LOCUS       NM_001037711            5006 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus cingulin (Cgn), transcript variant 1, mRNA.
ACCESSION   NM_001037711 XM_131052 XM_905695
VERSION     NM_001037711.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5006)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5006)
  AUTHORS   Zhu,G.J., Huang,Y., Zhang,L., Yan,K., Qiu,C., He,Y., Liu,Q.,
            Zhu,C., Morin,M., Moreno-Pelayo,M.A., Zhu,M.S., Cao,X., Zhou,H.,
            Qian,X., Xu,Z., Chen,J., Gao,X. and Wan,G.
  TITLE     Cingulin regulates hair cell cuticular plate morphology and is
            required for hearing in human and mouse
  JOURNAL   EMBO Mol Med 15 (11), e17611 (2023)
   PUBMED   37691516
  REMARK    GeneRIF: Cingulin regulates hair cell cuticular plate morphology
            and is required for hearing in human and mouse.
REFERENCE   3  (bases 1 to 5006)
  AUTHORS   Zhuravleva,K., Goertz,O., Wolkart,G., Guillemot,L., Petzelbauer,P.,
            Lehnhardt,M., Schmidt,K., Citi,S. and Schossleitner,K.
  TITLE     The tight junction protein cingulin regulates the vascular response
            to burn injury in a mouse model
  JOURNAL   Microvasc Res 132, 104067 (2020)
   PUBMED   32877697
  REMARK    GeneRIF: The tight junction protein cingulin regulates the vascular
            response to burn injury in a mouse model.
REFERENCE   4  (bases 1 to 5006)
  AUTHORS   Yano,T., Torisawa,T., Oiwa,K. and Tsukita,S.
  TITLE     AMPK-dependent phosphorylation of cingulin reversibly regulates its
            binding to actin filaments and microtubules
  JOURNAL   Sci Rep 8 (1), 15550 (2018)
   PUBMED   30341325
  REMARK    GeneRIF: The authors found that cingulin's binding properties to
            actin filaments and microtubules was regulated by AMPK-dependent
            phosphorylation that changed its conformation and binding
            properties.
            Erratum:[Sci Rep. 2018 Dec 17;8(1):17991. doi:
            10.1038/s41598-018-37079-4.. PMID: 30559483]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5006)
  AUTHORS   Shahbazi,M.N., Scialdone,A., Skorupska,N., Weberling,A., Recher,G.,
            Zhu,M., Jedrusik,A., Devito,L.G., Noli,L., Macaulay,I.C.,
            Buecker,C., Khalaf,Y., Ilic,D., Voet,T., Marioni,J.C. and
            Zernicka-Goetz,M.
  TITLE     Pluripotent state transitions coordinate morphogenesis in mouse and
            human embryos
  JOURNAL   Nature 552 (7684), 239-243 (2017)
   PUBMED   29186120
  REMARK    Erratum:[Nature. 2018 Feb 28;555(7694):126. doi:
            10.1038/nature25995.. PMID: 29493594]
REFERENCE   6  (bases 1 to 5006)
  AUTHORS   Karim,S.A., Johnson,K.J., Griffiths,I.R. and Vouyiouklis,D.A.
  TITLE     A physical map of the genomic region on mouse chromosome 3
            containing the hindshaker (hsh) mutation
  JOURNAL   Genomics 83 (2), 225-230 (2004)
   PUBMED   14706451
REFERENCE   7  (bases 1 to 5006)
  AUTHORS   Sheth,B., Fontaine,J.J., Ponza,E., McCallum,A., Page,A., Citi,S.,
            Louvard,D., Zahraoui,A. and Fleming,T.P.
  TITLE     Differentiation of the epithelial apical junctional complex during
            mouse preimplantation development: a role for rab13 in the early
            maturation of the tight junction
  JOURNAL   Mech Dev 97 (1-2), 93-104 (2000)
   PUBMED   11025210
REFERENCE   8  (bases 1 to 5006)
  AUTHORS   Javed,Q., Fleming,T.P., Hay,M. and Citi,S.
  TITLE     Tight junction protein cingulin is expressed by maternal and
            embryonic genomes during early mouse development
  JOURNAL   Development 117 (3), 1145-1151 (1993)
   PUBMED   8325239
REFERENCE   9  (bases 1 to 5006)
  AUTHORS   Fleming,T.P., Hay,M., Javed,Q. and Citi,S.
  TITLE     Localisation of tight junction protein cingulin is temporally and
            spatially regulated during early mouse development
  JOURNAL   Development 117 (3), 1135-1144 (1993)
   PUBMED   8325238
REFERENCE   10 (bases 1 to 5006)
  AUTHORS   Fleming,T.P., Javed,Q. and Hay,M.
  TITLE     Epithelial differentiation and intercellular junction formation in
            the mouse early embryo
  JOURNAL   Dev Suppl, 105-112 (1992)
   PUBMED   1299356
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087903.27.
            
            On Apr 13, 2019 this sequence version replaced NM_001037711.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173148.1, BC042459.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC087903.27        107918-108024       c
            108-976             AC087903.27        100692-101560       c
            977-1077            AC087903.27        99920-100020        c
            1078-1147           AC087903.27        99742-99811         c
            1148-1243           AC087903.27        99535-99630         c
            1244-1371           AC087903.27        97650-97777         c
            1372-1504           AC087903.27        96441-96573         c
            1505-1717           AC087903.27        95744-95956         c
            1718-1866           AC087903.27        95038-95186         c
            1867-1999           AC087903.27        94669-94801         c
            2000-2209           AC087903.27        92034-92243         c
            2210-2416           AC087903.27        91503-91709         c
            2417-2674           AC087903.27        90701-90958         c
            2675-2845           AC087903.27        88658-88828         c
            2846-3007           AC087903.27        87037-87198         c
            3008-3097           AC087903.27        86000-86089         c
            3098-3181           AC087903.27        84726-84809         c
            3182-3300           AC087903.27        84520-84638         c
            3301-3409           AC087903.27        84097-84205         c
            3410-3573           AC087903.27        83312-83475         c
            3574-5006           AC087903.27        81607-83039         c
FEATURES             Location/Qualifiers
     source          1..5006
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..5006
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /note="cingulin"
                     /db_xref="GeneID:70737"
                     /db_xref="MGI:MGI:1927237"
     exon            1..107
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            108..976
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..3715
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="cingulin isoform 1"
                     /protein_id="NP_001032800.3"
                     /db_xref="CCDS:CCDS50984.2"
                     /db_xref="GeneID:70737"
                     /db_xref="MGI:MGI:1927237"
                     /translation="MADPRGPVDHGVQIRFITEPEGATEMGTLRRSGRRPARDARAST
                     YGVAVRVQGIAGQPFVVLNSGEKGTDSFGVQIKGGNNRGSPGALSSDSELPENPYSQV
                     KGRPATSRSSTSDEEPKDHLNGKLIRSQSQASLTGLAFMSPSNRSTSLLELAPKPTSS
                     INTIDTAPLSSVDSLINKFDSQKGGQVRGRTGRRTRTLPHEQRKRSQSLDSRLPRDTR
                     EEREHQSANHWTRGTKYDNHVDSSKNPSQKQSPFSSFSRSRQTQDWVLQSFEETRDPA
                     MVQFKSTPDLLRDQRETAPPGSADHVKATIYGILREGSSESEASVRRKVSLVLEQMQP
                     LGMVSPASTKALAGQAELTRKMEELQKKLDEEVKKRQKLEPSRVGLERQLEEKAEECH
                     RLQELLERRKGEVQQSSKELQNMKLLLGQEEGLRHGLEAQVKELQLKLKHSQSPDSGK
                     ESLLKDLLDTRELLEELLEGKQRVEEQLRLRERELTALKGALKEEVASHDQEVEHVRL
                     QYQRDTEQLRRSMQDATQDHAALEAERQKMSSLVRELQRELEETSEETGHWQSMFQKN
                     KEELRATKQELLQLRMEKEEMEEELGEKMEVLQRDLEQARASTRDTHQVEELKKELRR
                     TQGELKELQAEQQNQEVTGRHQNQVLEKQLAALREEADRGRELEQQNLQLQKTLQQLR
                     QDCEEASKAKVASETEAMVLGQRRATVETTLRETQEENDEFRRRILGLEQQLKEARGL
                     AEGGEAVEARLRDKVHRLEVEKQQLEEALNAAREEEGNLAAAKRALEVRLDEAQRGLA
                     RLGQEQQALNRALEEEGKQREALRRSKAELEEQKRLLNRTVDRLNKELEQIGDDSKLA
                     LQQLQAQMEDYKEKARKEVADAQRQAKDWASEAEKNSGGLSRLQDELQRLRQALQTSQ
                     AERDTARLDKELLAQRLQGLEQEAENKKRFQDDKARQLKSLEEKVSRLEAELDEEKNT
                     VELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQK
                     PSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERRVKELSIQIDDERQHVNDQK
                     DQLTLRVKALKRQVDEAEEEIERLDSLRKKAQRELEEQHEVNEQLQARIKSLEKDAWR
                     KASRSAAESALKQEGLSSDEEFDNVYDPSSIASLLTESNLQTSSC"
     exon            977..1077
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1147
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1243
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1371
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1504
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1717
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1866
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1999
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2209
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2416
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2674
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2845
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3007
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3097
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3181
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3300
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3409
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3573
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3574..5006
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4974..4979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /note="hexamer: ATTAAA"
     regulatory      4981..4986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4999
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /note="major polyA site"
     polyA_site      5006
                     /gene="Cgn"
                     /gene_synonym="6330408J11Rik"
                     /note="major polyA site"
ORIGIN      
        1 agctcagagc tcggaggggc tgggctgcag cagcgcgtgt agctcggctg gtcggagcgc
       61 gatcccctgc ggggtgtgtg aatccgggag cactgatctg gaccggggaa ccctcctaca
      121 tgtgaggaag gcacacatga tggctgatcc ccggggcccc gtagaccatg gagttcaaat
      181 tcgatttatt acagagccag agggtgctac tgaaatgggc acccttcgtc gtagtgggcg
      241 gcgccctgca agggatgcaa gagccagtac ctatggggtc gctgtgcgtg tgcagggcat
      301 cgccgggcaa ccgtttgtgg ttcttaacag tggagagaaa gggactgact cctttggggt
      361 ccagatcaaa gggggcaaca accgggggtc cccaggtgca ctgagctccg attcagagct
      421 ccccgaaaac ccctactctc aagtcaaggg acgccctgcc acttctcgga gcagcacatc
      481 tgatgaggag cccaaggacc acttgaatgg aaaactgatc cgttcccagt cgcaagcctc
      541 tctgaccggg cttgccttta tgagtcctag taataggagc accagcttgc tggaactagc
      601 ccctaaaccg acttcctcga ttaacaccat tgacactgcc cccttgtctt cagtggactc
      661 gctcatcaac aagtttgata gtcagaaggg ggggcaggtc cggggtcgca ctgggcgccg
      721 cacaaggaca cttccccacg aacagcgcaa gcggagccag agtctggaca gcaggctccc
      781 acgggataca cgtgaggaac gggagcacca gtccgctaac cactggaccc gcggcacaaa
      841 gtatgacaac catgtggaca gttcaaagaa cccatcgcag aagcagagcc cgttcagcag
      901 cttcagccgt tcgcgtcaga ctcaagactg ggtgcttcag agttttgagg agacacggga
      961 tccagccatg gtgcagttca aatcaactcc agaccttctc agagaccaga gagagacagc
     1021 gccaccaggc agtgcggacc atgtgaaggc caccatctat ggcatcctaa gggagggaag
     1081 ctcggagagt gaggcatctg tgaggaggaa agttagtttg gtgctggagc aaatgcagcc
     1141 tctggggatg gtttctcctg cttctaccaa ggccctggca ggacaggctg agcttacccg
     1201 aaaaatggag gaacttcaga agaagctgga tgaggaggtg aagaagcggc agaagctaga
     1261 accatccagg gttgggctgg agaggcagct ggaggagaag gctgaagagt gccaccgact
     1321 gcaggagttg ctggagagga gaaaggggga ggtccagcag agcagcaagg aacttcagaa
     1381 catgaagctc ctgctaggcc aggaagaagg actacggcat gggctggagg cccaggtgaa
     1441 ggagctacag cttaagctca agcatagcca gagtcccgat tctggaaagg aaagtctcct
     1501 aaaggacttg ttagacaccc gggaacttct agaagaactc ttagagggca aacaacgagt
     1561 agaggagcag ctcaggctga gggaacggga gctgacagcc ctgaaggggg ccctgaaaga
     1621 ggaggtggcc tcccacgacc aggaggtgga acatgtccgg ctgcagtacc agcgagacac
     1681 ggagcagctt cgccggagca tgcaagatgc gacccaggac catgctgcac tggaggctga
     1741 gaggcagaag atgtcttccc tcgtgcggga gctgcaaaga gagctagagg agacctctga
     1801 ggagacaggg cattggcaga gcatgttcca gaagaacaag gaagagctga gagccaccaa
     1861 gcaggaactg ctgcaactgc ggatggagaa ggaggagatg gaagaggaac ttggggagaa
     1921 gatggaggtc ttacagaggg acttagagca ggcccgagcc agtacaagag atactcacca
     1981 ggttgaggaa cttaaaaagg agcttcgacg cacccagggg gagcttaaag agcttcaggc
     2041 agagcagcag aaccaggagg tgactgggcg acaccagaac caggtgttag agaagcagct
     2101 ggcagcgctg agggaggagg ctgatcgagg ccgagagctg gagcagcaga acctccagct
     2161 acaaaagacc ctgcagcaac tgcggcagga ctgtgaagag gcttccaagg ctaaggtggc
     2221 atcagagaca gaggccatgg tgctggggca gcgtcgggca accgtggaaa ccacacttcg
     2281 ggagacacaa gaggaaaatg acgaattccg aaggcgcatc ctgggtctgg agcagcagtt
     2341 gaaggaggcc cgaggtctgg cggaaggtgg ggaagcggtg gaggcacggc ttcgggacaa
     2401 agtgcatcgg ctggaggtag agaaacagca gctggaagag gctttgaatg ctgcccggga
     2461 ggaggagggg aacctggcag cagccaagcg ggctctggag gtccggctag atgaggccca
     2521 gcgggggctg gcacgccttg ggcaggaaca gcaagcactg aaccgggccc tagaggaaga
     2581 ggggaagcag cgggaggctc tccggaggag caaggcagag ttggaggagc agaagcgttt
     2641 gctgaacagg actgtagacc gactcaacaa agagctggag cagattgggg atgactccaa
     2701 gctagccctg cagcagctcc aggctcagat ggaagattac aaggaaaagg cccggaagga
     2761 agtagctgat gcccagcgtc aggccaagga ttgggccagt gaggctgaaa agaattcagg
     2821 ggggctgagc cggcttcagg atgagctgca aaggctgcgg caagccctgc agacatccca
     2881 ggctgagcgg gacacagcca ggctggacaa agagctgctg gcccagcgac tgcagggtct
     2941 agagcaagag gctgagaaca agaaacgctt ccaggacgac aaggctcgac agctgaagag
     3001 cctagaggag aaagtctcgc ggctggaagc ggagttagat gaagaaaaga acactgtgga
     3061 actgttaaca gatcgggtga accgtggccg ggatcaggtg gatcaactga ggacagagct
     3121 catgcaggag agatctgctc gacaggactt ggagtgtgac aaaatctcct tggagagaca
     3181 gaacaaggat ttgaagaccc ggttggccag ttcagagggc ttccagaaac ccagcgctag
     3241 cctctcccag cttgagtccc agaatcagct gctgcaagag cggctgcaag ctgaagagag
     3301 agagaagaca gttctgcagt ccaccaatcg caaactagaa cggagggtta aggagctctc
     3361 catccagatt gatgatgaac ggcagcatgt caacgaccag aaggaccagc taaccctgag
     3421 ggtgaaggct ttgaagcggc aggtggatga agcagaagag gaaattgagc ggctggacag
     3481 cctgaggaag aaggcacagc gggaactgga ggaacagcat gaggtcaatg aacagctcca
     3541 agcccggatc aaatccttgg aaaaggatgc ctggcggaaa gcttcccgct cagctgctga
     3601 gtcagccctc aaacaagagg ggctgagctc tgatgaggag tttgacaacg tctacgaccc
     3661 ctcatccatt gcatcactgc ttactgagag caacctgcag actagctcat gttagctcag
     3721 gctctgctca ggatcccagc cagccctgct ctgctctgct ctgtcttgcc tgcttcagag
     3781 tctttttttt ttttttccta caagtgatcc aattcagact taagactggt acaggtcaga
     3841 gtgatggtga taaactttag caatgagcgg atgggtgcac ttgtcctttt cactggagga
     3901 gtgggtgttt attcctgctg agtcagtcct tcctatagga cctctccatc atcccttaca
     3961 gtgggactaa tggtcagaat atacactgac tgggactgtg aaggacagga agggatggat
     4021 attgccatgt atgtaaagct ttatttcttt aatatttaac catatggctc agggaaatac
     4081 ccaatgttgt tctgctccct ggatccccgc aactgttttc cctcccactc tggagcaggg
     4141 agggaacatt atgggtaatg gacatgcagg cgtggcgcta cccacttctc agatacttct
     4201 ttttgcacag acataggtcc ttgcatctct tcagttgcaa tatttttgtt ttcccccagt
     4261 cactgggtcc aggagatcgt gtgtctttct tttccatccc tgccttgctg ctttactctc
     4321 agtgccttac cagtgtgaga tggatgagga tgctgttctt gccttttata aacctgcaca
     4381 ttcatacctc tccaaagacc agcctttcct cattgggggc cctcagcctg tcctcctacc
     4441 ccagtgactg agcagctaca ggctgctctg ccaagcagcc cctgggagaa gggctttgat
     4501 acgcctggta aggtggtggg gactggttct gctcagggtt tccatcttcc ttgccctctg
     4561 tgactgagga tgctgccata aggtggttgt acctgggaac catggcaact gttgatacag
     4621 gttctaaagt ccaaacatct agtccctgtg gcctccttat ggcttctcag atgtgcccag
     4681 ttctgtggga accaacagat ccttgctttt ctcaagaagt gggccctgat tcagagcctc
     4741 gcctggggtt ggaagctgac tctcagtaga gatgggaagg ggtcctggag aatgtattcc
     4801 tcctttgagt tttggggtgt gccaagctct tgtgggtgaa ggtaatgggg atggttcgcc
     4861 tcttatctcc aaagtaagtt ctggtctcat caatgacttg taatttcatg atttaaaaga
     4921 agatattctg caaatcagat attttctccc aatccagcct tggtttattt taaattaaat
     4981 attaaaaatg gcatatctat atgaaa
//
