LOCUS       NM_013733               3308 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus chromatin assembly factor 1, subunit A (Chaf1a), mRNA.
ACCESSION   NM_013733
VERSION     NM_013733.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3308)
  AUTHORS   Tao L, Moreno-Smith M, Ibarra-Garcia-Padilla R, Milazzo G, Drolet
            NA, Hernandez BE, Oh YS, Patel I, Kim JJ, Zorman B, Patel T, Kamal
            AHM, Zhao Y, Hicks J, Vasudevan SA, Putluri N, Coarfa C, Sumazin P,
            Perini G, Parchem RJ, Uribe RA and Barbieri E.
  TITLE     CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma
            Oncogenesis via Metabolic Reprogramming
  JOURNAL   Adv Sci (Weinh) 8 (19), e2005047 (2021)
   PUBMED   34365742
  REMARK    GeneRIF: CHAF1A Blocks Neuronal Differentiation and Promotes
            Neuroblastoma Oncogenesis via Metabolic Reprogramming.
REFERENCE   2  (bases 1 to 3308)
  AUTHORS   Cheng L, Zhang X, Wang Y, Gan H, Xu X, Lv X, Hua X, Que J, Ordog T
            and Zhang Z.
  TITLE     Chromatin Assembly Factor 1 (CAF-1) facilitates the establishment
            of facultative heterochromatin during pluripotency exit
  JOURNAL   Nucleic Acids Res 47 (21), 11114-11131 (2019)
   PUBMED   31586391
REFERENCE   3  (bases 1 to 3308)
  AUTHORS   Cheloufi S, Elling U, Hopfgartner B, Jung YL, Murn J, Ninova M,
            Hubmann M, Badeaux AI, Euong Ang C, Tenen D, Wesche DJ, Abazova N,
            Hogue M, Tasdemir N, Brumbaugh J, Rathert P, Jude J, Ferrari F,
            Blanco A, Fellner M, Wenzel D, Zinner M, Vidal SE, Bell O,
            Stadtfeld M, Chang HY, Almouzni G, Lowe SW, Rinn J, Wernig M,
            Aravin A, Shi Y, Park PJ, Penninger JM, Zuber J and Hochedlinger K.
  TITLE     The histone chaperone CAF-1 safeguards somatic cell identity
  JOURNAL   Nature 528 (7581), 218-224 (2015)
   PUBMED   26659182
  REMARK    GeneRIF: the histone chaperone CAF-1 to be a novel regulator of
            somatic cell identity during transcription-factor-induced cell-fate
            transitions and provide a potential strategy to modulate cellular
            plasticity in a regenerative setting
REFERENCE   4  (bases 1 to 3308)
  AUTHORS   Hatanaka Y, Inoue K, Oikawa M, Kamimura S, Ogonuki N, Kodama EN,
            Ohkawa Y, Tsukada Y and Ogura A.
  TITLE     Histone chaperone CAF-1 mediates repressive histone modifications
            to protect preimplantation mouse embryos from endogenous
            retrotransposons
  JOURNAL   Proc Natl Acad Sci U S A 112 (47), 14641-14646 (2015)
   PUBMED   26546670
  REMARK    GeneRIF: CAF-1 is an essential guardian of the genome in
            preimplantation mouse embryos.
REFERENCE   5  (bases 1 to 3308)
  AUTHORS   Heyd F, Chen R, Afshar K, Saba I, Lazure C, Fiolka K and Moroy T.
  TITLE     The p150 subunit of the histone chaperone Caf-1 interacts with the
            transcriptional repressor Gfi1
  JOURNAL   Biochim Biophys Acta 1809 (4-6), 255-261 (2011)
   PUBMED   21570500
  REMARK    GeneRIF: Findings suggest that p150 may link the DNA-bound Gfi1
            repressor complex to histones enabling modifications required for
            transcriptional silencing.
REFERENCE   6  (bases 1 to 3308)
  AUTHORS   Reese BE, Bachman KE, Baylin SB and Rountree MR.
  TITLE     The methyl-CpG binding protein MBD1 interacts with the p150 subunit
            of chromatin assembly factor 1
  JOURNAL   Mol Cell Biol 23 (9), 3226-3236 (2003)
   PUBMED   12697822
REFERENCE   7  (bases 1 to 3308)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3308)
  AUTHORS   Dong H, Lin W, Zhang CK, Xiong H, Fu G, Jin WR, Chen R, Chen Z, Qi
            ZT and Huang GM.
  TITLE     Genomic sequence and expression analyses of human chromatin
            assembly factor 1 p150 gene
  JOURNAL   Gene 264 (2), 187-196 (2001)
   PUBMED   11250073
REFERENCE   9  (bases 1 to 3308)
  AUTHORS   Brasher SV, Smith BO, Fogh RH, Nietlispach D, Thiru A, Nielsen PR,
            Broadhurst RW, Ball LJ, Murzina NV and Laue ED.
  TITLE     The structure of mouse HP1 suggests a unique mode of single peptide
            recognition by the shadow chromo domain dimer
  JOURNAL   EMBO J 19 (7), 1587-1597 (2000)
   PUBMED   10747027
REFERENCE   10 (bases 1 to 3308)
  AUTHORS   Murzina N, Verreault A, Laue E and Stillman B.
  TITLE     Heterochromatin dynamics in mouse cells: interaction between
            chromatin assembly factor 1 and HP1 proteins
  JOURNAL   Mol Cell 4 (4), 529-540 (1999)
   PUBMED   10549285
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK034839.1.
            
            [WARNING] On Jan 18, 2024 this sequence was replaced by
            NM_013733.4.
            
            On Apr 6, 2007 this sequence version replaced NM_013733.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034839.1, BC053740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3308              AK034839.1         2-3309
FEATURES             Location/Qualifiers
     source          1..3308
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.13 cM"
     gene            1..3308
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /note="chromatin assembly factor 1, subunit A"
                     /db_xref="GeneID:27221"
                     /db_xref="MGI:MGI:1351331"
     exon            1..136
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2832
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /note="CAF-Ip150; CAF-1 subunit A; CAF-I 150 kDa subunit;
                     chromatin assembly factor I p150 subunit; CAF-I p150"
                     /codon_start=1
                     /product="chromatin assembly factor 1 subunit A"
                     /protein_id="NP_038761.1"
                     /db_xref="CCDS:CCDS28892.1"
                     /db_xref="GeneID:27221"
                     /db_xref="MGI:MGI:1351331"
                     /translation="MLEEPEAATRTAAAVDCKDRPGFPVKRLIQARLPFKRLNLVPKE
                     KVEEDTSPKAAVESKVPDLQLSLGTFESQCHTGSHVGLSTKLVGGQGPIDSFLRATIK
                     PVPSVVIIDLTENCSDIPDSPEGHSELSPDTAGVVTTVEGAAKQQEHSAAELCLLETP
                     SDITCHMEEEPGSPGDPKRTGDCQAGSLQSCPELTPGSRTCPTKELSSWSKAGDLLFI
                     EKVPVVVLEDILATKPSIASLPMMSLDRSVTSESEILESCPEDDSILSHSSTNSSSPT
                     SSPEGPSTPPEHRGGRSSPSTPACRVAKNFVKGSTEKGRSKLHRDREQQREEKEKLRE
                     EIRRAKEEARKKKEEEKELKEKERREKREKDEKEKAEKQRLKEEKRKERQEALEAKLE
                     EKRKKEEEKRLREEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKFAPF
                     EIKEHMVLAPRCRAALDQDLCDQLDQLLQQQSVASTFLSDLKSRLPLRSGPTRVCGHD
                     TDIMNRDVVIVESSKVDGVSERKKFGRMKLLQFSENHRPAYWGTWNKKTAIIRPRNPW
                     AQDKDLLDYEVDSDDEWEEEEPGESLSHSEGDEDDDVGEDEDEDDGFFVPHGYLSEDE
                     GVTEECADPENHKVHQKLKAKEWDELLAKGKRFRVLQPVHVGCVWASEAANCTSSDLK
                     LLQQFTACLLDVASPDEPEPGASRREKRDQHILAQLLPLLHGNVNGSKVIIHEFQEQC
                     RRGLLTLPSPTPHLQMPNLEDAVAVPSKARLKRLISENSAYEKRPNFRMCWYVHPEVL
                     KSFGQECLPVPCQWTYITTMPSAPREDSGSASTEGPGQSTPMLLKRKPAATMCITQFM
                     KKRRYDGQVGSGDMDGFQADTEEDEEDDTDCMIIDVPDVGSDVSEAPIPAPTLCK"
     exon            137..187
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /inference="alignment:Splign:2.1.0"
     exon            188..999
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1056
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1259
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1341
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1410
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1637
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1806
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1887
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..1980
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2236
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2688
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..3308
                     /gene="Chaf1a"
                     /gene_synonym="Cac1p; CAF-1; p150"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accggtggga ggcggagtgt gcagcctggc cgcccgactg aagcctgagc cgccgccgcc
       61 gccgccgccg ccgccgccgc cgccgccgtc gcggagatgt tggaggagcc ggaggccgcg
      121 acgcggacag ccgcggccgt ggattgcaaa gacagacccg ggttcccagt gaagaggtta
      181 atacaagccc gcttgccctt caaacgcctg aaccttgttc ccaaggagaa agttgaggaa
      241 gacacatcac caaaagcagc tgtggaaagc aaagtcccgg atctacaatt gtctttgggc
      301 acttttgaaa gccagtgtca cacaggctct cacgtaggct tgagtacaaa gttggtcggt
      361 ggccagggcc ccattgatag cttcttgagg gcaacaatca agccagtacc gagtgtggtc
      421 attatcgacc tgacggagaa ctgcagtgac attccagaca gccctgaggg ccacagtgaa
      481 ctaagtcctg acactgctgg tgtggtcacc acagtggaag gagctgccaa gcagcaggag
      541 cactctgcag cagagctgtg tctcctagag accccttcag acatcacttg tcacatggaa
      601 gaggagcctg ggagtccagg agacccaaag aggacgggtg actgtcaggc tggttcacta
      661 cagagctgtc cggagctgac cccaggttct aggacatgcc ccaccaagga gttatcaagc
      721 tggagcaagg caggggatct cctatttata gagaaagtgc ctgtggtggt gctagaggac
      781 atcctggcca ctaagccctc cattgcctct cttcccatga tgtccctgga taggagtgtc
      841 acttcagaga gtgaaatact ggagtcctgc cccgaggatg actccatact gagccactcc
      901 tccaccaact cctcttctcc aaccagctct cctgagggac catccacacc cccagaacat
      961 cggggtggga gaagctcccc ctccacccca gcctgcagag ttgccaagaa ctttgtcaaa
     1021 ggctccacag agaagggcag gagcaaactg cacagagata gagaacagca gagggaagag
     1081 aaggaaaagc tgagggaaga gatacgacga gccaaggagg aggcacggaa gaagaaggag
     1141 gaggagaagg agctgaagga aaaggagcgg agggaaaagc gggagaaaga tgagaaggag
     1201 aaggcggaga agcagcggct aaaggaggaa aaacgcaagg agcggcagga agctctggag
     1261 gctaaactgg aggagaagag gaagaaggag gaagagaagc ggttacggga ggaagagaag
     1321 cggttacggg aagaagagaa gcgcattaag gcagaaaagg cagagatcac tcgattcttc
     1381 cagaaaccga agactccgca ggctcccaag accctggccg gttcctgtgg taagtttgcc
     1441 ccctttgaaa tcaaagaaca catggtgctg gctccacggt gccgagctgc cttggatcaa
     1501 gacctgtgcg atcagctgga ccagctcctg cagcagcaga gtgtggcaag caccttcctc
     1561 agtgacctaa aaagccggct gcccttgaga tcggggccca cccgggtctg tggccatgac
     1621 acagacatca tgaacaggga tgtggtcatt gtggagagca gcaaggtgga cggtgtgtct
     1681 gaaaggaaga agtttggccg catgaagctt ctgcagttct cagagaacca ccggccagca
     1741 tactggggga cgtggaacaa gaagacagcc atcatccgcc cccggaaccc ctgggcccag
     1801 gacaaagacc ttcttgacta tgaggtagac agtgacgatg agtgggaaga ggaggaacct
     1861 ggggagtctt tgtcccacag tgagggggat gaggatgacg atgtggggga agatgaggat
     1921 gaggacgatg gcttctttgt gccccatggg tacttatctg aagatgaagg cgtgactgag
     1981 gagtgtgcag accctgagaa ccacaaagta caccagaagc tgaaggccaa ggagtgggat
     2041 gagctcctag ccaagggcaa gcgctttcgt gtgctgcagc ctgtgcacgt gggatgtgta
     2101 tgggcatcag aggcagccaa ctgcacgagt tccgacttga agctgctgca gcagttcact
     2161 gcatgcctgc tggatgtggc atcccctgat gagccagaac ccggggcctc caggagggaa
     2221 aagagggacc agcatatcct ggcccagttg cttccgctgc tacatggcaa tgtgaatggg
     2281 agcaaggtga tcatccatga attccaggag caatgccgca ggggcctgct gacccttcca
     2341 agtcccaccc cacacctgca gatgcccaac ttggaggatg ctgttgctgt gccatccaag
     2401 gccaggctga agcgccttat ctctgagaac tctgcctatg agaagcggcc caacttccgt
     2461 atgtgctggt atgtgcaccc agaggtgctc aagagctttg gccaggagtg cctgccagtg
     2521 ccctgccagt ggacctacat caccaccatg ccctcagcac ccagggaaga cagtggcagt
     2581 gcttctactg aggggcctgg ccagagcaca cctatgctac tcaagcggaa gccagcggcc
     2641 accatgtgca tcacgcagtt tatgaagaag cggcgctatg atggacaggt tgggtctggg
     2701 gacatggatg gcttccaggc agacacagaa gaggatgaag aggatgacac agactgtatg
     2761 atcatagatg tgccagatgt tgggagtgac gtgtcagaag ctcccatacc tgctcccaca
     2821 ctttgcaagt gacaggtgtc aagttgaaag acctggggga aattgaccta ggtgacaggg
     2881 agtagtggag tgtaggcacc tgaagtgcaa ggttggtagt aggcatgttc tgggcagtgg
     2941 aggctgtgct tcccctcagc cttgtagagc tgctgaggga gatgggaatg gagaccagca
     3001 acagcctgct ccctgcagca tctgactagc aaccaccaga gtgagcctcc tgctgactct
     3061 catgataaag agcactttgt cctacattcc taggtctgga gtctggggga ggcctggaca
     3121 gctacttcca aattgtaaag actctgggtc cgtgtgctaa tctgcccttc ttaattgaca
     3181 gatgcctgct tgggccttaa tcacagcact tgctgtgggc aaacatctgc tatgaattgt
     3241 gctagggatg atgtggctgc tgtgcaggcc ctgggcaaat gtggacatgt ataaacatac
     3301 tctacttg
//
