LOCUS       NM_009767               7375 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus cysteine-rich hydrophobic domain 1 (Chic1), mRNA.
ACCESSION   NM_009767 XM_486740
VERSION     NM_009767.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7375)
  AUTHORS   Cajigas,I., Chakraborty,A., Swyter,K.R., Luo,H., Bastidas,M.,
            Nigro,M., Morris,E.R., Chen,S., VanGompel,M.J.W., Leib,D.,
            Kohtz,S.J., Martina,M., Koh,S., Ay,F. and Kohtz,J.D.
  TITLE     The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially
            Organizes Megabase Distant Genes in the Developing Forebrain
  JOURNAL   Mol Cell 71 (6), 956-972 (2018)
   PUBMED   30146317
REFERENCE   2  (bases 1 to 7375)
  AUTHORS   Kobayashi,S., Totoki,Y., Soma,M., Matsumoto,K., Fujihara,Y.,
            Toyoda,A., Sakaki,Y., Okabe,M. and Ishino,F.
  TITLE     Identification of an imprinted gene cluster in the X-inactivation
            center
  JOURNAL   PLoS One 8 (8), e71222 (2013)
   PUBMED   23940725
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7375)
  AUTHORS   Cox,B.J., Vollmer,M., Tamplin,O., Lu,M., Biechele,S.,
            Gertsenstein,M., van Campenhout,C., Floss,T., Kuhn,R., Wurst,W.,
            Lickert,H. and Rossant,J.
  TITLE     Phenotypic annotation of the mouse X chromosome
  JOURNAL   Genome Res 20 (8), 1154-1164 (2010)
   PUBMED   20548051
REFERENCE   4  (bases 1 to 7375)
  AUTHORS   Kalantry,S., Purushothaman,S., Bowen,R.B., Starmer,J. and
            Magnuson,T.
  TITLE     Evidence of Xist RNA-independent initiation of mouse imprinted
            X-chromosome inactivation
  JOURNAL   Nature 460 (7255), 647-651 (2009)
   PUBMED   19571810
REFERENCE   5  (bases 1 to 7375)
  AUTHORS   Kino,T., Takatori,H., Manoli,I., Wang,Y., Tiulpakov,A.,
            Blackman,M.R., Su,Y.A., Chrousos,G.P., DeCherney,A.H. and
            Segars,J.H.
  TITLE     Brx mediates the response of lymphocytes to osmotic stress through
            the activation of NFAT5
  JOURNAL   Sci Signal 2 (57), ra5 (2009)
   PUBMED   19211510
  REMARK    GeneRIF: Brx is essential for the expression of nfat5 in response
            to osmotic stress.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7375)
  AUTHORS   Chureau,C., Prissette,M., Bourdet,A., Barbe,V., Cattolico,L.,
            Jones,L., Eggen,A., Avner,P. and Duret,L.
  TITLE     Comparative sequence analysis of the X-inactivation center region
            in mouse, human, and bovine
  JOURNAL   Genome Res 12 (6), 894-908 (2002)
   PUBMED   12045143
REFERENCE   7  (bases 1 to 7375)
  AUTHORS   Cools,J., Mentens,N. and Marynen,P.
  TITLE     A new family of small, palmitoylated, membrane-associated proteins,
            characterized by the presence of a cysteine-rich hydrophobic motif
  JOURNAL   FEBS Lett 492 (3), 204-209 (2001)
   PUBMED   11257495
REFERENCE   8  (bases 1 to 7375)
  AUTHORS   Debrand,E., Chureau,C., Arnaud,D., Avner,P. and Heard,E.
  TITLE     Functional analysis of the DXPas34 locus, a 3' regulator of Xist
            expression
  JOURNAL   Mol Cell Biol 19 (12), 8513-8525 (1999)
   PUBMED   10567576
REFERENCE   9  (bases 1 to 7375)
  AUTHORS   Debrand,E., Heard,E. and Avner,P.
  TITLE     Cloning and localization of the murine Xpct gene: evidence for
            complex rearrangements during the evolution of the region around
            the Xist gene
  JOURNAL   Genomics 48 (3), 296-303 (1998)
   PUBMED   9545634
REFERENCE   10 (bases 1 to 7375)
  AUTHORS   Simmler,M.C., Heard,E., Rougeulle,C., Cruaud,C., Weissenbach,J. and
            Avner,P.
  TITLE     Localization and expression analysis of a novel conserved brain
            expressed transcript, Brx/BRX, lying within the Xic/XIC candidate
            region
  JOURNAL   Mamm Genome 8 (10), 760-766 (1997)
   PUBMED   9321471
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669964.18.
            
            On Feb 3, 2022 this sequence version replaced NM_009767.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034427.1, AK135974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               AL669964.18        50653-51039
            388-442             AL669964.18        60364-60418
            443-598             AL669964.18        67749-67904
            599-655             AL669964.18        81405-81461
            656-715             AL669964.18        82137-82196
            716-7375            AL669964.18        83610-90269
FEATURES             Location/Qualifiers
     source          1..7375
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 46.08 cM"
     gene            1..7375
                     /gene="Chic1"
                     /gene_synonym="Brx; Gm10454"
                     /note="cysteine-rich hydrophobic domain 1"
                     /db_xref="GeneID:12212"
                     /db_xref="MGI:MGI:1344694"
     exon            1..387
                     /gene="Chic1"
                     /gene_synonym="Brx; Gm10454"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..766
                     /gene="Chic1"
                     /gene_synonym="Brx; Gm10454"
                     /note="brain X-linked protein"
                     /codon_start=1
                     /product="cysteine-rich hydrophobic domain-containing
                     protein 1"
                     /protein_id="NP_033897.1"
                     /db_xref="CCDS:CCDS53165.1"
                     /db_xref="GeneID:12212"
                     /db_xref="MGI:MGI:1344694"
                     /translation="MSILLPNMAEFDTISELEEEEEAATSSSSPSSSPSSSSSSSVSG
                     PDEDEEDEEEEEEEDEEEEDEEEEEEEVPPPPRVVSEEHLRRYAPDPVLVRGAGHITV
                     FGLSNKFDTEFPSVLTGKVAPEEFKTSIGRVNSCLKKALPVNVKWLLCGCLCCCCTLG
                     CSLWPVICLNKRTRRSIQKLLEWENNRLYHKLALHWKLTKRKCETSNMMEYVILIEFL
                     PKYPIFRPD"
     exon            388..442
                     /gene="Chic1"
                     /gene_synonym="Brx; Gm10454"
                     /inference="alignment:Splign:2.1.0"
     exon            443..598
                     /gene="Chic1"
                     /gene_synonym="Brx; Gm10454"
                     /inference="alignment:Splign:2.1.0"
     exon            599..655
                     /gene="Chic1"
                     /gene_synonym="Brx; Gm10454"
                     /inference="alignment:Splign:2.1.0"
     exon            656..715
                     /gene="Chic1"
                     /gene_synonym="Brx; Gm10454"
                     /inference="alignment:Splign:2.1.0"
     exon            716..7375
                     /gene="Chic1"
                     /gene_synonym="Brx; Gm10454"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7326..7331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chic1"
                     /gene_synonym="Brx; Gm10454"
                     /note="hexamer: AATAAA"
     polyA_site      7347
                     /gene="Chic1"
                     /gene_synonym="Brx; Gm10454"
                     /note="major polyA site"
     polyA_site      7375
                     /gene="Chic1"
                     /gene_synonym="Brx; Gm10454"
ORIGIN      
        1 agtctgttcc ccctcctctc ccagcagctc cgcaggttca aactcttctc cgggagagtg
       61 gcggctatcg tgcggtcacg tgatgagcat cctgctgccc aacatggcgg agttcgacac
      121 catctcggaa ttggaggaag aagaagaggc agcaacatcg tcgtcgtctc catcgtcgtc
      181 tccgtcgtcg tcgtcgtcgt cgtcggtatc tgggcccgat gaggacgagg aagatgagga
      241 ggaggaagaa gaggaggatg aagaggagga ggacgaggaa gaagaggagg aggaggtgcc
      301 gcccccgcct cgggtagtga gcgaggagca tctgcggaga tatgccccag accctgtgtt
      361 ggtgcgcggc gccggccaca tcactgtgtt tggattgagc aacaagtttg ataccgaatt
      421 tccgtcagtt ctgacaggga aggtggctcc agaagaattt aagaccagca ttggccgtgt
      481 gaactcatgc ttgaaaaagg ctctccctgt caatgtgaaa tggctgctgt gtggatgtct
      541 ctgctgctgc tgtaccctgg ggtgcagcct gtggcccgtg atttgtctca acaaaagaac
      601 cagaagatcg attcagaagt tactagaatg ggaaaataac agattatacc acaagcttgc
      661 tctgcactgg aaactgacta aaaggaaatg tgaaactagc aatatgatgg agtatgtaat
      721 actaatagaa ttcttaccaa aataccccat attccgaccc gactgaggag ttttcttcag
      781 tctcttctgt gttatctgtc atttcctacc cttagtgcct tgtagatgat cttggaatgg
      841 agacagtctc cttcgctgtg ttcaatttat tctttacaac agtagactat tcttctcact
      901 cttttatttg tgttaattta agaaaatttg cacatctttt ttgttattaa atgaggcttg
      961 tgttttgcac tctcaatttt taaataaatg caaacatata cccgtattta tcgttaacac
     1021 taaaaacatc agtgctggtg tttaaagaaa caaaacaaaa accttgttct gagcatgctg
     1081 ccttatgatt ttcatactca ctgtttctaa atatgcatca tttttctagg ctatttaatg
     1141 ctctgtaatc ccttactgga cacacccaaa taagcttttg gtagctttta gaaatggttt
     1201 tactctgctc ttaaagaaaa tgcaattaat agcactggtt tcctcctgca ctttgctaaa
     1261 ttgtcactta tgttagtgga taaaatattt aaactcctaa agacttgtaa atattgtctc
     1321 tttgcataat gtaaaatgtg gtatgccatg gtttacagaa tgtattatta ttatcaatgt
     1381 attgccaaca attccacata gattttacta tgaatgatgt ttgtaagcat cctgttgaat
     1441 gtagagacct ttaacatgct gttttgtggc aaagccaaac tgagtatgtt aaatttcagg
     1501 tgtggggcgg agtgcccttc ctaataagtg gattaaaatt gaaatcatta cttcagatct
     1561 taggcatcac acctgagacc aagaaccttc ttttccattt acttcactgt tttccatttc
     1621 tcctccactc cacccccatc ttacagcctc actagctctc atttcctttc ccttctttga
     1681 aggtacacaa gatttcagtc tttaaatgtc ttaagagctg ggcacatacc gttaatcaat
     1741 cccagcactc agaagacaga gagaggccac agatctcttt gagttcaaga ccaacctggt
     1801 ctacagtatg agttccagga cagcctggtc tacagtatga attctgagac agccagggct
     1861 acacagggaa accctgtctt aaaaaaaaaa caaagtgtct tgagattttt gcctcttatg
     1921 tgaggtatca aggcctccgt gaaagccatg gcttatcctc ttctgaagtt cctgtatcct
     1981 acattgagaa agagcacaga gaagctctac ctacatagta ggctagtcag agttgagaaa
     2041 acagtttcag ccgtctgatt ggggatcttt tttaaacact tataaattat tgaggaaaga
     2101 caagtaaaat ttagataaaa ttgttttcgt ttgtaaattg gccacatttt ttgattgata
     2161 catgcatatt tctctggttt tttccataat taaattgagt gatgttacta ctttgattct
     2221 actataattt gaaattataa tataatataa taaatgtttt tctatcacat taattcaact
     2281 gcaagtgaat gcctgtatat gggcattgtt tgtaatttgc agtgactgac atacattcta
     2341 ttctctttgt ccttctattc ttaactgctt ttaagtaagc tcatctcagt gaacggaaca
     2401 agcttaacaa ggtcaagcct ttttaaggca cttttaagag ttatgcctaa tctgaaatcc
     2461 ttagtccttg gtggaaagag gaaggacatc ctgtttgata tgtggctcta atggtttgca
     2521 caaaatcttt ttgagccacc cagccacccc agatctctaa gttctaatat attatgtatg
     2581 cctgcaaata tgtctgcctg ctgcaaaatt gaaggtgtat ttttatagat aagaaggaag
     2641 cctttgaaaa tgcataccca atgtcttgtt ttatagctaa ggtcagggaa aaacatatct
     2701 atgtcttatg tttcagctaa tgtcatcaga tttatgcttc atactgtggt gttttaatac
     2761 caaaattgat ttccatcata atatagaatt tttaattctc actggtaaaa aaattacttg
     2821 tgaatgtcaa tcctcagcaa tcttacattt cgtctgtagc cttagaattt gaccaaatag
     2881 tcatcatagg aatttttttc tgccatgtac aaatcacact tcattttgtt caaaaaaaaa
     2941 aaatcaagaa gtgtaatgaa ttgtttccat gaaacaaata ttaagacagg aatagattgt
     3001 atatgaaagt gaccaagtat cattcaagtt acaatagtat ttgtcattta aaatatttat
     3061 cattacatgt catatcaatt tgaactcctc actaataact gtattatttt attgttcagt
     3121 atattgattg acaggtgata gttttctcgt tacttttctt ttttatgtga ctggtagttt
     3181 gagtggggaa gaagttcctt ttcattgaaa ttagtcacag caaatgctaa cccttcccct
     3241 ccaaacttct tttcttttaa cctcaggata gaatgtaact tgtatttttc tattgggtta
     3301 gccaagtatt ttgtgaaagt tatttttgac taaaaaagag aataattttg ttgatatata
     3361 atactccttt attaccatgg tagtttccaa aggaaaaaaa gttttgaaat aacattttgc
     3421 caaagcttct aaatctctat aggctttgag atttcaactt aaaggacttt tttttttttt
     3481 cttattctga aaagcctggc atggtggttt ataccccata aattagtgaa tcccagcatt
     3541 tatggggcta aggcaagaga attgctgtga atttgaagcc agcctgggct acaagctgtc
     3601 tcaagaaaaa aggaaaggaa aggaaaggaa aggaaaggaa aggaaaggaa aggaaaggaa
     3661 aggaaaggaa aggaaaggaa gttagttttt gttacttctc atttgatcca agattatggt
     3721 ttaataaatt gatccaattg gtcaatttaa agcttatgta aaaggccagt agcatctata
     3781 ttattaataa aaataagggc aaatgtcact tgcccttgtc tcagacatgt cctctacttg
     3841 tttcccacat taccccatgt taatttagga aaaagattat tgtaacttta gaaatagatg
     3901 ggaaagtgcc ttgtcttttt caaagataac gtggtatgta gaaggaagca gaataaatga
     3961 attaataatg attagaaatg cttcttttca agtaggcatg atagcactag gttattatat
     4021 ttctcttatt taaatccatt tacttatctt ctaataatgt tgtatattaa tgacaaaata
     4081 tcacagaata gaccaggcac ttaaaaattg gtatgatttt aatgctaata agcatagaat
     4141 ttaacacagt tctggaagga ctgtctttga ttgaagaccc taccaaaact cacttaagaa
     4201 ttaaatatcc caagccaggc agtggtggcg caagccttta atcccagcac ttgggaggca
     4261 aaggcaggca gatctctgag tttgaggcca gcctggtcta cacagtgagt tccaggacag
     4321 ccagggctac acagagaaac cctgtctcga aaaaccaaaa taataataat aataataata
     4381 ataattcccc attttttata ttaacatgac ctgtaaacat taatatctca gaaattaaac
     4441 tgtatttgtg cccagcattg ccatttttaa tgagaattat tgttgccttt gataacttta
     4501 ggagagctca ataccatttg taagcctaac aacaattagg tattttcaaa tgtggtgaga
     4561 cctttacaaa tccttagcac cttcattttt gcttacagat aagctgccac ttaaaaataa
     4621 accattactt gaacacaaag accccaaaca atattttatt tgagtttact gtatgtccta
     4681 agcaaataca gaatttacac tcatctgatt cattggacta acttcacata gtggaaatac
     4741 tttttcctaa attgactgga agtattcaat tcattgaaat taagtccaat tatacttata
     4801 attggactta agtctgcttc tttaaaaaaa aaaaggtcta ttttacaact atcaaatcat
     4861 tcaggttccc ttgagtggtg aactgttggg aaatttttcg tggtaaagaa taagtttatt
     4921 aatacttgtt catatacttt gtgagctaaa aataatagaa gggtatctat aagtatatcc
     4981 ttccatgtgt gagtgtgtat gtatatatat gtgtgtgtgt gtatatatgt atgtatgtat
     5041 gtgtataatt cttatcttgc tccagctttt ccactcacct gattctgagc cagccttttt
     5101 attttgatga tggcaacctg agaatatgtt ccattttctg tgaattttgt caaagtcaga
     5161 cttaatgaag aaactatcta atattgtggc cccaggcaag tggtctaaat tatgtgtcag
     5221 tgttttcctc tgtaaaagta gagggttgaa ccttgagcta gacaggaaat gagaggttag
     5281 ttaccattct gtggttctga gaagccacag aagatctttg ctgtgcagtg tgtgaaaatg
     5341 gttattctcg gatctgcact tggtggaaac tcacagtgcc ttgcacacag tttgagttca
     5401 gtttgctggc tggctgctag ttgatgtgtg ttagtgaaaa cacactcaaa gaacccaatg
     5461 cctggtagac cttattccct ctgtgctgat aaaagtgaat gtagtttccc taggaaggag
     5521 gggctgggat ctctgtttgc catgtggaat ctgactacgc agttggtatc aggtgtgaca
     5581 ttggtatccg cttagactgt gtgaagagtt gcaggctcaa tttcacatct ccttcagtgt
     5641 ctcaccaagt tccctgctca ccaaaaggat ctatccgaac ggacttagaa aattcggtgg
     5701 aaaggaaaat ggcatgaaag ttcaaaccca agtcacttct ggtttcattc ctagctctgc
     5761 tgcttaattc ctctgtacct catgtcctca ttgctgaagt ggggacaata ttctggacct
     5821 acctcacagg ggaattgagg gtctttttca tgtgtctgtg tgcttagaag ctgactaaaa
     5881 gaaatattgg atagcatgat tatataattt ctacgtagat gtgactttca gtctgcatta
     5941 tgttttcttt ctcagtaaca tcctacagag tgttctgact caattttttt cccaagtcat
     6001 ttttgttgct aatgccctat ttgttaaaca tgagtgattg tactatatta atacttgatt
     6061 tagggaggaa agcaggtggg tgtaaactag tggccctcag gttagagtag atgaaaaata
     6121 gcagtggaaa gtagccttga gcctttctca agaatcatta attcacataa cactaaaggc
     6181 cacacactga cctatcacat tccttctaca ccagccaaac aacacatgga atcaccatgc
     6241 attttgctca tgttctttcc tgttctgtct attgacatgc ttactgacac tgattaaaag
     6301 ctgtgaatgg aagtgtgctt gtaattaata gaaatgagaa agctgtcctt aagtgtactt
     6361 taatatatac ttgaaaatgg ggaaggaatt tagagatcca tataatgaaa atgttaggag
     6421 ccacttttaa gaagaactaa aattatttgg cctctcaaca cattgtgtcc tagtcctgaa
     6481 tgattggggg caagggggag agagagagag agagagagag agagagagaa aataaatgag
     6541 aattgactag attaagctat aaattcagat tataatttgc cttcagtttt ggtttgtctc
     6601 tggactctag aactgaactg attcagtggg gtgtgtccat gcacacacac acacaggatt
     6661 gcaaatgtac aggattgcag tgttctggtg tcatgttcta gcattagtct aagtaacagt
     6721 ttctcagcat ctgaaagtag ttctatgtgt aaagcctgta tggtaatcaa ggcaataagt
     6781 tctcaaatgg tccttttact cctgcttctt tgatttgctt ttatcttggc atagttttcc
     6841 tgcttttctg tttttattgt aagcaaatag ttgaaaattg ttctaatgcc aggactttgg
     6901 aacaagttac aaatgtttga aattatataa tctacaagct agtttgctgt ccttggacta
     6961 attatatata agtgtgaatt tctactgcaa ggacatccag atagagctgg cgttgttcta
     7021 aagattggat tgaaaaatga aacaacttct ccattttggc caaggattcc tgttggaaca
     7081 gctttcccag aagagaatca tagtggctat gtctgtcgaa ccaagaacat tcatgcatct
     7141 tgtagtgtta tgtagcctgt ggaatgaatt cctcttcccc ctggagtcca ggactgactc
     7201 tcctggaaga actcaaccta tatacagctg tgccaaaaga aggctacctg cctctgaaac
     7261 tcccactgct gcttctgtcg ttgttcactt gtcagataca attttattct caggatgcaa
     7321 attccaataa agtacaaacc catggtactg agttgaaccg tgtggctttg gggca
//
