LOCUS       NM_007695               1626 bp    mRNA    linear   ROD 26-SEP-2024
DEFINITION  Mus musculus chitinase 3 like 1 (Chi3l1), transcript variant 1,
            mRNA.
ACCESSION   NM_007695
VERSION     NM_007695.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1626)
  AUTHORS   Noguchi,K., Inai,T. and Kuwana,R.
  TITLE     Chitinase 3-Like 1 and C-X-C motif chemokine ligand 5 proteins and
            the hair cycle
  JOURNAL   Arch Dermatol Res 316 (8), 523 (2024)
   PUBMED   39150635
  REMARK    GeneRIF: Chitinase 3-Like 1 and C-X-C motif chemokine ligand 5
            proteins and the hair cycle.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1626)
  AUTHORS   Song,Y., Jiang,W., Afridi,S.K., Wang,T., Zhu,F., Xu,H., Nazir,F.H.,
            Liu,C., Wang,Y., Long,Y., Huang,Y.A., Qiu,W. and Tang,C.
  TITLE     Astrocyte-derived CHI3L1 signaling impairs neurogenesis and
            cognition in the demyelinated hippocampus
  JOURNAL   Cell Rep 43 (5), 114226 (2024)
   PUBMED   38733586
  REMARK    GeneRIF: Astrocyte-derived CHI3L1 signaling impairs neurogenesis
            and cognition in the demyelinated hippocampus.
REFERENCE   3  (bases 1 to 1626)
  AUTHORS   Xu,W., Chao,R., Xie,X., Mao,Y., Chen,X., Chen,X. and Zhang,S.
  TITLE     IL13Ralpha2 as a crucial receptor for Chi3l1 in osteoclast
            differentiation and bone resorption through the MAPK/AKT pathway
  JOURNAL   Cell Commun Signal 22 (1), 81 (2024)
   PUBMED   38291404
  REMARK    GeneRIF: IL13Ralpha2 as a crucial receptor for Chi3l1 in osteoclast
            differentiation and bone resorption through the MAPK/AKT pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1626)
  AUTHORS   Kui,L., Kim,A.D., Onyuru,J., Hoffman,H.M. and Feldstein,A.E.
  TITLE     BRP39 Regulates Neutrophil Recruitment in NLRP3
            Inflammasome-Induced Liver Inflammation
  JOURNAL   Cell Mol Gastroenterol Hepatol 17 (3), 481-497 (2024)
   PUBMED   38092312
  REMARK    GeneRIF: BRP39 Regulates Neutrophil Recruitment in NLRP3
            Inflammasome-Induced Liver Inflammation.
REFERENCE   5  (bases 1 to 1626)
  AUTHORS   Ahmad,I., Wergeland,S., Oveland,E. and Bo,L.
  TITLE     An Association of Chitinase-3 Like-Protein-1 With Neuronal
            Deterioration in Multiple Sclerosis
  JOURNAL   ASN Neuro 15, 17590914231198980 (2023)
   PUBMED   38062768
  REMARK    GeneRIF: An Association of Chitinase-3 Like-Protein-1 With Neuronal
            Deterioration in Multiple Sclerosis.
REFERENCE   6  (bases 1 to 1626)
  AUTHORS   Sancho-Shimizu,V., Khan,R., Mostowy,S., Lariviere,L., Wilkinson,R.,
            Riendeau,N., Behr,M. and Malo,D.
  TITLE     Molecular genetic analysis of two loci (Ity2 and Ity3) involved in
            the host response to infection with Salmonella typhimurium using
            congenic mice and expression profiling
  JOURNAL   Genetics 177 (2), 1125-1139 (2007)
   PUBMED   17660555
REFERENCE   7  (bases 1 to 1626)
  AUTHORS   Mizoguchi,E.
  TITLE     Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing
            bacterial adhesion and invasion in colonic epithelial cells
  JOURNAL   Gastroenterology 130 (2), 398-411 (2006)
   PUBMED   16472595
  REMARK    GeneRIF: pathogenic role in colitis, presumably by enhancing the
            adhesion and invasion of bacteria on/into colonic epithelial cells.
REFERENCE   8  (bases 1 to 1626)
  AUTHORS   Jin,H.M., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Kirkpatrick,R.B. and Rosenberg,M.
  TITLE     Genetic characterization of the murine Ym1 gene and identification
            of a cluster of highly homologous genes
  JOURNAL   Genomics 54 (2), 316-322 (1998)
   PUBMED   9828134
REFERENCE   9  (bases 1 to 1626)
  AUTHORS   Shackelton,L.M., Mann,D.M. and Millis,A.J.
  TITLE     Identification of a 38-kDa heparin-binding glycoprotein (gp38k) in
            differentiating vascular smooth muscle cells as a member of a group
            of proteins associated with tissue remodeling
  JOURNAL   J Biol Chem 270 (22), 13076-13083 (1995)
   PUBMED   7768902
REFERENCE   10 (bases 1 to 1626)
  AUTHORS   Morrison,B.W. and Leder,P.
  TITLE     neu and ras initiate murine mammary tumors that share genetic
            markers generally absent in c-myc and int-2-initiated tumors
  JOURNAL   Oncogene 9 (12), 3417-3426 (1994)
   PUBMED   7970700
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137104.11.
            
            On Jan 19, 2022 this sequence version replaced NM_007695.3.
            
            Sequence Note: This RefSeq is annotated with the 5'-most in-frame
            translation initiation codon. This start codon has a weak Kozak
            signal, so it is possible that leaky scanning by ribosomes may
            occur and translation may sometimes initiate at the next in-frame
            start codon. The second start codon has a strong Kozak signal and
            results in a protein that is 8 aa shorter at the N-terminus. The
            shorter protein has been reported in the literature (e.g.,
            PMID:19041398).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003780.1, AK051475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC137104.11        74077-74162         c
            87-116              AC137104.11        73820-73849         c
            117-321             AC137104.11        72928-73132         c
            322-378             AC137104.11        72449-72505         c
            379-529             AC137104.11        71330-71480         c
            530-651             AC137104.11        70003-70124         c
            652-775             AC137104.11        68636-68759         c
            776-958             AC137104.11        67952-68134         c
            959-1075            AC137104.11        67316-67432         c
            1076-1626           AC137104.11        66598-67148         c
FEATURES             Location/Qualifiers
     source          1..1626
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.15 cM"
     gene            1..1626
                     /gene="Chi3l1"
                     /gene_synonym="Brp39; Chil1; Gp39"
                     /note="chitinase 3 like 1"
                     /db_xref="GeneID:12654"
                     /db_xref="MGI:MGI:1340899"
     exon            1..86
                     /gene="Chi3l1"
                     /gene_synonym="Brp39; Chil1; Gp39"
                     /inference="alignment:Splign:2.1.0"
     exon            87..116
                     /gene="Chi3l1"
                     /gene_synonym="Brp39; Chil1; Gp39"
                     /inference="alignment:Splign:2.1.0"
     exon            117..321
                     /gene="Chi3l1"
                     /gene_synonym="Brp39; Chil1; Gp39"
                     /inference="alignment:Splign:2.1.0"
     exon            322..378
                     /gene="Chi3l1"
                     /gene_synonym="Brp39; Chil1; Gp39"
                     /inference="alignment:Splign:2.1.0"
     exon            379..529
                     /gene="Chi3l1"
                     /gene_synonym="Brp39; Chil1; Gp39"
                     /inference="alignment:Splign:2.1.0"
     exon            530..651
                     /gene="Chi3l1"
                     /gene_synonym="Brp39; Chil1; Gp39"
                     /inference="alignment:Splign:2.1.0"
     exon            652..775
                     /gene="Chi3l1"
                     /gene_synonym="Brp39; Chil1; Gp39"
                     /inference="alignment:Splign:2.1.0"
     exon            776..958
                     /gene="Chi3l1"
                     /gene_synonym="Brp39; Chil1; Gp39"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1075
                     /gene="Chi3l1"
                     /gene_synonym="Brp39; Chil1; Gp39"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1626
                     /gene="Chi3l1"
                     /gene_synonym="Brp39; Chil1; Gp39"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1607..1612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chi3l1"
                     /gene_synonym="Brp39; Chil1; Gp39"
                     /note="hexamer: AATAAA"
     polyA_site      1626
                     /gene="Chi3l1"
                     /gene_synonym="Brp39; Chil1; Gp39"
                     /note="major polyA site"
ORIGIN      
        1 gccctgacta ggaagctggg tactaggaga agccatcatg cacacctcta ctgaagccag
       61 gatgggcatg agggcggcac tgacaggctt tgcggtcctg atgctgctcc agagctgctc
      121 tgcgtacaag ctggtctgct acttcaccag ctggtcccag taccgggaag gcgttggaag
      181 cttcttacca gacgccatcc aacctttcct gtgcacccac atcatctaca gctttgccaa
      241 catcagcagc gacaacatgc ttagcacatg ggagtggaat gacgagtcga actatgacaa
      301 gctgaataaa ctgaagacca gaaacaccaa cctgaagacc ctcctgtctg ttggagggtg
      361 gaaatttggc gaaaaaagat tttccgagat tgcctccaac actgagagac gcactgcttt
      421 cgtccggtcg gtagccccgt tcctgcgttc ttatggcttt gatgggctgg atctcgcctg
      481 gctctaccct cgcttaagag acaagcagta tttctccacc ctgatcaagg aactgaatgc
      541 ggaattcaca aaggaggtcc agccaggcag agagaaactc ctgctcagcg cagctttgtc
      601 agcaggaaag gtggccattg acactggcta tgacatcgcc cagatagccc aacacctgga
      661 ttttatcaat ctcatgacct acgatttcca tggagtctgg cgccaaatca caggccatca
      721 cagccccctc ttccaaggcc agaaggacac taggtttgac agatacagca atgtgaacta
      781 tgccgtgcag tacatgatac gtctgggagc ccaggccagc aagctactga tgggcatccc
      841 cacctttggg aagagcttca ctctggcatc ttctgaaaat cagttgggag ctccaatctc
      901 aggggaagga ttaccaggcc ggttcaccaa ggaggcaggg accctggcct actacgagat
      961 atgcgacttc ctcaaaggag ctgaagtaca tcgactctcc aacgagaagg ttcccttcgc
     1021 taccaagggc aaccagtggg tggggtatga ggacaaggag agtgtcaaaa acaaggttgg
     1081 gttcctgaag gagaagaagc tggcaggagc catggtgtgg gcactggatt tggatgattt
     1141 ccagggcacc tgtcagccga aggaattctt cccgctcacc aacgccatca aggatgccct
     1201 ggcttagctc cccctttccc atatggtacc cccactctct ggccaggagt ttaatctctt
     1261 gcaatgttaa gtcccccaac tgagcctcag tttctccttc ccttggcacc tgtgtaaggg
     1321 gccacagcag gctcagctat ggagaacagg gaactagggt aggacgatgg tggggttgtg
     1381 agagtcacag tgtgagcaga tacacaaccc tgttaaggaa tgcaaattct cagactctaa
     1441 cctcccttta cccagcctga ccaaaggaca ccacttggat caagtaggca aatatcttac
     1501 aggattgagg gaccatacta attataccct ctgcaaagcc caacttgaat ccttccctta
     1561 ggaacttaat cgtcccactt ccctttccct aattccacag ctgttcaata aagcgccaga
     1621 acctaa
//
