LOCUS       NM_175329               1498 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus coiled-coil-helix-coiled-coil-helix domain containing
            10 (Chchd10), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_175329
VERSION     NM_175329.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1498)
  AUTHORS   Genin,E.C., di Borgo,P.P., Lorivel,T., Hugues,S., Farinelli,M.,
            Mauri-Crouzet,A., Lespinasse,F., Godin,L., Paquis-Flucklinger,V.
            and Petit-Paitel,A.
  TITLE     CHCHD10S59L/+ mouse model: Behavioral and neuropathological
            features of frontotemporal dementia
  JOURNAL   Neurobiol Dis 195, 106498 (2024)
   PUBMED   38583639
REFERENCE   2  (bases 1 to 1498)
  AUTHORS   Southwell,N., Manzo,O., Bacman,S., Zhao,D., Sayles,N.M., Dash,J.,
            Fujita,K., D'Aurelio,M., Di Lorenzo,A., Manfredi,G. and Kawamata,H.
  TITLE     High fat diet ameliorates mitochondrial cardiomyopathy in CHCHD10
            mutant mice
  JOURNAL   EMBO Mol Med 16 (6), 1352-1378 (2024)
   PUBMED   38724625
REFERENCE   3  (bases 1 to 1498)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1498)
  AUTHORS   Yu,X., Jiang,H., Li,J., Ding,J., Wu,T., Chen,K., Ding,Z. and Xu,X.
  TITLE     Mitochondrial protein CHCHD10 inhibits NDV replication and reduces
            pathological changes
  JOURNAL   Vet Microbiol 290, 109986 (2024)
   PUBMED   38244394
  REMARK    GeneRIF: Mitochondrial protein CHCHD10 inhibits NDV replication and
            reduces pathological changes.
REFERENCE   5  (bases 1 to 1498)
  AUTHORS   Shammas,M.K., Nie,Y., Gilsrud,A., Huang,X., Narendra,D.P. and
            Chinnery,P.F.
  TITLE     CHCHD10 mutations induce tissue-specific mitochondrial DNA
            deletions with a distinct signature
  JOURNAL   Hum Mol Genet 33 (1), 91-101 (2023)
   PUBMED   37815936
  REMARK    GeneRIF: CHCHD10 mutations induce tissue-specific mitochondrial DNA
            deletions with a distinct signature.
REFERENCE   6  (bases 1 to 1498)
  AUTHORS   Endoh-Yamagami,S., Karkar,K.M., May,S.R., Cobos,I., Thwin,M.T.,
            Long,J.E., Ashique,A.M., Zarbalis,K., Rubenstein,J.L. and
            Peterson,A.S.
  TITLE     A mutation in the pericentrin gene causes abnormal interneuron
            migration to the olfactory bulb in mice
  JOURNAL   Dev Biol 340 (1), 41-53 (2010)
   PUBMED   20096683
REFERENCE   7  (bases 1 to 1498)
  AUTHORS   Gilbert,F., Morissette,M., St-Hilaire,M., Paquet,B., Rouillard,C.,
            Di Paolo,T. and Levesque,D.
  TITLE     Nur77 gene knockout alters dopamine neuron biochemical activity and
            dopamine turnover
  JOURNAL   Biol Psychiatry 60 (6), 538-547 (2006)
   PUBMED   16893530
  REMARK    GeneRIF: Nur77 gene knockout alters dopamine neuron biochemical
            activity and dopamine turnover.
REFERENCE   8  (bases 1 to 1498)
  AUTHORS   Kochel,I., Rapak,A., Ziolo,E. and Strzadala,L.
  TITLE     Nur77 nuclear import and its NBRE-binding activity in thymic
            lymphoma cells are regulated by different mechanisms sensitive to
            FK506 or HA1004
  JOURNAL   Biochem Biophys Res Commun 334 (4), 1102-1106 (2005)
   PUBMED   16051191
  REMARK    GeneRIF: In the presence of HA1004, NBRE binding by Nur77 protein
            increases with time (6 h vs 2 h), whereas the final outcome of both
            inhibitors is apoptosis of thymic lymphoma cells.
REFERENCE   9  (bases 1 to 1498)
  AUTHORS   Kocher,O., Yesilaltay,A., Cirovic,C., Pal,R., Rigotti,A. and
            Krieger,M.
  TITLE     Targeted disruption of the PDZK1 gene in mice causes
            tissue-specific depletion of the high density lipoprotein receptor
            scavenger receptor class B type I and altered lipoprotein
            metabolism
  JOURNAL   J Biol Chem 278 (52), 52820-52825 (2003)
   PUBMED   14551195
REFERENCE   10 (bases 1 to 1498)
  AUTHORS   Rajpal,A., Cho,Y.A., Yelent,B., Koza-Taylor,P.H., Li,D., Chen,E.,
            Whang,M., Kang,C., Turi,T.G. and Winoto,A.
  TITLE     Transcriptional activation of known and novel apoptotic pathways by
            Nur77 orphan steroid receptor
  JOURNAL   EMBO J 22 (24), 6526-6536 (2003)
   PUBMED   14657025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM934773.1, BC083357.1 and W16247.1.
            
            On Feb 8, 2017 this sequence version replaced NM_175329.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               BM934773.1         11-347
            338-1488            BC083357.1         1-1151
            1489-1498           W16247.1           1-10                c
FEATURES             Location/Qualifiers
     source          1..1498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.62 cM"
     gene            1..1498
                     /gene="Chchd10"
                     /gene_synonym="1620401E04Rik; Ndg2"
                     /note="coiled-coil-helix-coiled-coil-helix domain
                     containing 10"
                     /db_xref="GeneID:103172"
                     /db_xref="MGI:MGI:2143558"
     exon            1..369
                     /gene="Chchd10"
                     /gene_synonym="1620401E04Rik; Ndg2"
                     /inference="alignment:Splign:2.1.0"
     exon            370..959
                     /gene="Chchd10"
                     /gene_synonym="1620401E04Rik; Ndg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             919..1335
                     /gene="Chchd10"
                     /gene_synonym="1620401E04Rik; Ndg2"
                     /note="Nur77 downstream gene 2"
                     /codon_start=1
                     /product="coiled-coil-helix-coiled-coil-helix
                     domain-containing protein 10, mitochondrial"
                     /protein_id="NP_780538.2"
                     /db_xref="CCDS:CCDS23938.1"
                     /db_xref="GeneID:103172"
                     /db_xref="MGI:MGI:2143558"
                     /translation="MPRGSRSAAARPVSRPAPPPAHPPPSAAAPAPAAPGQPGLMAQM
                     ASTAAGVAVGSAVGHVMGSALTSAFSGGNSEPAQPAVQQAPARPASHPLQMGPCSYEI
                     KQFLDCSTTQSDLTLCEGFSEALKQCKYNHGLSSLP"
     exon            960..1167
                     /gene="Chchd10"
                     /gene_synonym="1620401E04Rik; Ndg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1315
                     /gene="Chchd10"
                     /gene_synonym="1620401E04Rik; Ndg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1491
                     /gene="Chchd10"
                     /gene_synonym="1620401E04Rik; Ndg2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1464..1469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chchd10"
                     /gene_synonym="1620401E04Rik; Ndg2"
                     /note="hexamer: ATTAAA"
     polyA_site      1488
                     /gene="Chchd10"
                     /gene_synonym="1620401E04Rik; Ndg2"
                     /note="major polyA site"
ORIGIN      
        1 ttttttctct actagcaggc aactgggtca gttggctggg aggaaagggt cagggatgtt
       61 tgagttggac actggaatct caggttgttc cctggccggg gggcacacta gccaacaggc
      121 ttttcctgac cagtcaggct cagccatctg agacagggac agaatcacat ctgagaggga
      181 ggtctacgtg ctgaaaacag ttcaactact ctaatctctg cagcgagtgt ccaactgtgc
      241 agtgttccct cttggatgac aatggctcta caaggcactg caggcctctt ccaccaggcc
      301 ttcagctctc ttctgaattc tggtgggcca gtggggccct gagctgctgc aaagtagggg
      361 cagagagtga ggttatggca tgatcccagc caaggtctct gaggaaaagt ctgtgaaaac
      421 cgagttccag aggacaggga agggcctttg gtgatcctgg gatggttatt ttcaaactct
      481 gtcttgtgat gggtctcaga gaacacaacc tggcctgcag tctccattcg cttctccgct
      541 ggcggtctat gtgtctcttt ctttcctcct gggctcgtgg caaaccccta ttgcattgct
      601 tgagttctga cagaaagacc tgccctcgct gccccgtgcc taactaagcc ttgggctttc
      661 caaagctgac cggtgtcccc aggactcgcg tagctccgcc ctgcactggg atagctccgg
      721 agccctaaat ccaggaggtt aatggaaggg cgagctttgg cccctcccat ttggagggcg
      781 tggatcagag gccccgcccc agatcccgcc catttcacct gactctaagg acgctgccgt
      841 gttagttgcc cggcactgag cgagcggctg ctacggtcca cgcttcttac tcagctccaa
      901 cttgatccca ccgcagtcat gcctcgggga agccgcagtg cggctgccag gccggtcagc
      961 cgcccagccc cgcctcctgc gcacccacca ccctcagcgg ccgccccggc acctgccgct
     1021 cccggccagc cgggtcttat ggctcagatg gcatccaccg ccgcaggcgt agccgtgggc
     1081 tcagctgtag ggcatgtcat gggtagcgcc ctgaccagtg ccttcagtgg gggaaattca
     1141 gagcctgccc agcctgccgt ccagcaggcc cctgcccggc ctgcctctca ccccctgcag
     1201 atggggccct gctcctatga gatcaagcag ttcctggact gctccaccac tcagagcgac
     1261 ctaaccctgt gtgagggctt cagcgaggcc ctcaaacagt gcaaatacaa tcacggtctg
     1321 agctccctgc cctgaagagg ctgtgggcct gctcatcgcc taacccctca ccgacagctt
     1381 gatggaaagg agaggttcca tgtgactggg agtaaggaag gatcgttctc accccgcaga
     1441 ctaacaggag acataattat tcaattaaaa agtttacttt agaccacagc caaaaaaa
//
