LOCUS       NM_025351               1126 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus coiled-coil-helix-coiled-coil-helix domain containing
            6 (Chchd6), transcript variant 1, mRNA.
ACCESSION   NM_025351
VERSION     NM_025351.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1126)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1126)
  AUTHORS   Shang,Y., Sun,X., Chen,X., Wang,Q., Wang,E.J., Miller,E., Xu,R.,
            Pieper,A.A. and Qi,X.
  TITLE     A CHCHD6-APP axis connects amyloid and mitochondrial pathology in
            Alzheimer's disease
  JOURNAL   Acta Neuropathol 144 (5), 911-938 (2022)
   PUBMED   36104602
  REMARK    GeneRIF: A CHCHD6-APP axis connects amyloid and mitochondrial
            pathology in Alzheimer's disease.
REFERENCE   3  (bases 1 to 1126)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY278681.1 and AK015314.1.
            
            On Nov 13, 2009 this sequence version replaced NM_025351.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK015314.1, AK002980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               BY278681.1         2-240
            240-1126            AK015314.1         203-1089
FEATURES             Location/Qualifiers
     source          1..1126
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.91 cM"
     gene            1..1126
                     /gene="Chchd6"
                     /gene_synonym="0710001P09Rik; 1700021B03Rik; Micos25"
                     /note="coiled-coil-helix-coiled-coil-helix domain
                     containing 6"
                     /db_xref="GeneID:66098"
                     /db_xref="MGI:MGI:1913348"
     exon            1..194
                     /gene="Chchd6"
                     /gene_synonym="0710001P09Rik; 1700021B03Rik; Micos25"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..929
                     /gene="Chchd6"
                     /gene_synonym="0710001P09Rik; 1700021B03Rik; Micos25"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil-helix-coiled-coil-helix domain-containing
                     protein 6, mitochondrial; MICOS complex subunit Mic25"
                     /codon_start=1
                     /product="MICOS complex subunit Mic25 isoform 1"
                     /protein_id="NP_079627.3"
                     /db_xref="CCDS:CCDS39557.1"
                     /db_xref="GeneID:66098"
                     /db_xref="MGI:MGI:1913348"
                     /translation="MGSAESAEARRVSFEMDEEERVRVLQGIRLSESVVNRMKDCSQP
                     SAGEQLVPGFGPSSSAPVPTVPLPAISVPTVPAPTTPVPTAPSSSVRGLPGGTCKGPL
                     TDVKVPSAESGGGLQSSAVKEDLKKFQQEQLAVQDEMVRVAKKEKEAAEKHLKASLPK
                     KKASLTHEQQQSARLARELEDREAELSRRDTFYKEQQGRIQEKNAELYKLSSQQFHEA
                     ASKAESTIKPRRVEPVCSGLQAQILRCYRDHLHEVLLCSDLVKAYQHCVSTARKG"
     exon            195..417
                     /gene="Chchd6"
                     /gene_synonym="0710001P09Rik; 1700021B03Rik; Micos25"
                     /inference="alignment:Splign:2.1.0"
     exon            418..487
                     /gene="Chchd6"
                     /gene_synonym="0710001P09Rik; 1700021B03Rik; Micos25"
                     /inference="alignment:Splign:2.1.0"
     exon            488..632
                     /gene="Chchd6"
                     /gene_synonym="0710001P09Rik; 1700021B03Rik; Micos25"
                     /inference="alignment:Splign:2.1.0"
     exon            633..716
                     /gene="Chchd6"
                     /gene_synonym="0710001P09Rik; 1700021B03Rik; Micos25"
                     /inference="alignment:Splign:2.1.0"
     exon            717..787
                     /gene="Chchd6"
                     /gene_synonym="0710001P09Rik; 1700021B03Rik; Micos25"
                     /inference="alignment:Splign:2.1.0"
     exon            788..923
                     /gene="Chchd6"
                     /gene_synonym="0710001P09Rik; 1700021B03Rik; Micos25"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1126
                     /gene="Chchd6"
                     /gene_synonym="0710001P09Rik; 1700021B03Rik; Micos25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1085..1090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chchd6"
                     /gene_synonym="0710001P09Rik; 1700021B03Rik; Micos25"
                     /note="hexamer: AATAAA"
     polyA_site      1117
                     /gene="Chchd6"
                     /gene_synonym="0710001P09Rik; 1700021B03Rik; Micos25"
                     /note="major polyA site"
ORIGIN      
        1 gtgttgctgg cctgtgtccc gagtgacgag cgtaggccgc tgagcagcgt cgtcctggtt
       61 gctgtggagc cggctcgcgt ggcctcacgc cctgcccgcc tcctgtcatg ggcagcgccg
      121 agagcgccga ggcccgaagg gtgtccttcg agatggatga ggaggagcgg gtccgggtgc
      181 tgcagggcat ccggctgtct gaaagtgttg tgaaccgcat gaaggattgc agccagcctt
      241 cagcagggga acagctggtt cctggttttg gtccttcgtc ttctgctcct gtgcccactg
      301 tccctctacc agccatctct gtgcccactg tccctgcacc taccactcct gtgcctactg
      361 ctccttcatc ctctgtacgt ggcctgccag gaggcacctg taaaggccct ctgacagacg
      421 ttaaagtgcc cagtgcagag agtggtggtg gtctgcagtc ctcagcagtg aaggaggatc
      481 ttaagaagtt ccaacaggag cagttggcag tccaggatga gatggtcagg gtggcaaaaa
      541 aggaaaaaga ggcagctgag aagcacttga aggcatccct gcccaagaag aaggccagcc
      601 tcacccatga gcaacagcag tcagctcgac tagccaggga actggaggac agagaggccg
      661 agctcagccg ccgtgacacc ttctacaagg agcagcaggg gcgcatccag gaaaagaatg
      721 ctgagctgta taaactgtct tcccaacaat tccatgaggc ggcttcaaaa gcagagagca
      781 caataaagcc ccgcagagtg gagcctgtgt gctctggcct acaagcccag atcctccgct
      841 gttaccggga ccatctgcat gaagtgcttc tgtgctcgga cctggtcaag gcataccagc
      901 actgtgtgag cactgcccgc aagggctgag gagcagcatc cttcctggag ccttgaagaa
      961 gggaccgatc ataggaccac agaccatggc ccccaggccc tgcagtctct aactgagcac
     1021 ccatatgcct ctgagtgtgg ggctgccatg ctcgagaaac agtatgtgct actgattgaa
     1081 aacaaataaa gcagatgtct ttgtttgcag tcattcactc attggc
//
