LOCUS       NM_026929               1583 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus ChaC, cation transport regulator 1 (Chac1), mRNA.
ACCESSION   NM_026929
VERSION     NM_026929.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1583)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1583)
  AUTHORS   Shen,T., Wang,S., Huang,C., Zhu,S., Zhu,X., Li,N., Wang,H.,
            Huang,L., Ren,M., Han,Z., Ge,J., Chen,Z. and Ouyang,K.
  TITLE     Cardiac-specific deletion of heat shock protein 60 induces
            mitochondrial stress and disrupts heart development in mice
  JOURNAL   Biochem Biophys Res Commun 710, 149883 (2024)
   PUBMED   38588611
REFERENCE   3  (bases 1 to 1583)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1583)
  AUTHORS   Li,J., Lu,M., Ahn,Y., Cao,K., Pinkus,C.A., Stansfield,J.C., Wu,Z.
            and Zhang,B.B.
  TITLE     CHAC1 inactivation is effective to preserve muscle glutathione but
            is insufficient to protect against muscle wasting in cachexia
  JOURNAL   PLoS One 18 (4), e0283806 (2023)
   PUBMED   37014882
  REMARK    GeneRIF: CHAC1 inactivation is effective to preserve muscle
            glutathione but is insufficient to protect against muscle wasting
            in cachexia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1583)
  AUTHORS   Zhou,Z. and Zhang,H.
  TITLE     CHAC1 exacerbates LPS-induced ferroptosis and apoptosis in HK-2
            cells by promoting oxidative stress
  JOURNAL   Allergol Immunopathol (Madr) 51 (2), 99-110 (2023)
   PUBMED   36916093
  REMARK    GeneRIF: CHAC1 exacerbates LPS-induced ferroptosis and apoptosis in
            HK-2 cells by promoting oxidative stress.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1583)
  AUTHORS   Chi,Z., Zhang,J., Tokunaga,A., Harraz,M.M., Byrne,S.T., Dolinko,A.,
            Xu,J., Blackshaw,S., Gaiano,N., Dawson,T.M. and Dawson,V.L.
  TITLE     Botch promotes neurogenesis by antagonizing Notch
  JOURNAL   Dev Cell 22 (4), 707-720 (2012)
   PUBMED   22445366
REFERENCE   7  (bases 1 to 1583)
  AUTHORS   Wilson,D.G., Phamluong,K., Li,L., Sun,M., Cao,T.C., Liu,P.S.,
            Modrusan,Z., Sandoval,W.N., Rangell,L., Carano,R.A., Peterson,A.S.
            and Solloway,M.J.
  TITLE     Global defects in collagen secretion in a Mia3/TANGO1 knockout
            mouse
  JOURNAL   J Cell Biol 193 (5), 935-951 (2011)
   PUBMED   21606205
  REMARK    Erratum:[J Cell Biol. 2011 Jul 25;194(2):347]
REFERENCE   8  (bases 1 to 1583)
  AUTHORS   Cantagrel,V., Lefeber,D.J., Ng,B.G., Guan,Z., Silhavy,J.L.,
            Bielas,S.L., Lehle,L., Hombauer,H., Adamowicz,M., Swiezewska,E., De
            Brouwer,A.P., Blumel,P., Sykut-Cegielska,J., Houliston,S.,
            Swistun,D., Ali,B.R., Dobyns,W.B., Babovic-Vuksanovic,D., van
            Bokhoven,H., Wevers,R.A., Raetz,C.R., Freeze,H.H., Morava,E.,
            Al-Gazali,L. and Gleeson,J.G.
  TITLE     SRD5A3 is required for converting polyprenol to dolichol and is
            mutated in a congenital glycosylation disorder
  JOURNAL   Cell 142 (2), 203-217 (2010)
   PUBMED   20637498
REFERENCE   9  (bases 1 to 1583)
  AUTHORS   Kawakami,Y., Yoshida,K., Yang,J.H., Suzuki,T., Azuma,N., Sakai,K.,
            Hashikawa,T., Watanabe,M., Yasuda,K., Kuhara,S., Hirabayashi,Y. and
            Furuya,S.
  TITLE     Impaired neurogenesis in embryonic spinal cord of Phgdh knockout
            mice, a serine deficiency disorder model
  JOURNAL   Neurosci Res 63 (3), 184-193 (2009)
   PUBMED   19114063
REFERENCE   10 (bases 1 to 1583)
  AUTHORS   Yu,X., Bauer,K., Wernhoff,P., Koczan,D., Moller,S., Thiesen,H.J.
            and Ibrahim,S.M.
  TITLE     Fine mapping of collagen-induced arthritis quantitative trait loci
            in an advanced intercross line
  JOURNAL   J Immunol 177 (10), 7042-7049 (2006)
   PUBMED   17082620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI872476.1, AK007378.1 and BM899230.1.
            
            On Nov 22, 2008 this sequence version replaced NM_026929.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032218.1, AK007378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               BI872476.1         1-250
            251-1352            AK007378.1         204-1305
            1353-1583           BM899230.1         1-231               c
FEATURES             Location/Qualifiers
     source          1..1583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.97 cM"
     gene            1..1583
                     /gene="Chac1"
                     /gene_synonym="1810008K03Rik"
                     /note="ChaC, cation transport regulator 1"
                     /db_xref="GeneID:69065"
                     /db_xref="MGI:MGI:1916315"
     exon            1..395
                     /gene="Chac1"
                     /gene_synonym="1810008K03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..833
                     /gene="Chac1"
                     /gene_synonym="1810008K03Rik"
                     /EC_number="4.3.2.7"
                     /note="cation transport regulator-like protein 1; botch;
                     blocks Notch protein; ChaC, cation transport
                     regulator-like 1; gamma-GCG 1"
                     /codon_start=1
                     /product="glutathione-specific
                     gamma-glutamylcyclotransferase 1"
                     /protein_id="NP_081205.1"
                     /db_xref="CCDS:CCDS16601.1"
                     /db_xref="GeneID:69065"
                     /db_xref="MGI:MGI:1916315"
                     /translation="MKQESASQSTPPPSLSPAPSSAQPSWGDGDPQALWIFGYGSLVW
                     KPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDREGCTWGVAYQVRG
                     EQVNEALKYLNVREAVLGGYDTKEVTFYPQDTPDQPLTALAYVATPQNPGYLGPAPEE
                     VIATQILACRGFSGHNLEYLLRLADFMQLCGPQAQDEHLEAIVDAVGTLLPCSYLPEQ
                     PLALT"
     exon            396..431
                     /gene="Chac1"
                     /gene_synonym="1810008K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            432..1569
                     /gene="Chac1"
                     /gene_synonym="1810008K03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1539..1544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chac1"
                     /gene_synonym="1810008K03Rik"
                     /note="hexamer: CATAAA"
     polyA_site      1557
                     /gene="Chac1"
                     /gene_synonym="1810008K03Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggccttcctg gccggagggt ttaaagagcg cctctggagg gaccactcag ctggaacgac
       61 cgatcggtgc caggccaggt gtacgcgtcc gtcggtcctt ccgtgcccgt gccggagacc
      121 agtctcggag gccacccggg tccgtccctg cgcccggcac catgaagcag gagtccgcat
      181 cccagagcac tccgcctcct tcactgtccc ctgcaccatc atccgcgcag ccttcctggg
      241 gggatggcga cccccaagcc ctgtggattt tcgggtacgg ctccctagtg tggaagccgg
      301 actttgccta tagtgacagc cgtgtgggct tcgttcgtgg ctatagccga cggttctggc
      361 agggagacac cttccatagg ggcagcgaca agatgcctgg ccgagtggtg accctccttg
      421 aagaccgtga gggctgcact tggggtgtgg cataccaagt tcgaggggag caggtgaacg
      481 aggccctgaa gtacctgaat gtgagggaag ccgtgcttgg tggctatgac actaaggaag
      541 tcacctttta tcctcaagac acccctgacc aacccctcac agcactggcc tatgtggcca
      601 ccccacagaa ccctggctac ctgggccctg ctcctgaaga ggtcattgcc acacagatcc
      661 ttgcttgccg aggcttctct ggtcacaacc ttgagtactt attgcgtttg gcagacttca
      721 tgcagctctg tgggcctcag gcacaagatg agcacctgga agccattgtg gacgccgtag
      781 gaaccctgct accctgctct tacctacctg agcagcctct ggcactgacc tgaggagcca
      841 agctcctgca agaagtgtct gagtggtact ggtggacatc agtatgcagt acttgagata
      901 gacttgatgg agcaagagag agttgagaag gcatgctggg tggccagggg ctttgtgtct
      961 tatgccccgc ctgtctgcta gccttcagct cttccttcat tgacccttac tcactacttg
     1021 aacctttatt tattgcacca tgttggtgtg gtgggcaggg caggtggggg acctgccctg
     1081 gatgtgggcc ctgcagtgcg gtggctctgc cctagtcctc tggtatgtaa ccagaatccc
     1141 cccattgctg ctgccaattc cacaccaccc aggcctccgt agccccaggg accctccaag
     1201 atcgttgctc ctctgtccac ccagactacc ccagccgtgg tagtatcacc tgcccatgtt
     1261 ccgggccttc tggatgaggg acagcagaga aggaggcgaa gtagctcttc aagggccaag
     1321 ggtcagcatc cctcttcatt gacgggcccg gggcagagcc ggatcctatg cacagacaca
     1381 gttcctggga ctgggcctct cccccatccc tcttttttca tttccttatc cttttgtctg
     1441 tctgcttgtt tgtctggatc acttcctata gacccattgg tctgttcctg gaaaacacta
     1501 cagtccttgt ccattctcag ttgacccata ctgttaccca taaactgtct ttcattacct
     1561 ctgccagaaa aaaaaaaaaa aaa
//
