LOCUS       NM_007690               7918 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus chromodomain helicase DNA binding protein 1 (Chd1),
            mRNA.
ACCESSION   NM_007690
VERSION     NM_007690.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7918)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   2  (bases 1 to 7918)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7918)
  AUTHORS   Zengeler,K.E., Shapiro,D.A., Bruch,K.R., Lammert,C.R., Ennerfelt,H.
            and Lukens,J.R.
  TITLE     SSRI treatment modifies the effects of maternal inflammation on in
            utero physiology and offspring neurobiology
  JOURNAL   Brain Behav Immun 108, 80-97 (2023)
   PUBMED   36343752
REFERENCE   4  (bases 1 to 7918)
  AUTHORS   Bulut-Karslioglu,A., Jin,H., Kim,Y.K., Cho,B., Guzman-Ayala,M.,
            Williamson,A.J.K., Hejna,M., Stotzel,M., Whetton,A.D., Song,J.S.
            and Ramalho-Santos,M.
  TITLE     Chd1 protects genome integrity at promoters to sustain
            hypertranscription in embryonic stem cells
  JOURNAL   Nat Commun 12 (1), 4859 (2021)
   PUBMED   34381042
  REMARK    GeneRIF: Chd1 protects genome integrity at promoters to sustain
            hypertranscription in embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7918)
  AUTHORS   Zhu,Y., Wen,J., Huang,G., Mittlesteadt,J., Wen,X. and Lu,X.
  TITLE     CHD1 and SPOP synergistically protect prostate epithelial cells
            from DNA damage
  JOURNAL   Prostate 81 (1), 81-88 (2021)
   PUBMED   33022763
  REMARK    GeneRIF: CHD1 and SPOP synergistically protect prostate epithelial
            cells from DNA damage.
REFERENCE   6  (bases 1 to 7918)
  AUTHORS   Chen,Y.X., Yan,J., Keeshan,K., Tubbs,A.T., Wang,H., Silva,A.,
            Brown,E.J., Hess,J.L., Pear,W.S. and Hua,X.
  TITLE     The tumor suppressor menin regulates hematopoiesis and myeloid
            transformation by influencing Hox gene expression
  JOURNAL   Proc Natl Acad Sci U S A 103 (4), 1018-1023 (2006)
   PUBMED   16415155
REFERENCE   7  (bases 1 to 7918)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 7918)
  AUTHORS   Jones,D.O., Cowell,I.G. and Singh,P.B.
  TITLE     Mammalian chromodomain proteins: their role in genome organisation
            and expression
  JOURNAL   Bioessays 22 (2), 124-137 (2000)
   PUBMED   10655032
  REMARK    Review article
REFERENCE   9  (bases 1 to 7918)
  AUTHORS   Woodage,T., Basrai,M.A., Baxevanis,A.D., Hieter,P. and Collins,F.S.
  TITLE     Characterization of the CHD family of proteins
  JOURNAL   Proc Natl Acad Sci U S A 94 (21), 11472-11477 (1997)
   PUBMED   9326634
REFERENCE   10 (bases 1 to 7918)
  AUTHORS   Delmas,V., Stokes,D.G. and Perry,R.P.
  TITLE     A mammalian DNA-binding protein that contains a chromodomain and an
            SNF2/SWI2-like helicase domain
  JOURNAL   Proc Natl Acad Sci U S A 90 (6), 2414-2418 (1993)
   PUBMED   8460153
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT033750.18 and AC102745.10.
            
            On Jun 17, 2009 this sequence version replaced NM_007690.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L10410.1, SRR10223971.16466.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               CT033750.18        230899-231244
            347-546             CT033750.18        232872-233071
            547-748             CT033750.18        251201-251402
            749-862             CT033750.18        252181-252294
            863-927             CT033750.18        254119-254183
            928-1077            CT033750.18        256415-256564
            1078-1346           CT033750.18        256681-256949
            1347-1572           CT033750.18        257786-258011
            1573-1673           CT033750.18        258471-258571
            1674-1852           CT033750.18        258917-259095
            1853-1980           CT033750.18        260163-260290
            1981-2197           CT033750.18        261560-261776
            2198-2287           CT033750.18        262792-262881
            2288-2478           CT033750.18        264414-264604
            2479-2667           CT033750.18        265438-265626
            2668-2830           CT033750.18        268089-268251
            2831-2983           AC102745.10        185281-185433       c
            2984-3055           AC102745.10        181305-181376       c
            3056-3205           AC102745.10        180594-180743       c
            3206-3354           AC102745.10        178990-179138       c
            3355-3451           AC102745.10        178567-178663       c
            3452-3547           AC102745.10        178377-178472       c
            3548-3724           AC102745.10        176013-176189       c
            3725-3885           AC102745.10        173430-173590       c
            3886-3927           AC102745.10        171710-171751       c
            3928-4058           AC102745.10        170764-170894       c
            4059-4197           AC102745.10        170098-170236       c
            4198-4348           AC102745.10        169779-169929       c
            4349-4471           AC102745.10        168061-168183       c
            4472-4600           AC102745.10        167104-167232       c
            4601-4741           AC102745.10        165989-166129       c
            4742-4920           AC102745.10        163490-163668       c
            4921-5017           AC102745.10        162084-162180       c
            5018-5072           AC102745.10        161007-161061       c
            5073-5283           AC102745.10        159735-159945       c
            5284-7918           AC102745.10        155899-158533       c
FEATURES             Location/Qualifiers
     source          1..7918
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.95 cM"
     gene            1..7918
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /note="chromodomain helicase DNA binding protein 1"
                     /db_xref="GeneID:12648"
                     /db_xref="MGI:MGI:88393"
     exon            1..346
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            347..546
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             494..5629
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /EC_number="3.6.4.12"
                     /note="CHD-1; ATP-dependent helicase CHD1"
                     /codon_start=1
                     /product="chromodomain-helicase-DNA-binding protein 1"
                     /protein_id="NP_031716.2"
                     /db_xref="CCDS:CCDS28416.1"
                     /db_xref="GeneID:12648"
                     /db_xref="MGI:MGI:88393"
                     /translation="MNGHSDEESVRNGSGESSQSGDDCGSASGSGSGSSSGSSSDGSS
                     SQSGSSDSDSGSDSGSQSESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAML
                     RKQPQQAQQQRPASSNSGSEEDSSSSEDSDDSSSGAKRKKHNDEDWQMSGSGSPSQSG
                     SDSESEEERDKSSCDGTESDYEPKNKVRSRKPQNRSKSKNGKKILGQKKRQIDSSEDE
                     DDEDYDNDKRSSRRQATVNVSYKEDEEMKTDSDDLLEVCGEDVPQPEDEEFETIERVM
                     DCRVGRKGATGATTTIYAVEADGDPNAGFERNKEPGDIQYLIKWKGWSHIHNTWETEE
                     TLKQQNVRGMKKLDNYKKKDQETKRWLKNASPEDVEYYNCQQELTDDLHKQYQIVERI
                     IAHSNQKSAAGLPDYYCKWQGLPYSECSWEDGALISKKFQTCIDEYFSRNQSKTTPFK
                     DCKVLKQRPRFVALKKQPSYIGGHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGL
                     GKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWASQMNAVVYLGDINSR
                     NMIRTHEWMHPQTKRLKFNILLTTYEILLKDKAFLGGLNWAFIGVDEAHRLKNDDSLL
                     YKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYGYA
                     SLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSALQKQYYKWILTRNYKALSKGSK
                     GSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEALQHLIRSSGKLILLDKLLIRL
                     RERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKGELRKQALDHFNAEGSEDF
                     CFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKG
                     SVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEELSAILKFGAE
                     ELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLSVGDELLSQFKVANFSNMDEDDI
                     ELEPERNSKNWEEIIPEEQRRRLEEEERQKELEEIYMLPRMRNCAKQISFNGSEGRRS
                     RSRRYSGSDSDSISERKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKKFGGPLERL
                     DAIARDAELVDKSETDLRRLGELVHNGCVKALKDSSSGTERAGGRLGKVKGPTFRISG
                     VQVNAKLVIAHEDELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSNLLIG
                     IYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKREA
                     QRLCGAGGSKRRKTRAKKSKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKLNDSKPESK
                     DRSKKSVVSDAPVHITASGEPVPIAEESEELDQKTFSICKERMRPVKAALKQLDRPEK
                     GLSEREQLEHTRQCLIKIGDHITECLKEYSNPEQIKQWRKNLWIFVSKFTEFDARKLH
                     KLYKHAIKKRQESQQNSDQNSNVATTHVIRNPDMERLKENTNHDDSSRDSYSSDRHLS
                     QYHDHHKDRHQGDSYKKSDSRKRPYSSFSNGKDHREWDHYRQDSRYYSDREKHRKLDD
                     HRSREHRPSLEGGLKDRCHSDHRSHSDHRMHSDHRSSSEHTHHKSSRDYRYLSDWQLD
                     HRAASSGPRSPLDQRSPYGSRSPFEHSAEHRSTPEHTWSSRKT"
     exon            547..748
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            749..862
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            863..927
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1077
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1346
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1572
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1673
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1852
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1980
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2197
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2287
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2478
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2667
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2830
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2983
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3055
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3205
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3354
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..3451
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3547
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3548..3724
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3725..3885
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3886..3927
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3928..4058
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4059..4197
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4198..4348
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4349..4471
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4472..4600
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4601..4741
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4742..4920
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4921..5017
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5018..5072
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5073..5283
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5284..7918
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6777..6782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      6797
                     /gene="Chd1"
                     /gene_synonym="4930525N21Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggaggcgga ggcgacagcg acctcggcgg cgccgcgcgg cggagacggt tgcgctcgat
       61 cgcggtcttg gcgtcatggc ggctgccggc ggccgataag cggcggggcg ggagcgcgga
      121 cggaggaggc gccctcggta cttcccgctc ggcccgggcg cccggagatg aactgatcgt
      181 cggacccgct ccccagctcc gcgcgtctcc gcccgctgcc tcccctcccc ctctgccgtc
      241 cgcggcgcgg gtcccgcggc ctgggcatcc aggatcgcgg gcccccgcgc ggggcatcct
      301 ccgcccgagg cgccggcccg cgccaccctt cgccctgtgc ccgccggtga cacagagaga
      361 gccccaggaa acccgtgaat gttgaagaaa attcatcttt gaaattttga tattcgagga
      421 aatctgcatt catactcatc ttttattaat ctgaggggat ttttgtttta tttaaaactt
      481 cttgatattt acaatgaatg gacacagtga tgaagaaagt gttagaaatg gcagcggaga
      541 atcaagtcag tcaggtgatg attgtgggtc agcatcaggc tctggatctg gctcgagttc
      601 tggcagcagc agtgacggaa gcagcagcca atccgggagc agcgactctg attctggctc
      661 tgactcagga agtcaatcag agtctgaatc agacacatcc cgagagaaca aggttcaagc
      721 aaaaccacca aaagtcgacg gagccgagtt ttggaaatct agccccagta ttctggctgt
      781 ccagagatct gcaatgctta ggaagcagcc acagcaggcc cagcagcagc gcccagcttc
      841 atctaatagt ggatccgaag aagactcgtc cagcagtgaa gactccgacg actcgtccag
      901 cggtgccaag aggaagaagc acaatgatga agactggcag atgtctgggt ccggatctcc
      961 atctcagtct ggttcagact cagaatctga agaagagcga gataaaagca gctgcgacgg
     1021 gacagagtcc gactacgagc cgaaaaacaa agtcagaagc cgaaagcctc agaatagatc
     1081 taagtcaaaa aatgggaaaa aaattcttgg acaaaaaaag agacagattg attcatctga
     1141 ggatgaagat gatgaagatt atgataatga taaacgaagc tctcgccgcc aagccaccgt
     1201 caatgtgagc tacaaggagg atgaagaaat gaaaaccgac tccgatgacc tgctggaggt
     1261 ctgcggcgag gacgtccctc agcctgagga cgaggagttt gagacaatag agagggttat
     1321 ggattgcaga gtggggcgga aaggagctac tggtgctact acaaccattt atgctgtcga
     1381 agcagatggt gacccaaatg caggatttga aagaaacaaa gagccaggag acatacagta
     1441 tttaattaag tggaaaggat ggtctcacat ccacaacaca tgggagacag aagagaccct
     1501 gaagcagcag aacgttagag ggatgaaaaa attggataat tataagaaaa aagatcaaga
     1561 gacgaaacga tggctgaaaa atgcttctcc agaagatgtg gaatattata attgccagca
     1621 agagcttaca gatgatctac acaaacagta tcagatagtg gagcgcataa ttgctcattc
     1681 caatcaaaaa tcagcagctg gtcttcctga ttattattgc aaatggcagg ggcttccata
     1741 ctcagagtgc agctgggagg atggagctct catttccaaa aagtttcaga catgcatcga
     1801 tgaatatttt agcaggaatc agtcaaaaac gacacctttt aaagattgca aagtattgaa
     1861 acaaagacca agatttgtag ctctgaagaa acaaccatcc tatattggag gacatgaggg
     1921 cttagaactg agagactatc agctgaatgg tttaaactgg ctcgctcact cttggtgcaa
     1981 aggaaatagt tgcatacttg ctgatgaaat gggccttggg aaaacaatac agacgatctc
     2041 atttttgaac tatttgttcc atgaacatca gttatatggg ccgtttctac tagttgtccc
     2101 gctctccact ctgacttcct ggcagaggga gatacagacg tgggcgtctc agatgaatgc
     2161 tgtggtttac ttaggcgaca ttaacagcag aaacatgata agaactcatg aatggatgca
     2221 tccccagacc aaacggttaa aatttaatat acttttaaca acgtatgaaa ttttattgaa
     2281 ggataaggca ttccttggtg gtctgaattg ggcattcata ggtgttgatg aagcgcatcg
     2341 attaaagaat gatgattccc ttctgtacaa aactttaatc gactttaaat ctaaccatcg
     2401 ccttctgatc actggaaccc ctctacagaa ctccctgaag gagctctggt cactgctgca
     2461 cttcattatg ccggagaagt tttcttcatg ggaagatttt gaagaagaac atggcaaagg
     2521 cagagaatat ggttatgcaa gcctccacaa ggagcttgag ccatttctgt tacgcagagt
     2581 taagaaagat gtggaaaaat ctcttcctgc caaggtggag cagattttaa gaatggagat
     2641 gagtgcttta cagaagcaat attacaagtg gattttaact aggaattata aagccctcag
     2701 caaaggttcc aagggcagta cctcaggctt tttgaacatt atgatggagc taaagaaatg
     2761 ttgtaaccat tgctacctca ttaaaccacc agataataat gaattctata ataaacagga
     2821 ggccttacaa cacttaatcc gtagtagcgg aaaactcatc cttctcgaca agctgttgat
     2881 tcgcctaaga gaaagaggca accgagtgct cattttctct cagatggtgc ggatgttaga
     2941 catactcgca gagtatttga agtaccgcca gttccccttt caaagattag atggatcgat
     3001 aaaaggggag ctgaggaagc aggctttgga tcactttaat gccgagggct cagaggattt
     3061 ctgctttttg ctttctaccc gagctggggg tttaggcatt aacctagcct ctgctgacac
     3121 cgttgttata ttcgattctg attggaatcc acaaaatgat cttcaggctc aggcaagagc
     3181 tcaccgaatt ggacagaaga aacaggtgaa tatatatcgc ttggttacaa agggatcagt
     3241 tgaagaagat attcttgaaa gggccaaaaa gaaaatggtt ttggatcatc ttgttattca
     3301 aagaatggat accactggga agacagtgct gcacacaggc tcggctccgt caagttccac
     3361 ccccttcaat aaagaggagt tatccgccat tttaaaattc ggtgctgagg agctctttaa
     3421 ggagcctgaa ggagaggagc aggagccaca ggaaatggat atcgatgaaa tcctgaagag
     3481 agccgagact cacgagaacg agccaggccc actgagtgtg ggggatgagc tgctttctca
     3541 gtttaaggtt gccaattttt caaatatgga tgaagatgac attgaattgg aacctgaaag
     3601 aaattcaaag aactgggagg agatcattcc agaagagcaa agacggcgac tagaagagga
     3661 ggagagacaa aaggaactgg aggaaattta tatgctcccg agaatgagaa actgtgcaaa
     3721 gcagataagt ttcaatggaa gtgaagggag gcggagtaga agcaggagat attctggatc
     3781 tgatagtgat tcaatctcgg aaaggaaacg gccgaagaaa cgtgggcgac cccgcactat
     3841 ccctcgggag aatattaaag gatttagtga tgcggagatt cggcggttta tcaagagcta
     3901 taagaaattt ggtggccccc tggagaggtt agatgcaatt gctcgagatg ctgaattggt
     3961 tgataagtca gaaacagatc tcagaagact aggagaactg gtgcataatg gttgtgttaa
     4021 agctttaaaa gacagttctt caggaacaga gcgagcaggt ggcagacttg gaaaagtgaa
     4081 ggggccaaca ttccgcatct ctggagtcca agtgaatgcc aagctggtca ttgcccatga
     4141 ggatgagctg atccctctgc ataagtccat cccttcggac ccggaggaga ggaagcagta
     4201 tacaatcccc tgccatacaa aggctgcgca ctttgatata gactggggca aagaagatga
     4261 ttctaatttg ttaattggta tctatgagta tggctatgga agctgggaaa tgattaaaat
     4321 ggatccagac ctcagtttaa cacacaagat tcttccagat gatcctgata aaaaaccaca
     4381 agcaaaacag ttacagaccc gtgcagacta cctcatcaaa ctacttagca gagatcttgc
     4441 aaaaagagag gctcagagac tttgtggtgc gggaggttca aagaggagaa aaacgagagc
     4501 taaaaagagt aaggcaatga agtccatcaa agtgaaagag gaaataaaga gtgactcgtc
     4561 gcccctgcct tcagagaagt ctgacgagga tgacgataaa ctgaatgact ccaagcctga
     4621 aagtaaagac cgatccaaaa agtctgtagt gtccgatgct cccgttcaca tcactgcgag
     4681 tggagagccc gttcccatag ctgaagagtc tgaagagctg gatcagaaga cattcagtat
     4741 ttgtaaagaa agaatgagac cggtgaaagc agctttgaaa caacttgaca ggcctgagaa
     4801 aggcctttca gaaagagagc agctggaaca cactagacag tgcttaatca agatcggaga
     4861 ccatatcact gaatgcttga aggaatattc caatcctgaa caaattaagc agtggaggaa
     4921 aaacctgtgg atttttgtat ctaagtttac tgagtttgat gcaaggaaat tacataaatt
     4981 atataagcat gctattaaaa aacgacaaga atctcagcaa aacagtgacc agaatagcaa
     5041 tgttgctacc actcatgtga ttaggaatcc agatatggaa aggttaaaag agaatacaaa
     5101 tcatgatgac agtagcaggg acagctattc ttctgacaga cacttatctc agtaccatga
     5161 tcatcacaag gaccgccatc agggagattc ttataaaaag agtgactctc ggaagagacc
     5221 ctactcctca tttagcaatg gcaaagacca ccgcgagtgg gatcactaca ggcaagacag
     5281 caggtactat agtgaccgag agaaacacag aaaactggat gaccacagga gtcgagagca
     5341 caggccaagt ttggaaggag gcttaaagga caggtgtcac tctgaccacc gatctcactc
     5401 ggaccatcga atgcactcag accatcgctc aagctccgag cacacacatc ataaatcctc
     5461 cagggattat cggtatctct cagattggca gttggaccac cgagctgcca gcagtggccc
     5521 taggtcacct ttagatcaga ggtctccata tggctccagg tccccatttg aacattcagc
     5581 tgaacacaga agtacgcctg aacacacctg gagtagtcgg aagacatgac agaagctcat
     5641 gagtttgtct tccgggactt tgttttagcc atagatcata aaccaacaca gtaattgcct
     5701 tacatgactt gaaagattca aacagctctt ctgtcagtag cagtattgtt acttctctcc
     5761 aggacgcaag gtctattatc ccaacagaag agaaaatatt tttatattta aggattatgc
     5821 tgcactgtac tgcgatactg cagtaccttt tttttctttt tttaaagaaa tggaaaatgt
     5881 ttactatgcc agggacctca gcactgccct cccgtgtagg ctgtataaaa ctgtttttat
     5941 gtcagtgatt ttagactgac tccatttaaa ttatgtttgt atatgaactt tactctgacc
     6001 tgtgatcatg tttcaggaag gaataaaaga gaggtctttt cttaataaag aaaaatcact
     6061 caaggacttt gttcactttc caaagctact tgtttacatt gtacactgcg accaccttgc
     6121 cgctcccatc acaagcttga atatttaaat cctgtactta agtttgtaat atagccggga
     6181 atttcctgtc tgtgattatt attatgcctt tttacagaag aagatggctg taaattattg
     6241 taaatggatt aaatgagctg ccctgccctg cccttctcag gcttcttttg actgttcctt
     6301 tccctaccaa ctcaggcctt cttattaaaa aaaaaaatca gtgtaataac actttttaat
     6361 gatttgtctt gatggaatca ttgtttagaa tgtaaaaatg gggaaagggg ccacttattt
     6421 cttttagtcc tttttatatt gagtattttt attagataca tgttttgccc ctccttttta
     6481 aagtcaatat tgtgtttgta gttttacaga agcagtggcg agggttacat gtgagacaaa
     6541 ctcggtgctc tgggagagtc cccagtgcat tgggttgaaa gggtggtagg tgtatgaaca
     6601 cttaaaatcc aaacggccaa acgttcttgt aaatgcattg cttttccctt tcatgtgggc
     6661 aataatgtca aacgtgctat gcagccaggt taacatttga ggtaaacttg attggcttta
     6721 atataaaaac tgttacagta cacactgatt gtatataaaa accttatata tgacaaatta
     6781 aattttaaga aaaaggatat gtgggctcct gtagttttct gctgcattct tgtttccacg
     6841 agcatttaat ctttgcttta agtaacagct gccagaaaga aaggtatttt ggtcagcaac
     6901 tgagaactgt tgatatgtaa tcctaaaact gcctacgtct gtatagatga atcagtcttc
     6961 tatgaagtaa aacagattct agcagtctcg gcttcctgta gacattcctc taggatgtct
     7021 tactcgtcac ctcgtttctc cttatattca gtgggaattt tggatgtatg ttgtgtaacc
     7081 attaataacc tttactcctg gtcatgtctc catggagtag ctgtggggct acctaaagtt
     7141 agtctgtggc tttgtatttt catatctttt tttttacatg gataaatata aaatttatgc
     7201 tgtgtataca aacaaacttt ttttttttaa aaggaatttc atctttggcc taaagttatc
     7261 ctgaagcaaa caatgtcttt ttatttttga tatgcaaggt aatgtgttgg ggaataactc
     7321 aacttttaaa cgtctagtta taattaaaga taaaaacgat gatacgattc agtgctggca
     7381 cacgactttt aaaatttttc attttcctcc acgtttaatg taaatgatca ttttattccc
     7441 aaagaacact tcccataaat cctaatatta acacagcaaa tagctcaggg ttggcgctac
     7501 atgcctttgt ggctaggtca tttgcttaaa agcctgttgt aaagaatttg tagaaaaata
     7561 atgcaatttt gaagaatggg cttttttttt ttttttaaca atttgccatt taattgagtt
     7621 aactagctga gttgaatgaa gcattcttaa acctgtatgt aacatttgag tgttaattat
     7681 atgtaaaaag taacaactac atagtaaagg agcaagccat acagttacta agatgcacgg
     7741 acagcgtcag tccttaggga taacagggac attacgctta tttctgtctt tacatgctca
     7801 ttctgcttct ctatctatct atttgtttaa tttttttaaa gatgagagat tatgcatagc
     7861 attgtaccaa ctaaccttcc attttaataa taaacaataa aagattctta ttaaaagc
//
