LOCUS       NM_009889                691 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus glycoprotein hormones, alpha subunit (Cga), mRNA.
ACCESSION   NM_009889
VERSION     NM_009889.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 691)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   2  (bases 1 to 691)
  AUTHORS   Huang,C., Zhao,S., Yang,Y., Guo,T., Ke,H., Mi,X., Qin,Y., Chen,Z.J.
            and Zhao,S.
  TITLE     TP63 gain-of-function mutations cause premature ovarian
            insufficiency by inducing oocyte apoptosis
  JOURNAL   J Clin Invest 133 (5), e162315 (2023)
   PUBMED   36856110
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 691)
  AUTHORS   Gonzalez-Meljem,J.M., Ivins,S., Andoniadou,C.L., Le Tissier,P.,
            Scambler,P. and Martinez-Barbera,J.P.
  TITLE     An expression and function analysis of the CXCR4/SDF-1 signalling
            axis during pituitary gland development
  JOURNAL   PLoS One 18 (2), e0280001 (2023)
   PUBMED   36800350
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 691)
  AUTHORS   Rupani,D.N., Thege,F.I., Chandra,V., Rajaei,H., Cowan,R.W.,
            Wormann,S.M., Le Roux,O., Malaney,P., Manning,S.L., Hashem,J.,
            Bailey-Lundberg,J., Rhim,A.D. and McAllister,F.
  TITLE     Adar1 deletion causes degeneration of the exocrine pancreas via
            Mavs-dependent interferon signaling
  JOURNAL   Development 150 (2) (2023)
   PUBMED   36458554
REFERENCE   5  (bases 1 to 691)
  AUTHORS   Laporte,E., De Vriendt,S., Hoekx,J. and Vankelecom,H.
  TITLE     Interleukin-6 is dispensable in pituitary normal development and
            homeostasis but needed for pituitary stem cell activation following
            local injury
  JOURNAL   Front Endocrinol (Lausanne) 13, 1092063 (2022)
   PUBMED   36619565
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 691)
  AUTHORS   Lin,C., Lin,S.C., Chang,C.P. and Rosenfeld,M.G.
  TITLE     Pit-1-dependent expression of the receptor for growth hormone
            releasing factor mediates pituitary cell growth
  JOURNAL   Nature 360 (6406), 765-768 (1992)
   PUBMED   1334535
REFERENCE   7  (bases 1 to 691)
  AUTHORS   Bahary,N., Pachter,J.E., Felman,R., Leibel,R.L., Albright,K.,
            Cram,S. and Friedman,J.M.
  TITLE     Molecular mapping of mouse chromosomes 4 and 6: use of a
            flow-sorted Robertsonian chromosome
  JOURNAL   Genomics 13 (3), 761-769 (1992)
   PUBMED   1639403
REFERENCE   8  (bases 1 to 691)
  AUTHORS   Schoderbek,W.E., Kim,K.E., Ridgway,E.C., Mellon,P.L. and
            Maurer,R.A.
  TITLE     Analysis of DNA sequences required for pituitary-specific
            expression of the glycoprotein hormone alpha-subunit gene
  JOURNAL   Mol Endocrinol 6 (6), 893-903 (1992)
   PUBMED   1379672
REFERENCE   9  (bases 1 to 691)
  AUTHORS   Horn,F., Windle,J.J., Barnhart,K.M. and Mellon,P.L.
  TITLE     Tissue-specific gene expression in the pituitary: the glycoprotein
            hormone alpha-subunit gene is regulated by a gonadotrope-specific
            protein
  JOURNAL   Mol Cell Biol 12 (5), 2143-2153 (1992)
   PUBMED   1373809
REFERENCE   10 (bases 1 to 691)
  AUTHORS   Cutting,G.R., Curristin,S., Zoghbi,H., O'Hara,B., Seldin,M.F. and
            Uhl,G.R.
  TITLE     Identification of a putative gamma-aminobutyric acid (GABA)
            receptor subunit rho2 cDNA and colocalization of the genes encoding
            rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and
            mouse chromosome 4
  JOURNAL   Genomics 12 (4), 801-806 (1992)
   PUBMED   1315307
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL929565.16.
            
            On Nov 17, 2006 this sequence version replaced NM_009889.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB232038.1, CJ048537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AL929565.16        10440-10522
            84-197              AL929565.16        20654-20767
            198-382             AL929565.16        21739-21923
            383-691             AL929565.16        23727-24035
FEATURES             Location/Qualifiers
     source          1..691
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 16.86 cM"
     gene            1..691
                     /gene="Cga"
                     /gene_synonym="aGSU; alpha-GSU; alphaGSU; alphaSU;
                     CG-alpha; FSHA; GPHA1; GPHalpha; HCG; LHA; Tsha"
                     /note="glycoprotein hormones, alpha subunit"
                     /db_xref="GeneID:12640"
                     /db_xref="MGI:MGI:88390"
     exon            1..83
                     /gene="Cga"
                     /gene_synonym="aGSU; alpha-GSU; alphaGSU; alphaSU;
                     CG-alpha; FSHA; GPHA1; GPHalpha; HCG; LHA; Tsha"
                     /inference="alignment:Splign:2.1.0"
     exon            84..197
                     /gene="Cga"
                     /gene_synonym="aGSU; alpha-GSU; alphaGSU; alphaSU;
                     CG-alpha; FSHA; GPHA1; GPHalpha; HCG; LHA; Tsha"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..460
                     /gene="Cga"
                     /gene_synonym="aGSU; alpha-GSU; alphaGSU; alphaSU;
                     CG-alpha; FSHA; GPHA1; GPHalpha; HCG; LHA; Tsha"
                     /note="glycoprotein hormones alpha chain; FSH-alpha;
                     LSH-alpha; TSH-alpha; lutropin alpha chain; follitropin
                     alpha chain; thyrotropin alpha chain; luteinizing hormone
                     alpha chain; thyroid-stimulating hormone alpha chain;
                     follicle-stimulating hormone alpha chain; anterior
                     pituitary glycoprotein hormones common subunit alpha"
                     /codon_start=1
                     /product="glycoprotein hormones alpha chain precursor"
                     /protein_id="NP_034019.1"
                     /db_xref="CCDS:CCDS18035.1"
                     /db_xref="GeneID:12640"
                     /db_xref="MGI:MGI:88390"
                     /translation="MDYYRKYAAVILVMLSMFLHILHSLPDGDFIIQGCPECKLKENK
                     YFSKLGAPIYQCMGCCFSRAYPTPARSKKTMLVPKNITSEATCCVAKAFTKATVMGNA
                     RVENHTECHCSTCYYHKS"
     exon            198..382
                     /gene="Cga"
                     /gene_synonym="aGSU; alpha-GSU; alphaGSU; alphaSU;
                     CG-alpha; FSHA; GPHA1; GPHalpha; HCG; LHA; Tsha"
                     /inference="alignment:Splign:2.1.0"
     exon            383..691
                     /gene="Cga"
                     /gene_synonym="aGSU; alpha-GSU; alphaGSU; alphaSU;
                     CG-alpha; FSHA; GPHA1; GPHalpha; HCG; LHA; Tsha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      665..670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cga"
                     /gene_synonym="aGSU; alpha-GSU; alphaGSU; alphaSU;
                     CG-alpha; FSHA; GPHA1; GPHalpha; HCG; LHA; Tsha"
                     /note="hexamer: AATAAA"
     polyA_site      687
                     /gene="Cga"
                     /gene_synonym="aGSU; alpha-GSU; alphaGSU; alphaSU;
                     CG-alpha; FSHA; GPHA1; GPHalpha; HCG; LHA; Tsha"
                     /note="major polyA site"
ORIGIN      
        1 gcaggcactg aaaaatccag agacattgtt cccctcagat cgacaatcac ctgcccagaa
       61 cacatccctc aaaaagtcca gagcttgcag aagagctatg gattactaca gaaaatatgc
      121 agctgtcatt ctggtcatgc tgtccatgtt cctgcatatt cttcattctc ttcctgatgg
      181 agactttatt attcagggtt gcccagaatg taaactaaag gaaaataaat acttctccaa
      241 gctaggagcc cccatctacc agtgtatggg ctgttgcttc tccagggcat atcccactcc
      301 cgccaggtcc aagaagacaa tgctggttcc aaagaatatt acctcggagg ccacatgctg
      361 tgtggccaaa gcatttacta aggccacagt aatgggaaat gccagagtgg agaatcatac
      421 ggagtgccac tgtagcactt gctactacca caagtcgtag cttctgagcg cgcagagggc
      481 tgtgctgacg gctgctgagc cgagccattc aatggcgctg tgtgtcacca cctcctccct
      541 accagacttc tgacgcgctt cagttacaca ctgcctcttt acggttacat cccttatact
      601 tcagtacaat ctgcagtctc ttctcgttag ggaaatatgt agtatttacc acggttccgt
      661 cagaaataaa gccttttaaa tcatcaatcc c
//
