LOCUS       NM_007689               1697 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus chondroadherin (Chad), mRNA.
ACCESSION   NM_007689
VERSION     NM_007689.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1697)
  AUTHORS   Yin,W., Liontos,A., Koepke,J., Ghoul,M., Mazzocchi,L., Liu,X.,
            Lu,C., Wu,H., Fysikopoulos,A., Sountoulidis,A., Seeger,W.,
            Ruppert,C., Gunther,A., Stainier,D.Y.R. and Samakovlis,C.
  TITLE     An essential function for autocrine hedgehog signaling in
            epithelial proliferation and differentiation in the trachea
  JOURNAL   Development 149 (3) (2022)
   PUBMED   35112129
REFERENCE   2  (bases 1 to 1697)
  AUTHORS   Sah,R.K., Ma,J., Bah,F.B., Xing,Z., Adlat,S., Oo,Z.M., Wang,Y.,
            Bahadar,N., Bohio,A.A., Nagi,F.H., Feng,X., Zhang,L. and Zheng,Y.
  TITLE     Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung
            Development and Prenatal Lethality
  JOURNAL   Int J Mol Sci 21 (21), 8223 (2020)
   PUBMED   33153107
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1697)
  AUTHORS   Cai,T., Yang,L., Cai,W., Guo,S., Yu,P., Li,J., Hu,X., Yan,M.,
            Shao,Q., Jin,Y., Sun,Z.S. and Luo,Z.J.
  TITLE     Dysplastic spondylolysis is caused by mutations in the diastrophic
            dysplasia sulfate transporter gene
  JOURNAL   Proc Natl Acad Sci U S A 112 (26), 8064-8069 (2015)
   PUBMED   26077908
REFERENCE   4  (bases 1 to 1697)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1697)
  AUTHORS   Batista,M.A., Nia,H.T., Onnerfjord,P., Cox,K.A., Ortiz,C.,
            Grodzinsky,A.J., Heinegard,D. and Han,L.
  TITLE     Nanomechanical phenotype of chondroadherin-null murine articular
            cartilage
  JOURNAL   Matrix Biol 38, 84-90 (2014)
   PUBMED   24892719
  REMARK    GeneRIF: Chondroadherin likely affects cartilage modulus by
            regulating collagen network.
REFERENCE   6  (bases 1 to 1697)
  AUTHORS   Sagane,K., Yamazaki,K., Mizui,Y. and Tanaka,I.
  TITLE     Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23
  JOURNAL   Gene 236 (1), 79-86 (1999)
   PUBMED   10433968
REFERENCE   7  (bases 1 to 1697)
  AUTHORS   Nasir,J., Maclean,A., Engelender,S., Duan,K., Margolis,R.L.,
            Kleiderlein,J.J., Ross,C.A. and Hayden,M.R.
  TITLE     Chromosomal localization of the Huntingtin associated protein
            (HAP-1) gene in mouse and humans with radiation hybrid and
            interspecific backcross mapping
  JOURNAL   Mamm Genome 10 (4), 397-398 (1999)
   PUBMED   10087300
REFERENCE   8  (bases 1 to 1697)
  AUTHORS   Aszodi,A., Chan,D., Hunziker,E., Bateman,J.F. and Fassler,R.
  TITLE     Collagen II is essential for the removal of the notochord and the
            formation of intervertebral discs
  JOURNAL   J Cell Biol 143 (5), 1399-1412 (1998)
   PUBMED   9832566
REFERENCE   9  (bases 1 to 1697)
  AUTHORS   Lin,L., Peters,L.L., Ciciotte,S.L. and Chishti,A.H.
  TITLE     cDNA sequence and chromosomal localization of mouse Dlgh3 gene
            adjacent to the BRCA1 tumor suppressor locus
  JOURNAL   Biochim Biophys Acta 1443 (1-2), 211-216 (1998)
   PUBMED   9838122
REFERENCE   10 (bases 1 to 1697)
  AUTHORS   Landgren,C., Beier,D.R., Fassler,R., Heinegard,D. and Sommarin,Y.
  TITLE     The mouse chondroadherin gene: characterization and chromosomal
            localization
  JOURNAL   Genomics 47 (1), 84-91 (1998)
   PUBMED   9465299
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158297.1, AL645809.8 and BQ175638.1.
            
            On Feb 14, 2018 this sequence version replaced NM_007689.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158297.1, AK160489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AK158297.1         2-108
            108-108             AL645809.8         87534-87534
            109-1194            AK158297.1         110-1195
            1195-1697           BQ175638.1         1-503               c
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 58.9 cM"
     gene            1..1697
                     /gene="Chad"
                     /gene_synonym="SLRR4A"
                     /note="chondroadherin"
                     /db_xref="GeneID:12643"
                     /db_xref="MGI:MGI:1096866"
     exon            1..822
                     /gene="Chad"
                     /gene_synonym="SLRR4A"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1128
                     /gene="Chad"
                     /gene_synonym="SLRR4A"
                     /note="cartilage leucine-rich protein"
                     /codon_start=1
                     /product="chondroadherin precursor"
                     /protein_id="NP_031715.1"
                     /db_xref="CCDS:CCDS25260.1"
                     /db_xref="GeneID:12643"
                     /db_xref="MGI:MGI:1096866"
                     /translation="MARALLFSLVFLAILLPALAACPQNCHCHGDLQHVICDKVGLQK
                     IPKVSETTKLLNLQRNNFPVLAANSFRTMPNLVSLHLQHCNIREVAAGAFRGLKQLIY
                     LYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVSELPRGLLSPLVNLFILQLNNNKIRE
                     LRAGAFQGAKDLRWLYLSENALSSLQPGSLDDVENLAKFHLDKNQLSSYPSAALSKLR
                     VVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDAAFSGVTTLKHVHLDN
                     NRLNQLPSSFPFDNLETLTLTNNPWKCTCQLRGLRRWLEAKASRPDATCSSPAKFKGQ
                     RIRDTDALRSCKSPTKRSKKAGRH"
     exon            823..986
                     /gene="Chad"
                     /gene_synonym="SLRR4A"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1132
                     /gene="Chad"
                     /gene_synonym="SLRR4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1680
                     /gene="Chad"
                     /gene_synonym="SLRR4A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1654..1659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chad"
                     /gene_synonym="SLRR4A"
                     /note="hexamer: CATAAA"
     polyA_site      1680
                     /gene="Chad"
                     /gene_synonym="SLRR4A"
                     /note="major polyA site"
ORIGIN      
        1 gaggacttgt cgctgcctta gcccccagcc caggctcaag gcgttccaac catggcccgc
       61 gcgctcttat tcagtctggt ctttcttgcc atcctcctgc ctgcgctagc cgcctgcccc
      121 caaaactgcc actgccatgg agatctgcag catgtcatct gcgacaaggt ggggctgcag
      181 aagatcccca aggtatcaga gacaaccaaa ctgctcaatc tccagcgcaa caacttcccg
      241 gtgctggctg ccaactcgtt tcggaccatg ccgaacctgg tctccctgca cctgcaacac
      301 tgcaacatcc gcgaggtggc ggctggtgcc ttccgaggcc tgaagcagct tatctacctg
      361 tacctgtccc acaacgacat ccgggtattg cgagctggag ccttcgacga cctgactgaa
      421 ctcacttacc tctatctaga ccacaacaaa gtgtcggaac tgccccgggg gttgctctct
      481 cctctggtca acctcttcat cttgcaactc aacaacaaca aaatccgaga gctgcgtgct
      541 ggagctttcc agggggccaa ggacctgcgc tggctctacc tgtcagaaaa tgccctcagt
      601 tccctgcagc ctggttccct ggatgatgtg gagaacctag ccaagttcca cctggacaag
      661 aaccagctgt ctagctaccc ctcagccgcc ctgagcaaac ttcgggtggt ggaggagctg
      721 aagctgtctc acaaccctct gaagagcatc ccagacaatg ccttccagtc cttcggtaga
      781 tatctggaga ccctctggct ggataacacc aacctggaga agttctcaga tgctgccttc
      841 tcgggtgtga ccacactgaa acacgtccat ctggacaaca accgcctgaa ccaactgcct
      901 tcctccttcc cctttgacaa cctggagacc ctcactctca ccaacaaccc atggaaatgc
      961 acctgccagc tccgtggcct tcggcggtgg ttggaagcca aggcttctcg accggatgct
     1021 acctgctcct cgccagccaa gttcaagggt cagcggattc gtgacacaga tgcccttcgc
     1081 agctgcaaat ccccgaccaa gaggtccaag aaagctggcc gccattaaac aggtcctgat
     1141 ccagccagtc ctggcgactg ccttccgctg gagagactac tgacgttccc tcccattatc
     1201 cacaccttct cctacagcct ctgcggatgc acagcgctgc cccgcccccg cccccaccta
     1261 ggtacatcct ggcaggggca ctgggctctc tatcaccatc ccagctccac ccagtggggt
     1321 cctaggaaag acacagaatc cctccccagc cactgtgtct gggctctgcc atggctcctt
     1381 tgagagaagc tattgtagaa cctcctaccc tctgtccatc ggagctaaag cgcagtggtc
     1441 attgggatga ccacgttatt accaccttcc tcggttccct ctgtccctgc catttggaaa
     1501 caaacatcag gcccctgacc caccctgatt gccagaaaga atttcaggcc catgccccaa
     1561 ctctgccagt tcctgcctgc caggacatgc taccaggata ccagtagcgc ttggctgcat
     1621 atccttcctg tttgcgctcc agatttctat aaacataaat gtatgtgtgt tcaacattca
     1681 aaaaaaaaaa aaaaaaa
//
