LOCUS       NM_001403592            6518 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus chromodomain helicase DNA binding protein 4 (Chd4),
            transcript variant 1, mRNA.
ACCESSION   NM_001403592 XM_006505286
VERSION     NM_001403592.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6518)
  AUTHORS   Shi,W., Wasson,L.K., Dorr,K.M., Robbe,Z.L., Wilczewski,C.M.,
            Hepperla,A.J., Davis,I.J., Seidman,C.E., Seidman,J.G. and
            Conlon,F.L.
  TITLE     CHD4 and SMYD1 repress common transcriptional programs in the
            developing heart
  JOURNAL   Development 151 (8) (2024)
   PUBMED   38619323
REFERENCE   2  (bases 1 to 6518)
  AUTHORS   Li,C., Wang,Z., Yao,L., Lin,X., Jian,Y., Li,Y., Zhang,J., Shao,J.,
            Tran,P.D., Hagman,J.R., Cao,M., Cong,Y., Li,H.Y., Goding,C.R.,
            Xu,Z.X., Liao,X., Miao,X. and Cui,R.
  TITLE     Mi-2beta promotes immune evasion in melanoma by activating EZH2
            methylation
  JOURNAL   Nat Commun 15 (1), 2163 (2024)
   PUBMED   38461299
  REMARK    GeneRIF: Mi-2beta promotes immune evasion in melanoma by activating
            EZH2 methylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6518)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6518)
  AUTHORS   Larrigan,S., Joshi,S.V. and Mattar,P.
  TITLE     Divergent phenotypes in constitutive versus conditional mutant
            mouse models of Sifrim-Hitz-Weiss syndrome
  JOURNAL   Hum Mol Genet 32 (24), 3361-3373 (2023)
   PUBMED   37738575
REFERENCE   5  (bases 1 to 6518)
  AUTHORS   Shi,W., Scialdone,A.P., Emerson,J.I., Mei,L., Wasson,L.K.,
            Davies,H.A., Seidman,C.E., Seidman,J.G., Cook,J.G. and Conlon,F.L.
  TITLE     Missense Mutation in Human CHD4 Causes Ventricular Noncompaction by
            Repressing ADAMTS1
  JOURNAL   Circ Res 133 (1), 48-67 (2023)
   PUBMED   37254794
REFERENCE   6  (bases 1 to 6518)
  AUTHORS   McClive,P.J., Hurley,T.M., Sarraj,M.A., van den Bergen,J.A. and
            Sinclair,A.H.
  TITLE     Subtractive hybridisation screen identifies sexually dimorphic gene
            expression in the embryonic mouse gonad
  JOURNAL   Genesis 37 (2), 84-90 (2003)
   PUBMED   14595844
REFERENCE   7  (bases 1 to 6518)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 6518)
  AUTHORS   Loebel,D.A., O'Rourke,M.P., Steiner,K.A., Banyer,J. and Tam,P.P.
  TITLE     Isolation of differentially expressed genes from wild-type and
            Twist mutant mouse limb buds
  JOURNAL   Genesis 33 (3), 103-113 (2002)
   PUBMED   12124942
REFERENCE   9  (bases 1 to 6518)
  AUTHORS   Jones,D.O., Cowell,I.G. and Singh,P.B.
  TITLE     Mammalian chromodomain proteins: their role in genome organisation
            and expression
  JOURNAL   Bioessays 22 (2), 124-137 (2000)
   PUBMED   10655032
  REMARK    Review article
REFERENCE   10 (bases 1 to 6518)
  AUTHORS   Kim,J., Sif,S., Jones,B., Jackson,A., Koipally,J., Heller,E.,
            Winandy,S., Viel,A., Sawyer,A., Ikeda,T., Kingston,R. and
            Georgopoulos,K.
  TITLE     Ikaros DNA-binding proteins direct formation of chromatin
            remodeling complexes in lymphocytes
  JOURNAL   Immunity 10 (3), 345-355 (1999)
   PUBMED   10204490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134529.6 and AC166162.6.
            
            On Apr 1, 2022 this sequence version replaced XM_006505286.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.7026.1,
                                           SRR9219381.355127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC134529.6         140208-140287
            81-259              AC134529.6         141114-141292
            260-381             AC134529.6         144495-144616
            382-597             AC134529.6         144805-145020
            598-716             AC134529.6         145245-145363
            717-958             AC134529.6         145480-145721
            959-1086            AC134529.6         145909-146036
            1087-1222           AC134529.6         146190-146325
            1223-1401           AC134529.6         146459-146637
            1402-1641           AC134529.6         146820-147059
            1642-1845           AC134529.6         148894-149097
            1846-2051           AC134529.6         149203-149408
            2052-2183           AC134529.6         150436-150567
            2184-2280           AC134529.6         150667-150763
            2281-2472           AC134529.6         151495-151686
            2473-2673           AC134529.6         152308-152508
            2674-2811           AC134529.6         152686-152823
            2812-2933           AC134529.6         153079-153200
            2934-3107           AC134529.6         153319-153492
            3108-3249           AC134529.6         153806-153947
            3250-3381           AC134529.6         154038-154169
            3382-3499           AC134529.6         154280-154397
            3500-3624           AC134529.6         157492-157616
            3625-3862           AC134529.6         157927-158164
            3863-4038           AC134529.6         158318-158493
            4039-4219           AC134529.6         164232-164412
            4220-4306           AC134529.6         164497-164583
            4307-4395           AC134529.6         164671-164759
            4396-4529           AC134529.6         164867-165000
            4530-4674           AC134529.6         165300-165444
            4675-4840           AC134529.6         165543-165708
            4841-4938           AC134529.6         165959-166056
            4939-5098           AC134529.6         166150-166309
            5099-5170           AC166162.6         95798-95869
            5171-5308           AC166162.6         96139-96276
            5309-5417           AC166162.6         96661-96769
            5418-5550           AC166162.6         96870-97002
            5551-5746           AC166162.6         102113-102308
            5747-6518           AC166162.6         103141-103912
FEATURES             Location/Qualifiers
     source          1..6518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.28 cM"
     gene            1..6518
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /note="chromodomain helicase DNA binding protein 4"
                     /db_xref="GeneID:107932"
                     /db_xref="MGI:MGI:1344380"
     exon            1..80
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            81..259
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            260..381
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            382..597
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            598..716
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            717..958
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1086
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1222
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1401
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1641
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1845
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2051
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2183
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2280
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2472
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2673
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2811
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2933
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3107
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3249
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3381
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3499
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..3624
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            3625..3862
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            3863..4038
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            4039..4219
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            4220..4306
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..4395
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            4396..4529
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            4530..4674
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            4675..4840
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            4841..4938
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            4939..5098
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            5099..5170
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            5171..5308
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            5309..5417
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            5418..5550
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            5551..5746
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     exon            5747..6518
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6496..6501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /note="hexamer: AATAAA"
     polyA_site      6518
                     /gene="Chd4"
                     /gene_synonym="9530019N15Rik; D6Ertd380e; Mi-2beta;
                     mKIAA4075"
                     /note="major polyA site"
ORIGIN      
        1 ccccccttcg gccgcggcga ggaggagctg gagcgggagt gacaccggcg agacccagcg
       61 cgacctgagg cggctctagg tgactcgggc cagtgcagag ggccccaggc cgcaggcagg
      121 agcagctggg ccaattccct ggccggggaa cggaagggga tggcgtcggg cctgggctcc
      181 ccgtccccct gctcagcggg cagtgaggag gaggatatgg acgcacttct gaacaacagc
      241 ctgcccccac cccatccaga aaatgaggaa gacccagacg aggatttatc cgaagcagag
      301 actccaaagc tcaagaagaa gaaaaagcct aagaaacctc gagaccctaa aatccctaag
      361 agcaagcgcc aaaaaaagga gcgtttactc ttatgccggc agctggggga cagctctggg
      421 gaggggccag agtttgtgga ggaggaggaa gaggtggctc tgcgctcaga cagtgagggc
      481 agcgactata ctcctggcaa gaagaagaaa aagaagctcg gacctaagaa agagaagaag
      541 agcaaatcca agcggaagga ggaggaggaa gaggaggacg aggatgatga ctcgaaggaa
      601 cctaagtcat cagcccagct tttagaagac tggggtatgg aagacatcga ccatgtgttc
      661 tcagaggagg attatcggac cctcaccaac tacaaggcct tcagccaatt tgttagaccc
      721 ctgattgctg ctaaaaaccc caagattgct gtctccaaga tgatgatggt cttgggtgca
      781 aagtggaggg aattcagtac caacaacccc ttcaagggca gctccggagc atcagtggca
      841 gctgcggcgg cggcggctgt ggctgtggtt gagagcatgg tgacagctac tgaagtcgcc
      901 cctccccctc cccctgtgga ggtgccgatc cgcaaggcca agaccaagga gggcaaaggt
      961 cccaatgctc ggaggaagcc gaaaggcagc ccgcgagtgc ctgacgccaa gaagcccaaa
     1021 cccaagaaag tagctcctct gaagatcaag ctgggagggt tcggctccaa gcggaagaga
     1081 tcctcgagtg aggacgacga tttagatgta gagtctgact tcgacgatgc cagtatcaac
     1141 agctattctg tttcggatgg ttccaccagc cgcagtagtc ggagccgtaa gaaactccgg
     1201 accgctaaaa agaaaaagaa aggcgaggag gaggtgactg ctgtggatgg ttatgagaca
     1261 gaccaccagg actattgcga ggtgtgccag caaggcggcg agatcatcct gtgtgatacc
     1321 tgtccccgag cctaccatat ggtgtgcctg gacccagaca tggagaaggc cccggagggc
     1381 aagtggagct gtccgcactg tgagaaggag gggatccagt gggaagctaa ggaggacaat
     1441 tctgagggtg aggagattct ggaagaagtc gggggggacc cagaagagga ggatgaccat
     1501 cacatggaat tctgtcgcgt ctgcaaggac ggcggggagc tcctgtgctg tgacacatgc
     1561 ccttcttcct accacatcca ctgcctgaac cccccgctgc cagagatccc aaacggcgaa
     1621 tggctctgtc cccgctgtac ttgtccagct cttaagggca aagtgcagaa gatcctaatt
     1681 tggaagtggg gccagccacc gtctcccaca ccagtgcctc ggcctccaga tgctgaccct
     1741 aataccccgt cgcccaagcc cttggagggg cggccagaga ggcagttctt tgtgaaatgg
     1801 caaggcatgt cttactggca ctgctcctgg gtgtcagaac tgcagttgga gctgcactgt
     1861 caggtgatgt tcagaaacta ccagcggaag aatgatatgg acgagccgcc ttctggggac
     1921 tttggtggag atgaagagaa gagccggaag cgaaagaaca aggaccctaa gtttgcagag
     1981 atggaagagc gcttctaccg ctatggaata aaaccggagt ggatgatgat ccaccgcatc
     2041 ctcaaccaca gtgtggacaa gaagggccac gttcactatt taatcaagtg gcgagacctg
     2101 ccctatgacc aggcgtcctg ggagagcgag gacgtggaga ttcaggacta cgacctgttc
     2161 aagcagagct actggaacca cagggagtta atgaggggtg aagaaggacg acccggcaag
     2221 aagcttaaga aggtgaagct acggaaactg gaaaggcctc cggagacccc aactgttgat
     2281 cccaccgtga agtatgagcg acagccggag tatctggatg cgacgggtgg aaccctgcat
     2341 ccctaccaaa tggaaggctt aaactggctc cgcttctcct gggctcaggg aaccgatact
     2401 atcttggctg atgagatggg ccttgggaaa actgtgcaga cagcagtctt cctctactcc
     2461 ctctataagg agggtcactc caaaggcccc ttcttagtga gcgctcctct gtccaccatc
     2521 atcaactggg agagagagtt tgagatgtgg gctcctgata tgtatgtggt aacctatgtg
     2581 ggtgacaagg acagccgtgc catcatccgg gaaaatgagt tctcctttga agacaatgcc
     2641 attcgtggtg gcaagaaggc ctcgaggatg aagaaagaag catcggtgaa attccatgtt
     2701 ctgctgacat cctatgagtt gatcaccatt gatatggcca tcttgggttc tattgactgg
     2761 gcctgcctca ttgtggatga agcccatcgg ctgaagaaca accagtctaa gttctttcga
     2821 gttttgaatg gttactcact ccagcacaag ctgttgctaa ctggaactcc gttacagaac
     2881 aatctagagg aactgtttca tctgctcaac tttctcaccc ctgagaggtt ccacaactta
     2941 gaaggcttct tggaggagtt tgcagacatt gccaaagagg accagattaa aaaactccac
     3001 gacatgctgg ggcctcatat gttgcggcgg ctcaaagctg acgtcttcaa gaatatgcca
     3061 tccaagacag agctgattgt gcgcgtggag ttgagtccta tgcagaagaa gtactacaag
     3121 tatattctca cgcggaattt cgaagcactt aatgctcgag gtggtggcaa ccaggtttct
     3181 ctgctgaacg tggtgatgga tcttaagaaa tgctgcaacc acccttatct cttccctgtg
     3241 gcagcaatgg aagcccctaa gatgcctaat ggtatgtatg atggcagtgc cctaatcaga
     3301 gcatctggga agttgttgct gctgcagaag atgcttaaga acctgaaaga gggagggcat
     3361 cgtgtgctca tcttctccca gatgaccaag atgttggact tgctagagga ttttttagaa
     3421 catgaaggtt ataaatatga acgtattgat ggtggaatca ctgggaacat gcgtcaggag
     3481 gccattgatc gcttcaatgc accgggtgct caacagttct gcttcttgct ttccactcga
     3541 gctgggggcc ttgggatcaa tctggccact gcggacacag ttattatata tgactctgac
     3601 tggaaccccc ataatgacat ccaggccttt agcagagccc accgtattgg gcaaaataag
     3661 aaggtgatga tctaccggtt tgtgacccgt gcatcagtgg aggagcgcat cacgcaggtg
     3721 gcaaagaaga agatgatgct gacacattta gtggtacggc ctggcctggg ctccaagaca
     3781 ggctcaatgt ctaaacagga gcttgatgat atcctcaaat ttggcactga ggagctattc
     3841 aaggatgaag ccacggatgg aggaggagac aacaaggagg gagaagacag cagtgttatc
     3901 cactatgacg ataaggccat tgaacgactg ctggatcgaa accaggatga gactgaagac
     3961 acagaattgc agggcatgaa tgaatatttg agctcattca aagtggctca gtatgtggta
     4021 cgggaagaag agatggggga ggaagaggag gtagaacggg aaatcataaa acaggaagaa
     4081 agtgtggatc ctgactactg ggagaaattg ctgcggcacc attatgagca gcagcaagaa
     4141 gatctagccc gaaatctggg caaaggaaaa agaatccgta aacaggtcaa ctacaatgat
     4201 ggctcacagg aggaccgaga ttggcaggac gaccagtccg acaaccagtc cgattactca
     4261 gtggcctcag aggaaggtga tgaagacttt gacgaacggt cagaagctcc ccgcaggccc
     4321 agtcgcaagg gcctgcggaa tgataaagat aagccattac ctcctctgtt ggcccgtgtt
     4381 ggtgggaata ttgaagtact tggttttaat gctcgtcagc gaaaagcatt tcttaatgca
     4441 attatgcgat atggcatgcc acctcaggat gcttttacca ctcagtggct tgtgagagat
     4501 cttcgaggca agtcagagaa agaatttaag gcttatgtgt cactcttcat gcgacatttg
     4561 tgtgagcctg gggcagatgg ggctgagacc tttgctgatg gcgtcccacg agaaggcctg
     4621 tctcgtcaac atgttctcac taggatcggt gtcatgtctc tgattcgaaa gaaggttcag
     4681 gagtttgaac atgttaatgg acgctggagc atgcccgaac tggctgaagt agaggaaaac
     4741 aaaaaaatgt ctcagccagg ttcaccttct ccaaagactc ctacaccttc cacaccaggg
     4801 gacacacaac ccaatactcc tgcgcctgtg ccacctgctg aggatgggat aaaaatagag
     4861 gaaaatagcc ttaaagaaga agagagcaca gaaggagaga aggaagttaa atctacagcc
     4921 cctgaggcga ctgtggagtg tgcacagccc cctgcccctg cccctgccac tgcccctgcc
     4981 actgccactg cccctgagga tgacaaggct cctgctgagc ctcctgaggg ggaggaaaaa
     5041 gtggaaaagg cagaggtgaa ggagagaaca gaggagccta tggagacaga ggccaaaggt
     5101 actactgagg tggagaaagt ggaggagaag tctgcggtag acctgacccc gatcgtggtg
     5161 gaagacaaag aagagaagaa ggaggaggag gagaaaaagg acgtgatgct tcagaatgga
     5221 gaaactccca aggatcttag tgatgagaag cagaagaaaa acagcaaaca gcgtttcatg
     5281 ttcaacattg cagatggtgg ttttactgag ttgcactcac tgtggcagaa tgaagagcgg
     5341 gcagccacag tcactaagaa gacttacgag atctggcacc gtcgccatga ttactggctg
     5401 ctggctggca ttataaacca cggctatgcc cggtggcagg acatccagaa tgacccacgg
     5461 tatgccatcc tcaatgagcc tttcaagggt gaaatgaatc gtggcaattt tctagagatc
     5521 aagaataaat ttttagctcg aagattcaag ctcttagaac aagccctggt gatcgaggag
     5581 cagcttcgca gggcagctta cctgaacatg tccgaggacc cctctcaccc gtctatggcc
     5641 cttaacaccc gcttcgctga ggtggagtgt ttggcagaaa gtcaccagca cctgtccaag
     5701 gagtcgatgg cagggaataa gccggccaat gcagtcctac acaaagtcct gaaacagctg
     5761 gaggaactgt tgagtgacat gaaagctgat gtgacgcggc tcccagccac cattgcccgc
     5821 atccccccag tcgctgtgag gttacagatg tcagagcgga acattctcag ccgcctggca
     5881 aacagggcgc cagaacctcc cccacagcag gtagcccagc agcagtgaaa gacccagagt
     5941 gatatccacc tccaccactc agcagtgacc ttcctcactt tctcttgtcc cggctgcccc
     6001 tgggggccag agagaccctt gccttccttc tgcccatctt ctgagttgta aaggaacagc
     6061 cctgcgcagt ggggcaggga gggagggaga agcaatggtg cccttcctgc tggagagaca
     6121 agcagcagta gcgcagcgcc cgcccgccat gtgcaggagc tggcgggctg gctgccttct
     6181 ggaccctggc ttctccccac cgtgcgcctg ttacaaactg ttgtggattc tgccaggctc
     6241 gaagaaaatg atctgaattt cttcctcttt ttggttttat tttgttggtt tactttgtgt
     6301 tttctccttt ttggggggta ttcagagtgg gccgggcccc tgggcgagac acagctacct
     6361 ctgttggcat ctttttaata ccaggaaccc agcggctcca gccactgagc agctaaataa
     6421 agttggaaaa aaaaaaaaaa agaaaaagaa ccaaaagcat aaaaaaccac agcaaatttc
     6481 ttgatgagaa ctgaaaataa aagtttcctt gtatttta
//
