LOCUS       NM_001284524            1580 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus chitinase 1 (Chit1), transcript variant 2, mRNA.
ACCESSION   NM_001284524
VERSION     NM_001284524.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1580)
  AUTHORS   Sklepkiewicz,P., Dymek,B.A., Mlacki,M., Koralewski,R., Mazur,M.,
            Nejman-Gryz,P., Korur,S., Zagozdzon,A., Rymaszewska,A., von der
            Thusen,J.H., Siwinska,A.M., Guner,N.C., Cheda,L.,
            Paplinska-Goryca,M., Proboszcz,M., van den Bosch,T.P.P., Gorska,K.,
            Golab,J., Kaminski,R.M., Krenke,R., Golebiowski,A., Dzwonek,K. and
            Dobrzanski,P.
  TITLE     Inhibition of CHIT1 as a novel therapeutic approach in idiopathic
            pulmonary fibrosis
  JOURNAL   Eur J Pharmacol 919, 174792 (2022)
   PUBMED   35122869
REFERENCE   2  (bases 1 to 1580)
  AUTHORS   Kimura,M., Watanabe,T., Sekine,K., Ishizuka,H., Ikejiri,A.,
            Sakaguchi,M., Kamaya,M., Yamanaka,D., Matoska,V., Bauer,P.O. and
            Oyama,F.
  TITLE     Comparative functional analysis between human and mouse
            chitotriosidase: Substitution at amino acid 218 modulates the
            chitinolytic and transglycosylation activity
  JOURNAL   Int J Biol Macromol 164, 2895-2902 (2020)
   PUBMED   32853624
  REMARK    GeneRIF: Comparative functional analysis between human and mouse
            chitotriosidase: Substitution at amino acid 218 modulates the
            chitinolytic and transglycosylation activity.
REFERENCE   3  (bases 1 to 1580)
  AUTHORS   Sharma,L., Amick,A.K., Vasudevan,S., Lee,S.W., Marion,C.R., Liu,W.,
            Brady,V., Losier,A., Bermejo,S.D., Britto,C.J., Lee,C.G.,
            Elias,J.A. and Dela Cruz,C.S.
  TITLE     Regulation and Role of Chitotriosidase during Lung Infection with
            Klebsiella pneumoniae
  JOURNAL   J Immunol 201 (2), 615-626 (2018)
   PUBMED   29891554
  REMARK    GeneRIF: these data show a detrimental role of chit1 in Klebsiella
            pneumoniae lung infections
REFERENCE   4  (bases 1 to 1580)
  AUTHORS   Van Dyken,S.J., Liang,H.E., Naikawadi,R.P., Woodruff,P.G.,
            Wolters,P.J., Erle,D.J. and Locksley,R.M.
  TITLE     Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic
            Lung Disease
  JOURNAL   Cell 169 (3), 497-509 (2017)
   PUBMED   28431248
REFERENCE   5  (bases 1 to 1580)
  AUTHORS   Canto,E., Espejo,C., Costa,C., Montalban,X. and Comabella,M.
  TITLE     Breast regression protein-39 is not required for experimental
            autoimmune encephalomyelitis induction
  JOURNAL   Clin Immunol 160 (2), 133-141 (2015)
   PUBMED   26079949
  REMARK    GeneRIF: No significant differences were observed between
            experimental autoimmune encephalitis and control groups for CHIT-1
            expression.
REFERENCE   6  (bases 1 to 1580)
  AUTHORS   Wiesner,D.L., Specht,C.A., Lee,C.K., Smith,K.D., Mukaremera,L.,
            Lee,S.T., Lee,C.G., Elias,J.A., Nielsen,J.N., Boulware,D.R.,
            Bohjanen,P.R., Jenkins,M.K., Levitz,S.M. and Nielsen,K.
  TITLE     Chitin recognition via chitotriosidase promotes pathologic type-2
            helper T cell responses to cryptococcal infection
  JOURNAL   PLoS Pathog 11 (3), e1004701 (2015)
   PUBMED   25764512
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1580)
  AUTHORS   Kitamoto,S., Egashira,K., Ichiki,T., Han,X., McCurdy,S., Sakuda,S.,
            Sunagawa,K. and Boisvert,W.A.
  TITLE     Chitinase inhibition promotes atherosclerosis in hyperlipidemic
            mice
  JOURNAL   Am J Pathol 183 (1), 313-325 (2013)
   PUBMED   23685110
  REMARK    GeneRIF: CHIT1 exerts protective effects against atherosclerosis by
            suppressing inflammatory responses and polarizing macrophages
            toward an M2 phenotype, and promoting lipid uptake and cholesterol
            efflux in macrophages.
REFERENCE   8  (bases 1 to 1580)
  AUTHORS   Lee,C.G., Herzog,E.L., Ahangari,F., Zhou,Y., Gulati,M., Lee,C.M.,
            Peng,X., Feghali-Bostwick,C., Jimenez,S.A., Varga,J. and Elias,J.A.
  TITLE     Chitinase 1 is a biomarker for and therapeutic target in
            scleroderma-associated interstitial lung disease that augments
            TGF-beta1 signaling
  JOURNAL   J Immunol 189 (5), 2635-2644 (2012)
   PUBMED   22826322
REFERENCE   9  (bases 1 to 1580)
  AUTHORS   Boot,R.G., Bussink,A.P., Verhoek,M., de Boer,P.A., Moorman,A.F. and
            Aerts,J.M.
  TITLE     Marked differences in tissue-specific expression of chitinases in
            mouse and man
  JOURNAL   J Histochem Cytochem 53 (10), 1283-1292 (2005)
   PUBMED   15923370
REFERENCE   10 (bases 1 to 1580)
  AUTHORS   Zheng,T., Rabach,M., Chen,N.Y., Rabach,L., Hu,X., Elias,J.A. and
            Zhu,Z.
  TITLE     Molecular cloning and functional characterization of mouse
            chitotriosidase
  JOURNAL   Gene 357 (1), 37-46 (2005)
   PUBMED   16005164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009012.1 and AV087814.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an alternate exon in the 3' coding region which causes a
            frameshift, compared to variant 1. The resulting protein (isoform
            2) is shorter and has a distinct C-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009012.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1511              AK009012.1         2-1512
            1512-1529           AV087814.1         224-241
            1530-1580           AK009012.1         1531-1581
FEATURES             Location/Qualifiers
     source          1..1580
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.12 cM"
     gene            1..1580
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /note="chitinase 1"
                     /db_xref="GeneID:71884"
                     /db_xref="MGI:MGI:1919134"
     exon            1..121
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            122..253
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1419
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /EC_number="3.2.1.14"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; chitotriosidase-1; chitinase 1
                     (chitotriosidase)"
                     /codon_start=1
                     /product="chitotriosidase-1 isoform 2 precursor"
                     /protein_id="NP_001271453.1"
                     /db_xref="CCDS:CCDS69943.1"
                     /db_xref="GeneID:71884"
                     /db_xref="MGI:MGI:1919134"
                     /translation="MVQSLAWAGVMTLLMVQWGSAAKLVCYLTNWSQYRTEAVRFFPR
                     DVDPNLCTHVIFAFAGMDNHQLSTVEHNDELLYQELNSLKTKNPKLKTLLAVGGWTFG
                     TQKFTDMVATASNRQTFVKSALSFLRTQGFDGLDLDWEFPGGRGSPTVDKERFTALIQ
                     DLAKAFQEEAQSSGKERLLLTAAVPSDRGLVDAGYEVDKIAQSLDFINLMAYDFHSSL
                     EKTTGHNSPLYKRQGESGAAAEQNVDAAVTLWLQKGTPASKLILGMPTYGRSFTLASS
                     SDNGVGAPATGPGAPGPYTKDKGVLAYYEACSWKERHRIEDQKVPYAFQDNQWVSFDD
                     VESFKAKAKLMGSTPTLETSPLTTTVEEGGCSSRAVLQAWCLEPLANVVPGAKFLEPH
                     PTPV"
     exon            254..283
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            284..485
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            486..542
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            543..708
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            709..833
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            834..957
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1143
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1251
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1580
                     /gene="Chit1"
                     /gene_synonym="2300002L19Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtttctcct gactgcagtt ggaacaagtt gtagagctct cggctccttc tccagcacca
       61 agtcggccta gacagtgcca tgcttctcac catgatgatg atggattaaa ccgctgaaac
      121 tgcccgtcag aggagagcag atcaggacct gtggagccag tcacaggaga gcacggcagg
      181 acctgtggag cgggtactca cagagctgat atccccagag ccttcatcat ggtgcagtcc
      241 ctggcctggg caggtgtgat gactctgctg atggtccagt ggggctctgc tgcaaaactg
      301 gtctgctacc tcaccaactg gtcccagtac cggacggagg cagttcggtt ctttcccagg
      361 gatgtggatc ccaacctgtg tacccacgtc atctttgctt ttgctggaat ggacaaccat
      421 cagctcagca ctgtggagca caatgacgaa cttctctacc aggagctgaa cagcctaaag
      481 actaagaacc ccaagctcaa gaccctgtta gccgttggag gctggacctt tggtacccag
      541 aagttcacag acatggtggc caccgccagc aaccggcaga cctttgtgaa gtcagcccta
      601 agtttcctgc gcactcaagg ttttgatggc cttgaccttg actgggagtt cccaggtgga
      661 cgtgggagcc ccacagtaga caaagagaga ttcacagccc tgatacagga cttggccaaa
      721 gccttccagg aggaagccca gtcctcaggg aaggaacgcc tccttctgac tgcagctgta
      781 ccgagtgatc gaggcctggt ggatgctggc tacgaggtgg acaagattgc ccagagcttg
      841 gatttcatca accttatggc ctacgacttc cacagctcct tggaaaagac cacagggcat
      901 aacagccccc tctacaaaag gcaaggagaa agtggggcag ccgctgagca aaacgtggat
      961 gctgctgtga cgctctggct gcagaagggg accccagcca gcaaactgat ccttggcatg
     1021 cctacctatg gacgctcttt caccttggcc tcctcgtcag acaatggagt tggggcccca
     1081 gccacagggc ctggtgcccc aggcccctat acgaaggaca aaggggtcct ggcttactat
     1141 gaggcctgct cctggaagga aagacacaga atcgaggacc agaaggtgcc ttacgccttc
     1201 caggacaacc agtgggtgag ctttgacgac gtggaaagct tcaaagccaa ggcaaagctg
     1261 atggggtcta ccccaaccct ggagacgagt ccacttacta caactgtgga ggagggcggc
     1321 tgttccagca gagctgtcct ccaggcctgg tgtttagagc ctcttgcaaa tgttgtacct
     1381 ggagctaagt tcctggaacc ccatccaact ccagtctgag gccaggcttg gggtccccca
     1441 ccacctgcct ctgctttccc tggggcctgc aggcctctct gttccttcca tgcccccacc
     1501 tctgatcagc ttcttggttt cctttttgtc tcttttaggc ttcctcttta tctgaaaaat
     1561 aaacatattt ttcacccctg
//
