LOCUS       NM_007694               2376 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus chromogranin B (Chgb), mRNA.
ACCESSION   NM_007694
VERSION     NM_007694.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2376)
  AUTHORS   Zhang,Y., Kunii,M., Taniguchi,M., Yoshimura,S.I. and Harada,A.
  TITLE     Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is
            Essential for the Establishment of Neuronal Polarity and Brain
            Formation
  JOURNAL   J Neurosci 44 (27), e2334232024 (2024)
   PUBMED   38830762
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2376)
  AUTHORS   Shue,Y.T., Drainas,A.P., Li,N.Y., Pearsall,S.M., Morgan,D.,
            Sinnott-Armstrong,N., Hipkins,S.Q., Coles,G.L., Lim,J.S., Oro,A.E.,
            Simpson,K.L., Dive,C. and Sage,J.
  TITLE     A conserved YAP/Notch/REST network controls the neuroendocrine cell
            fate in the lungs
  JOURNAL   Nat Commun 13 (1), 2690 (2022)
   PUBMED   35577801
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2376)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   4  (bases 1 to 2376)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2376)
  AUTHORS   Kameneva,P., Artemov,A.V., Kastriti,M.E., Faure,L., Olsen,T.K.,
            Otte,J., Erickson,A., Semsch,B., Andersson,E.R., Ratz,M.,
            Frisen,J., Tischler,A.S., de Krijger,R.R., Bouderlique,T.,
            Akkuratova,N., Vorontsova,M., Gusev,O., Fried,K., Sundstrom,E.,
            Mei,S., Kogner,P., Baryawno,N., Kharchenko,P.V. and Adameyko,I.
  TITLE     Single-cell transcriptomics of human embryos identifies multiple
            sympathoblast lineages with potential implications for
            neuroblastoma origin
  JOURNAL   Nat Genet 53 (5), 694-706 (2021)
   PUBMED   33833454
REFERENCE   6  (bases 1 to 2376)
  AUTHORS   Zuberi,A.R. and Roopenian,D.C.
  TITLE     High-resolution mapping of a minor histocompatibility antigen gene
            on mouse chromosome 2
  JOURNAL   Mamm Genome 4 (9), 516-522 (1993)
   PUBMED   8118101
REFERENCE   7  (bases 1 to 2376)
  AUTHORS   Jenkins,N.A., Mattei,M.G., Gilbert,D.J., Linard,C.G., Mbikay,M.,
            Chretien,M. and Copeland,N.G.
  TITLE     Assignment of secretogranin I locus to mouse chromosome 2 by in
            situ hybridization and interspecific backcross analysis
  JOURNAL   Genomics 11 (2), 479-480 (1991)
   PUBMED   1685143
REFERENCE   8  (bases 1 to 2376)
  AUTHORS   Pohl,T.M., Phillips,E., Song,K.Y., Gerdes,H.H., Huttner,W.B. and
            Ruther,U.
  TITLE     The organisation of the mouse chromogranin B (secretogranin I) gene
  JOURNAL   FEBS Lett 262 (2), 219-224 (1990)
   PUBMED   2335203
REFERENCE   9  (bases 1 to 2376)
  AUTHORS   Linard,C.G., Mbikay,M., Seidah,N.G. and Chretien,M.
  TITLE     Primary structure of mouse chromogranin B deduced from cDNA
            sequence
  JOURNAL   Nucleic Acids Res 18 (5), 1298 (1990)
   PUBMED   2320426
REFERENCE   10 (bases 1 to 2376)
  AUTHORS   Eiden,L.E., Huttner,W.B., Mallet,J., O'Connor,D.T., Winkler,H. and
            Zanini,A.
  TITLE     A nomenclature proposal for the chromogranin/secretogranin proteins
  JOURNAL   Neuroscience 21 (3), 1019-1021 (1987)
   PUBMED   3627430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929562.12.
            
            On Apr 21, 2018 this sequence version replaced NM_007694.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014736.1, X53028.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AL929562.12        11645-11785
            142-188             AL929562.12        15987-16033
            189-282             AL929562.12        16456-16549
            283-2048            AL929562.12        22333-24098
            2049-2376           AL929562.12        24755-25082
FEATURES             Location/Qualifiers
     source          1..2376
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 64.74 cM"
     gene            1..2376
                     /gene="Chgb"
                     /gene_synonym="cgB; Scg-1; sgI"
                     /note="chromogranin B"
                     /db_xref="GeneID:12653"
                     /db_xref="MGI:MGI:88395"
     exon            1..141
                     /gene="Chgb"
                     /gene_synonym="cgB; Scg-1; sgI"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2126
                     /gene="Chgb"
                     /gene_synonym="cgB; Scg-1; sgI"
                     /note="secretogranin-1; secretogranin I"
                     /codon_start=1
                     /product="secretogranin-1 precursor"
                     /protein_id="NP_031720.1"
                     /db_xref="CCDS:CCDS16777.1"
                     /db_xref="GeneID:12653"
                     /db_xref="MGI:MGI:88395"
                     /translation="MQPAMLLGLLGAAALAAVSSAPVDNRDHNEEMVTRCIIEVLSNA
                     LSKSSVPTITPECRQVLKKSGKEVKGEEKGENQNSKFEVRLLRDPADASGTRWASSRE
                     DAGAPVEDSQGQTKVGNEKWTEGGGHSREGVDDQESLRPSNQQASKEAKIYHSEERVG
                     KEREKEEGKIYPMGEHREDAGEEKKHIEDSGEKPNTFSNKRSEASAKKKDESVARADA
                     HSMELEEKTHSREQSSQESGEETRRQEKPQELTDQDQSQEESQEGEEGEEGEEGEEGE
                     EDSASEVTKRRPRHHHGRSGSNKSSYEGHPLSEERRPSPKESKEADVATVRLGEKRSH
                     HLAHYRASEEEPEYGEESRSYRGLQYRGRGSEEDRAPRPRSEESQEREYKRNHPDSEL
                     ESTANRHGEETEEERSYEGANGRQHRGRGREPGAHSALDTREEKRLLDEGHYPVRESP
                     IDTAKRYPQSKWQEQEKNYLNYGEEGDQGRWWQQEEQLGPEESREEVRFPDRQYEPYP
                     ITEKRKRLGALFNPYFDPLQWKNSDFEKRGNPDDSFLEDEGEDRNGVTLTEKNSFPEY
                     NYDWWERRPFSEDVNWGYEKRSFARAPQLDLKRQYDGVAELDQLLHYRKKADEFPDFY
                     DSEEQMGPHQEANDEKARADQRVLTAEEKKELENLAAMDLELQKIAEKFSQRG"
     exon            142..188
                     /gene="Chgb"
                     /gene_synonym="cgB; Scg-1; sgI"
                     /inference="alignment:Splign:2.1.0"
     exon            189..282
                     /gene="Chgb"
                     /gene_synonym="cgB; Scg-1; sgI"
                     /inference="alignment:Splign:2.1.0"
     exon            283..2048
                     /gene="Chgb"
                     /gene_synonym="cgB; Scg-1; sgI"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2376
                     /gene="Chgb"
                     /gene_synonym="cgB; Scg-1; sgI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2352..2357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chgb"
                     /gene_synonym="cgB; Scg-1; sgI"
                     /note="hexamer: AATAAA"
     polyA_site      2376
                     /gene="Chgb"
                     /gene_synonym="cgB; Scg-1; sgI"
                     /note="major polyA site"
ORIGIN      
        1 ataagagcca ggcctgcgcc caccgcgcca cagctgctct gcggagcccg cacccgccga
       61 gctcctccta cactcagctg gcgagaggca ccatgcagcc ggctatgctc ctcggcctcc
      121 tgggcgcagc ggctctggcc gctgtcagct cagctccagt ggataacagg gatcacaatg
      181 aagaaatggt gactcgctgc attatcgaag tcctctcaaa tgccctatcc aagtccagtg
      241 ttccaacgat cacccctgag tgccggcaag tcctgaagaa gagtggaaaa gaggtcaaag
      301 gtgaagagaa aggtgaaaac cagaactcga agtttgaagt acggttgcta agagacccag
      361 ccgatgcctc aggaacccgc tgggcctcca gtagggagga tgcaggcgct ccagtagaag
      421 actctcaagg ccagacgaag gtaggcaatg agaagtggac agaaggagga ggacacagcc
      481 gagagggagt ggatgatcaa gagagtctcc gtccctccaa ccaacaagcg tccaaagaag
      541 caaagatata ccattcggaa gagagggtgg gaaaagagag ggagaaagaa gaaggcaaga
      601 tttacccaat gggggagcac agggaagatg ctggtgaaga gaagaaacac attgaagatt
      661 ctggagagaa gccgaacacc ttctccaaca aaagaagcga ggcttccgct aagaaaaaag
      721 atgagtcagt ggccagagca gatgcacact ccatggagct ggaggagaag acacacagta
      781 gggagcaaag cagccaggag agtggagagg agacaaggag gcaggagaaa ccccaggagc
      841 ttaccgacca ggaccagagc caggaagaat cccaggaagg cgaggaaggt gaggaaggcg
      901 aggaaggcga ggaaggcgag gaagactcag cctctgaagt aaccaaacgc aggcccagac
      961 accaccacgg gagaagcggg tccaacaagt cctcttacga agggcatcct ctatctgagg
     1021 aaaggagacc ctctcccaag gagtccaagg aggcagatgt ggccacagtc cgtttagggg
     1081 aaaaaaggag tcaccatcta gctcactaca gggcttcaga agaagaacct gaatatgggg
     1141 aagaatcgag aagctatcgg ggactacagt accggggtag aggaagcgaa gaggacagag
     1201 ccccaaggcc tcggagtgag gagagtcagg aaagggagta taagagaaac caccccgact
     1261 ctgaactgga aagcacagca aacagacatg gtgaagaaac cgaggaagag aggagctacg
     1321 agggggcaaa tggacgccaa cacagaggca gggggcggga gccaggagcc cattctgctc
     1381 ttgacaccag agaagaaaaa aggctcttgg atgaagggca ctaccctgtt cgcgaaagcc
     1441 caatagatac ggcaaaaagg tacccacaaa gcaaatggca agagcaggag aaaaactacc
     1501 tcaactatgg cgaggaaggg gaccaaggga gatggtggca gcaggaagag cagctaggac
     1561 cggaagaaag cagggaggaa gtaaggtttc cagacagaca atatgagccc tatcccatca
     1621 ctgaaaagag gaagaggtta ggggcgctgt tcaacccgta ctttgaccct ctccagtgga
     1681 agaatagtga ctttgagaaa agaggcaacc cagatgacag ttttcttgag gatgaaggtg
     1741 aagacagaaa tggggtgacc ttgactgaga agaattcctt cccagagtac aactatgact
     1801 ggtgggagag aaggcccttc tcagaggatg tgaattgggg atatgagaag agaagctttg
     1861 ccagggcccc tcagctcgac ttgaaacggc aatatgatgg agtggccgag ttggaccagc
     1921 tgcttcacta caggaagaag gcagacgaat ttcccgattt ctacgactcg gaggagcaga
     1981 tggggcctca ccaggaggca aacgatgaaa aggccagggc tgaccagaga gttctgacgg
     2041 cggaagagaa aaaggaactg gagaacttgg ctgcgatgga tctggaactc cagaagatag
     2101 cggaaaagtt cagccagcgg ggctgacagt tggagagacg agcctttcac tgaaggacac
     2161 cattgattca cccacaggca gaaagcagaa tttactgttt attaaatgtt tgatgcagtt
     2221 ggaaatatca tttatctttg ccagaatgct aatgccatgt gactagcgtg acttgtagcg
     2281 tattcttcct gcaaaataga tgtttcacgt gtctgtgaca atgaccgtgt tactgttgtt
     2341 gaaacacaaa caataaaaag atttacctga aacaaa
//
