LOCUS       NM_001419178            2300 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus chromatin assembly factor 1, subunit B (Chaf1b),
            transcript variant 2, mRNA.
ACCESSION   NM_001419178
VERSION     NM_001419178.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2300)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2300)
  AUTHORS   Dean,S.T., Ishikawa,C., Zhu,X., Walulik,S., Nixon,T., Jordan,J.K.,
            Henderson,S., Wyder,M., Salomonis,N., Wunderlich,M., Greis,K.D.,
            Starczynowski,D.T. and Volk,A.G.
  TITLE     Repression of TRIM13 by chromatin assembly factor CHAF1B is
            critical for AML development
  JOURNAL   Blood Adv 7 (17), 4822-4837 (2023)
   PUBMED   37205848
  REMARK    GeneRIF: Repression of TRIM13 by chromatin assembly factor CHAF1B
            is critical for AML development.
REFERENCE   3  (bases 1 to 2300)
  AUTHORS   Franklin,R., Guo,Y., He,S., Chen,M., Ji,F., Zhou,X.,
            Frankhouser,D., Do,B.T., Chiem,C., Jang,M., Blanco,M.A., Vander
            Heiden,M.G., Rockne,R.C., Ninova,M., Sykes,D.B., Hochedlinger,K.,
            Lu,R., Sadreyev,R.I., Murn,J., Volk,A. and Cheloufi,S.
  TITLE     Regulation of chromatin accessibility by the histone chaperone
            CAF-1 sustains lineage fidelity
  JOURNAL   Nat Commun 13 (1), 2350 (2022)
   PUBMED   35487911
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2300)
  AUTHORS   Zhang,Y., Yang,Y., Qiao,P., Wang,X., Yu,R., Sun,H., Xing,X.,
            Zhang,Y. and Su,J.
  TITLE     CHAF1b, chromatin assembly factor-1 subunit b, is essential for
            mouse preimplantation embryos
  JOURNAL   Int J Biol Macromol 195, 547-557 (2022)
   PUBMED   34906611
  REMARK    GeneRIF: CHAF1b, chromatin assembly factor-1 subunit b, is
            essential for mouse preimplantation embryos.
REFERENCE   5  (bases 1 to 2300)
  AUTHORS   Xu,Y., Ma,J., Luo,H., Shi,Y., Liu,H., Sun,A., Xu,C., Ji,H. and
            Liu,X.
  TITLE     Chromatin assembly factor 1B critically controls the early
            development but not function acquisition of invariant natural
            killer T cells in mice
  JOURNAL   Eur J Immunol 51 (7), 1698-1714 (2021)
   PUBMED   33949677
  REMARK    GeneRIF: Chromatin assembly factor 1B critically controls the early
            development but not function acquisition of invariant natural
            killer T cells in mice.
REFERENCE   6  (bases 1 to 2300)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 2300)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   8  (bases 1 to 2300)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   9  (bases 1 to 2300)
  AUTHORS   Pletcher,M.T., Wiltshire,T., Cabin,D.E., Villanueva,M. and
            Reeves,R.H.
  TITLE     Use of comparative physical and sequence mapping to annotate mouse
            chromosome 16 and human chromosome 21
  JOURNAL   Genomics 74 (1), 45-54 (2001)
   PUBMED   11374901
REFERENCE   10 (bases 1 to 2300)
  AUTHORS   Cabin,D.E., McKee-Johnson,J.W., Matesic,L.E., Wiltshire,T.,
            Rue,E.E., Mjaatvedt,A.E., Huo,Y.K., Korenberg,J.R. and Reeves,R.H.
  TITLE     Physical and comparative mapping of distal mouse chromosome 16. 5
            p5
  JOURNAL   Genome Res 8 (9), 940-950 (1998)
   PUBMED   9750193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC168220.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.4541617.1,
                                           SRR13861889.106644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-453               AC168220.1         113788-114240       c
            454-609             AC168220.1         113532-113687       c
            610-742             AC168220.1         112662-112794       c
            743-860             AC168220.1         110914-111031       c
            861-964             AC168220.1         110008-110111       c
            965-1061            AC168220.1         106557-106653       c
            1062-1146           AC168220.1         105955-106039       c
            1147-1240           AC168220.1         105328-105421       c
            1241-1310           AC168220.1         103347-103416       c
            1311-1402           AC168220.1         103167-103258       c
            1403-1565           AC168220.1         97968-98130         c
            1566-1997           AC168220.1         96797-97228         c
            1998-2089           AC168220.1         93056-93147         c
            2090-2300           AC168220.1         92038-92248         c
FEATURES             Location/Qualifiers
     source          1..2300
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 54.96 cM"
     gene            1..2300
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /note="chromatin assembly factor 1, subunit B"
                     /db_xref="GeneID:110749"
                     /db_xref="MGI:MGI:1314881"
     exon            1..453
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /inference="alignment:Splign:2.1.0"
     exon            454..609
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /inference="alignment:Splign:2.1.0"
     CDS             484..2202
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /note="isoform 1 is encoded by transcript variant 2;
                     chromatin assembly factor I p60 subunit; CAF-1 subunit B;
                     CAF-I 60 kDa subunit; chromatin assembly factor 1, subunit
                     B (p60)"
                     /codon_start=1
                     /product="chromatin assembly factor 1 subunit B isoform 1"
                     /protein_id="NP_001406107.1"
                     /db_xref="GeneID:110749"
                     /db_xref="MGI:MGI:1314881"
                     /translation="MKVITCEIAWHNKEPVYSLDFQHGATWKIHRLASAGVDTAVRIW
                     KLERGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKMNDSKEPE
                     QIAFQDEEEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWDVSK
                     GQKISIFNEHKSYVQGVTWDPLGQYIATLSCDRVLRIYNTQKKRVAFNISKMLSGQGP
                     EGEARSFRMFHDDSMKSFFRRLSFTPDGSLLLTPAGCMESGENVTNTTYVFSRKHLKR
                     PIAHLPCPGKATLAVRCCPVYFELRPVAETEKASEEPSPELVNLPYRMVFAVASEDSV
                     LLYDTQQSFPFGYVSNIHYHTLSDISWSSDGAFLAISSTDGYCTFVTFEKGELGIPLK
                     EKPVLSIRTPDTAKKAKNQTHQGSSPGSRSVEGTPSNRTQDPSSPCTTPSPTTQSPAP
                     SAIKDSPSAIPAGKSPLPQPSEEKTLQPAGQNMKAPQPRRVTLNTLQTWGKTAPRRIN
                     LTPLKTDTVPNPQPNSGTAPSTEEVQPEAPGEPPEEPPELKRPRLEEREGDAQNLAPD
                     DSSKTV"
     exon            610..742
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /inference="alignment:Splign:2.1.0"
     exon            743..860
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /inference="alignment:Splign:2.1.0"
     exon            861..964
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1061
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1146
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1240
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1310
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1402
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1565
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1997
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2089
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2300
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2267..2272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /note="hexamer: AATAAA"
     polyA_site      2300
                     /gene="Chaf1b"
                     /gene_synonym="2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1;
                     CAF1A; CAF1P60; MPHOSPH7"
                     /note="major polyA site"
ORIGIN      
        1 gtggcctgcg gcgcgcggga agctgcgggc tgtggcggcc ccgggtggac cgagttactg
       61 caggtaggtt tgctgatacc cggcttccgc gcttctgacc tgggttgggc tgcagctcct
      121 caccggggcc gtgagttctg atctcagcgc gggcgcaggc agaaggcagt tcgtcccaga
      181 ccacagtccc caccgggacc gggactcgcg cgccttccgc caggccgggt tgggccgccc
      241 ggacccgcgc ccctccccgt gaactccctc ccttgctgct ccccgggatg atagccagta
      301 ctccggtacc ggtctctggg accccacctc aacacgatgc tctgtgctgc ccgtcctcgc
      361 ctccgtctgg ggtgtttggt ttctttctct tccggaaccg tacactggtg gaagtctctc
      421 tacctgcggg agcattttag ctgaagattg cagcctccct ttgcctggcg gaaactctgg
      481 aggatgaaag tgatcacgtg tgaaatcgcc tggcacaaca aggagccagt gtacagcctg
      541 gacttccagc atggggcaac ctggaagatc cacaggctgg catccgcggg ggtggacacc
      601 gccgtcagga tctggaagtt ggagaggggg ccagatggga aagccattgt ggaatttctc
      661 tccaatcttg ctcgacacac caaagctgtc aatgttgtac gcttttctcc aactggggag
      721 attttagcat ctggaggaga tgatgccgtc attctgttgt ggaagatgaa tgacagcaag
      781 gagccggagc agatcgcctt tcaggatgag gaggaggcgc agctgaataa ggagaactgg
      841 actgtggtaa agaccctgag gggccactta gaagatgtgt atgatatttg ctgggcaacc
      901 gatgggaatt tgatgacctc tgcctctgtg gataacacag ttatcatatg ggatgtcagt
      961 aaagggcaga aaatttccat tttcaacgag cataaaagtt atgtgcaagg agtcacctgg
     1021 gatcctttgg gtcaatatat tgcgaccctg agctgtgaca gggtgctgcg gatctataat
     1081 acccagaaaa agcgtgtggc tttcaacatt tcaaagatgc tctctggaca ggggcctgaa
     1141 ggagaggcaa gaagtttccg gatgtttcac gacgacagca tgaagtcgtt cttccgaaga
     1201 ctcagcttta ctccagatgg atctttgctc ctcactccag ccggatgtat ggaatctggt
     1261 gagaatgtga caaacaccac ttatgtgttc tccagaaaac acctgaaaag gccaatcgcc
     1321 catcttccgt gccctgggaa agcgactctt gctgtccgct gttgtcctgt ctactttgaa
     1381 ttgaggccag tggcagaaac agagaaagca tcagaggagc ccagccccga gctggtgaac
     1441 ctgccctacc gtatggtgtt cgcggtggct tccgaggact ctgtgttgct ctatgacact
     1501 caacagtctt tcccatttgg ctatgtgtct aacatccatt accataccct gagtgacatt
     1561 tcctggtcca gcgatggggc cttcttggcc atttcctcca cggatggcta ttgcacattt
     1621 gtgaccttcg agaaaggtga acttggcata cctttgaaag agaagccagt gctgagcata
     1681 aggactcccg acacagccaa gaaagccaag aaccagacac accagggatc ttcgccggga
     1741 tccagatcag tcgaagggac ccccagcaac agaacccaag accccagcag tccctgtacc
     1801 actccttcac caaccacaca gtctccagct ccgtcggcca tcaaggacag tccctcagcc
     1861 atcccggctg gcaaaagccc cttgccacaa ccttctgaag agaagaccct gcaacctgct
     1921 gggcaaaaca tgaaagcccc ccaaccccgc agggtcaccc tgaacacgct gcagacttgg
     1981 ggcaagacag ccccccggag aataaattta acaccattga aaacagacac tgtgccaaat
     2041 ccacagccca atagcgggac cgccccctcc acagaagagg tccagccaga ggctcctggg
     2101 gagccaccgg aggagcctcc tgaactgaag agacccaggc ttgaggaacg tgaaggagat
     2161 gcccaaaacc tggcccctga tgactcttcc aagactgtct gagcctgcta tgcacctgcg
     2221 tgcagaggag gcaaggccaa agctcgaagg ctggtgatgg tggccaaata aacactcatg
     2281 aattggttca catagaaaaa
//
