LOCUS       NM_026539               3020 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus chromodomain helicase DNA binding protein 1-like
            (Chd1l), transcript variant 1, mRNA.
ACCESSION   NM_026539
VERSION     NM_026539.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3020)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3020)
  AUTHORS   Hewitt,G., Borel,V., Segura-Bayona,S., Takaki,T., Ruis,P.,
            Bellelli,R., Lehmann,L.C., Sommerova,L., Vancevska,A.,
            Tomas-Loba,A., Zhu,K., Cooper,C., Fugger,K., Patel,H.,
            Goldstone,R., Schneider-Luftman,D., Herbert,E., Stamp,G.,
            Brough,R., Pettitt,S., Lord,C.J., West,S.C., Ahel,I., Ahel,D.,
            Chapman,J.R., Deindl,S. and Boulton,S.J.
  TITLE     Defective ALC1 nucleosome remodeling confers PARPi sensitization
            and synthetic lethality with HRD
  JOURNAL   Mol Cell 81 (4), 767-783 (2021)
   PUBMED   33333017
  REMARK    GeneRIF: Defective ALC1 nucleosome remodeling confers PARPi
            sensitization and synthetic lethality with HRD.
REFERENCE   3  (bases 1 to 3020)
  AUTHORS   Dou,D., Zhao,H., Li,Z., Xu,L., Xiong,X., Wu,X., Sun,Y., Zeng,S.,
            Ouyang,Q., Zhou,D., Ma,N., Lin,G. and Hu,L.
  TITLE     CHD1L Promotes Neuronal Differentiation in Human Embryonic Stem
            Cells by Upregulating PAX6
  JOURNAL   Stem Cells Dev 26 (22), 1626-1636 (2017)
   PUBMED   28946814
  REMARK    GeneRIF: overexpression of CHD1L in embryonic cells upregulated the
            expression of ectoderm genes, especially PAX6
REFERENCE   4  (bases 1 to 3020)
  AUTHORS   Liu,M., Chen,L., Ma,N.F., Chow,R.K., Li,Y., Song,Y., Chan,T.H.,
            Fang,S., Yang,X., Xi,S., Jiang,L., Li,Y., Zeng,T.T., Li,Y.,
            Yuan,Y.F. and Guan,X.Y.
  TITLE     CHD1L promotes lineage reversion of hepatocellular carcinoma
            through opening chromatin for key developmental transcription
            factors
  JOURNAL   Hepatology 63 (5), 1544-1559 (2016)
   PUBMED   27100146
  REMARK    GeneRIF: found a significant correlation of CHD1L with
            developmental transcriptional factors and lineage differentiation
            markers in clinical hepatocellular carcinoma patients
REFERENCE   5  (bases 1 to 3020)
  AUTHORS   Jiang,B.H., Chen,W.Y., Li,H.Y., Chien,Y., Chang,W.C., Hsieh,P.C.,
            Wu,P., Chen,C.Y., Song,H.Y., Chien,C.S., Sung,Y.J. and Chiou,S.H.
  TITLE     CHD1L Regulated PARP1-Driven Pluripotency and Chromatin Remodeling
            During the Early-Stage Cell Reprogramming
  JOURNAL   Stem Cells 33 (10), 2961-2972 (2015)
   PUBMED   26201266
  REMARK    GeneRIF: these results identify CHD1L as a key chromatin remodeler
            involved in PARP1/PARylation-regulated early-stage reprogramming
            and pluripotency in stem cells.
REFERENCE   6  (bases 1 to 3020)
  AUTHORS   Chen,M., Huang,J.D., Hu,L., Zheng,B.J., Chen,L., Tsang,S.L. and
            Guan,X.Y.
  TITLE     Transgenic CHD1L expression in mouse induces spontaneous tumors
  JOURNAL   PLoS One 4 (8), e6727 (2009)
   PUBMED   19701453
  REMARK    GeneRIF: our data strongly support that CHD1L is a novel oncogene
            and plays an important role in hepatocellular carcinoma
            pathogenesis
            GeneRIF: Reports that transgenic CHD1L (Alc1) expression induces
            spontaneous tumors in mice.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3020)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 3020)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3020)
  AUTHORS   Yan,L., Echenique,V., Busso,C., SanMiguel,P., Ramakrishna,W.,
            Bennetzen,J.L., Harrington,S. and Dubcovsky,J.
  TITLE     Cereal genes similar to Snf2 define a new subfamily that includes
            human and mouse genes
  JOURNAL   Mol Genet Genomics 268 (4), 488-499 (2002)
   PUBMED   12471446
REFERENCE   10 (bases 1 to 3020)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140839.9.
            
            On Mar 23, 2023 this sequence version replaced NM_026539.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062966.1, AK014473.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AC140839.9         29781-29931
            152-264             AC140839.9         34784-34896
            265-371             AC140839.9         36228-36334
            372-486             AC140839.9         36871-36985
            487-518             AC140839.9         37941-37972
            519-600             AC140839.9         42221-42302
            601-763             AC140839.9         45824-45986
            764-919             AC140839.9         48634-48789
            920-1012            AC140839.9         49348-49440
            1013-1109           AC140839.9         49992-50088
            1110-1183           AC140839.9         51681-51754
            1184-1294           AC140839.9         52773-52883
            1295-1409           AC140839.9         56072-56186
            1410-1563           AC140839.9         57124-57277
            1564-1762           AC140839.9         58817-59015
            1763-1911           AC140839.9         67285-67433
            1912-2075           AC140839.9         68927-69090
            2076-2278           AC140839.9         69590-69792
            2279-2377           AC140839.9         70795-70893
            2378-2448           AC140839.9         73165-73235
            2449-2563           AC140839.9         76423-76537
            2564-2672           AC140839.9         77307-77415
            2673-3020           AC140839.9         78907-79254
FEATURES             Location/Qualifiers
     source          1..3020
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.17 cM"
     gene            1..3020
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /note="chromodomain helicase DNA binding protein 1-like"
                     /db_xref="GeneID:68058"
                     /db_xref="MGI:MGI:1915308"
     exon            1..151
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2745
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /EC_number="3.6.4.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     amplified in liver cancer 1"
                     /codon_start=1
                     /product="chromodomain-helicase-DNA-binding protein 1-like
                     isoform 1"
                     /protein_id="NP_080815.1"
                     /db_xref="CCDS:CCDS38561.1"
                     /db_xref="GeneID:68058"
                     /db_xref="MGI:MGI:1915308"
                     /translation="MASGLPRFLQALPAEHGPEPLRTRVQEPDLQQWGLTGIRLRSYQ
                     LEGVNWLVQCFHCQNGCILGDEMGLGKTCQTIALLIYLVGRLNDEGPFLVLCPLSVLS
                     NWKEEMERFAPGLSCVTYTGDKEERARLQQDLRQESGFHVLLTTYEICLKDASFLKSF
                     SWSVLAVDEAHRLKNQSSLLHRTLSEFSAVFRLLLTGTPIQNSLRELYSLLCVVEPDL
                     FCREQVEDFVQRYQDIEKESKSASELHRLLQPFLLRRVKAQVATELPKKTEVVVYHGM
                     SALQKKYYKAILMKDLDAFENETAKKVKLQNILTQLRKCVDHPYLFDGVEPEPFEVGE
                     HLIEASGKLHLLDRLLAFLYSGGHRVLLFSQMTHMLDILQDYMDYRGYSYERVDGSVR
                     GEERHLAIKNFGNQPIFVFLLSTRAGGVGMNLTAADTVIFVDSDFNPQNDLQAAARAH
                     RIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLTNMVIEGGHFTPGAQKPSAEADFQL
                     SEILKFGLDKLLSSEGSSMEDIDLKSILGETKDGQWTPDALPAAAAAGGGSLEPEEGS
                     ELESRSYENHMYLFEGRDYSKEPSKEDRKSFEQLVNLQKTLLEKTSHGGRTLRNKGSV
                     LIPGLAEGPIKRKKILSPEELEDRRKKRQEAAAKRKRLMEEKRKEKEEAEHRKKMAWW
                     ESNGYQSFCLSSEDSELEDLEGGDESSAELAYEDLDSTSINYVSGDVTHPQAGEEDAV
                     IVHCVDDSGRWGRGGLFTALEVRSAEPRKIYELAGKMEDLSLGDVLLFPIDDKESRDK
                     GQDLLALVVAQHRDRTNVLSGIKMAALEEGLKKIFLAAKKKKASVHLPRIGHATKGFN
                     WYGTERLIRKHLATRGIPTYIYYFPRSKARHSQPASSSSAPLVP"
     exon            152..264
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            265..371
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            372..486
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            487..518
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            519..600
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            601..763
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            764..919
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1012
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1109
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1183
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1294
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1409
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1563
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1762
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1911
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2075
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2278
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2377
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2448
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2563
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2672
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..3020
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3001..3006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /note="hexamer: AATAGA"
     polyA_site      3020
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /note="major polyA site"
ORIGIN      
        1 gtactccgca cgcgcgggag cgaaggcgcg gggcctctcg ggatggcgag cggcttgccg
       61 cgcttcctgc aggcgctgcc ggccgaacac gggccggagc cgcttcggac gcgggtgcag
      121 gaaccggact tacagcagtg gggcttgact gggattcgtc tacgttctta ccaactggaa
      181 ggagtcaatt ggctagtcca gtgcttccat tgccagaatg gctgcatcct gggagatgag
      241 atgggcttgg ggaagacctg ccagactatc gctctcctca tttacttggt ggggagactg
      301 aatgatgaag ggccgtttct ggttctctgt cccttgtctg ttttgagcaa ctggaaagaa
      361 gagatggaga gatttgctcc aggtctttcc tgtgtgacat acacaggtga caaggaggag
      421 agagcccgcc ttcagcagga cctaagacag gagtcaggtt ttcacgtgct gctgacgaca
      481 tacgagattt gcttgaaaga tgcctcattt ctaaaatcct tctcttggag cgttcttgct
      541 gtggatgaag ctcacagatt gaaaaaccag agctccctgc tgcacaggac actttcagag
      601 ttctcagcgg tcttccgtct cctgctcacc ggaacgccca tccagaacag cctccgggag
      661 ctctactccc tcctctgtgt cgtggagcct gacctcttct gcagagaaca ggtggaagat
      721 ttcgttcagc gttaccagga catcgagaaa gagtccaaat cagcaagcga gctgcacagg
      781 ctcttgcagc catttctcct gaggcgtgtg aaagctcagg tagccacaga gctccccaag
      841 aagacagagg tggtggtgta ccacggcatg tccgctctgc agaaaaagta ctacaaggcc
      901 atcctgatga aagacctgga tgcatttgag aacgagacag ccaagaaagt caaactccag
      961 aacatcctga cgcagcttcg gaagtgtgtg gaccacccgt atctgttcga tggtgtggaa
     1021 ccagagccct ttgaagttgg agagcacctg attgaggcca gtgggaagct tcacctgctg
     1081 gacaggctgc tggcgtttct gtattctggg ggccatcggg ttttactttt ctcccagatg
     1141 acacacatgc tggatattct gcaggactat atggactaca gaggctacag ctacgagcgt
     1201 gtggatggct ccgtgagagg agaggagaga cacctggcca ttaagaactt tggaaaccag
     1261 cccatttttg tttttctcct gagcacccgg gcaggtggag tgggcatgaa cttaacagcg
     1321 gcagacaccg tcatttttgt cgacagcgac ttcaaccctc agaatgactt gcaggcggcc
     1381 gccagagctc accgaattgg ccagaacaag tctgttaaag tcatccggct gatcggccgc
     1441 gacaccgtgg aagaaatcgt gtataggaag gcggcctcca aactgcagct taccaacatg
     1501 gtcatagaag gaggtcattt cacaccagga gcccagaaac cttcagccga ggccgacttc
     1561 cagttaagtg agattctcaa attcggcttg gataaactgc tgtcctctga ggggagctcc
     1621 atggaggata tagacctgaa gtccatcctg ggagaaacca aagatggcca gtggacccct
     1681 gatgctctgc ccgcagcagc agcagcagga ggaggaagcc tagaaccaga ggaaggaagt
     1741 gaattggaat ccaggtctta tgaaaaccac atgtacttgt ttgaaggtag agactattct
     1801 aaggagccca gtaaggaaga cagaaagtca tttgagcagc tggtgaatct tcagaaaacc
     1861 cttctagaga agacaagcca tgggggccgg accctccgga acaaaggcag cgttcttatc
     1921 ccaggccttg cagaagggcc catcaaaagg aagaagatcc ttagcccaga ggagctggag
     1981 gacagacgga agaaaagaca ggaagcagcg gccaagagga agagactgat ggaggagaag
     2041 aggaaggaga aggaggaggc tgaacacagg aagaagatgg cctggtggga atccaacggt
     2101 taccagtcct tctgcctgtc ctcggaggac agcgagcttg aggacctgga gggcggagat
     2161 gagtcttctg ccgagctggc ttatgaagat ctagactcaa cctccattaa ctatgttagt
     2221 ggcgacgtca cccaccccca ggctggcgaa gaagatgctg tcattgtgca ctgtgtagat
     2281 gattctggcc gctggggcag aggtggctta ttcacagctc tggaagtacg atcagctgaa
     2341 ccaagaaaaa tatacgagct ggctgggaaa atggaagacc tgagtttggg tgatgtcctt
     2401 ctatttccta tcgacgataa agagtcacga gacaaggggc aagatctgtt ggccttggtt
     2461 gtggctcagc accgtgatcg caccaatgtc ctgtctggca ttaagatggc agccctagaa
     2521 gagggcctga agaagatatt tttagcagca aagaaaaaga aagcaagcgt tcatcttcca
     2581 cgaattggac atgctacaaa gggttttaac tggtatggta ccgaacgact tatccggaaa
     2641 catttggcta cacgaggcat cccaacttac atatactact ttcccagaag taaggcccgc
     2701 cattcacagc ctgcatcctc ctcctcagca ccactggttc cctagcaacc agcccagcat
     2761 tgggtccagt tttcagcaac cagttagatt cttgctccca gattgactgt tagttttcag
     2821 gaaacaaggc tatctttggt catattctct gctctggaat ttctgggcta gtctttcctg
     2881 aattctaatt ttgttgctct ggaagtgtta actgtgatcc agtacctgta atacaggaac
     2941 acacaatgta tatggggaag ccctttggct tcagattgcc tatgtttgaa taataataat
     3001 aatagatggc ctattgttaa
//
