LOCUS NP_079612 227 aa linear ROD 09-OCT-2024 DEFINITION MICOS complex subunit Mic19 [Mus musculus]. ACCESSION NP_079612 XP_915751 XP_926809 VERSION NP_079612.1 DBSOURCE REFSEQ: accession NM_025336.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (residues 1 to 227) AUTHORS Dong,J., Chen,L., Ye,F., Tang,J., Liu,B., Lin,J., Zhou,P.H., Lu,B., Wu,M., Lu,J.H., He,J.J., Engelender,S., Meng,Q., Song,Z. and He,H. TITLE Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease JOURNAL Nat Commun 15 (1), 168 (2024) PUBMED 38168065 REMARK GeneRIF: Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease. Publication Status: Online-Only REFERENCE 2 (residues 1 to 227) AUTHORS Sohn,J.H., Mutlu,B., Latorre-Muro,P., Liang,J., Bennett,C.F., Sharabi,K., Kantorovich,N., Jedrychowski,M., Gygi,S.P., Banks,A.S. and Puigserver,P. TITLE Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism JOURNAL Cell Metab 35 (8), 1356-1372 (2023) PUBMED 37473754 REMARK GeneRIF: Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism. REFERENCE 3 (residues 1 to 227) AUTHORS Bedogni,F. and Hevner,R.F. TITLE Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development JOURNAL Front Mol Neurosci 14, 686034 (2021) PUBMED 34321999 REMARK Publication Status: Online-Only REFERENCE 4 (residues 1 to 227) AUTHORS Nakano,Y., Wiechert,S. and Banfi,B. TITLE Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST JOURNAL Cell Rep 27 (3), 860-871 (2019) PUBMED 30995482 REFERENCE 5 (residues 1 to 227) AUTHORS Hadsell,D.L., Hadsell,L.A., Olea,W., Rijnkels,M., Creighton,C.J., Smyth,I., Short,K.M., Cox,L.L. and Cox,T.C. TITLE In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci JOURNAL Mamm Genome 26 (1-2), 57-79 (2015) PUBMED 25552398 REFERENCE 6 (residues 1 to 227) AUTHORS Darshi,M., Mendiola,V.L., Mackey,M.R., Murphy,A.N., Koller,A., Perkins,G.A., Ellisman,M.H. and Taylor,S.S. TITLE ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function JOURNAL J Biol Chem 286 (4), 2918-2932 (2011) PUBMED 21081504 REMARK GeneRIF: ChChd3 is a scaffolding protein that stabilizes protein complexes involved in maintaining crista architecture and protein import and is thus essential for maintaining mitochondrial structure and function. REFERENCE 7 (residues 1 to 227) AUTHORS Schauble,S., King,C.C., Darshi,M., Koller,A., Shah,K. and Taylor,S.S. TITLE Identification of ChChd3 as a novel substrate of the cAMP-dependent protein kinase (PKA) using an analog-sensitive catalytic subunit JOURNAL J Biol Chem 282 (20), 14952-14959 (2007) PUBMED 17242405 REFERENCE 8 (residues 1 to 227) AUTHORS Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M., Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S., Kamal,M., Patterson,N., Lander,E.S. and Mann,M. TITLE Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria JOURNAL Cell 115 (5), 629-640 (2003) PUBMED 14651853 REFERENCE 9 (residues 1 to 227) AUTHORS Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and Martinou,J.C. TITLE Proteomic analysis of the mouse liver mitochondrial inner membrane JOURNAL J Biol Chem 278 (42), 41566-41571 (2003) PUBMED 12865426 REFERENCE 10 (residues 1 to 227) AUTHORS Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A., Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L., Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E. TITLE BayGenomics: a resource of insertional mutations in mouse embryonic stem cells JOURNAL Nucleic Acids Res 31 (1), 278-281 (2003) PUBMED 12520002 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC156288.5 and AC152943.1. On or before Dec 7, 2005 this sequence version replaced XP_915751.1, XP_926809.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032987.1, AK003519.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849390 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..227 /organism="Mus musculus" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="6" /map="6 13.97 cM" Protein 1..227 /product="MICOS complex subunit Mic19" /note="coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial" /calculated_mol_wt=26203 Region 29..174 /region_name="MIC19_MIC25" /note="MICOS complex subunit MIC19/MIC25; pfam05300" /db_xref="CDD:461615" Site 29 /site_type="phosphorylation" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9CRB9.1)" Region 32..57 /region_name="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" /note="propagated from UniProtKB/Swiss-Prot (Q9CRB9.1)" Site 49 /site_type="phosphorylation" /note="Phosphotyrosine. /evidence=ECO:0000250|UniProtKB:Q9NX63; propagated from UniProtKB/Swiss-Prot (Q9CRB9.1)" Site 50 /site_type="phosphorylation" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9CRB9.1)" Site 51 /site_type="phosphorylation" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9CRB9.1)" Site 56 /site_type="phosphorylation" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9CRB9.1)" Site 58 /site_type="phosphorylation" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q9NX63; propagated from UniProtKB/Swiss-Prot (Q9CRB9.1)" Region 73..92 /region_name="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" /note="propagated from UniProtKB/Swiss-Prot (Q9CRB9.1)" Site 142 /site_type="acetylation" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:Q9NX63; propagated from UniProtKB/Swiss-Prot (Q9CRB9.1)" Region 183..215 /region_name="CHCH" /note="CHCH domain; pfam06747" /db_xref="CDD:429096" Region 183..193 /region_name="Cx9C motif 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01150" /note="propagated from UniProtKB/Swiss-Prot (Q9CRB9.1)" Region 204..214 /region_name="Cx9C motif 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01150" /note="propagated from UniProtKB/Swiss-Prot (Q9CRB9.1)" CDS 1..227 /gene="Chchd3" /gene_synonym="0610041L09Rik; 1700039J09Rik; Micos19" /coded_by="NM_025336.2:181..864" /db_xref="CCDS:CCDS19986.1" /db_xref="GeneID:66075" /db_xref="MGI:MGI:1913325" ORIGIN 1 mggtastrrv tfeadeneni tvvkgirlse nvidrmkess psgsksqrys svygasvsde 61 dlkrrvaeel aleqakkese hqrrlkqard lereraaane qltravlrer isseeermka 121 khlarqleek drvmrkqdaf ykeqlarlee rssefykvtt eeyqkaaeev eakfkryeyh 181 pvcadlqtki lqcyrqntqq tlscsalasq ymhcvnhakq smlekgg //