LOCUS       NP_080815                900 aa            linear   ROD 02-MAY-2024
DEFINITION  chromodomain-helicase-DNA-binding protein 1-like isoform 1 [Mus
            musculus].
ACCESSION   NP_080815
VERSION     NP_080815.1
DBSOURCE    REFSEQ: accession NM_026539.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 900)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 900)
  AUTHORS   Hewitt,G., Borel,V., Segura-Bayona,S., Takaki,T., Ruis,P.,
            Bellelli,R., Lehmann,L.C., Sommerova,L., Vancevska,A.,
            Tomas-Loba,A., Zhu,K., Cooper,C., Fugger,K., Patel,H.,
            Goldstone,R., Schneider-Luftman,D., Herbert,E., Stamp,G.,
            Brough,R., Pettitt,S., Lord,C.J., West,S.C., Ahel,I., Ahel,D.,
            Chapman,J.R., Deindl,S. and Boulton,S.J.
  TITLE     Defective ALC1 nucleosome remodeling confers PARPi sensitization
            and synthetic lethality with HRD
  JOURNAL   Mol Cell 81 (4), 767-783 (2021)
   PUBMED   33333017
  REMARK    GeneRIF: Defective ALC1 nucleosome remodeling confers PARPi
            sensitization and synthetic lethality with HRD.
REFERENCE   3  (residues 1 to 900)
  AUTHORS   Dou,D., Zhao,H., Li,Z., Xu,L., Xiong,X., Wu,X., Sun,Y., Zeng,S.,
            Ouyang,Q., Zhou,D., Ma,N., Lin,G. and Hu,L.
  TITLE     CHD1L Promotes Neuronal Differentiation in Human Embryonic Stem
            Cells by Upregulating PAX6
  JOURNAL   Stem Cells Dev 26 (22), 1626-1636 (2017)
   PUBMED   28946814
  REMARK    GeneRIF: overexpression of CHD1L in embryonic cells upregulated the
            expression of ectoderm genes, especially PAX6
REFERENCE   4  (residues 1 to 900)
  AUTHORS   Liu,M., Chen,L., Ma,N.F., Chow,R.K., Li,Y., Song,Y., Chan,T.H.,
            Fang,S., Yang,X., Xi,S., Jiang,L., Li,Y., Zeng,T.T., Li,Y.,
            Yuan,Y.F. and Guan,X.Y.
  TITLE     CHD1L promotes lineage reversion of hepatocellular carcinoma
            through opening chromatin for key developmental transcription
            factors
  JOURNAL   Hepatology 63 (5), 1544-1559 (2016)
   PUBMED   27100146
  REMARK    GeneRIF: found a significant correlation of CHD1L with
            developmental transcriptional factors and lineage differentiation
            markers in clinical hepatocellular carcinoma patients
REFERENCE   5  (residues 1 to 900)
  AUTHORS   Jiang,B.H., Chen,W.Y., Li,H.Y., Chien,Y., Chang,W.C., Hsieh,P.C.,
            Wu,P., Chen,C.Y., Song,H.Y., Chien,C.S., Sung,Y.J. and Chiou,S.H.
  TITLE     CHD1L Regulated PARP1-Driven Pluripotency and Chromatin Remodeling
            During the Early-Stage Cell Reprogramming
  JOURNAL   Stem Cells 33 (10), 2961-2972 (2015)
   PUBMED   26201266
  REMARK    GeneRIF: these results identify CHD1L as a key chromatin remodeler
            involved in PARP1/PARylation-regulated early-stage reprogramming
            and pluripotency in stem cells.
REFERENCE   6  (residues 1 to 900)
  AUTHORS   Chen,M., Huang,J.D., Hu,L., Zheng,B.J., Chen,L., Tsang,S.L. and
            Guan,X.Y.
  TITLE     Transgenic CHD1L expression in mouse induces spontaneous tumors
  JOURNAL   PLoS One 4 (8), e6727 (2009)
   PUBMED   19701453
  REMARK    GeneRIF: our data strongly support that CHD1L is a novel oncogene
            and plays an important role in hepatocellular carcinoma
            pathogenesis
            GeneRIF: Reports that transgenic CHD1L (Alc1) expression induces
            spontaneous tumors in mice.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 900)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (residues 1 to 900)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 900)
  AUTHORS   Yan,L., Echenique,V., Busso,C., SanMiguel,P., Ramakrishna,W.,
            Bennetzen,J.L., Harrington,S. and Dubcovsky,J.
  TITLE     Cereal genes similar to Snf2 define a new subfamily that includes
            human and mouse genes
  JOURNAL   Mol Genet Genomics 268 (4), 488-499 (2002)
   PUBMED   12471446
REFERENCE   10 (residues 1 to 900)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140839.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062966.1, AK014473.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..900
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.17 cM"
     Protein         1..900
                     /product="chromodomain-helicase-DNA-binding protein 1-like
                     isoform 1"
                     /EC_number="3.6.4.12"
                     /note="amplified in liver cancer 1"
                     /calculated_mol_wt=101307
     Region          39..>549
                     /region_name="PLN03142"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional"
                     /db_xref="CDD:215601"
     Region          168..171
                     /region_name="DEAH box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CXF7.1)"
     Site            534
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86WJ1; propagated from
                     UniProtKB/Swiss-Prot (Q9CXF7.1)"
     Region          546..569
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CXF7.1)"
     Region          606..640
                     /region_name="Regulatory linker segment (RLS).
                     /evidence=ECO:0000250|UniProtKB:Q86WJ1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CXF7.1)"
     Site            612
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86WJ1; propagated from
                     UniProtKB/Swiss-Prot (Q9CXF7.1)"
     Region          620..678
                     /region_name="Required for ATPase activity.
                     /evidence=ECO:0000250|UniProtKB:Q86WJ1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CXF7.1)"
     Site            623
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86WJ1; propagated from
                     UniProtKB/Swiss-Prot (Q9CXF7.1)"
     Region          641..673
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CXF7.1)"
     Site            641
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86WJ1; propagated from
                     UniProtKB/Swiss-Prot (Q9CXF7.1)"
     Region          721..871
                     /region_name="Macro_Poa1p-like_SNF2"
                     /note="macrodomain, Poa1p-like family, SNF2 subfamily;
                     cd03331"
                     /db_xref="CDD:394880"
     Site            order(727..730,743..746,750..756,758,808..809,846..853)
                     /site_type="other"
                     /note="putative ADP-ribose binding site [chemical
                     binding]"
                     /db_xref="CDD:394880"
     Site            894
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86WJ1; propagated from
                     UniProtKB/Swiss-Prot (Q9CXF7.1)"
     CDS             1..900
                     /gene="Chd1l"
                     /gene_synonym="4432404A22Rik; Alc1; Snf2p"
                     /coded_by="NM_026539.3:43..2745"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS38561.1"
                     /db_xref="GeneID:68058"
                     /db_xref="MGI:MGI:1915308"
ORIGIN      
        1 masglprflq alpaehgpep lrtrvqepdl qqwgltgirl rsyqlegvnw lvqcfhcqng
       61 cilgdemglg ktcqtialli ylvgrlndeg pflvlcplsv lsnwkeemer fapglscvty
      121 tgdkeerarl qqdlrqesgf hvllttyeic lkdasflksf swsvlavdea hrlknqssll
      181 hrtlsefsav frllltgtpi qnslrelysl lcvvepdlfc reqvedfvqr yqdiekesks
      241 aselhrllqp fllrrvkaqv atelpkktev vvyhgmsalq kkyykailmk dldafeneta
      301 kkvklqnilt qlrkcvdhpy lfdgvepepf evgehlieas gklhlldrll aflysgghrv
      361 llfsqmthml dilqdymdyr gysyervdgs vrgeerhlai knfgnqpifv fllstraggv
      421 gmnltaadtv ifvdsdfnpq ndlqaaarah rigqnksvkv irligrdtve eivyrkaask
      481 lqltnmvieg ghftpgaqkp saeadfqlse ilkfgldkll ssegssmedi dlksilgetk
      541 dgqwtpdalp aaaaagggsl epeegseles rsyenhmylf egrdyskeps kedrksfeql
      601 vnlqktllek tshggrtlrn kgsvlipgla egpikrkkil speeledrrk krqeaaakrk
      661 rlmeekrkek eeaehrkkma wwesngyqsf clssedsele dleggdessa elayedldst
      721 sinyvsgdvt hpqageedav ivhcvddsgr wgrgglftal evrsaeprki yelagkmedl
      781 slgdvllfpi ddkesrdkgq dllalvvaqh rdrtnvlsgi kmaaleeglk kiflaakkkk
      841 asvhlprigh atkgfnwygt erlirkhlat rgiptyiyyf prskarhsqp assssaplvp
//
