LOCUS       NP_079612                227 aa            linear   ROD 09-OCT-2024
DEFINITION  MICOS complex subunit Mic19 [Mus musculus].
ACCESSION   NP_079612 XP_915751 XP_926809
VERSION     NP_079612.1
DBSOURCE    REFSEQ: accession NM_025336.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 227)
  AUTHORS   Dong,J., Chen,L., Ye,F., Tang,J., Liu,B., Lin,J., Zhou,P.H., Lu,B.,
            Wu,M., Lu,J.H., He,J.J., Engelender,S., Meng,Q., Song,Z. and He,H.
  TITLE     Mic19 depletion impairs endoplasmic reticulum-mitochondrial
            contacts and mitochondrial lipid metabolism and triggers liver
            disease
  JOURNAL   Nat Commun 15 (1), 168 (2024)
   PUBMED   38168065
  REMARK    GeneRIF: Mic19 depletion impairs endoplasmic
            reticulum-mitochondrial contacts and mitochondrial lipid metabolism
            and triggers liver disease.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 227)
  AUTHORS   Sohn,J.H., Mutlu,B., Latorre-Muro,P., Liang,J., Bennett,C.F.,
            Sharabi,K., Kantorovich,N., Jedrychowski,M., Gygi,S.P., Banks,A.S.
            and Puigserver,P.
  TITLE     Liver mitochondrial cristae organizing protein MIC19 promotes
            energy expenditure and pedestrian locomotion by altering nucleotide
            metabolism
  JOURNAL   Cell Metab 35 (8), 1356-1372 (2023)
   PUBMED   37473754
  REMARK    GeneRIF: Liver mitochondrial cristae organizing protein MIC19
            promotes energy expenditure and pedestrian locomotion by altering
            nucleotide metabolism.
REFERENCE   3  (residues 1 to 227)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 227)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   5  (residues 1 to 227)
  AUTHORS   Hadsell,D.L., Hadsell,L.A., Olea,W., Rijnkels,M., Creighton,C.J.,
            Smyth,I., Short,K.M., Cox,L.L. and Cox,T.C.
  TITLE     In-silico QTL mapping of postpubertal mammary ductal development in
            the mouse uncovers potential human breast cancer risk loci
  JOURNAL   Mamm Genome 26 (1-2), 57-79 (2015)
   PUBMED   25552398
REFERENCE   6  (residues 1 to 227)
  AUTHORS   Darshi,M., Mendiola,V.L., Mackey,M.R., Murphy,A.N., Koller,A.,
            Perkins,G.A., Ellisman,M.H. and Taylor,S.S.
  TITLE     ChChd3, an inner mitochondrial membrane protein, is essential for
            maintaining crista integrity and mitochondrial function
  JOURNAL   J Biol Chem 286 (4), 2918-2932 (2011)
   PUBMED   21081504
  REMARK    GeneRIF: ChChd3 is a scaffolding protein that stabilizes protein
            complexes involved in maintaining crista architecture and protein
            import and is thus essential for maintaining mitochondrial
            structure and function.
REFERENCE   7  (residues 1 to 227)
  AUTHORS   Schauble,S., King,C.C., Darshi,M., Koller,A., Shah,K. and
            Taylor,S.S.
  TITLE     Identification of ChChd3 as a novel substrate of the cAMP-dependent
            protein kinase (PKA) using an analog-sensitive catalytic subunit
  JOURNAL   J Biol Chem 282 (20), 14952-14959 (2007)
   PUBMED   17242405
REFERENCE   8  (residues 1 to 227)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (residues 1 to 227)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (residues 1 to 227)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156288.5 and AC152943.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XP_915751.1, XP_926809.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032987.1, AK003519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..227
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 13.97 cM"
     Protein         1..227
                     /product="MICOS complex subunit Mic19"
                     /note="coiled-coil-helix-coiled-coil-helix
                     domain-containing protein 3, mitochondrial"
                     /calculated_mol_wt=26203
     Region          29..174
                     /region_name="MIC19_MIC25"
                     /note="MICOS complex subunit MIC19/MIC25; pfam05300"
                     /db_xref="CDD:461615"
     Site            29
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9CRB9.1)"
     Region          32..57
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CRB9.1)"
     Site            49
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9NX63; propagated from
                     UniProtKB/Swiss-Prot (Q9CRB9.1)"
     Site            50
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9CRB9.1)"
     Site            51
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9CRB9.1)"
     Site            56
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9CRB9.1)"
     Site            58
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NX63; propagated from
                     UniProtKB/Swiss-Prot (Q9CRB9.1)"
     Region          73..92
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CRB9.1)"
     Site            142
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9NX63; propagated from
                     UniProtKB/Swiss-Prot (Q9CRB9.1)"
     Region          183..215
                     /region_name="CHCH"
                     /note="CHCH domain; pfam06747"
                     /db_xref="CDD:429096"
     Region          183..193
                     /region_name="Cx9C motif 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01150"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CRB9.1)"
     Region          204..214
                     /region_name="Cx9C motif 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01150"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CRB9.1)"
     CDS             1..227
                     /gene="Chchd3"
                     /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19"
                     /coded_by="NM_025336.2:181..864"
                     /db_xref="CCDS:CCDS19986.1"
                     /db_xref="GeneID:66075"
                     /db_xref="MGI:MGI:1913325"
ORIGIN      
        1 mggtastrrv tfeadeneni tvvkgirlse nvidrmkess psgsksqrys svygasvsde
       61 dlkrrvaeel aleqakkese hqrrlkqard lereraaane qltravlrer isseeermka
      121 khlarqleek drvmrkqdaf ykeqlarlee rssefykvtt eeyqkaaeev eakfkryeyh
      181 pvcadlqtki lqcyrqntqq tlscsalasq ymhcvnhakq smlekgg
//
