LOCUS       NM_001369243            9359 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus chromodomain helicase DNA binding protein 5 (Chd5),
            transcript variant 3, mRNA.
ACCESSION   NM_001369243 XM_006538932
VERSION     NM_001369243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9359)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 9359)
  AUTHORS   Shrestha,P., Jaganathan,A., Huilgol,D., Ballon,C., Hwangbo,Y. and
            Mills,A.A.
  TITLE     Chd5 Regulates the Transcription Factor Six3 to Promote Neuronal
            Differentiation
  JOURNAL   Stem Cells 41 (3), 242-251 (2023)
   PUBMED   36636025
  REMARK    GeneRIF: Chd5 Regulates the Transcription Factor Six3 to Promote
            Neuronal Differentiation.
REFERENCE   3  (bases 1 to 9359)
  AUTHORS   Price,J.D., Lindtner,S., Ypsilanti,A., Binyameen,F., Johnson,J.R.,
            Newton,B.W., Krogan,N.J. and Rubenstein,J.L.R.
  TITLE     DLX1 and the NuRD complex cooperate in enhancer decommissioning and
            transcriptional repression
  JOURNAL   Development 149 (11) (2022)
   PUBMED   35695185
REFERENCE   4  (bases 1 to 9359)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9359)
  AUTHORS   Fell,S.M., Li,S., Wallis,K., Kock,A., Surova,O., Rraklli,V.,
            Hofig,C.S., Li,W., Mittag,J., Henriksson,M.A., Kenchappa,R.S.,
            Holmberg,J., Kogner,P. and Schlisio,S.
  TITLE     Neuroblast differentiation during development and in neuroblastoma
            requires KIF1Bbeta-mediated transport of TRKA
  JOURNAL   Genes Dev 31 (10), 1036-1053 (2017)
   PUBMED   28637693
REFERENCE   6  (bases 1 to 9359)
  AUTHORS   Gehman,L.T., Meera,P., Stoilov,P., Shiue,L., O'Brien,J.E.,
            Meisler,M.H., Ares,M. Jr., Otis,T.S. and Black,D.L.
  TITLE     The splicing regulator Rbfox2 is required for both cerebellar
            development and mature motor function
  JOURNAL   Genes Dev 26 (5), 445-460 (2012)
   PUBMED   22357600
REFERENCE   7  (bases 1 to 9359)
  AUTHORS   Cai,C., Ashktorab,H., Pang,X., Zhao,Y., Sha,W., Liu,Y. and Gu,X.
  TITLE     MicroRNA-211 expression promotes colorectal cancer cell growth in
            vitro and in vivo by targeting tumor suppressor CHD5
  JOURNAL   PLoS One 7 (1), e29750 (2012)
   PUBMED   22235338
  REMARK    GeneRIF: the association of between miR-211-regulated CHD5
            expression and CHD5 function in colorectal tumorigenesis
REFERENCE   8  (bases 1 to 9359)
  AUTHORS   Potts,R.C., Zhang,P., Wurster,A.L., Precht,P., Mughal,M.R.,
            Wood,W.H. 3rd, Zhang,Y., Becker,K.G., Mattson,M.P. and Pazin,M.J.
  TITLE     CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes,
            regulates expression of neuronal genes
  JOURNAL   PLoS One 6 (9), e24515 (2011)
   PUBMED   21931736
  REMARK    GeneRIF: CHD5 regulates expression of neuronal genes, cell cycle
            genes and remodeling genes, and is linked to regulation of genes
            implicated in aging and Alzheimer's disease.
REFERENCE   9  (bases 1 to 9359)
  AUTHORS   Bagchi,A., Papazoglu,C., Wu,Y., Capurso,D., Brodt,M., Francis,D.,
            Bredel,M., Vogel,H. and Mills,A.A.
  TITLE     CHD5 is a tumor suppressor at human 1p36
  JOURNAL   Cell 128 (3), 459-475 (2007)
   PUBMED   17289567
REFERENCE   10 (bases 1 to 9359)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL611985.22.
            
            On Mar 29, 2019 this sequence version replaced XM_006538932.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-377               AL611985.22        79447-79823
            378-505             AL611985.22        88729-88856
            506-694             AL611985.22        94334-94522
            695-813             AL611985.22        96874-96992
            814-1052            AL611985.22        97413-97651
            1053-1174           AL611985.22        99291-99412
            1175-1298           AL611985.22        100481-100604
            1299-1465           AL611985.22        101357-101523
            1466-1687           AL611985.22        101614-101835
            1688-1894           AL611985.22        103678-103884
            1895-2106           AL611985.22        104068-104279
            2107-2238           AL611985.22        106920-107051
            2239-2347           AL611985.22        107154-107262
            2348-2539           AL611985.22        108075-108266
            2540-2740           AL611985.22        108622-108822
            2741-2878           AL611985.22        111298-111435
            2879-3000           AL611985.22        111521-111642
            3001-3174           AL611985.22        112371-112544
            3175-3316           AL611985.22        112877-113018
            3317-3448           AL611985.22        114239-114370
            3449-3566           AL611985.22        115125-115242
            3567-3691           AL611985.22        115870-115994
            3692-3923           AL611985.22        116929-117160
            3924-4034           AL611985.22        117373-117483
            4035-4207           AL611985.22        117762-117934
            4208-4382           AL611985.22        118409-118583
            4383-4475           AL611985.22        118971-119063
            4476-4564           AL611985.22        119251-119339
            4565-4698           AL611985.22        119523-119656
            4699-4843           AL611985.22        120158-120302
            4844-5003           AL611985.22        120613-120772
            5004-5083           AL611985.22        121241-121320
            5084-5216           AL611985.22        121940-122072
            5217-5294           AL611985.22        123128-123205
            5295-5432           AL611985.22        123685-123822
            5433-5541           AL611985.22        124063-124171
            5542-5674           AL611985.22        124917-125049
            5675-5870           AL611985.22        125278-125473
            5871-6034           AL611985.22        126226-126389
            6035-6088           AL611985.22        126742-126795
            6089-9359           AL611985.22        127708-130978
FEATURES             Location/Qualifiers
     source          1..9359
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 83.04 cM"
     gene            1..9359
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /note="chromodomain helicase DNA binding protein 5"
                     /db_xref="GeneID:269610"
                     /db_xref="MGI:MGI:3036258"
     exon            1..377
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..6139
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /EC_number="3.6.4.12"
                     /note="isoform 3 is encoded by transcript variant 3;
                     ATP-dependent helicase CHD5"
                     /codon_start=1
                     /product="chromodomain-helicase-DNA-binding protein 5
                     isoform 3"
                     /protein_id="NP_001356172.1"
                     /db_xref="CCDS:CCDS89866.1"
                     /db_xref="GeneID:269610"
                     /db_xref="MGI:MGI:3036258"
                     /translation="MRGPLGTEEELPRLFAEEMENEEEMSEEEDGGLEGFEDFFPAEP
                     VSLPKKKPKKLKESKSSKGKRKKKEGSNDEMSDNEEDLEEKSESEGSDYSPTKKKKKK
                     LKEKKEKKEKKEKRKKRGEDEDDNDDGGLKEPKSSGQLMAEWGLDDVDYLFSEDDYHT
                     LTNYKAFSQFLRPLIAKKNPKIPMSKMMTVLGAKWREFSANNPFKGSSAAAAAAAVAA
                     AVETVTIAPPLAISPQQVPQTLPIRKAKTKEGKGPGVRKKNKGAKDSKKKGRGKRVAG
                     LKFRFGGISKRKKGSSSEEDEREDSDLDNASIHSSSVRSECSAALGKKNKRRRKKKRI
                     DDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCEKE
                     GIQWEPKDDDEEEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACPSSYHLHCLNPPLP
                     EIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFVVGLPGPEVEPGMPPPRPLEGI
                     PEREFFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGK
                     SEKRKNKDPLYAKMEERFYRYGIKPEWMMVHRILNHSFDKKGDIHYLIKWKDLPYDQC
                     TWEIDEIDIPYYDNLKQAYWGHRELMLGEDARLPKRLVKKGKKLKDDKQEKPPDTPIV
                     DPTVKFDKQPWYIDATGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVF
                     LYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFS
                     FEDNAIRGGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKN
                     NQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADIS
                     KEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNFEA
                     LNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGSSLVKSSGKLML
                     LQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRF
                     NAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVM
                     IYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFK
                     DDVEGMMSQGQRPTTPIPDIQSTKGGSLTAGAKKKHGSTPPGDNKDVEDSSVIHYDDA
                     AISKLLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREVIKQEENVDPD
                     YWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDASQEDQEWQDELSDNQSEYSIGS
                     EDEDEDFEERPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLN
                     AIMRWGMPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPR
                     EGLSRQHVLTRIGVMSLVRKKVQEFEHVNGKYSTPDLVPEGAEGKKPGEVISSDPNTP
                     VPASPAQLPPAPLGLTDKMEAQLGYTDEKESGMQKPKKSLEIQTLPTALDRVEGEDKH
                     QSSDSKDRAREERTEEVEKAQGSPEQPLKEEVLPDKEPIPDKPELSLGHSGDFRPDDP
                     KTEEKEPGETQQNGDREEDEEGKKEDKNGKFKFMFNIADGGFTELHTLWQNEERAAVS
                     SGKIYEIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYMILNEPFKSEIHKGNYLEMKN
                     KFLARRFKLLEQALVIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECLAESHQHLSK
                     ESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSR
                     LTNRAGDPTIQQTSSRRRDFPLFQRSFPAEPSHLPNPRGREKLQPF"
     exon            378..505
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            506..694
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            695..813
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1052
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1174
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1298
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1465
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1687
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1894
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2106
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2238
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2347
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2539
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2740
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2878
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3000
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3174
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3175..3316
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3448
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3566
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3567..3691
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3692..3923
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3924..4034
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4035..4207
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4208..4382
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4383..4475
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4476..4564
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4565..4698
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4699..4843
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4844..5003
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5004..5083
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5084..5216
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5217..5294
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5295..5432
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5433..5541
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5542..5674
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5675..5870
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5871..6034
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            6035..6088
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            6089..9359
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6399..6404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /note="hexamer: GATAAA"
     polyA_site      6424
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /note="major polyA site"
ORIGIN      
        1 gtgccgccgt gccgcgggcg ctgccgccgc caccctcggc cggctgcggg actcgcgctg
       61 cggggcgcgg tgggcggagc ggcccgggct tggcgggtgc gggcagaggc ggcctagagc
      121 ttgcggggtc gaaacggggg ggtggaggtt tggggggctg ggggggccgg cggccgccat
      181 cttcttgccg agaccgcctc gcccgccgcg cgggtccgtc cggcagcgca cgggttaagg
      241 ctggcaccgc gcccggcggg aggggggcgc ccaccttcct tccccccccg cgccgggcat
      301 gcggggcccg ctgggcaccg aggaggagct gccgcggctg ttcgcggagg agatggagaa
      361 cgaggaggag atgtcagaag aagaagacgg tggccttgaa ggctttgagg acttcttccc
      421 tgcagagccc gtgagtcttc ccaagaagaa gccgaagaag ctgaaagaga gcaagtcctc
      481 caaaggtaaa aggaagaaga aagaggggag caatgacgag atgtcagaca acgaggagga
      541 cctggaagag aagtcagaga gcgaaggtag cgactactcc cccaccaaga agaagaagaa
      601 gaaactgaag gagaagaagg agaagaagga gaagaaggag aagcggaaaa agaggggtga
      661 ggatgaagat gataacgacg acggaggctt gaaggagccc aagtcctcgg gacaactcat
      721 ggcggagtgg gggctggacg acgtggacta cctgttttct gaggatgact accacacact
      781 gaccaactac aaagccttca gccagttcct caggcccctt attgccaaga agaatccgaa
      841 gatccccatg tccaaaatga tgactgtcct gggggccaag tggcgagaat tcagcgccaa
      901 caacccgttt aagggtagct cggcagcagc agctgcggcg gccgtggccg cggccgtgga
      961 gacagtgacc attgctcctc ccttggccat cagtccccag caagtgcccc agactctgcc
     1021 catacgaaag gccaagacca aagagggcaa ggggcccgga gtgaggaaga agaacaaagg
     1081 cgccaaagat tccaagaaaa agggcagggg caagagagtg gcagggctca agttccgctt
     1141 cggagggatc agcaagagga agaagggttc ctcgagcgag gaggatgaac gggaggactc
     1201 agacttggac aatgccagca tccacagctc ttctgtgcgt tctgagtgct ctgcagctct
     1261 gggcaagaag aacaagagga ggcgcaagaa gaagaggatt gacgatggtg acggctatga
     1321 gacagaccac caggactact gtgaggtgtg ccagcaggga ggcgagatca ttctctgtga
     1381 cacctgcccg agggcatatc acctagtctg cctggacccg gagctggaga aggctccaga
     1441 gggcaagtgg agctgcccac actgtgagaa ggaggggatc cagtgggagc cgaaggatga
     1501 tgatgaagag gaggaggagg gcggctgcga ggaagaggag gatgaccaca tggagttctg
     1561 ccgcgtgtgc aaggacggtg gcgagctcct gtgctgtgat gcctgtccct cctcctacca
     1621 cttgcactgc ctcaacccgc cgctgccgga gataccgaac ggtgaatggc tctgcccgcg
     1681 ctgtacatgt cccccgctga agggcaaagt tcagcggatc ctacactgga ggtggacaga
     1741 acccccggct ccctttgtgg tggggctgcc aggaccagag gtggagccag gcatgccccc
     1801 gcccaggcct ctggagggca ttcctgagag agagttcttt gtcaagtggg ctggtctctc
     1861 ctactggcac tgctcctggg tgaaggagct acagttggag ctgtaccaca ccgtgatgta
     1921 tcgcaactac caaagaaaga atgacatgga cgaaccgcca ccctttgatt acggctctgg
     1981 cgatgaggat ggtaagagcg agaaacggaa gaacaaggac cctctctacg ccaagatgga
     2041 ggaacgcttc taccgctacg gcatcaagcc cgagtggatg atggttcacc gcatcctgaa
     2101 ccacagcttt gacaagaagg gggacataca ttacctgatc aagtggaagg acctgcccta
     2161 cgaccagtgc acctgggaga ttgatgagat tgacattccc tactacgaca acctgaagca
     2221 ggcctactgg ggccacaggg agctgatgct gggggaagat gccaggctgc ccaagcggct
     2281 ggtgaagaag ggcaagaagc tgaaggacga taaacaagag aagccacccg atacgcccat
     2341 cgtggacccc acagtcaagt tcgacaagca gccgtggtac atcgacgcca caggaggcac
     2401 gctgcaccct taccagctgg agggccttaa ctggttacgc ttctcctggg cccagggcac
     2461 cgacactatc ctggctgacg agatgggttt ggggaagaca gtacagacca ttgtgtttct
     2521 ctattctctg tacaaggagg gccactccaa ggggccttac ctggtcagcg cgcccctgtc
     2581 caccatcatc aactgggaac gggagtttga gatgtgggcg cctgactttt acgtggtcac
     2641 ctacacgggg gacaaggaga gccgctctgt gatccgtgag aacgagtttt cctttgagga
     2701 caacgccatt cgcggtggca agaaagtatt ccgcatgaag aaggaagtgc agatcaaatt
     2761 ccacgtgctg ctcacctctt atgagctcat caccattgac caagccatcc tgggctccat
     2821 cgagtgggcc tgcctcgtgg tggacgaggc ccaccggctc aagaacaacc agtccaagtt
     2881 ctttagggtc ttgaatagct acaagatcga ctacaagctg ctgctgacag ggacccccct
     2941 ccagaacaac ctggaggaac tgttccatct cctcaacttc ctgactccag agaggttcaa
     3001 caatctggaa ggcttcttgg aggagtttgc tgacatatcc aaggaagatc agatcaaaaa
     3061 gctgcatgat ctattggggc cgcacatgct tcggcggctc aaggccgacg tgttcaagaa
     3121 catgccggct aagacagagc tgattgtccg agtggagctg agccagatgc agaagaagta
     3181 ctacaagttc atcctgactc ggaactttga ggcgctcaat tccaaggggg gtggcaacca
     3241 ggtgtctcta ctcaatatca tgatggatct gaagaagtgc tgcaaccatc cgtacctctt
     3301 ccctgtggct gctgtggaag cccctgtact gcccaatggc tcctacgatg gcagctccct
     3361 ggtcaagtct tcggggaagc tcatgctatt gcagaagatg ctcaagaaac tgcgggatga
     3421 agggcacaga gtgctgatct tctcccagat gaccaagatg ttggacctct tggaggactt
     3481 cctggagtac gagggctaca agtatgagcg gatcgacggt ggcatcactg ggggcctccg
     3541 gcaagaggcc atcgacagat tcaacgctcc tggggcccaa cagttctgct tcctgctctc
     3601 aacacgtgcc ggtggcctgg gcatcaacct ggccacagca gacacggtca tcatctatga
     3661 ctcggactgg aaccctcaca atgacatcca ggccttcagc cgtgctcacc gcatcgggca
     3721 gaacaagaag gtcatgatct atcgcttcgt gacacgggcc tccgtggagg agcgcatcac
     3781 tcaggtggcc aagcgtaaga tgatgctcac acacctggtg gtgcggcctg gcttgggctc
     3841 caagtcgggc tccatgacca agcaggaact ggatgatatc cttaagttcg ggacagagga
     3901 gcttttcaag gacgacgtgg aaggcatgat gtcccagggc cagaggccta ccacacccat
     3961 ccctgacata caatctacca agggcggatc tctgaccgcc ggcgcaaaga aaaagcacgg
     4021 cagcaccccg ccaggcgata acaaagatgt agaagacagc agtgtgatcc attatgacga
     4081 cgcagccata tccaagctgc tggatcggaa ccaggacgcc acggatgaca ccgagctgca
     4141 gaacatgaac gagtacctga gctccttcaa ggtggcacag tatgtggtcc gcgaggaaga
     4201 tggcgtggag gaggtagaga gggaggtgat caagcaggag gagaacgtgg accctgacta
     4261 ctgggagaag ctgctgcgcc atcactatga acagcagcag gaggacttgg cccgcaacct
     4321 gggcaagggc aagcgcatcc gcaagcaggt caactacaat gatgcctccc aggaggacca
     4381 ggagtggcag gatgagctct cggacaacca gtcggagtat tccatcggtt ctgaggatga
     4441 ggacgaggac tttgaggagc gaccagaagg gcagagtgga cgacgacaat ccaggaggca
     4501 gcttaagagt gacagggaca agcccctgcc tccccttctg gctcgggttg ggggcaacat
     4561 tgaggttctg ggcttcaatg ccagacagag gaaggctttt ttgaacgcca tcatgcgctg
     4621 gggcatgccg cctcaggatg ccttcaactc ccactggctg gtgcgggacc ttcgagggaa
     4681 gagtgagaag gaatttaggg cctatgtatc actcttcatg cgccacctgt gtgagccggg
     4741 cgcagacggc gcggagacct tcgcagacgg cgtgccccgg gagggcctgt ctaggcagca
     4801 cgtgctcacg cgtattgggg tcatgtcgct ggttaggaag aaggtgcagg agtttgagca
     4861 tgtcaacggc aagtacagca ccccagacct ggtccccgag ggggccgagg gcaagaagcc
     4921 gggcgaggtc atctcctcag accccaacac acctgtgcct gccagccctg cacagcttcc
     4981 accggcccca ctgggcctga cagacaaaat ggaagcccag ctgggctaca cagatgagaa
     5041 ggagtcaggc atgcagaagc caaagaagtc cctggaaatc cagaccctgc caactgccct
     5101 ggacagagta gagggtgaag acaaacatca gagctcagac agcaaggaca gggctcggga
     5161 ggagaggaca gaagaggtgg agaaggccca ggggtctcca gagcagccac tgaaagagga
     5221 agtgctgccg gacaaggagc cgatcccaga caagccggag ctgagcttgg gtcacagcgg
     5281 ggatttcagg ccagatgacc ccaagactga ggagaaggag cccggggaga ctcagcaaaa
     5341 cggcgacaga gaggaagatg aggaaggcaa gaaagaagac aaaaatggga aattcaaatt
     5401 catgttcaac attgcagatg gcggtttcac agagctgcac actctgtggc agaacgagga
     5461 gcgggcggct gtgtcctcgg ggaaaatcta cgaaatctgg caccgccgtc acgactactg
     5521 gctgctggca ggcattgtga cgcatggcta tgcccgctgg caggacattc agaatgaccc
     5581 gagatacatg atcctaaatg aacctttcaa gtctgagatc cacaagggca actacttgga
     5641 gatgaagaac aagtttttgg cccgtaggtt caagctgctg gagcaggcgc tggtgattga
     5701 ggagcagctc cggagggcag cgtacctcaa catgacccag gatcccaacc acccagccat
     5761 ggcgctcaat gctcgcctgg cagaggtgga gtgccttgcc gagagccacc agcacctatc
     5821 caaggagtcc ctcgccggaa acaagcctgc caatgctgtc ctgcacaagg tcctaaacca
     5881 gctggaggag ctgctgagtg acatgaaagc agatgtgaca cgcttgccct ccatgttgtc
     5941 acgcatcccc ccggtggccg cccgtctgca gatgtctgaa cgcagcatct tgagtcgcct
     6001 gaccaaccga gctggtgacc ccaccatcca gcagacatct agccgtcgtc gtgacttccc
     6061 cctgtttcag cgctcctttc cagctgagcc aagccacctg cccaaccccc gcgggagaga
     6121 aaagctacag cccttttagg agttggtgcg gtgttggggt acaaaaggga aaccatgaaa
     6181 ttctatcaca cggaggacag gcccaggctg gctgcgcaag agtccagaag tgccacctca
     6241 tcgtagttga agccttcttc cacacggcat cccatctaca gctacgcctg gcaaggtcct
     6301 ggcgcctttt ccagagtgac tgacttagag gaaattccat ttacctgtaa attttttttt
     6361 tggcactttc ctactgaaga tgcaaacatg tttgtcttga taaaaagttg gatgacgtgt
     6421 ggaagattca gattcacgac actcctgtct gtcaccggct ccagacctca aggggaagct
     6481 ctttggaggc ccttggtgct gctgctctat ggattcaact gcggccgaag agaatgcagc
     6541 atccagtgct ctggaaaccc ttagtctgcc ccccgccccc gtctgtaccc gtgtgactgc
     6601 tccagacccc tgcctgcttg ggaccctagt gctagcctag ccagggaggg gatcaggtct
     6661 ggagagtggc tgcctaccct gctgatgccc agcatgggag acggcccggt acatcccact
     6721 tctgggcagg agcgcatatc tcaaggtctc tggcatctct catttccagt ggacacgtgg
     6781 tggtgccagc aatgtgtggc aggttgaagt gagggtacct cgctcagagg gtggagcaga
     6841 tttagacctt ggacaaagcc ccctgcaggg gtttttggac attttctgtc tgcaggagtg
     6901 tggtatagat aggtgtgagc tggtgtccca gagaagggtg gtgtttgttg ggtggccctg
     6961 cgagacttgt cccactcacc ttggcaaaga caagcatctt ggagtgtcct gggccacaca
     7021 gatgccagca gcccctccca gagctgaatt gatctctgtt gtcttggtcc tagagaagcc
     7081 ttgactaggg tgacttctgc atgaagtagg ggccacaggg gcctttgctg gatctccgag
     7141 ggtatggaga gagctgtgct tggagtgggg cctggagctg atggtgactt tagatccttc
     7201 ctacccggag ccttcaaggc ttctgacctc atttcctgca gggaagcctt aagagtgcca
     7261 ggcccatctt cccatgtcac tgttgacacg ccacttgtct tgctctaccc cagcctgtgg
     7321 caccacgtaa cgctccatgc tggggtgggg gtgggtggag cctgccaggc tccaggcctg
     7381 tgtctgaact tcttactggc ccttggctca acctggagag atcctggggt tcagtttacc
     7441 ctgaagatga ggacggggct tgtggagaga agccagtcgg gtccgaggga gcttggtagg
     7501 ggtcagattg tccctggaaa aggagttggg gggtatgcag catctctggg cctgccaaaa
     7561 atgggggcag gtctccatgg cttgttttga ggacactggg caggtggctg gcctttactt
     7621 agcccagata tgtacacatc tgtaacatag ttcctcctct gctcctggag ggctggaccc
     7681 ccacagcttc ttatactttg ccactcctat acttgagtgt ctatccaagt cttaaggcta
     7741 gcaactggcc gcacactgtg ggtaggcggg gagggggagg ggactctggc catagacagg
     7801 accactgaag gcttgagtgc attatggtgg ctgaccccgc tctccaagaa gggctgtcct
     7861 ctgcacagga gtgtcttccc tagttcgctc cccaacccag acctctgtgc taatcccaag
     7921 atgggcaaga tggtcagccc tgttggcctc agttgccaca ctgacatcct aagacttagg
     7981 cctgcaggct cacgtgggac agaatagggt ctgtgtctct tgacttcagg ggtccatccc
     8041 ttccctgaag acttccccca ggagtcttgc tctgtccatc catctctgct tcttcctggg
     8101 ccatacccac cctctgtggc cttcccctct ccacagccac cttgacctga gacccctgct
     8161 ggcctgggag ggccttagcg cctcagttct ccagggtaga ctgcccaggc agctgaggag
     8221 aggacaaagt ccttcagagt gttcgcatct tggcccttca gctgtcgcct gctagagagt
     8281 gataggatag aggtggcatc ttgaggtggc tctcattttg ctgctgatag aactgggtcc
     8341 tcatgcccga gctgtcagag ctgcagtgac agtgatttct agctgctttg gcttgcttaa
     8401 ttctatagga tctctgtgga aggtgtgggg tggctctcgg tgacataggg gtttgggtca
     8461 gagctacatc atctgagggc accccctcac ccctgttctg aattgcttac tccccatacc
     8521 ccaggggcca cctgtgagcc agggttccct cccccagcct ctgggtgctc cctagcccat
     8581 gtgggctgct ggctcagtga caccggcaac cagtctaagt cttgagtcct gcagggggca
     8641 cgtggagggt aggctagggg gccagggctc tttgtagtct catagagtgg gcaagtgttg
     8701 atgcttggag tgtctcgtgt gtgccaagga agggggttgg gggcctaggc tgaccctccc
     8761 tccaacttcg ctgtcttggt ctacccacaa gggctcctgc gcagaccaca gccaggagga
     8821 ggaggaggcc aacctgccca atttatatac ccgaaagttt acaggtcgtg gcgcgtcagc
     8881 ccaaagtctt tggtgtccct gcgtttatgg atatttccct cttaattttc agattttttt
     8941 ttttaaaaac aaaagtattt ttttaggtat gataaacccg gaaagggcct gttgggtatg
     9001 tgtgtatgtc ctgaactctc cacaaagcca cacggaccag agcccaggtc agaggcagct
     9061 cttccacctg gcctggaggg gagggagggt cccctgctgc ctaccagggt caagctagac
     9121 tgcagggatt ctcttcctgc ccaggccggg ctggcatctg tcctaccctt gcccaatcga
     9181 gcacaccctg atgaagtcag agtaggtgct tggggtcagc tgggagcacc tcagcagggg
     9241 tcccaagggc acatcaggag cccctctgaa ggctgggcag accagtggta tctccacttg
     9301 tattctctgt gtgtatgttt tggtttctgt gttttaataa accctttggg aagggatgg
//
