LOCUS       NP_001356172            1946 aa            linear   ROD 24-DEC-2024
DEFINITION  chromodomain-helicase-DNA-binding protein 5 isoform 3 [Mus
            musculus].
ACCESSION   NP_001356172 XP_006538995
VERSION     NP_001356172.1
DBSOURCE    REFSEQ: accession NM_001369243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1946)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1946)
  AUTHORS   Shrestha,P., Jaganathan,A., Huilgol,D., Ballon,C., Hwangbo,Y. and
            Mills,A.A.
  TITLE     Chd5 Regulates the Transcription Factor Six3 to Promote Neuronal
            Differentiation
  JOURNAL   Stem Cells 41 (3), 242-251 (2023)
   PUBMED   36636025
  REMARK    GeneRIF: Chd5 Regulates the Transcription Factor Six3 to Promote
            Neuronal Differentiation.
REFERENCE   3  (residues 1 to 1946)
  AUTHORS   Price,J.D., Lindtner,S., Ypsilanti,A., Binyameen,F., Johnson,J.R.,
            Newton,B.W., Krogan,N.J. and Rubenstein,J.L.R.
  TITLE     DLX1 and the NuRD complex cooperate in enhancer decommissioning and
            transcriptional repression
  JOURNAL   Development 149 (11) (2022)
   PUBMED   35695185
REFERENCE   4  (residues 1 to 1946)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1946)
  AUTHORS   Fell,S.M., Li,S., Wallis,K., Kock,A., Surova,O., Rraklli,V.,
            Hofig,C.S., Li,W., Mittag,J., Henriksson,M.A., Kenchappa,R.S.,
            Holmberg,J., Kogner,P. and Schlisio,S.
  TITLE     Neuroblast differentiation during development and in neuroblastoma
            requires KIF1Bbeta-mediated transport of TRKA
  JOURNAL   Genes Dev 31 (10), 1036-1053 (2017)
   PUBMED   28637693
REFERENCE   6  (residues 1 to 1946)
  AUTHORS   Gehman,L.T., Meera,P., Stoilov,P., Shiue,L., O'Brien,J.E.,
            Meisler,M.H., Ares,M. Jr., Otis,T.S. and Black,D.L.
  TITLE     The splicing regulator Rbfox2 is required for both cerebellar
            development and mature motor function
  JOURNAL   Genes Dev 26 (5), 445-460 (2012)
   PUBMED   22357600
REFERENCE   7  (residues 1 to 1946)
  AUTHORS   Cai,C., Ashktorab,H., Pang,X., Zhao,Y., Sha,W., Liu,Y. and Gu,X.
  TITLE     MicroRNA-211 expression promotes colorectal cancer cell growth in
            vitro and in vivo by targeting tumor suppressor CHD5
  JOURNAL   PLoS One 7 (1), e29750 (2012)
   PUBMED   22235338
  REMARK    GeneRIF: the association of between miR-211-regulated CHD5
            expression and CHD5 function in colorectal tumorigenesis
REFERENCE   8  (residues 1 to 1946)
  AUTHORS   Potts,R.C., Zhang,P., Wurster,A.L., Precht,P., Mughal,M.R.,
            Wood,W.H. 3rd, Zhang,Y., Becker,K.G., Mattson,M.P. and Pazin,M.J.
  TITLE     CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes,
            regulates expression of neuronal genes
  JOURNAL   PLoS One 6 (9), e24515 (2011)
   PUBMED   21931736
  REMARK    GeneRIF: CHD5 regulates expression of neuronal genes, cell cycle
            genes and remodeling genes, and is linked to regulation of genes
            implicated in aging and Alzheimer's disease.
REFERENCE   9  (residues 1 to 1946)
  AUTHORS   Bagchi,A., Papazoglu,C., Wu,Y., Capurso,D., Brodt,M., Francis,D.,
            Bredel,M., Vogel,H. and Mills,A.A.
  TITLE     CHD5 is a tumor suppressor at human 1p36
  JOURNAL   Cell 128 (3), 459-475 (2007)
   PUBMED   17289567
REFERENCE   10 (residues 1 to 1946)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL611985.22.
            
            On Mar 29, 2019 this sequence version replaced XP_006538995.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 83.04 cM"
     Protein         1..1946
                     /product="chromodomain-helicase-DNA-binding protein 5
                     isoform 3"
                     /EC_number="3.6.4.12"
                     /note="ATP-dependent helicase CHD5"
                     /calculated_mol_wt=222385
     Region          1..140
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A8L1.1)"
     Region          148..203
                     /region_name="CHDNT"
                     /note="CHDNT (NUC034) domain; pfam08073"
                     /db_xref="CDD:462357"
     Region          236..272
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A8L1.1)"
     Region          285..340
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A8L1.1)"
     Region          345..655
                     /region_name="Histone-binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A8L1.1)"
     Region          347..389
                     /region_name="PHD1_CHD_II"
                     /note="PHD finger 1 found in class II
                     Chromodomain-Helicase-DNA binding (CHD) proteins; cd15531"
                     /db_xref="CDD:277006"
     Site            order(347,356..360,364,384)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277006"
     Region          420..462
                     /region_name="PHD2_CHD_II"
                     /note="PHD finger 2 found in class II
                     Chromodomain-Helicase-DNA binding (CHD) proteins; cd15532"
                     /db_xref="CDD:277007"
     Site            order(420,429..433,437,457)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277007"
     Region          467..546
                     /region_name="CD1_tandem_CHD3-4_like"
                     /note="repeat 1 of the paired tandem chromodomains of
                     chromodomain helicase DNA-binding protein 3 and 4, and
                     similar proteins; cd18667"
                     /db_xref="CDD:349314"
     Site            order(469,517,519..520,524)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:349314"
     Region          551..573
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A8L1.1)"
     Region          591..644
                     /region_name="CD2_tandem_CHD3-4_like"
                     /note="repeat 2 of the paired tandem chromodomains of
                     chromodomain helicase DNA-binding protein 3 and 4, and
                     similar proteins; cd18662"
                     /db_xref="CDD:349309"
     Site            order(611,628)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:349309"
     Region          700..>1218
                     /region_name="PLN03142"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional"
                     /db_xref="CDD:215601"
     Region          849..852
                     /region_name="DEAH box"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A8L1.1)"
     Region          1210..1254
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A8L1.1)"
     Region          1300..1353
                     /region_name="DUF1087"
                     /note="CHD subfamily II, DUF1087; pfam06465"
                     /db_xref="CDD:461922"
     Region          1353..1413
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A8L1.1)"
     Region          1391..1531
                     /region_name="CHDII_SANT-like"
                     /note="CHD subfamily II, SANT-like domain; pfam06461"
                     /db_xref="CDD:461920"
     Site            1392
                     /site_type="methylation"
                     /note="N5-methylglutamine.
                     /evidence=ECO:0000250|UniProtKB:Q8TDI0; propagated from
                     UniProtKB/Swiss-Prot (A2A8L1.1)"
     Region          1525..1566
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A8L1.1)"
     Region          <1532..1684
                     /region_name="LGT"
                     /note="Prolipoprotein diacylglyceryl transferase; cl00478"
                     /db_xref="CDD:469786"
     Site            1556
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (A2A8L1.1)"
     Region          1579..1696
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A8L1.1)"
     Region          1731..1876
                     /region_name="CHDCT2"
                     /note="CHDCT2 (NUC038) domain; pfam08074"
                     /db_xref="CDD:462358"
     Region          1926..1946
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A8L1.1)"
     CDS             1..1946
                     /gene="Chd5"
                     /gene_synonym="4930532L22Rik; B230399N07Rik; CHD-5"
                     /coded_by="NM_001369243.1:299..6139"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS89866.1"
                     /db_xref="GeneID:269610"
                     /db_xref="MGI:MGI:3036258"
ORIGIN      
        1 mrgplgteee lprlfaeeme neeemseeed gglegfedff paepvslpkk kpkklkesks
       61 skgkrkkkeg sndemsdnee dleekseseg sdysptkkkk kklkekkekk ekkekrkkrg
      121 ededdnddgg lkepkssgql maewglddvd ylfseddyht ltnykafsqf lrpliakknp
      181 kipmskmmtv lgakwrefsa nnpfkgssaa aaaaavaaav etvtiappla ispqqvpqtl
      241 pirkaktkeg kgpgvrkknk gakdskkkgr gkrvaglkfr fggiskrkkg ssseedered
      301 sdldnasihs ssvrsecsaa lgkknkrrrk kkriddgdgy etdhqdycev cqqggeiilc
      361 dtcprayhlv cldpelekap egkwscphce kegiqwepkd ddeeeeeggc eeeeddhmef
      421 crvckdggel lccdacpssy hlhclnpplp eipngewlcp rctcpplkgk vqrilhwrwt
      481 eppapfvvgl pgpevepgmp pprplegipe reffvkwagl sywhcswvke lqlelyhtvm
      541 yrnyqrkndm depppfdygs gdedgksekr knkdplyakm eerfyrygik pewmmvhril
      601 nhsfdkkgdi hylikwkdlp ydqctweide idipyydnlk qaywghrelm lgedarlpkr
      661 lvkkgkklkd dkqekppdtp ivdptvkfdk qpwyidatgg tlhpyqlegl nwlrfswaqg
      721 tdtilademg lgktvqtivf lyslykeghs kgpylvsapl stiinweref emwapdfyvv
      781 tytgdkesrs virenefsfe dnairggkkv frmkkevqik fhvlltsyel itidqailgs
      841 iewaclvvde ahrlknnqsk ffrvlnsyki dykllltgtp lqnnleelfh llnfltperf
      901 nnlegfleef adiskedqik klhdllgphm lrrlkadvfk nmpakteliv rvelsqmqkk
      961 yykfiltrnf ealnskgggn qvsllnimmd lkkccnhpyl fpvaaveapv lpngsydgss
     1021 lvkssgklml lqkmlkklrd eghrvlifsq mtkmldlled fleyegykye ridggitggl
     1081 rqeaidrfna pgaqqfcfll stragglgin latadtviiy dsdwnphndi qafsrahrig
     1141 qnkkvmiyrf vtrasveeri tqvakrkmml thlvvrpglg sksgsmtkqe lddilkfgte
     1201 elfkddvegm msqgqrpttp ipdiqstkgg sltagakkkh gstppgdnkd vedssvihyd
     1261 daaisklldr nqdatddtel qnmneylssf kvaqyvvree dgveeverev ikqeenvdpd
     1321 ywekllrhhy eqqqedlarn lgkgkrirkq vnyndasqed qewqdelsdn qseysigsed
     1381 ededfeerpe gqsgrrqsrr qlksdrdkpl ppllarvggn ievlgfnarq rkaflnaimr
     1441 wgmppqdafn shwlvrdlrg ksekefrayv slfmrhlcep gadgaetfad gvpreglsrq
     1501 hvltrigvms lvrkkvqefe hvngkystpd lvpegaegkk pgevissdpn tpvpaspaql
     1561 ppaplgltdk meaqlgytde kesgmqkpkk sleiqtlpta ldrvegedkh qssdskdrar
     1621 eerteeveka qgspeqplke evlpdkepip dkpelslghs gdfrpddpkt eekepgetqq
     1681 ngdreedeeg kkedkngkfk fmfniadggf telhtlwqne eraavssgki yeiwhrrhdy
     1741 wllagivthg yarwqdiqnd prymilnepf kseihkgnyl emknkflarr fklleqalvi
     1801 eeqlrraayl nmtqdpnhpa malnarlaev eclaeshqhl skeslagnkp anavlhkvln
     1861 qleellsdmk advtrlpsml srippvaarl qmsersilsr ltnragdpti qqtssrrrdf
     1921 plfqrsfpae pshlpnprgr eklqpf
//
