LOCUS       NP_666131               2055 aa            linear   ROD 25-FEB-2025
DEFINITION  chromodomain-helicase-DNA-binding protein 3 [Mus musculus].
ACCESSION   NP_666131 XP_484041 XP_913784 XP_997561
VERSION     NP_666131.3
DBSOURCE    REFSEQ: accession NM_146019.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2055)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   2  (residues 1 to 2055)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 2055)
  AUTHORS   Price,J.D., Lindtner,S., Ypsilanti,A., Binyameen,F., Johnson,J.R.,
            Newton,B.W., Krogan,N.J. and Rubenstein,J.L.R.
  TITLE     DLX1 and the NuRD complex cooperate in enhancer decommissioning and
            transcriptional repression
  JOURNAL   Development 149 (11) (2022)
   PUBMED   35695185
REFERENCE   4  (residues 1 to 2055)
  AUTHORS   de Castro,R.O., Carbajal,A., Previato de Almeida,L., Goitea,V.,
            Griffin,C.T. and Pezza,R.J.
  TITLE     Mouse Chd4-NURD is required for neonatal spermatogonia survival and
            normal gonad development
  JOURNAL   Epigenetics Chromatin 15 (1), 16 (2022)
   PUBMED   35568926
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2055)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2055)
  AUTHORS   Le Guezennec,X., Vermeulen,M., Brinkman,A.B., Hoeijmakers,W.A.,
            Cohen,A., Lasonder,E. and Stunnenberg,H.G.
  TITLE     MBD2/NuRD and MBD3/NuRD, two distinct complexes with different
            biochemical and functional properties
  JOURNAL   Mol Cell Biol 26 (3), 843-851 (2006)
   PUBMED   16428440
REFERENCE   7  (residues 1 to 2055)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (residues 1 to 2055)
  AUTHORS   Jones,D.O., Cowell,I.G. and Singh,P.B.
  TITLE     Mammalian chromodomain proteins: their role in genome organisation
            and expression
  JOURNAL   Bioessays 22 (2), 124-137 (2000)
   PUBMED   10655032
  REMARK    Review article
REFERENCE   9  (residues 1 to 2055)
  AUTHORS   Kim,J., Sif,S., Jones,B., Jackson,A., Koipally,J., Heller,E.,
            Winandy,S., Viel,A., Sawyer,A., Ikeda,T., Kingston,R. and
            Georgopoulos,K.
  TITLE     Ikaros DNA-binding proteins direct formation of chromatin
            remodeling complexes in lymphocytes
  JOURNAL   Immunity 10 (3), 345-355 (1999)
   PUBMED   10204490
REFERENCE   10 (residues 1 to 2055)
  AUTHORS   Ermekova,K.S., Zambrano,N., Linn,H., Minopoli,G., Gertler,F.,
            Russo,T. and Sudol,M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ119759.1, AK045449.1, BC060721.1, BU702731.1, BM950040.1 and
            BC030435.1.
            
            On Nov 18, 2011 this sequence version replaced NP_666131.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164138,
                              SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2055
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.53 cM"
     Protein         1..2055
                     /product="chromodomain-helicase-DNA-binding protein 3"
                     /EC_number="3.6.4.12"
                     /note="Mi-2 alpha"
                     /calculated_mol_wt=232616
     Region          200..253
                     /region_name="CHDNT"
                     /note="CHDNT (NUC034) domain; pfam08073"
                     /db_xref="CDD:462357"
     Region          434..476
                     /region_name="PHD1_CHD_II"
                     /note="PHD finger 1 found in class II
                     Chromodomain-Helicase-DNA binding (CHD) proteins; cd15531"
                     /db_xref="CDD:277006"
     Site            order(434,443..447,451,471)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277006"
     Region          510..552
                     /region_name="PHD2_CHD_II"
                     /note="PHD finger 2 found in class II
                     Chromodomain-Helicase-DNA binding (CHD) proteins; cd15532"
                     /db_xref="CDD:277007"
     Site            order(510,519..523,527,547)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277007"
     Region          557..635
                     /region_name="CD1_tandem_CHD3-4_like"
                     /note="repeat 1 of the paired tandem chromodomains of
                     chromodomain helicase DNA-binding protein 3 and 4, and
                     similar proteins; cd18667"
                     /db_xref="CDD:349314"
     Site            order(559,606,608..609,613)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:349314"
     Region          680..734
                     /region_name="CD2_tandem_CHD3-4_like"
                     /note="repeat 2 of the paired tandem chromodomains of
                     chromodomain helicase DNA-binding protein 3 and 4, and
                     similar proteins; cd18662"
                     /db_xref="CDD:349309"
     Site            order(700,717)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:349309"
     Region          771..>1325
                     /region_name="PLN03142"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional"
                     /db_xref="CDD:215601"
     Region          788..1019
                     /region_name="DEXHc_CHD3"
                     /note="DEAH-box helicase domain of the chromodomain
                     helicase DNA binding protein 3; cd18055"
                     /db_xref="CDD:350813"
     Site            order(815..821,855,935..936)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350813"
     Region          <1366..1409
                     /region_name="DUF1087"
                     /note="CHD subfamily II, DUF1087; pfam06465"
                     /db_xref="CDD:461922"
     Region          1430..1569
                     /region_name="CHDII_SANT-like"
                     /note="CHD subfamily II, SANT-like domain; pfam06461"
                     /db_xref="CDD:461920"
     Region          <1561..>1746
                     /region_name="PHA03169"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:223003"
     Region          1790..1935
                     /region_name="CHDCT2"
                     /note="CHDCT2 (NUC038) domain; pfam08074"
                     /db_xref="CDD:462358"
     CDS             1..2055
                     /gene="Chd3"
                     /gene_synonym="2600010P09Rik; Chd7; Prp7; Prp9-1"
                     /coded_by="NM_146019.4:36..6203"
                     /db_xref="CCDS:CCDS48825.2"
                     /db_xref="GeneID:216848"
                     /db_xref="MGI:MGI:1344395"
ORIGIN      
        1 masplrdeee eeeemvvsee eeeeeeegde eeeeveaade ddeeedeegv lgrgpghdrs
       61 rdrhsppsch lfpppppplp pppppdkddi rllpsalgvk krkrgpkkqk enkpgkprkr
      121 kkldseeefg serdeyreks esggseygtg pgrkrrrkhr ekkekktkrr krgegdgghk
      181 qveqkssatl lltwgledve hvfseedyht ltnykafsqf mrpliakknp kipmskmmti
      241 lgakwrefsa nnpfkgsaaa vaaaaaaaaa avaeqvsaav ssatpiapsg pppalppppa
      301 peiqpppirr aktkegkgpg hkrrnksprv pdgrkklrgk kmaplkiklg llggkrkkag
      361 scafqseegh epeaeesdld sgsvhsasgw pdgpvrakkl krgrpgrkkk kvlgcpavtg
      421 eeevdgyetd hqdycevcqq ggeiilcdtc prayhlvcld peldrapegk wscphcekeg
      481 vqweakeeee eyeeegeege keeeddhmey crvckdggel lccdacissy hihclnpplp
      541 dipngewlcp rctcpvlkgr vqkilhwrwg eppvavpapq qadgnpdvpp prplqgrser
      601 effvkwvgls ywhcswakel qleifhlvmy rnyqrkndmd epppldygsg eddgksdkrk
      661 vkdphyaeme ekyyrfgikp ewmtvhriin hsmdkkgnyh ylvkwkdlpy dqstweedem
      721 nipeyddhkq sywrhrelim gedpaqprky kkkkkelqgd gppssptndp tvkyetqprf
      781 itatggtlhm yqleglnwlr fswaqgtdti lademglgkt iqtivflysl ykeghtkgpf
      841 lvsaplstii nwerefqmwa pkfyvvtytg dkdsraiire nefsfednai kggkkafkmk
      901 reaqvkfhvl ltsyelitid qaalgsirwa clvvdeahrl knnqskffrv lngykidhkl
      961 lltgtplqnn leelfhllnf ltperfnnle gfleefadis kedqikklhd llgphmlrrl
     1021 kadvfknmpa ktelivrvel spmqkkyyky iltrnfealn srgggnqvsl lnimmdlkkc
     1081 cnhpylfpva amespklpsg ayeggaliks sgkllllqkm lrklkeqghr vlifsqmtkm
     1141 ldlledfldy egykyeridg gitgalrqea idrfnapgaq qfcfllstra gglginlata
     1201 dtviifdsdw nphndiqafs rahrigqank vmiyrfvtra sveeritqva krkmmlthlv
     1261 vrpglgskag smskqelddi lkfgteelfk denegenkee dssvihydne aiarlldrnq
     1321 datedtdvqn mneylssfkv aqyvvreedk ieeiereiik qeenvdpdyw ekllrhhyeq
     1381 qqedlarnlg kgkrvrkqvn yndaaqedqd nqseysvgse eededfderp egrrqskrql
     1441 rnekdkplpp llarvggnie vlgfntrqrk aflnavmrwg mppqdafttq wlvrdlrgkt
     1501 ekefkayvsl fmrhlcepga dgsetfadgv preglsrqqv ltrigvmslv kkkvqefehi
     1561 ngrwsmpelm pdpsaeskrs srassptkts pttpeasttn spctskpatp apsekgdgvr
     1621 tpldkddten qeekpeknsk vgekmeaevd spspapslge rlehrkille deapgvpget
     1681 epepgyrgdr eksaseptpg ergeekpldv qehrertege tgdlgkredv kadrelrlgp
     1741 prdeprpngr reekvekprf mfniadggft elhtlwqnee raaissgkln eiwhrrhdyw
     1801 llagivlhgy arwqdiqnda qfaiinepfk teankgnfle mknkflarrf klleqalvie
     1861 eqlrraayln lsqepahpam alharfaeae claeshqhls keslagnkpa navlhkvlnq
     1921 leellsdmka dvtrlpatls rippiaarlq msersilsrl askgtephpt pafppgpyat
     1981 ppgygaafsa apvgalaaag anysqmpags fitattngpp vlvkkekemv galvsdglgl
     2041 drkepragev icidd
//
