LOCUS       NM_007693               1920 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus chromogranin A (Chga), mRNA.
ACCESSION   NM_007693
VERSION     NM_007693.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1920)
  AUTHORS   Scavuzzo,M.A., Szlachcic,W.J., Hill,M.C., Ziojla,N.M., Teaw,J.,
            Carlson,J.C., Tiessen,J., Chmielowiec,J., Martin,J.F. and
            Borowiak,M.
  TITLE     Pancreatic organogenesis mapped through space and time
  JOURNAL   Exp Mol Med 57 (1), 204-220 (2025)
   PUBMED   39779976
REFERENCE   2  (bases 1 to 1920)
  AUTHORS   Mulet,I., Grueso-Cortina,C., Cortes-Cano,M., Gerovska,D., Wu,G.,
            Iakab,S.A., Jimenez-Blasco,D., Curtabbi,A., Hernansanz-Agustin,P.,
            Ketchum,H., Manjarres-Raza,I., Wunderlich,F.T., Bolanos,J.P.,
            Dawlaty,M.M., Hopf,C., Enriquez,J.A., Arauzo-Bravo,M.J. and
            Tapia,N.
  TITLE     TET3 regulates terminal cell differentiation at the metabolic level
  JOURNAL   Nat Commun 15 (1), 9749 (2024)
   PUBMED   39557858
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1920)
  AUTHORS   Ortiz,J.A., Ghazalli,N., Lopez,K., Rawson,J., McCown,E.M., Oh,E.,
            Irimia,J.M., Jou,K., Mares,J., Chen,M.H., Wu,X., Zook,H.N.,
            Quijano,J.C., Erdem,N., Lizarraga,A., Kandeel,F., Fueger,P.T.,
            Thurmond,D.C. and Ku,H.T.
  TITLE     Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is
            Required for the Development of Islets and for beta-Cell Function
            During Aging
  JOURNAL   Diabetes 73 (9), 1447-1461 (2024)
   PUBMED   38905124
REFERENCE   4  (bases 1 to 1920)
  AUTHORS   Kane,E., Mak,T.C.S. and Latreille,M.
  TITLE     MicroRNA-7 regulates endocrine progenitor delamination and
            endocrine cell mass in developing pancreatic islets
  JOURNAL   iScience 27 (7), 110332 (2024)
   PUBMED   39055950
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1920)
  AUTHORS   Kumar,N., Prakash,P.G., Wentland,C., Kurian,S.M., Jethva,G.,
            Brinkmann,V., Mollenkopf,H.J., Krammer,T., Toussaint,C.,
            Saliba,A.E., Biebl,M., Jurgensen,C., Wiedenmann,B., Meyer,T.F.,
            Gurumurthy,R.K. and Chumduri,C.
  TITLE     Decoding spatiotemporal transcriptional dynamics and epithelial
            fibroblast crosstalk during gastroesophageal junction development
            through single cell analysis
  JOURNAL   Nat Commun 15 (1), 3064 (2024)
   PUBMED   38594232
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1920)
  AUTHORS   Wu,H., Rozansky,D.J., Webster,N.J. and O'Connor,D.T.
  TITLE     Cell type-specific gene expression in the neuroendocrine system. A
            neuroendocrine-specific regulatory element in the promoter of
            chromogranin A, a ubiquitous secretory granule core protein
  JOURNAL   J Clin Invest 94 (1), 118-129 (1994)
   PUBMED   8040254
REFERENCE   7  (bases 1 to 1920)
  AUTHORS   Abbott,C. and Chambers,D.
  TITLE     Analysis of CAG trinucleotide repeats from mouse cDNA sequences
  JOURNAL   Ann Hum Genet 58 (2), 87-94 (1994)
   PUBMED   7979162
REFERENCE   8  (bases 1 to 1920)
  AUTHORS   Rowland,E.C., Lozykowski,M.G. and McCormick,T.S.
  TITLE     Differential cardiac histopathology in inbred mouse strains
            chronically infected with Trypanosoma cruzi
  JOURNAL   J Parasitol 78 (6), 1059-1066 (1992)
   PUBMED   1491299
REFERENCE   9  (bases 1 to 1920)
  AUTHORS   Wu,H.J., Rozansky,D.J., Parmer,R.J., Gill,B.M. and O'Connor,D.T.
  TITLE     Structure and function of the chromogranin A gene. Clues to
            evolution and tissue-specific expression
  JOURNAL   J Biol Chem 266 (20), 13130-13134 (1991)
   PUBMED   2071596
REFERENCE   10 (bases 1 to 1920)
  AUTHORS   Modi,W.S., Levine,M.A., Seuanez,H.N., Dean,M. and O'Brien,S.J.
  TITLE     The human chromogranin A gene: chromosome assignment and RFLP
            analysis
  JOURNAL   Am J Hum Genet 45 (5), 814-818 (1989)
   PUBMED   2573279
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY250052.1 and M64278.1.
            
            On Nov 10, 2015 this sequence version replaced NM_007693.1.
            
            Summary: This gene encodes a member of the granin family of acidic
            secretory glycoproteins that are expressed in endocrine cells and
            neurons. The encoded preproprotein undergoes proteolytic processing
            to generate multiple functions peptides including pancreastatin,
            catestatin and serpinin. The encoded protein plays important roles
            in the neuroendocrine system including regulated secretion of
            peptide hormones and neurotransmitters. Mice lacking the encoded
            protein exhibit elevated blood pressure which can be rescued by
            transgenic expression of the human ortholog. [provided by RefSeq,
            Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M64278.1, AK144504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BY250052.1         1-28
            29-1920             M64278.1           1-1892
FEATURES             Location/Qualifiers
     source          1..1920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 51.66 cM"
     gene            1..1920
                     /gene="Chga"
                     /gene_synonym="cgA; ChrA"
                     /note="chromogranin A"
                     /db_xref="GeneID:12652"
                     /db_xref="MGI:MGI:88394"
     exon            1..230
                     /gene="Chga"
                     /gene_synonym="cgA; ChrA"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1576
                     /gene="Chga"
                     /gene_synonym="cgA; ChrA"
                     /codon_start=1
                     /product="chromogranin-A preproprotein"
                     /protein_id="NP_031719.1"
                     /db_xref="CCDS:CCDS26120.1"
                     /db_xref="GeneID:12652"
                     /db_xref="MGI:MGI:88394"
                     /translation="MRSTAVLALLLCAGQVFALPVNSPMTKGDTKVMKCVLEVISDSL
                     SKPSPMPVSPECLETLQGDERILSILRHQNLLKELQDLALQGAKERAQQPLKQQQPPK
                     QQQQQQQQQQQEQQHSSFEDELSEVFENQSPDAKHRDAAAEVPSRDTMEKRKDSDKGQ
                     QDGFEATTEGPRPQAFPEPNQESPMMGDSESPGEDTATNTQSPTSLPSQEHVDPQATG
                     DSERGLSAQQQARKAKQEEKEEEEEEEAVAREKAGPEEVPTAASSSHFHAGYKAIQKD
                     DGQSDSQAVDGDGKTEASEALPSEGKGELEHSQQEEDGEEAMVGTPQGLFPQGGKGRE
                     LEHKQEEEEEEEERLSREWEDKRWSRMDQLAKELTAEKRLEGEDDPDRSMKLSFRTRA
                     YGFRDPGPQLRRGWRPSSREDSVEARSDFEEKKEEEGSANRRAEDQELESLSAIEAEL
                     EKVAHQLQALRRG"
     exon            231..277
                     /gene="Chga"
                     /gene_synonym="cgA; ChrA"
                     /inference="alignment:Splign:2.1.0"
     exon            278..371
                     /gene="Chga"
                     /gene_synonym="cgA; ChrA"
                     /inference="alignment:Splign:2.1.0"
     exon            372..440
                     /gene="Chga"
                     /gene_synonym="cgA; ChrA"
                     /inference="alignment:Splign:2.1.0"
     exon            441..599
                     /gene="Chga"
                     /gene_synonym="cgA; ChrA"
                     /inference="alignment:Splign:2.1.0"
     exon            600..1016
                     /gene="Chga"
                     /gene_synonym="cgA; ChrA"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1492
                     /gene="Chga"
                     /gene_synonym="cgA; ChrA"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1910
                     /gene="Chga"
                     /gene_synonym="cgA; ChrA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1889..1894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chga"
                     /gene_synonym="cgA; ChrA"
                     /note="hexamer: AATAAA"
     polyA_site      1910
                     /gene="Chga"
                     /gene_synonym="cgA; ChrA"
                     /note="major polyA site"
ORIGIN      
        1 gtgtatataa aagccggcat agcattgctg ctgctgccgc cgccaccgcc accatcaccg
       61 ctgttaccac caccgctact gcagtgttcc cgctggtgca gagctttggt agccagacta
      121 cagacccact cccgccatcc tcctgcagca gctcgtccac tctttccgca ccgtccggct
      181 cgctatgcgc tccaccgcgg ttctggcgct tctgctgtgc gccgggcaag tttttgccct
      241 tcctgtgaac agccccatga caaaagggga caccaaggtg atgaagtgcg tcctggaagt
      301 catctccgac tcgctgtcca aacccagccc catgcctgtc agccctgagt gtctggagac
      361 cctccaagga gacgagagga tcctctctat cctgcgacac cagaatctgc tgaaggaact
      421 tcaagacctg gctctccaag gtgccaagga gcgggcccag cagccgctga agcagcagca
      481 gccgccgaag cagcagcagc agcagcagca gcagcagcag caggagcagc aacacagcag
      541 ctttgaggat gaactctcag aagtgtttga gaaccagagc cctgatgcca agcacagaga
      601 cgcagcagca gaagtgccct ccagggacac tatggagaag agaaaggatt ctgacaaggg
      661 acaacaggat ggctttgagg caaccacaga gggacctagg cctcaggcct ttccagagcc
      721 taaccaagag tcccccatga tgggagacag tgagtcccct ggggaggaca cagccaccaa
      781 tacccaatca ccaaccagcc tccccagcca ggagcatgtg gacccacagg ccacgggaga
      841 cagtgagaga ggcctgagtg cccaacagca agccagaaaa gccaagcaag aggagaaaga
      901 agaggaggag gaagaggagg ctgtggctag agagaaggct gggcctgaag aagtccccac
      961 tgcagcatcc agttcccact tccatgcagg ctacaaagcg atccagaaag atgatggtca
     1021 gtcggactct caggcagtgg atggagatgg aaagacagag gcttccgaag ctctgccgtc
     1081 tgaagggaag ggggagctgg agcactctca gcaggaggaa gatggggaag aggccatggt
     1141 agggaccccc caaggtctct tcccccaagg cgggaagggc cgggagctgg aacataagca
     1201 ggaggaagag gaagaggagg aggagcgtct gtccagagaa tgggaggaca agcgatggag
     1261 caggatggac cagctggcca aagagctgac agcagagaag cggctggagg gcgaggatga
     1321 ccctgaccgc tccatgaagc tctccttccg gacccgcgcc tatggcttca gagatcctgg
     1381 gcctcagcta cgcaggggct ggaggccatc ttccagagaa gacagtgtgg aggcccgaag
     1441 tgactttgag gaaaagaagg aagaggaggg cagcgccaac cgcagagcag aggaccagga
     1501 gctagagagc ctgtcagcca tcgaggcaga gctggagaag gtggcccacc agctgcaggc
     1561 tttgcggcgg ggatgaggcc ctggctggtg gggccagcca tggcttcaag gccagactgc
     1621 tgctcgagta gggctgcttc cagccacaga gcccaggtta ccccctttgc ccctcacctt
     1681 ctcttgttct cagcccctgc cctggacact tctgcagggc agccctgaat gtcagcacag
     1741 attccttctc tgaacacagg cagctttcta gaagtttctc ttccaccttc ttatccatgg
     1801 ggcacaactg caataacttc tgacctttgg gcgaaagccg agaactcctg actattaaga
     1861 tattccagat aaaatatatt gaaggaagaa taaagtgctt tgggctcttt aaaaaaaaaa
//
