LOCUS       NM_133928               1245 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus coiled-coil-helix-coiled-coil-helix domain containing
            4 (Chchd4), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_133928
VERSION     NM_133928.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1245)
  AUTHORS   Ma,J., Wang,P.Y., Zhuang,J., Son,A.Y., Karius,A.K., Syed,A.M.,
            Nishi,M., Wu,Z., Mori,M.P., Kim,Y.C. and Hwang,P.M.
  TITLE     CHCHD4-TRIAP1 regulation of innate immune signaling mediates
            skeletal muscle adaptation to exercise
  JOURNAL   Cell Rep 43 (1), 113626 (2024)
   PUBMED   38157298
  REMARK    GeneRIF: CHCHD4-TRIAP1 regulation of innate immune signaling
            mediates skeletal muscle adaptation to exercise.
REFERENCE   2  (bases 1 to 1245)
  AUTHORS   Cocomazzi,P., Tarantino,D., Mastrangelo,E. and Aliverti,A.
  TITLE     Ligand Binding in Allosteric Flavoproteins: Part 2. Quantitative
            Analysis of the Redox-Dependent Interaction of the
            Apoptosis-Inducing Factor (AIF) with Its Protein Partner
  JOURNAL   Methods Mol Biol 2280, 189-198 (2021)
   PUBMED   33751436
  REMARK    GeneRIF: Ligand Binding in Allosteric Flavoproteins: Part 2.
            Quantitative Analysis of the Redox-Dependent Interaction of the
            Apoptosis-Inducing Factor (AIF) with Its Protein Partner.
REFERENCE   3  (bases 1 to 1245)
  AUTHORS   Erdogan,A.J., Ali,M., Habich,M., Salscheider,S.L., Schu,L.,
            Petrungaro,C., Thomas,L.W., Ashcroft,M., Leichert,L.I., Roma,L.P.
            and Riemer,J.
  TITLE     The mitochondrial oxidoreductase CHCHD4 is present in a
            semi-oxidized state in vivo
  JOURNAL   Redox Biol 17, 200-206 (2018)
   PUBMED   29704824
  REMARK    GeneRIF: To test whether differences in the ratio between CHCHD4
            and ALR might explain tissue-specific differences in the CHCHD4
            redox state, we determined the molar ratio of both proteins in
            different mouse tissues. Surprisingly, ALR is superstoichiometric
            over CHCHD4 in most tissues.
REFERENCE   4  (bases 1 to 1245)
  AUTHORS   Sun,Y., Li,T., Xie,C., Xu,Y., Zhou,K., Rodriguez,J., Han,W.,
            Wang,X., Kroemer,G., Modjtahedi,N., Blomgren,K. and Zhu,C.
  TITLE     Haploinsufficiency in the mitochondrial protein CHCHD4 reduces
            brain injury in a mouse model of neonatal hypoxia-ischemia
  JOURNAL   Cell Death Dis 8 (5), e2781 (2017)
   PUBMED   28492551
  REMARK    GeneRIF: These results suggest that CHCHD4 haploinsufficiency
            afforded persistent neuroprotection related to reduced release of
            mitochondrial intermembrane space proteins.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1245)
  AUTHORS   Zhuang,J., Kamp,W.M., Li,J., Liu,C., Kang,J.G., Wang,P.Y. and
            Hwang,P.M.
  TITLE     Forkhead Box O3A (FOXO3) and the Mitochondrial Disulfide Relay
            Carrier (CHCHD4) Regulate p53 Protein Nuclear Activity in Response
            to Exercise
  JOURNAL   J Biol Chem 291 (48), 24819-24827 (2016)
   PUBMED   27687729
  REMARK    GeneRIF: Mechanistically, exercise-induced nuclear transcription
            factor FOXO3 binds to the CHCHD4 promoter and represses its
            expression, preventing the translocation of p53 to the mitochondria
            and thereby increasing p53 nuclear localization.
REFERENCE   6  (bases 1 to 1245)
  AUTHORS   Zhuang,J., Wang,P.Y., Huang,X., Chen,X., Kang,J.G. and Hwang,P.M.
  TITLE     Mitochondrial disulfide relay mediates translocation of p53 and
            partitions its subcellular activity
  JOURNAL   Proc Natl Acad Sci U S A 110 (43), 17356-17361 (2013)
   PUBMED   24101517
REFERENCE   7  (bases 1 to 1245)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   8  (bases 1 to 1245)
  AUTHORS   Vadasz,C., Saito,M., Gyetvai,B.M., Oros,M., Szakall,I.,
            Kovacs,K.M., Prasad,V.V., Morahan,G. and Toth,R.
  TITLE     Mapping of QTLs for oral alcohol self-administration in B6.C and
            B6.I quasi-congenic RQI strains
  JOURNAL   Neurochem Res 32 (7), 1099-1112 (2007)
   PUBMED   17273929
REFERENCE   9  (bases 1 to 1245)
  AUTHORS   Hofmann,S., Rothbauer,U., Muhlenbein,N., Baiker,K., Hell,K. and
            Bauer,M.F.
  TITLE     Functional and mutational characterization of human MIA40 acting
            during import into the mitochondrial intermembrane space
  JOURNAL   J Mol Biol 353 (3), 517-528 (2005)
   PUBMED   16185709
REFERENCE   10 (bases 1 to 1245)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC161456.3.
            
            On Nov 17, 2006 this sequence version replaced NM_133928.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019405.1, BI158389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC161456.3         62589-62696
            109-207             AC161456.3         68231-68329
            208-1245            AC161456.3         70699-71736
FEATURES             Location/Qualifiers
     source          1..1245
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 40.53 cM"
     gene            1..1245
                     /gene="Chchd4"
                     /gene_synonym="2410012P20Rik; 2810014D17Rik"
                     /note="coiled-coil-helix-coiled-coil-helix domain
                     containing 4"
                     /db_xref="GeneID:72170"
                     /db_xref="MGI:MGI:1919420"
     exon            1..108
                     /gene="Chchd4"
                     /gene_synonym="2410012P20Rik; 2810014D17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..506
                     /gene="Chchd4"
                     /gene_synonym="2410012P20Rik; 2810014D17Rik"
                     /note="coiled-coil-helix-coiled-coil-helix
                     domain-containing protein 4"
                     /codon_start=1
                     /product="mitochondrial intermembrane space import and
                     assembly protein 40"
                     /protein_id="NP_598689.1"
                     /db_xref="CCDS:CCDS20367.1"
                     /db_xref="GeneID:72170"
                     /db_xref="MGI:MGI:1919420"
                     /translation="MSYCRQEGKDRIIFVTKEDHETPSSAELVADDPNDPYEEHGLIL
                     PNGDINWNCPCLGGMASGPCGEQFKSAFSCFHYSTEDIKGSDCIDQFRAMQECMQKYP
                     DLYPQDEEEEEEAKPVEPVEETADTKVSAAKEQGTSS"
     exon            109..207
                     /gene="Chchd4"
                     /gene_synonym="2410012P20Rik; 2810014D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            208..1245
                     /gene="Chchd4"
                     /gene_synonym="2410012P20Rik; 2810014D17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1220..1225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chchd4"
                     /gene_synonym="2410012P20Rik; 2810014D17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1245
                     /gene="Chchd4"
                     /gene_synonym="2410012P20Rik; 2810014D17Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcgagggag gtcacggcga gaaggtgtat ccgctccagc cgcgcccgct gcctctgcga
       61 gctgcagagg actgtcggga acaaccatgt cctactgccg gcaggaaggg aaggatcgga
      121 tcatatttgt gaccaaagaa gaccatgaaa ctcctagcag tgccgagctg gtagctgatg
      181 accccaatga tccctatgag gagcacgggt tgatactgcc taacggagat attaactgga
      241 attgtccatg tcttggggga atggccagcg gcccctgtgg ggagcagttc aagtctgcct
      301 tctcctgctt ccactacagc acagaggata tcaaggggtc agactgtata gaccagttcc
      361 gggccatgca agagtgcatg cagaagtacc cggacctcta tccccaagac gaggaggagg
      421 aagaggaggc aaagccagtg gagccggtgg aggagacagc tgacactaag gtctctgcag
      481 ccaaagagca agggacaagc tcttgaaggc cacatggctg ccactcacca tgggactttc
      541 tgtacaatgc cttttggtca cttttgtgaa agttctttcc ctctgtgcac tgtaatatac
      601 aaaataactt attttaatga tcaggggtct tggccgtata cactgaagaa aagggcgtgt
      661 gtgcacctgt gtcctgcata aacctgtcct taaacattag tccactcctg gatgtactac
      721 tctgtgattg ccctggattt tgccactttg aaataatgtg ttgagacttc tcagcaacca
      781 aaagttgtta ctcaggaaag tttatcgtga gaaagctgat ctattctgat ccattttggt
      841 atcccttttg gtagatttta cacctctttt ggaaattaag taaatagatg ccaaaactcc
      901 tttaagagtg ggtccattcc tactggaaga ggctggtggt caggtgcttg ctggagtaca
      961 tggggctgct gcctcgttcc cgacagctaa ttgtctgttt gctgtccagg ctccagtgcc
     1021 tacagctgca gggtggcatt ggatcctgtg actcccggtc cttcctaagt gaaaggatgg
     1081 gctgggtttg cagtttattg ttttgctgtt ctaagagccc tggtttgggg cccatgttca
     1141 ctcagttgtg atattgaggt ggggacctag ctgcttccag agcagaagcc aacagaggaa
     1201 tgtctgaatg aagtactcaa ttaaaaagaa accatttcta tctga
//
