LOCUS       NM_145126               1510 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus chitinase-like 4 (Chil4), mRNA.
ACCESSION   NM_145126 XM_983554
VERSION     NM_145126.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1510)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1510)
  AUTHORS   Wang,L., Ren,W., Li,X., Zhang,X., Tian,H., Bhattarai,J.P.,
            Challis,R.C., Lee,A.C., Zhao,S., Yu,H., Ma,M. and Yu,Y.
  TITLE     Chitinase-Like Protein Ym2 (Chil4) Regulates Regeneration of the
            Olfactory Epithelium via Interaction with Inflammation
  JOURNAL   J Neurosci 41 (26), 5620-5637 (2021)
   PUBMED   34016714
  REMARK    GeneRIF: Chitinase-Like Protein Ym2 (Chil4) Regulates Regeneration
            of the Olfactory Epithelium via Interaction with Inflammation.
REFERENCE   3  (bases 1 to 1510)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1510)
  AUTHORS   Van Dyken,S.J., Liang,H.E., Naikawadi,R.P., Woodruff,P.G.,
            Wolters,P.J., Erle,D.J. and Locksley,R.M.
  TITLE     Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic
            Lung Disease
  JOURNAL   Cell 169 (3), 497-509 (2017)
   PUBMED   28431248
REFERENCE   5  (bases 1 to 1510)
  AUTHORS   Ohno,M., Kida,Y., Sakaguchi,M., Sugahara,Y. and Oyama,F.
  TITLE     Establishment of a quantitative PCR system for discriminating
            chitinase-like proteins: catalytically inactive breast regression
            protein-39 and Ym1 are constitutive genes in mouse lung
  JOURNAL   BMC Mol Biol 15, 23 (2014)
   PUBMED   25294623
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1510)
  AUTHORS   Lee,E., Yook,J., Haa,K. and Chang,H.W.
  TITLE     Induction of Ym1/2 in mouse bone marrow-derived mast cells by IL-4
            and identification of Ym1/2 in connective tissue type-like mast
            cells derived from bone marrow cells cultured with IL-4 and stem
            cell factor
  JOURNAL   Immunol Cell Biol 83 (5), 468-474 (2005)
   PUBMED   16174095
  REMARK    GeneRIF: Induced only in the presence of IL-4.
REFERENCE   7  (bases 1 to 1510)
  AUTHORS   Nio,J., Fujimoto,W., Konno,A., Kon,Y., Owhashi,M. and Iwanaga,T.
  TITLE     Cellular expression of murine Ym1 and Ym2, chitinase family
            proteins, as revealed by in situ hybridization and
            immunohistochemistry
  JOURNAL   Histochem Cell Biol 121 (6), 473-482 (2004)
   PUBMED   15148607
REFERENCE   8  (bases 1 to 1510)
  AUTHORS   Webb,D.C., McKenzie,A.N. and Foster,P.S.
  TITLE     Expression of the Ym2 lectin-binding protein is dependent on
            interleukin (IL)-4 and IL-13 signal transduction: identification of
            a novel allergy-associated protein
  JOURNAL   J Biol Chem 276 (45), 41969-41976 (2001)
   PUBMED   11553626
REFERENCE   9  (bases 1 to 1510)
  AUTHORS   Ward,J.M., Yoon,M., Anver,M.R., Haines,D.C., Kudo,G., Gonzalez,F.J.
            and Kimura,S.
  TITLE     Hyalinosis and Ym1/Ym2 gene expression in the stomach and
            respiratory tract of 129S4/SvJae and wild-type and CYP1A2-null B6,
            129 mice
  JOURNAL   Am J Pathol 158 (1), 323-332 (2001)
   PUBMED   11141507
  REMARK    GeneRIF: The eosinophilic protein Ym2 (chitinase 3-like 4) was
            isolated from characteristic hyaline gastric lesion mainly found in
            female CYP1A2-null mice. The relation between Ym2 and CYP1A2 is
            unknown.
REFERENCE   10 (bases 1 to 1510)
  AUTHORS   Jin,H.M., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Kirkpatrick,R.B. and Rosenberg,M.
  TITLE     Genetic characterization of the murine Ym1 gene and identification
            of a cluster of highly homologous genes
  JOURNAL   Genomics 54 (2), 316-322 (1998)
   PUBMED   9828134
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131914.1.
            
            On Jul 8, 2009 this sequence version replaced NM_145126.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131914.1, BC130015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1510              AK131914.1         2-1511
FEATURES             Location/Qualifiers
     source          1..1510
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.49 cM"
     gene            1..1510
                     /gene="Chil4"
                     /gene_synonym="Chi3l4; Ym2"
                     /note="chitinase-like 4"
                     /db_xref="GeneID:104183"
                     /db_xref="MGI:MGI:1341098"
     exon            1..40
                     /gene="Chil4"
                     /gene_synonym="Chi3l4; Ym2"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1224
                     /gene="Chil4"
                     /gene_synonym="Chi3l4; Ym2"
                     /note="chitinase-3-like protein 4; secreted protein Ym2;
                     chitinase 3-like 4, Chil4; chitinase-like protein 4"
                     /codon_start=1
                     /product="chitinase-like protein 4 precursor"
                     /protein_id="NP_660108.2"
                     /db_xref="CCDS:CCDS17719.1"
                     /db_xref="GeneID:104183"
                     /db_xref="MGI:MGI:1341098"
                     /translation="MAKLILVTGLAILLNVQLGSSYQLMCYYTSWAKDRPTEGSFKPG
                     NIDPCLCTHLIYAFAGMKNNEITYLSEQDLRDYEALNGLKDRNTELKTLLAIGGWKFG
                     PAPFSSMVSTPQNRQTFIKSVIRFLRQYNFDGLNLDWQYPGSRGSPPKDKHLFSVLVQ
                     EMRKAFEEESTLNHIPRLLLTSTGAGFIDVIKSGYKIPELSQSLDYIQVMTYDLHDPK
                     NGYTGENSPLYKSPYDIGKSADLNVDSIITYWKDHGAASEKLIVGFPAYGHTFILSDP
                     SKNGIGDPTVSAGPPGKYTNEQGLLAYFEICTFLNEGATEIFDATQEVPYAYLGNEWV
                     GYDNVRSFKLKAQWLKDNNLGGAVVWPLDMDDFSGSFCHQGRFPLTTTLKRDLNVHSA
                     SCKASYRGEL"
     exon            41..70
                     /gene="Chil4"
                     /gene_synonym="Chi3l4; Ym2"
                     /inference="alignment:Splign:2.1.0"
     exon            71..272
                     /gene="Chil4"
                     /gene_synonym="Chi3l4; Ym2"
                     /inference="alignment:Splign:2.1.0"
     exon            273..329
                     /gene="Chil4"
                     /gene_synonym="Chi3l4; Ym2"
                     /inference="alignment:Splign:2.1.0"
     exon            330..495
                     /gene="Chil4"
                     /gene_synonym="Chi3l4; Ym2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..620
                     /gene="Chil4"
                     /gene_synonym="Chi3l4; Ym2"
                     /inference="alignment:Splign:2.1.0"
     exon            621..744
                     /gene="Chil4"
                     /gene_synonym="Chi3l4; Ym2"
                     /inference="alignment:Splign:2.1.0"
     exon            745..930
                     /gene="Chil4"
                     /gene_synonym="Chi3l4; Ym2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1050
                     /gene="Chil4"
                     /gene_synonym="Chi3l4; Ym2"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1192
                     /gene="Chil4"
                     /gene_synonym="Chi3l4; Ym2"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1510
                     /gene="Chil4"
                     /gene_synonym="Chi3l4; Ym2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1490..1495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chil4"
                     /gene_synonym="Chi3l4; Ym2"
                     /note="hexamer: AATAAA"
     polyA_site      1509
                     /gene="Chil4"
                     /gene_synonym="Chi3l4; Ym2"
                     /note="major polyA site"
ORIGIN      
        1 aatcctgaag acaccatggc caagctcatt cttgtcacag gtctggcaat tcttctgaat
       61 gtacagctgg gatcttccta ccagctgatg tgctactata ccagctgggc taaggacagg
      121 ccaacagaag ggagtttcaa acctggtaat attgacccct gcctgtgtac tcacctgatc
      181 tatgcctttg ctgggatgaa gaataatgag atcacttact taagtgagca agacttgcgt
      241 gactatgaag cattaaatgg tctgaaagac aggaacactg agctaaaaac tctcctggcc
      301 attggaggat ggaagtttgg acctgccccg ttcagttcca tggtctctac tcctcagaac
      361 cgtcagacat tcattaagtc agttatcaga ttccttcgtc aatataactt tgatggcctc
      421 aacctggact ggcagtaccc tgggtctcga ggaagccctc ctaaggacaa acatctcttc
      481 agtgttctgg tgcaggaaat gcgtaaagct tttgaggaag aatccacttt gaaccacatt
      541 ccaaggctgc tactcacttc cacaggagct ggattcattg acgtaatcaa gtctgggtac
      601 aagatccctg aactgtctca gtctctcgac tatattcagg tcatgacata tgatctccat
      661 gatcctaaga atggctacac tggagaaaat agtcccctct ataaatctcc atatgacatt
      721 ggaaagagtg ctgatctcaa tgtggattca attattacct actggaagga ccatggagca
      781 gcttctgaga agctcattgt gggatttcca gcatatggtc atacctttat cctgagtgac
      841 ccttctaaga atggaatagg tgaccctact gttagtgctg gaccaccagg aaagtacaca
      901 aatgaacaag gactcctggc ttactttgag atttgtacat ttctgaatga aggagccact
      961 gagatctttg atgccaccca ggaagtaccc tatgcctatc tgggtaatga gtgggttggt
     1021 tatgacaatg tcaggagctt caagttgaag gctcagtggc tcaaggacaa caatttagga
     1081 ggtgccgtgg tctggcccct ggacatggat gacttcagtg gttctttctg tcaccaggga
     1141 cgtttccctc tgacaactac tttaaagaga gatctgaatg tacacagtgc aagttgcaag
     1201 gcctcttatc gaggggagct ttagacaatg atttctactt gaaactctca gaataagagc
     1261 aacttcaacg gtttttccac gatggattct gcatcatgct tccatggaga ataatagaac
     1321 taagtcacga tctttcctga attgaatccc agagtagaac taagatatat gtcttgtctg
     1381 ctataccagc agaaaagaaa caaaaaaatt atcttcatct gtcagctttg gctaagctct
     1441 gaacattttt gcttcctgta aaaccacctt ccttgtttct tcctttcata ataaattcca
     1501 agttcaaagc
//
