitotriosidase: Substitution at amino acid 218 modulates the
            chitinolytic and transglycosylation activity.
REFERENCE   3  (residues 1 to 464)
  AUTHORS   Sharma,L., Amick,A.K., Vasudevan,S., Lee,S.W., Marion,C.R., Liu,W.,
            Brady,V., Losier,A., Bermejo,S.D., Britto,C.J., Lee,C.G.,
            Elias,J.A. and Dela Cruz,C.S.
  TITLE     Regulation and Role of Chitotriosidase during Lung Infection with
            Klebsiella pneumoniae
  JOURNAL   J Immunol 201 (2), 615-626 (2018)
   PUBMED   29891554
  REMARK    GeneRIF: these data show a detrimental role of chit1 in Klebsiella
            pneumoniae lung infections
REFERENCE   4  (residues 1 to 464)
  AUTHORS   Van Dyken,S.J., Liang,H.E., Naikawadi,R.P., Woodruff,P.G.,
            Wolters,P.J., Erle,D.J. and Locksley,R.M.
  TITLE     Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic
            Lung Disease
  JOURNAL   Cell 169 (3), 497-509 (2017)
   PUBMED   28431248
REFERENCE   5  (residues 1 to 464)
  AUTHORS   Canto,E., Espejo,C., Costa,C., Montalban,X. and Comabella,M.
  TITLE     Breast regression protein-39 is not required for experimental
            autoimmune encephalomyelitis induction
  JOURNAL   Clin Immunol 160 (2), 133-141 (2015)
   PUBMED   26079949
  REMARK    GeneRIF: No significant differences were observed between
            experimental autoimmune encephalitis and control groups for CHIT-1
            expression.
REFERENCE   6  (residues 1 to 464)
  AUTHORS   Wiesner,D.L., Specht,C.A., Lee,C.K., Smith,K.D., Mukaremera,L.,
            Lee,S.T., Lee,C.G., Elias,J.A., Nielsen,J.N., Boulware,D.R.,
            Bohjanen,P.R., Jenkins,M.K., Levitz,S.M. and Nielsen,K.
  TITLE     Chitin recognition via chitotriosidase promotes pathologic type-2
            helper T cell responses to cryptococcal infection
  JOURNAL   PLoS Pathog 11 (3), e1004701 (2015)
   PUBMED   25764512
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 464)
  AUTHORS   Kitamoto,S., Egashira,K., Ichiki,T., Han,X., McCurdy,S., Sakuda,S.,
            Sunagawa,K. and Boisvert,W.A.
  TITLE     Chitinase inhibition promotes atherosclerosis in hyperlipidemic
            mice
  JOURNAL   Am J Pathol 183 (1), 313-325 (2013)
   PUBMED   23685110
  REMARK    GeneRIF: CHIT1 exerts protective effects against atherosclerosis by
            suppressing inflammatory responses and polarizing macrophages
            toward an M2 phenotype, and promoting lipid uptake and cholesterol
            efflux in macrophages.
REFERENCE   8  (residues 1 to 464)
  AUTHORS   Lee,C.G., Herzog,E.L., Ahangari,F., Zhou,Y., Gulati,M., Lee,C.M.,
            Peng,X., Feghali-Bostwick,C., Jimenez,S.A., Varga,J. and Elias,J.A.
  TITLE     Chitinase 1 is a biomarker for and therapeutic target in
            scleroderma-associated interstitial lung disease that augments
            TGF-beta1 signaling
  JOURNAL   J Immunol 189 (5), 2635-2644 (2012)
   PUBMED   22826322
REFERENCE   9  (residues 1 to 464)
  AUTHORS   Boot,R.G., Bussink,A.P., Verhoek,M., de Boer,P.A., Moorman,A.F. and
            Aerts,J.M.
  TITLE     Marked differences in tissue-specific expression of chitinases in
            mouse and man
  JOURNAL   J Histochem Cytochem 53 (10), 1283-1292 (2005)
   PUBMED   15923370
REFERENCE   10 (residues 1 to 464)
  AUTHORS   Zheng,T., Rabach,M., Chen,N.Y., Rabach,L., Hu,X., Elias,J.A. and
            Zhu,Z.
  TITLE     Molecular cloning and functional characterization of mouse
            chitotriosidase
  JOURNAL   Gene 357 (1), 37-46 (2005)
   PUBMED   16005164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009012.1, BC138765.1 and AY536287.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer protein (isoform 1). Variants 1
            and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138765.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.12 cM"
     Protein         1..464
                     /product="chitotriosidase-1 isoform 1 precursor"
                     /EC_number="3.2.1.14"
                     /note="chitotriosidase-1; chitinase 1 (chitotriosidase)"
                     /calculated_mol_wt=48850
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2280
     mat_peptide     22..464
                     /product="Chitotriosidase-1. /id=PRO_0000011942"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D7Q1.2)"
                     /calculated_mol_wt=48850
     Region          24..383
                     /region_name="GH18_chitolectin_chitotriosidase"
                     /note="This conserved domain family includes a large
                     number of catalytically inactive chitinase-like lectins
                     (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1,
                     oviductin, and AMCase (acidic mammalian chitinase), as
                     well as catalytically active...; cd02872"
                     /db_xref="CDD:119351"
     Site            order(27,31,99..100,138,140..141,186..187,210,212..213,
                     218,267,269,297,356)
                     /site_type="active"
                     /db_xref="CDD:119351"
     Region          385..416
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D7Q1.2)"
     Region          416..464
                     /region_name="ChtBD2"
                     /note="Chitin-binding domain type 2; smart00494"
                     /db_xref="CDD:214696"
     CDS             1..464
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /coded_by="NM_001284525.1:265..1659"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS15304.1"
                     /db_xref="GeneID:71884"
                     /db_xref="MGI:MGI:1919134"
ORIGIN      
        1 mvqslawagv mtllmvqwgs aaklvcyltn wsqyrteavr ffprdvdpnl cthvifafag
       61 mdnhqlstve hndellyqel nslktknpkl ktllavggwt fgtqkftdmv atasnrqtfv
      121 ksalsflrtq gfdgldldwe fpggrgsptv dkerftaliq dlakafqeea qssgkerlll
      181 taavpsdrgl vdagyevdki aqsldfinlm aydfhsslek ttghnsplyk rqgesgaaae
      241 qnvdaavtlw lqkgtpaskl ilgmptygrs ftlasssdng vgapatgpga pgpytkdkgv
      301 layyeacswk erhriedqkv pyafqdnqwv sfddvesfka kaaylkqkgl ggamvwvldl
      361 ddfkgsfcnq gpyplirtlr qelnlpsetp rspeqiipep rpssmpeqgp spgldnfcqg
      421 kadgvypnpg destyyncgg grlfqqscpp glvfrasckc ctws
//
