LOCUS       NM_023186               1557 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus chitinase, acidic 1 (Chia1), mRNA.
ACCESSION   NM_023186 XM_986563 XM_986603
VERSION     NM_023186.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1557)
  AUTHORS   Diaz,R.E., Ecker,A.K., Correy,G.J., Asthana,P., Young,I.D.,
            Faust,B., Thompson,M.C., Seiple,I.B., Van Dyken,S., Locksley,R.M.
            and Fraser,J.S.
  TITLE     Structural characterization of ligand binding and pH-specific
            enzymatic activity of mouse Acidic Mammalian Chitinase
  JOURNAL   Elife 12, 89918 (2024)
   PUBMED   38884443
  REMARK    GeneRIF: Structural characterization of ligand binding and
            pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1557)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1557)
  AUTHORS   Kim,D.H., Wang,Y., Jung,H., Field,R.L., Zhang,X., Liu,T.C., Ma,C.,
            Fraser,J.S., Brestoff,J.R. and Van Dyken,S.J.
  TITLE     A type 2 immune circuit in the stomach controls mammalian
            adaptation to dietary chitin
  JOURNAL   Science 381 (6662), 1092-1098 (2023)
   PUBMED   37676935
REFERENCE   4  (bases 1 to 1557)
  AUTHORS   Sklepkiewicz,P., Dymek,B.A., Mlacki,M., Koralewski,R., Mazur,M.,
            Nejman-Gryz,P., Korur,S., Zagozdzon,A., Rymaszewska,A., von der
            Thusen,J.H., Siwinska,A.M., Guner,N.C., Cheda,L.,
            Paplinska-Goryca,M., Proboszcz,M., van den Bosch,T.P.P., Gorska,K.,
            Golab,J., Kaminski,R.M., Krenke,R., Golebiowski,A., Dzwonek,K. and
            Dobrzanski,P.
  TITLE     Inhibition of CHIT1 as a novel therapeutic approach in idiopathic
            pulmonary fibrosis
  JOURNAL   Eur J Pharmacol 919, 174792 (2022)
   PUBMED   35122869
REFERENCE   5  (bases 1 to 1557)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1557)
  AUTHORS   Bussink,A.P., Vreede,J., Aerts,J.M. and Boot,R.G.
  TITLE     A single histidine residue modulates enzymatic activity in acidic
            mammalian chitinase
  JOURNAL   FEBS Lett 582 (6), 931-935 (2008)
   PUBMED   18294964
REFERENCE   7  (bases 1 to 1557)
  AUTHORS   Homer,R.J., Zhu,Z., Cohn,L., Lee,C.G., White,W.I., Chen,S. and
            Elias,J.A.
  TITLE     Differential expression of chitinases identify subsets of murine
            airway epithelial cells in allergic inflammation
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 291 (3), L502-L511 (2006)
   PUBMED   16556727
  REMARK    GeneRIF: AMCase provides the first positive molecular marker of
            distal Clara cell secretory protein-expressing cells under these
            conditions.
REFERENCE   8  (bases 1 to 1557)
  AUTHORS   Zhu,Z., Zheng,T., Homer,R.J., Kim,Y.K., Chen,N.Y., Cohn,L.,
            Hamid,Q. and Elias,J.A.
  TITLE     Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13
            pathway activation
  JOURNAL   Science 304 (5677), 1678-1682 (2004)
   PUBMED   15192232
  REMARK    GeneRIF: findings show that acidic mammalian chitinase is induced
            via a T helper-2 (Th2)-specific, interleukin-13 (IL-13)-mediated
            pathway in epithelial cells and macrophages in an aeroallergen
            asthma model
REFERENCE   9  (bases 1 to 1557)
  AUTHORS   Suzuki,M., Fujimoto,W., Goto,M., Morimatsu,M., Syuto,B. and
            Iwanaga,T.
  TITLE     Cellular expression of gut chitinase mRNA in the gastrointestinal
            tract of mice and chickens
  JOURNAL   J Histochem Cytochem 50 (8), 1081-1089 (2002)
   PUBMED   12133911
REFERENCE   10 (bases 1 to 1557)
  AUTHORS   Boot,R.G., Blommaart,E.F., Swart,E., Ghauharali-van der Vlugt,K.,
            Bijl,N., Moe,C., Place,A. and Aerts,J.M.
  TITLE     Identification of a novel acidic mammalian chitinase distinct from
            chitotriosidase
  JOURNAL   J Biol Chem 276 (9), 6770-6778 (2001)
   PUBMED   11085997
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC034548.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_986603.1, XM_986563.1, NM_023186.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034548.1, BC011134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1557
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.49 cM"
     gene            1..1557
                     /gene="Chia1"
                     /gene_synonym="2200003E03Rik; AMCase; Chia; YNL"
                     /note="chitinase, acidic 1"
                     /db_xref="GeneID:81600"
                     /db_xref="MGI:MGI:1932052"
     exon            1..28
                     /gene="Chia1"
                     /gene_synonym="2200003E03Rik; AMCase; Chia; YNL"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..1425
                     /gene="Chia1"
                     /gene_synonym="2200003E03Rik; AMCase; Chia; YNL"
                     /EC_number="3.2.1.14"
                     /note="acidic mammalian chitinase; acidic chitinase"
                     /codon_start=1
                     /product="acidic mammalian chitinase precursor"
                     /protein_id="NP_075675.2"
                     /db_xref="CCDS:CCDS38585.1"
                     /db_xref="GeneID:81600"
                     /db_xref="MGI:MGI:1932052"
                     /translation="MAKLLLVTGLALLLNAQLGSAYNLICYFTNWAQYRPGLGSFKPD
                     DINPCLCTHLIYAFAGMQNNEITTIEWNDVTLYKAFNDLKNRNSKLKTLLAIGGWNFG
                     TAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVK
                     EMREAFEQEAIESNRPRLMVTAAVAGGISNIQAGYEIPELSKYLDFIHVMTYDLHGSW
                     EGYTGENSPLYKYPTETGSNAYLNVDYVMNYWKNNGAPAEKLIVGFPEYGHTFILRNP
                     SDNGIGAPTSGDGPAGPYTRQAGFWAYYEICTFLRSGATEVWDASQEVPYAYKANEWL
                     GYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTSTLNKALGISTE
                     GCTAPDVPSEPVTTPPGSGSGGGSSGGSSGGSGFCADKADGLYPVADDRNAFWQCING
                     ITYQQHCQAGLVFDTSCNCCNWP"
     exon            29..58
                     /gene="Chia1"
                     /gene_synonym="2200003E03Rik; AMCase; Chia; YNL"
                     /inference="alignment:Splign:2.1.0"
     exon            59..260
                     /gene="Chia1"
                     /gene_synonym="2200003E03Rik; AMCase; Chia; YNL"
                     /inference="alignment:Splign:2.1.0"
     exon            261..317
                     /gene="Chia1"
                     /gene_synonym="2200003E03Rik; AMCase; Chia; YNL"
                     /inference="alignment:Splign:2.1.0"
     exon            318..483
                     /gene="Chia1"
                     /gene_synonym="2200003E03Rik; AMCase; Chia; YNL"
                     /inference="alignment:Splign:2.1.0"
     exon            484..608
                     /gene="Chia1"
                     /gene_synonym="2200003E03Rik; AMCase; Chia; YNL"
                     /inference="alignment:Splign:2.1.0"
     exon            609..732
                     /gene="Chia1"
                     /gene_synonym="2200003E03Rik; AMCase; Chia; YNL"
                     /inference="alignment:Splign:2.1.0"
     exon            733..918
                     /gene="Chia1"
                     /gene_synonym="2200003E03Rik; AMCase; Chia; YNL"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1038
                     /gene="Chia1"
                     /gene_synonym="2200003E03Rik; AMCase; Chia; YNL"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1180
                     /gene="Chia1"
                     /gene_synonym="2200003E03Rik; AMCase; Chia; YNL"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1526
                     /gene="Chia1"
                     /gene_synonym="2200003E03Rik; AMCase; Chia; YNL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1507..1512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chia1"
                     /gene_synonym="2200003E03Rik; AMCase; Chia; YNL"
                     /note="hexamer: AATAAA"
     polyA_site      1526
                     /gene="Chia1"
                     /gene_synonym="2200003E03Rik; AMCase; Chia; YNL"
                     /note="major polyA site"
ORIGIN      
        1 acgatggcca agctacttct cgtcacaggt ctggctcttc tgctgaatgc tcagctgggg
       61 tctgcctaca atctgatatg ctatttcacc aactgggccc agtatcggcc aggtctgggg
      121 agcttcaagc ctgatgacat taacccctgc ctgtgtactc acctgatcta tgcctttgct
      181 gggatgcaga acaatgagat caccaccata gaatggaatg atgttactct ctataaagct
      241 ttcaatgact tgaaaaacag gaacagcaaa ctgaaaaccc tcctggcaat tggaggctgg
      301 aactttggaa ctgctccttt cactaccatg gtttccactt ctcagaaccg ccagaccttc
      361 attacctcag tcatcaaatt tctgcgtcag tatgggtttg atggactgga cctggactgg
      421 gaatacccag gctcacgtgg gagccctcct caggacaagc atctcttcac tgtcctggtg
      481 aaggaaatgc gtgaagcttt tgagcaggag gctattgaga gcaacaggcc cagactgatg
      541 gttactgctg ctgtagctgg tgggatttcc aacatccagg ctggctatga gatccctgaa
      601 ctttctaagt acctggattt catccatgtc atgacatatg acctccatgg ctcctgggag
      661 ggctacactg gggagaatag tcctctttac aaatacccta ctgagactgg tagcaatgcc
      721 tacctcaatg tggattatgt catgaactat tggaagaaca atggagcccc agctgagaag
      781 ctcattgttg gattcccaga gtatggacac accttcatcc tgagaaaccc ctctgataat
      841 ggaattggtg cccctacctc tggtgatggc cctgctgggc cctataccag acaggctggg
      901 ttctgggcct actatgagat ttgcaccttt ctgagaagtg gagccactga ggtctgggat
      961 gcctcccaag aagtgcccta tgcctataag gccaacgagt ggcttggcta tgacaatatc
     1021 aagagcttca gtgttaaggc tcagtggctt aagcagaaca attttggagg tgccatgatc
     1081 tgggccattg accttgatga cttcactggc tctttctgtg atcagggaaa atttcctctg
     1141 acttctactt tgaacaaagc ccttggcata tccactgaag gttgcacagc tcctgacgtg
     1201 ccttccgagc cagtgactac tcctccagga agtgggagtg ggggtggaag ctccggagga
     1261 agctctggag gcagtggatt ctgtgccgac aaagcagatg gcctctaccc tgtggcagat
     1321 gacagaaatg ctttttggca gtgcatcaat ggaatcacat accagcagca ttgtcaagca
     1381 gggcttgttt ttgataccag ctgtaattgc tgcaactggc catgaaccta atgccattct
     1441 tccagaaatt tctgcactct cctttactcc tcaccaaaag taactatctt ccctttaacc
     1501 ttatgcaata aaattggtag ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
