LOCUS       NM_026770               1257 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cell growth regulator with EF hand domain 1 (Cgref1),
            transcript variant 1, mRNA.
ACCESSION   NM_026770 XM_181420 XM_908550
VERSION     NM_026770.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1257)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1257)
  AUTHORS   Inoue,S.I., Takahara,S., Yoshikawa,T., Niihori,T., Yanai,K.,
            Matsubara,Y. and Aoki,Y.
  TITLE     Activated Braf induces esophageal dilation and gastric epithelial
            hyperplasia in mice
  JOURNAL   Hum Mol Genet 26 (23), 4715-4727 (2017)
   PUBMED   28973166
REFERENCE   3  (bases 1 to 1257)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1257)
  AUTHORS   Devnath,S., Kataoka,T., Miura,K., Kusuda,M., Kitamura,K.,
            Kumada,Y., Mochiduki,A., Kaneko,K., Adachi,A. and Inoue,K.
  TITLE     Cgr11 encodes a secretory protein involved in cell adhesion
  JOURNAL   Eur J Cell Biol 88 (9), 521-529 (2009)
   PUBMED   19473726
REFERENCE   5  (bases 1 to 1257)
  AUTHORS   Hecht,J., Seitz,V., Urban,M., Wagner,F., Robinson,P.N., Stiege,A.,
            Dieterich,C., Kornak,U., Wilkening,U., Brieske,N., Zwingman,C.,
            Kidess,A., Stricker,S. and Mundlos,S.
  TITLE     Detection of novel skeletogenesis target genes by comprehensive
            analysis of a Runx2(-/-) mouse model
  JOURNAL   Gene Expr Patterns 7 (1-2), 102-112 (2007)
   PUBMED   16829211
REFERENCE   6  (bases 1 to 1257)
  AUTHORS   Garcia-Frigola,C., Burgaya,F., Calbet,M., Lopez-Domenech,G., de
            Lecea,L. and Soriano,E.
  TITLE     A collection of cDNAs enriched in upper cortical layers of the
            embryonic mouse brain
  JOURNAL   Brain Res Mol Brain Res 122 (2), 133-150 (2004)
   PUBMED   15010206
REFERENCE   7  (bases 1 to 1257)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109606.11.
            
            On Jul 21, 2021 this sequence version replaced NM_026770.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023116.1, AK003420.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC109606.11        169176-169224       c
            50-152              AC109606.11        159696-159798       c
            153-218             AC109606.11        158361-158426       c
            219-289             AC109606.11        158197-158267       c
            290-411             AC109606.11        157978-158099       c
            412-1257            AC109606.11        156961-157806       c
FEATURES             Location/Qualifiers
     source          1..1257
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 16.9 cM"
     gene            1..1257
                     /gene="Cgref1"
                     /gene_synonym="1110004G24Rik; Cgr11"
                     /note="cell growth regulator with EF hand domain 1"
                     /db_xref="GeneID:68567"
                     /db_xref="MGI:MGI:1915817"
     exon            1..49
                     /gene="Cgref1"
                     /gene_synonym="1110004G24Rik; Cgr11"
                     /inference="alignment:Splign:2.1.0"
     exon            50..152
                     /gene="Cgref1"
                     /gene_synonym="1110004G24Rik; Cgr11"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..909
                     /gene="Cgref1"
                     /gene_synonym="1110004G24Rik; Cgr11"
                     /note="cell growth regulatory with EF-hand domain; cell
                     growth regulator with EF hand domain protein 1;
                     hydrophobestin; cell growth regulatory gene 11 protein"
                     /codon_start=1
                     /product="cell growth regulator with EF hand domain
                     protein 1 precursor"
                     /protein_id="NP_081046.2"
                     /db_xref="CCDS:CCDS51454.1"
                     /db_xref="GeneID:68567"
                     /db_xref="MGI:MGI:1915817"
                     /translation="MFQWLMQALMLPLLLLPLGRAAPKDGVARLDPEVQQQLTPNPFQ
                     PGPEQLRHLQNYLKGLEKMEEDPEHMDREQVLLSLFALHDYDQNGQLDGLELLSMLTA
                     ALAPGAAHFPINPVILVVDSVLETQDLDGDGLMTPAELINFPEVPKHTESLPPALQEP
                     QPAGSQPLLANSPLQSETQQSLGTKEIRSQVEAKRASLEPEQEAGHQTEGKVDTLSPE
                     EEARGQAESEGDVPGPREGAEEQVEIKDNEGEAKELLVETLESLNTPNEAEAHSIQLE
                     NDEI"
     exon            153..218
                     /gene="Cgref1"
                     /gene_synonym="1110004G24Rik; Cgr11"
                     /inference="alignment:Splign:2.1.0"
     exon            219..289
                     /gene="Cgref1"
                     /gene_synonym="1110004G24Rik; Cgr11"
                     /inference="alignment:Splign:2.1.0"
     exon            290..411
                     /gene="Cgref1"
                     /gene_synonym="1110004G24Rik; Cgr11"
                     /inference="alignment:Splign:2.1.0"
     exon            412..1257
                     /gene="Cgref1"
                     /gene_synonym="1110004G24Rik; Cgr11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1228..1233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cgref1"
                     /gene_synonym="1110004G24Rik; Cgr11"
                     /note="hexamer: AATAAA"
     polyA_site      1257
                     /gene="Cgref1"
                     /gene_synonym="1110004G24Rik; Cgr11"
                     /note="major polyA site"
ORIGIN      
        1 agagttcacg aagccggagc cccagtcgcg cacagcgccg ccgcagcagc tccagtttcc
       61 agcaggatgt tccagtggct gatgcaagcg ttgatgctgc cactattgct gctcccttta
      121 ggtcgagctg ctcccaagga tggagttgca aggttggacc ctgaggtaca acagcagctc
      181 acacccaacc ctttccagcc aggccctgag cagctccgac atctgcagaa ttatctcaag
      241 ggactagaga agatggaaga ggatcctgag cacatggacc gggagcaagt cctgctttcg
      301 ctctttgctc ttcatgacta tgaccagaat ggacagctgg acggcctgga gctactgtcc
      361 atgctgacag cagctctggc ccctggagct gcacactttc ccatcaaccc ggtgatccta
      421 gtagtagact cggtgctcga gactcaggac ctggatggag acgggctcat gactcctgca
      481 gagctcatca acttcccaga agtccccaaa cacacagagt cccttccccc agctctccag
      541 gagccacaac ctgctggaag tcagccactt ttagccaaca gtccactgca gtcagaaacc
      601 cagcagtccc tggggactaa agaaattagg agccaggtag aggccaagag ggcgtccttg
      661 gagcctgaac aggaggctgg acatcagaca gagggaaaag tagataccct aagccctgaa
      721 gaggaggcta ggggacaggc agagtctgaa ggagatgttc caggtcccag agaaggtgct
      781 gaggaacagg tggagatcaa ggacaatgaa ggagaagcca aagaactgct ggtggaaaca
      841 ctggagagcc taaacactcc aaatgaggct gaggctcata gcatccaatt ggagaacgat
      901 gagatatgag cccgacggca taggctcaag cccctcagaa tctcagtgca gagcagaagc
      961 atggtgttga atatggtggg gttagagcca cctctgacat ggggacggtg gtgcaagcta
     1021 gtaaccccag aagcattgag agctccgggc tagcctaggc cacatagcaa gtttgaagcc
     1081 aggctgggct actgcgtaag accctgtctt gatgaggggg aaaaaagcac tcccatgtct
     1141 cctttctggc ttcagtggaa agtaggactt tctgtgcagc tcagggagac cataagctga
     1201 gaagcagctt tcaggccaca aacaaccaat aaagaacaga acaaatctgt ctccaca
//
