LOCUS       NM_009892               1511 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus chitinase-like 3 (Chil3), mRNA.
ACCESSION   NM_009892 XM_909605
VERSION     NM_009892.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1511)
  AUTHORS   Heyndrickx,I., Deswarte,K., Verstraete,K., Verschueren,K.H.G.,
            Smole,U., Aegerter,H., Dansercoer,A., Hammad,H., Savvides,S.N. and
            Lambrecht,B.N.
  TITLE     Ym1 protein crystals promote type 2 immunity
  JOURNAL   Elife 12, 90676 (2024)
   PUBMED   38194250
  REMARK    GeneRIF: Ym1 protein crystals promote type 2 immunity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1511)
  AUTHORS   Okawa,K., Tabata,E., Kida,Y., Uno,K., Suzuki,H., Kamaya,M.,
            Bauer,P.O. and Oyama,F.
  TITLE     Irreversible evolutionary loss of chitin-degrading ability in the
            chitinase-like protein Ym1 under positive selection in rodents
  JOURNAL   Protein Sci 32 (4), e4620 (2023)
   PUBMED   36883357
  REMARK    GeneRIF: Irreversible evolutionary loss of chitin-degrading ability
            in the chitinase-like protein Ym1 under positive selection in
            rodents.
REFERENCE   3  (bases 1 to 1511)
  AUTHORS   Ikeda,N., Kubota,H., Suzuki,R., Morita,M., Yoshimura,A., Osada,Y.,
            Kishida,K., Kitamura,D., Iwata,A., Yotsumoto,S., Kurotaki,D.,
            Nishimura,K., Nishiyama,A., Tamura,T., Kamatani,T., Tsunoda,T.,
            Murakawa,M., Asahina,Y., Hayashi,Y., Harada,H., Harada,Y.,
            Yokota,A., Hirai,H., Seki,T., Kuwahara,M., Yamashita,M.,
            Shichino,S., Tanaka,M. and Asano,K.
  TITLE     The early neutrophil-committed progenitors aberrantly differentiate
            into immunoregulatory monocytes during emergency myelopoiesis
  JOURNAL   Cell Rep 42 (3), 112165 (2023)
   PUBMED   36862552
REFERENCE   4  (bases 1 to 1511)
  AUTHORS   Kang,Q., Li,L., Pang,Y., Zhu,W. and Meng,L.
  TITLE     An update on Ym1 and its immunoregulatory role in diseases
  JOURNAL   Front Immunol 13, 891220 (2022)
   PUBMED   35967383
  REMARK    GeneRIF: An update on Ym1 and its immunoregulatory role in
            diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1511)
  AUTHORS   Nio-Kobayashi,J., Owhashi,M. and Iwanaga,T.
  TITLE     Pathological examination of Ym1, a chitinase family protein, in
            Mesocestoides corti-infected mice
  JOURNAL   Biomed Res 43 (5), 161-171 (2022)
   PUBMED   36244794
  REMARK    GeneRIF: Pathological examination of Ym1, a chitinase family
            protein, in Mesocestoides corti-infected mice.
REFERENCE   6  (bases 1 to 1511)
  AUTHORS   Chang,N.C., Hung,S.I., Hwa,K.Y., Kato,I., Chen,J.E., Liu,C.H. and
            Chang,A.C.
  TITLE     A macrophage protein, Ym1, transiently expressed during
            inflammation is a novel mammalian lectin
  JOURNAL   J Biol Chem 276 (20), 17497-17506 (2001)
   PUBMED   11297523
REFERENCE   7  (bases 1 to 1511)
  AUTHORS   Sun,Y.J., Chang,N.C., Hung,S.I., Chang,A.C., Chou,C.C. and
            Hsiao,C.D.
  TITLE     The crystal structure of a novel mammalian lectin, Ym1, suggests a
            saccharide binding site
  JOURNAL   J Biol Chem 276 (20), 17507-17514 (2001)
   PUBMED   11278670
REFERENCE   8  (bases 1 to 1511)
  AUTHORS   Ward,J.M., Yoon,M., Anver,M.R., Haines,D.C., Kudo,G., Gonzalez,F.J.
            and Kimura,S.
  TITLE     Hyalinosis and Ym1/Ym2 gene expression in the stomach and
            respiratory tract of 129S4/SvJae and wild-type and CYP1A2-null B6,
            129 mice
  JOURNAL   Am J Pathol 158 (1), 323-332 (2001)
   PUBMED   11141507
  REMARK    GeneRIF: Hyalinosis is due to the overexpression of ym1 (now
            chi3I3) in cells and tissues, often associated with disease in that
            tissue.
REFERENCE   9  (bases 1 to 1511)
  AUTHORS   Owhashi,M., Arita,H. and Hayai,N.
  TITLE     Identification of a novel eosinophil chemotactic cytokine (ECF-L)
            as a chitinase family protein
  JOURNAL   J Biol Chem 275 (2), 1279-1286 (2000)
   PUBMED   10625674
REFERENCE   10 (bases 1 to 1511)
  AUTHORS   Jin,H.M., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Kirkpatrick,R.B. and Rosenberg,M.
  TITLE     Genetic characterization of the murine Ym1 gene and identification
            of a cluster of highly homologous genes
  JOURNAL   Genomics 54 (2), 316-322 (1998)
   PUBMED   9828134
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125461.4.
            
            On Oct 5, 2022 this sequence version replaced NM_009892.3.
            
            Summary: The protein encoded by this gene is similar to bacterial
            chitinases but lacks chitinase activity. The encoded protein is
            thought to function as a lectin and may be involved in inflammation
            and allergy. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061154.1, M94584.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC125461.4         86499-86538
            41-70               AC125461.4         89203-89232
            71-272              AC125461.4         89744-89945
            273-329             AC125461.4         92805-92861
            330-495             AC125461.4         93502-93667
            496-620             AC125461.4         98243-98367
            621-744             AC125461.4         103794-103917
            745-930             AC125461.4         104138-104323
            931-1050            AC125461.4         105114-105233
            1051-1192           AC125461.4         105315-105456
            1193-1511           AC125461.4         106163-106481
FEATURES             Location/Qualifiers
     source          1..1511
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.49 cM"
     gene            1..1511
                     /gene="Chil3"
                     /gene_synonym="Chi3l3; ECF-L; Ym1"
                     /note="chitinase-like 3"
                     /db_xref="GeneID:12655"
                     /db_xref="MGI:MGI:1330860"
     exon            1..40
                     /gene="Chil3"
                     /gene_synonym="Chi3l3; ECF-L; Ym1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1212
                     /gene="Chil3"
                     /gene_synonym="Chi3l3; ECF-L; Ym1"
                     /EC_number="3.2.1.52"
                     /note="eosinophil chemotactic factor-L; secreted protein
                     Ym1; eosinophil chemotactic cytokine;
                     beta-N-acetylhexosaminidase Ym1; chitinase-like protein 3"
                     /codon_start=1
                     /product="chitinase-like protein 3 precursor"
                     /protein_id="NP_034022.2"
                     /db_xref="CCDS:CCDS17718.1"
                     /db_xref="GeneID:12655"
                     /db_xref="MGI:MGI:1330860"
                     /translation="MAKLILVTGLAILLNVQLGSSYQLMCYYTSWAKDRPIEGSFKPG
                     NIDPCLCTHLIYAFAGMQNNEITYTHEQDLRDYEALNGLKDKNTELKTLLAIGGWKFG
                     PAPFSAMVSTPQNRQIFIQSVIRFLRQYNFDGLNLDWQYPGSRGSPPKDKHLFSVLVK
                     EMRKAFEEESVEKDIPRLLLTSTGAGIIDVIKSGYKIPELSQSLDYIQVMTYDLHDPK
                     DGYTGENSPLYKSPYDIGKSADLNVDSIISYWKDHGAASEKLIVGFPAYGHTFILSDP
                     SKTGIGAPTISTGPPGKYTDESGLLAYYEVCTFLNEGATEVWDAPQEVPYAYQGNEWV
                     GYDNVRSFKLKAQWLKDNNLGGAVVWPLDMDDFSGSFCHQRHFPLTSTLKGDLNIHSA
                     SCKGPY"
     exon            41..70
                     /gene="Chil3"
                     /gene_synonym="Chi3l3; ECF-L; Ym1"
                     /inference="alignment:Splign:2.1.0"
     exon            71..272
                     /gene="Chil3"
                     /gene_synonym="Chi3l3; ECF-L; Ym1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..329
                     /gene="Chil3"
                     /gene_synonym="Chi3l3; ECF-L; Ym1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..495
                     /gene="Chil3"
                     /gene_synonym="Chi3l3; ECF-L; Ym1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..620
                     /gene="Chil3"
                     /gene_synonym="Chi3l3; ECF-L; Ym1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..744
                     /gene="Chil3"
                     /gene_synonym="Chi3l3; ECF-L; Ym1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..930
                     /gene="Chil3"
                     /gene_synonym="Chi3l3; ECF-L; Ym1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1050
                     /gene="Chil3"
                     /gene_synonym="Chi3l3; ECF-L; Ym1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1192
                     /gene="Chil3"
                     /gene_synonym="Chi3l3; ECF-L; Ym1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1511
                     /gene="Chil3"
                     /gene_synonym="Chi3l3; ECF-L; Ym1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1490..1495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chil3"
                     /gene_synonym="Chi3l3; ECF-L; Ym1"
                     /note="hexamer: AATAAA"
     polyA_site      1511
                     /gene="Chil3"
                     /gene_synonym="Chi3l3; ECF-L; Ym1"
                     /note="major polyA site"
ORIGIN      
        1 aatcctgaag acaccatggc caagctcatt cttgtcacag gtctggcaat tcttctgaac
       61 gtacagctgg gatcttccta ccagctgatg tgctactata ccagttgggc taaggacagg
      121 ccaatagaag ggagtttcaa acctggtaat attgacccct gcctgtgtac tcacctgatc
      181 tatgcctttg ctggaatgca gaataatgag atcacttaca cacatgagca agacttgcgt
      241 gactatgaag cattgaatgg tctgaaagac aagaacactg agctaaaaac tctcctggcc
      301 attggaggat ggaagtttgg acctgccccg ttcagtgcca tggtctctac tcctcagaac
      361 cgtcagatat tcattcagtc agttatcaga ttccttcgtc aatataactt tgatggcctc
      421 aacctggact ggcagtaccc tgggtctcga ggaagccctc ctaaggacaa acatctcttc
      481 agtgttctgg tgaaggaaat gcgtaaagct tttgaggaag aatctgtgga gaaagacatt
      541 ccaaggctgc tactcacttc cacaggagca ggaatcattg acgtaatcaa gtctgggtac
      601 aagatccctg aactgtctca gtctcttgac tatattcagg tcatgacata tgatctccat
      661 gatcctaagg atggctacac tggagaaaat agtcccctct ataaatctcc atatgacatt
      721 ggaaagagtg ctgatctcaa tgtggattca atcatttcct actggaagga ccatggagca
      781 gcttctgaga agctcattgt gggatttcca gcatatgggc atacctttat cctgagtgac
      841 ccttctaaga ctggaattgg tgcccctaca attagtactg gcccaccagg aaagtacaca
      901 gatgaatcag gactcctggc ttactatgag gtttgtacat ttctgaatga aggagccact
      961 gaggtctggg atgcccccca ggaagtaccc tatgcctatc agggtaatga gtgggttggt
     1021 tatgacaatg tcaggagctt caagttgaag gctcagtggc tcaaggacaa caatttagga
     1081 ggtgccgtgg tctggcccct ggacatggat gacttcagtg gttctttctg tcaccagaga
     1141 catttccctc tgacatctac tttaaaggga gatctcaata tacacagtgc aagttgcaag
     1201 ggcccttatt gagaggagct ttacacaatg atttgtcctt gaaactctca gaataagatc
     1261 aagttcaacg gtttttccac agtgcattct gcatcatgct tccatggaga ataatagaaa
     1321 taagtcatga actttcctaa attgaatccc agagtagtac taagatggat gtcttgtctg
     1381 ctgtaccagc tgggaagaaa caaaaaatgc tcttcatctg tcagctttgg ctaagctctg
     1441 aacatctttt gcttcctgta aaaccaccat gcttgtttct tgctctcaca ataaattcca
     1501 cattcatagc a
//
