LOCUS       NM_025336               1560 bp    mRNA    linear   ROD 09-OCT-2024
DEFINITION  Mus musculus coiled-coil-helix-coiled-coil-helix domain containing
            3 (Chchd3), transcript variant 1, mRNA.
ACCESSION   NM_025336 XM_910658 XM_921716
VERSION     NM_025336.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1560)
  AUTHORS   Dong,J., Chen,L., Ye,F., Tang,J., Liu,B., Lin,J., Zhou,P.H., Lu,B.,
            Wu,M., Lu,J.H., He,J.J., Engelender,S., Meng,Q., Song,Z. and He,H.
  TITLE     Mic19 depletion impairs endoplasmic reticulum-mitochondrial
            contacts and mitochondrial lipid metabolism and triggers liver
            disease
  JOURNAL   Nat Commun 15 (1), 168 (2024)
   PUBMED   38168065
  REMARK    GeneRIF: Mic19 depletion impairs endoplasmic
            reticulum-mitochondrial contacts and mitochondrial lipid metabolism
            and triggers liver disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1560)
  AUTHORS   Sohn,J.H., Mutlu,B., Latorre-Muro,P., Liang,J., Bennett,C.F.,
            Sharabi,K., Kantorovich,N., Jedrychowski,M., Gygi,S.P., Banks,A.S.
            and Puigserver,P.
  TITLE     Liver mitochondrial cristae organizing protein MIC19 promotes
            energy expenditure and pedestrian locomotion by altering nucleotide
            metabolism
  JOURNAL   Cell Metab 35 (8), 1356-1372 (2023)
   PUBMED   37473754
  REMARK    GeneRIF: Liver mitochondrial cristae organizing protein MIC19
            promotes energy expenditure and pedestrian locomotion by altering
            nucleotide metabolism.
REFERENCE   3  (bases 1 to 1560)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1560)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   5  (bases 1 to 1560)
  AUTHORS   Hadsell,D.L., Hadsell,L.A., Olea,W., Rijnkels,M., Creighton,C.J.,
            Smyth,I., Short,K.M., Cox,L.L. and Cox,T.C.
  TITLE     In-silico QTL mapping of postpubertal mammary ductal development in
            the mouse uncovers potential human breast cancer risk loci
  JOURNAL   Mamm Genome 26 (1-2), 57-79 (2015)
   PUBMED   25552398
REFERENCE   6  (bases 1 to 1560)
  AUTHORS   Darshi,M., Mendiola,V.L., Mackey,M.R., Murphy,A.N., Koller,A.,
            Perkins,G.A., Ellisman,M.H. and Taylor,S.S.
  TITLE     ChChd3, an inner mitochondrial membrane protein, is essential for
            maintaining crista integrity and mitochondrial function
  JOURNAL   J Biol Chem 286 (4), 2918-2932 (2011)
   PUBMED   21081504
  REMARK    GeneRIF: ChChd3 is a scaffolding protein that stabilizes protein
            complexes involved in maintaining crista architecture and protein
            import and is thus essential for maintaining mitochondrial
            structure and function.
REFERENCE   7  (bases 1 to 1560)
  AUTHORS   Schauble,S., King,C.C., Darshi,M., Koller,A., Shah,K. and
            Taylor,S.S.
  TITLE     Identification of ChChd3 as a novel substrate of the cAMP-dependent
            protein kinase (PKA) using an analog-sensitive catalytic subunit
  JOURNAL   J Biol Chem 282 (20), 14952-14959 (2007)
   PUBMED   17242405
REFERENCE   8  (bases 1 to 1560)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 1560)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 1560)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156288.5 and AC152943.1.
            
            On Sep 23, 2017 this sequence version replaced NM_025336.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032987.1, AK003519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               AC156288.5         165744-166004       c
            262-349             AC156288.5         155081-155168       c
            350-431             AC156288.5         114227-114308       c
            432-549             AC156288.5         73945-74062         c
            550-633             AC152943.1         51726-51809
            634-704             AC152943.1         91886-91956
            705-840             AC152943.1         140076-140211
            841-1560            AC152943.1         151175-151894
FEATURES             Location/Qualifiers
     source          1..1560
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 13.97 cM"
     gene            1..1560
                     /gene="Chchd3"
                     /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19"
                     /note="coiled-coil-helix-coiled-coil-helix domain
                     containing 3"
                     /db_xref="GeneID:66075"
                     /db_xref="MGI:MGI:1913325"
     exon            1..261
                     /gene="Chchd3"
                     /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..864
                     /gene="Chchd3"
                     /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19"
                     /note="coiled-coil-helix-coiled-coil-helix
                     domain-containing protein 3, mitochondrial"
                     /codon_start=1
                     /product="MICOS complex subunit Mic19"
                     /protein_id="NP_079612.1"
                     /db_xref="CCDS:CCDS19986.1"
                     /db_xref="GeneID:66075"
                     /db_xref="MGI:MGI:1913325"
                     /translation="MGGTASTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGS
                     KSQRYSSVYGASVSDEDLKRRVAEELALEQAKKESEHQRRLKQARDLERERAAANEQL
                     TRAVLRERISSEEERMKAKHLARQLEEKDRVMRKQDAFYKEQLARLEERSSEFYKVTT
                     EEYQKAAEEVEAKFKRYEYHPVCADLQTKILQCYRQNTQQTLSCSALASQYMHCVNHA
                     KQSMLEKGG"
     exon            262..349
                     /gene="Chchd3"
                     /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19"
                     /inference="alignment:Splign:2.1.0"
     exon            350..431
                     /gene="Chchd3"
                     /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19"
                     /inference="alignment:Splign:2.1.0"
     exon            432..549
                     /gene="Chchd3"
                     /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19"
                     /inference="alignment:Splign:2.1.0"
     exon            550..633
                     /gene="Chchd3"
                     /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19"
                     /inference="alignment:Splign:2.1.0"
     exon            634..704
                     /gene="Chchd3"
                     /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19"
                     /inference="alignment:Splign:2.1.0"
     exon            705..840
                     /gene="Chchd3"
                     /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1560
                     /gene="Chchd3"
                     /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1100..1105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chchd3"
                     /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19"
                     /note="hexamer: AATAAA"
     polyA_site      1126
                     /gene="Chchd3"
                     /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19"
                     /note="major polyA site"
     regulatory      1521..1526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chchd3"
                     /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19"
                     /note="hexamer: AATAAA"
     polyA_site      1542
                     /gene="Chchd3"
                     /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19"
                     /note="major polyA site"
ORIGIN      
        1 gtgaccggag gaggcgggct tttgggaccg gcgccttctc cttgcttctt ttttggggtc
       61 gtggccttgc tcctgccctg caagagaagc gtccagggct ttcacgcgca agtgtgcgcg
      121 tgggtcctga cgtgctcgta ggtccacgct ccagactctg cggggacaga agcaggagcc
      181 atgggcggga ccgctagcac ccgccgggtc accttcgagg cggacgagaa cgagaacatc
      241 accgtggtga agggcatccg gctttcagaa aatgtgatcg accggatgaa ggagtcctct
      301 ccatctggct ctaagtctca gcgatattcc agcgtttatg gtgcttcagt ttctgatgaa
      361 gatttgaaaa gaagagtagc tgaggagctg gcattggagc aagccaaaaa ggagtcagaa
      421 caccagagac gccttaagca agcaagggac ctagaaagag aaagggctgc agccaatgag
      481 cagctgacca gagctgtcct tcgggaaaga atatccagtg aagaggagcg catgaaggcg
      541 aagcatctgg ctcggcagct ggaagagaaa gaccgagtga tgcggaagca ggatgcattc
      601 tacaaagagc agctggccag actggaggag aggagctcag agttctacaa agtcaccacc
      661 gaggagtatc agaaagctgc tgaagaggtg gaagccaagt tcaagcggta tgaatatcat
      721 ccagtctgtg cagatctgca gaccaaaatc ctccagtgtt accgtcagaa cacccagcag
      781 actctcagct gctctgctct ggctagccaa tacatgcact gtgtcaacca tgccaaacag
      841 agcatgctgg agaagggagg ctaaagttac cctgagaaca tgcaagctcc ttcaacgtta
      901 attccagagg tggaacattt ttcttttcct agtatgaaaa tgacccattt aaagagaaga
      961 ccactaaaga cagacaggca ctggaaaatg gactcaactg aatcataacg tgttttgatc
     1021 aacagtttaa aaagccatgt tctagatcag cgatcagtca tcaaagaaca ctgttaagtg
     1081 ttaatgaaac cacaaaatga ataaaagagg aaggcagtcc accccacctt tttgtactct
     1141 ctttccagct tccactgata taaaacgttc tcgtcactcc aggctccatc cagcatttag
     1201 tgacttccac tctgacaaag ctgggaggag ggacattaaa ctatttcaga tggagagaca
     1261 gcaagaaagc actgggctgg ggcaacagtg tagacttgcc aagactgtgg agcctgggtg
     1321 tgctcttctc attatataga agctaattca ttgtaactta tgatgatctt tcaaggaaga
     1381 cagaaaggag agaaaatgta cctcttttac tggaataatg tttatgatta caggtaaaat
     1441 aaggcatttt tgtcaatata aaggcaacct tggcttgttc aaccaagtag tgaatactga
     1501 caacttcact cactatcaat aataaatcta ttttctgact aagactggca ttttctgact
//
