LOCUS       NM_024166                910 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus coiled-coil-helix-coiled-coil-helix domain containing
            2 (Chchd2), mRNA.
ACCESSION   NM_024166 XM_974787
VERSION     NM_024166.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 910)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 910)
  AUTHORS   Liu,X., Wang,F., Fan,X., Chen,M., Xu,X., Xu,Q., Zhu,H., Xu,A.,
            Pouladi,M.A. and Xu,X.
  TITLE     CHCHD2 up-regulation in Huntington disease mediates a compensatory
            protective response against oxidative stress
  JOURNAL   Cell Death Dis 15 (2), 126 (2024)
   PUBMED   38341417
  REMARK    GeneRIF: CHCHD2 up-regulation in Huntington disease mediates a
            compensatory protective response against oxidative stress.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 910)
  AUTHORS   Torii,S., Arakawa,S., Sato,S., Ishikawa,K.I., Taniguchi,D.,
            Sakurai,H.T., Honda,S., Hiraoka,Y., Ono,M., Akamatsu,W., Hattori,N.
            and Shimizu,S.
  TITLE     Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the
            pathogenesis of familial Parkinson's disease caused by CHCHD2
  JOURNAL   EMBO Mol Med 15 (9), e17451 (2023)
   PUBMED   37578019
  REMARK    GeneRIF: Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in
            the pathogenesis of familial Parkinson's disease caused by CHCHD2.
REFERENCE   4  (bases 1 to 910)
  AUTHORS   Fan,L., Zhang,S., Li,X., Hu,Z., Yang,J., Zhang,S., Zheng,H., Su,Y.,
            Luo,H., Liu,X., Fan,Y., Sun,H., Zhang,Z., Miao,J., Song,B., Xia,Z.,
            Shi,C., Mao,C. and Xu,Y.
  TITLE     CHCHD2 p.Thr61Ile knock-in mice exhibit motor defects and
            neuropathological features of Parkinson's disease
  JOURNAL   Brain Pathol 33 (3), e13124 (2023)
   PUBMED   36322611
  REMARK    GeneRIF: CHCHD2 p.Thr61Ile knock-in mice exhibit motor defects and
            neuropathological features of Parkinson's disease.
REFERENCE   5  (bases 1 to 910)
  AUTHORS   Li,Y., Xiu,W., Xu,J., Chen,X., Wang,G., Duan,J., Sun,L., Liu,B.,
            Xie,W., Pu,G., Wang,Q. and Wang,C.
  TITLE     Increased CHCHD2 expression promotes liver fibrosis in nonalcoholic
            steatohepatitis via Notch/osteopontin signaling
  JOURNAL   JCI Insight 7 (23), e162402 (2022)
   PUBMED   36477358
  REMARK    GeneRIF: Increased CHCHD2 expression promotes liver fibrosis in
            nonalcoholic steatohepatitis via Notch/osteopontin signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 910)
  AUTHORS   Seo,M., Lee,W.H. and Suk,K.
  TITLE     Identification of novel cell migration-promoting genes by a
            functional genetic screen
  JOURNAL   FASEB J 24 (2), 464-478 (2010)
   PUBMED   19812375
  REMARK    GeneRIF: Intracellular localization and further functional studies
            suggested that CHCHD2 and HABP1 may mutually regulate each other to
            balance cell migration.
REFERENCE   7  (bases 1 to 910)
  AUTHORS   Lee,J., Xu,Y., Chen,Y., Sprung,R., Kim,S.C., Xie,S. and Zhao,Y.
  TITLE     Mitochondrial phosphoproteome revealed by an improved IMAC method
            and MS/MS/MS
  JOURNAL   Mol Cell Proteomics 6 (4), 669-676 (2007)
   PUBMED   17208939
REFERENCE   8  (bases 1 to 910)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 910)
  AUTHORS   McClive,P.J., Hurley,T.M., Sarraj,M.A., van den Bergen,J.A. and
            Sinclair,A.H.
  TITLE     Subtractive hybridisation screen identifies sexually dimorphic gene
            expression in the embryonic mouse gonad
  JOURNAL   Genesis 37 (2), 84-90 (2003)
   PUBMED   14595844
REFERENCE   10 (bases 1 to 910)
  AUTHORS   Rout,U.K., Krawetz,S.A. and Armant,D.R.
  TITLE     Ethanol-induced intracellular calcium mobilization rapidly alters
            gene expression in the mouse blastocyst
  JOURNAL   Cell Calcium 22 (6), 463-474 (1997)
   PUBMED   9502196
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC164071.3 and
            AC242408.2.
            
            On Apr 29, 2007 this sequence version replaced NM_024166.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088374.1, AK003399.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC164071.3         35967-36108         c
            143-273             AC242408.2         1-131
            274-523             AC242408.2         3146-3395
            524-674             AC242408.2         4750-4900
            675-910             AC242408.2         5933-6168
FEATURES             Location/Qualifiers
     source          1..910
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 68.26 cM"
     gene            1..910
                     /gene="Chchd2"
                     /gene_synonym="Etohi6"
                     /note="coiled-coil-helix-coiled-coil-helix domain
                     containing 2"
                     /db_xref="GeneID:14004"
                     /db_xref="MGI:MGI:1261428"
     exon            1..273
                     /gene="Chchd2"
                     /gene_synonym="Etohi6"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..685
                     /gene="Chchd2"
                     /gene_synonym="Etohi6"
                     /EC_number="2.3.1.15"
                     /note="ethanol induced 6;
                     coiled-coil-helix-coiled-coil-helix domain-containing
                     protein 2, mitochondrial"
                     /codon_start=1
                     /product="coiled-coil-helix-coiled-coil-helix
                     domain-containing protein 2 precursor"
                     /protein_id="NP_077128.2"
                     /db_xref="CCDS:CCDS19702.1"
                     /db_xref="GeneID:14004"
                     /db_xref="MGI:MGI:1261428"
                     /translation="MPRGSRSRTSRVTPPASRAPQMRAAPRRAPAAQPPAAAAPSAVG
                     SPAAAPRQPGLMAQMATTAAGVAVGSAVGHTLGHAITGGFSGGGSAEPAKPDITYQEP
                     QGAQLQNQQSFGPCSLEIKQFLECAQNQSDVKLCEGFNEVLRQCRIANGLM"
     exon            274..523
                     /gene="Chchd2"
                     /gene_synonym="Etohi6"
                     /inference="alignment:Splign:2.1.0"
     exon            524..674
                     /gene="Chchd2"
                     /gene_synonym="Etohi6"
                     /inference="alignment:Splign:2.1.0"
     exon            675..910
                     /gene="Chchd2"
                     /gene_synonym="Etohi6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacttcgtaa cttccgggcc taggacgctg agtccaggct ctgcccatta ctgatatctc
       61 ctttgtccaa taacctttag cgcccgagct tttcctgatt tcttattggt tgcccggtga
      121 ggtaccgcct ccacccttcc tctctccttg gtagaaattg ctggacgctt ctgtacgttt
      181 cgcagtttgt cttcgctgat cggtgagact tcgagcagtt aggatgccgc gtggaagccg
      241 aagccgcact tcccgggtga ctcctccggc cagccgggcc cctcagatga gggctgctcc
      301 ccgaagagca cctgcagctc agcctccagc agcagctgcg ccatctgcag ttggctcacc
      361 tgccgctgcg ccccggcagc caggcctgat ggcccagatg gctaccaccg cggccggtgt
      421 ggctgtgggc tctgcagtgg gacacaccct gggtcacgcc atcactgggg gcttcagcgg
      481 aggtggcagt gctgagcccg caaagcccga catcacttac caggagcctc agggagccca
      541 gctgcagaac cagcagtctt ttggaccttg ctctctagag atcaagcagt ttctggagtg
      601 tgctcagaac cagagcgatg tcaagctctg tgagggcttc aacgaggtgc tgcggcagtg
      661 caggattgca aatggtttaa tgtaatcaag aaattcaagc tgaagagatg taacattggt
      721 tctgtataat tgatagtaca agtgtggacc cttatatttc taacagttca ttgctttgga
      781 atggccgtga aagagatcta actgtggatg cttactgagg cttgtatgta gtgttggtta
      841 ctggggaagt gtttggcctc cttggactgt gttgtgattg tgagttaaaa aaaataaatt
      901 ggttattctg
//
