LOCUS       NM_008823               1636 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus complement factor properdin (Cfp), mRNA.
ACCESSION   NM_008823
VERSION     NM_008823.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1636)
  AUTHORS   Liu,P.Y., Li,H.Q., Dong,M.Q., Gu,X.Y., Xu,S.Y., Xia,S.N., Bao,X.Y.,
            Xu,Y. and Cao,X.
  TITLE     Infiltrating myeloid cell-derived properdin markedly promotes
            microglia-mediated neuroinflammation after ischemic stroke
  JOURNAL   J Neuroinflammation 20 (1), 260 (2023)
   PUBMED   37951917
  REMARK    GeneRIF: Infiltrating myeloid cell-derived properdin markedly
            promotes microglia-mediated neuroinflammation after ischemic
            stroke.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1636)
  AUTHORS   Wu,Y., Huang,L., Sai,W., Chen,F., Liu,Y., Han,C., Barker,J.M.,
            Zwaini,Z.D., Lowe,M.P., Brunskill,N.J. and Yang,B.
  TITLE     HBSP improves kidney ischemia-reperfusion injury and promotes
            repair in properdin deficient mice via enhancing phagocytosis of
            tubular epithelial cells
  JOURNAL   Front Immunol 14, 1183768 (2023)
   PUBMED   37207230
  REMARK    GeneRIF: HBSP improves kidney ischemia-reperfusion injury and
            promotes repair in properdin deficient mice via enhancing
            phagocytosis of tubular epithelial cells.
            Erratum:[Front Immunol. 2023 Jun 29;14:1242436. doi:
            10.3389/fimmu.2023.1242436.. PMID: 37457728]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1636)
  AUTHORS   Linde,I.L., Prestwood,T.R., Qiu,J., Pilarowski,G., Linde,M.H.,
            Zhang,X., Shen,L., Reticker-Flynn,N.E., Chiu,D.K., Sheu,L.Y., Van
            Deursen,S., Tolentino,L.L., Song,W.C. and Engleman,E.G.
  TITLE     Neutrophil-activating therapy for the treatment of cancer
  JOURNAL   Cancer Cell 41 (2), 356-372 (2023)
   PUBMED   36706760
REFERENCE   4  (bases 1 to 1636)
  AUTHORS   Wu,Y., Zwaini,Z.D., Brunskill,N.J., Zhang,X., Wang,H., Chana,R.,
            Stover,C.M. and Yang,B.
  TITLE     Properdin Deficiency Impairs Phagocytosis and Enhances Injury at
            Kidney Repair Phase Post Ischemia-Reperfusion
  JOURNAL   Front Immunol 12, 697760 (2021)
   PUBMED   34552582
  REMARK    GeneRIF: Properdin Deficiency Impairs Phagocytosis and Enhances
            Injury at Kidney Repair Phase Post Ischemia-Reperfusion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1636)
  AUTHORS   Alaridhee,H., Alharbi,A., Saeed,Z., Thomas,R.C. and Stover,C.M.
  TITLE     Complement Properdin Determines Disease Activity in MRL/lpr Mice
  JOURNAL   Medicina (Kaunas) 56 (9), 430 (2020)
   PUBMED   32867176
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1636)
  AUTHORS   Laval,S.H. and Boyd,Y.
  TITLE     Novel sequences conserved on the human and mouse X chromosomes
  JOURNAL   Genomics 15 (3), 483-491 (1993)
   PUBMED   8468042
REFERENCE   7  (bases 1 to 1636)
  AUTHORS   Laval,S.H., Chen,Z.Y. and Boyd,Y.
  TITLE     The properdin structural locus (Pfc) lies close to the locus for
            tissue inhibitor of metallothionine proteases (Timp) on the mouse X
            chromosome
  JOURNAL   Genomics 10 (4), 1030-1034 (1991)
   PUBMED   1916808
REFERENCE   8  (bases 1 to 1636)
  AUTHORS   Evans,E.P., Burtenshaw,M.D., Laval,S.H., Goundis,D., Reid,K.B. and
            Boyd,Y.
  TITLE     Localization of the properdin factor complement locus Pfc to band
            A3 on the mouse X chromosome
  JOURNAL   Genet Res 56 (2-3), 153-155 (1990)
   PUBMED   2272504
REFERENCE   9  (bases 1 to 1636)
  AUTHORS   Goundis,D. and Reid,K.B.
  TITLE     Properdin, the terminal complement components, thrombospondin and
            the circumsporozoite protein of malaria parasites contain similar
            sequence motifs
  JOURNAL   Nature 335 (6185), 82-85 (1988)
   PUBMED   3045564
REFERENCE   10 (bases 1 to 1636)
  AUTHORS   Farrar,J.J., Howard,M., Fuller-Farrar,J. and Paul,W.E.
  TITLE     Biochemical and physicochemical characterization of mouse B cell
            growth factor: a lymphokine distinct from interleukin 2
  JOURNAL   J Immunol 131 (4), 1838-1842 (1983)
   PUBMED   6352806
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY347370.1, AK159291.1 and AL671853.7.
            
            On Aug 25, 2015 this sequence version replaced NM_008823.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154306.1, AK159291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BY347370.1         1-31
            32-1555             AK159291.1         2-1525
            1556-1636           AL671853.7         14239-14319         c
FEATURES             Location/Qualifiers
     source          1..1636
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 16.44 cM"
     gene            1..1636
                     /gene="Cfp"
                     /gene_synonym="BCFG; Pfc"
                     /note="complement factor properdin"
                     /db_xref="GeneID:18636"
                     /db_xref="MGI:MGI:97545"
     exon            1..165
                     /gene="Cfp"
                     /gene_synonym="BCFG; Pfc"
                     /inference="alignment:Splign:2.1.0"
     exon            166..316
                     /gene="Cfp"
                     /gene_synonym="BCFG; Pfc"
                     /inference="alignment:Splign:2.1.0"
     exon            317..492
                     /gene="Cfp"
                     /gene_synonym="BCFG; Pfc"
                     /inference="alignment:Splign:2.1.0"
     exon            493..663
                     /gene="Cfp"
                     /gene_synonym="BCFG; Pfc"
                     /inference="alignment:Splign:2.1.0"
     exon            664..855
                     /gene="Cfp"
                     /gene_synonym="BCFG; Pfc"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1029
                     /gene="Cfp"
                     /gene_synonym="BCFG; Pfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1218
                     /gene="Cfp"
                     /gene_synonym="BCFG; Pfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1330
                     /gene="Cfp"
                     /gene_synonym="BCFG; Pfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1636
                     /gene="Cfp"
                     /gene_synonym="BCFG; Pfc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1539..1544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfp"
                     /gene_synonym="BCFG; Pfc"
                     /note="hexamer: AATAAA"
     polyA_site      1558
                     /gene="Cfp"
                     /gene_synonym="BCFG; Pfc"
                     /note="major polyA site"
ORIGIN      
        1 tcccagttcc tcctgccctg ggttcctctt tctggagcag gtcagtccag acaaaaccaa
       61 ggcctcctct ctgtgaggag tgcagaaaca tagtgttcaa aatgcctgct gaaatgcaag
      121 cccctcagtg gctcctgctg ctactggtta tcctgccagc cacaggctca gaccctgtgc
      181 tctgcttcac ccagtatgag gagtcctctg gcaggtgcaa aggcctactt gggagagaca
      241 tcagggtaga agactgctgt ctcaacgctg cctatgcctt ccaggagcat gatggtggcc
      301 tctgtcaggc atgcaggtct ccacaatggt cagcatggtc cttatggggg ccctgctcag
      361 ttacatgttc tgaggggtcc cagctgcgac acaggcgctg tgtgggcaga ggtggtcagt
      421 gctctgagaa tgtggctcct ggaactcttg agtggcagct acaggcctgt gaggaccagc
      481 catgctgtcc agagatgggt ggctggtctg agtggggacc ctgggggcct tgctctgtca
      541 catgctccaa aggaacccag atccgtcaac gagtatgtga taatcctgct cctaagtgtg
      601 ggggccactg cccaggagag gcccagcaat cacaggcctg tgacacccag aagacctgcc
      661 ccacacatgg ggcctgggca tcctggggcc cctggagccc ctgctcagga tcctgccttg
      721 gtggtgctca agaacctaag gagacacgaa gccgctcatg ttctgcacca gcaccttcac
      781 accagccccc tgggaaaccc tgctcaggac cagcctatga gcataaggcc tgcagtggcc
      841 taccaccttg cccagtggct ggtggctggg ggccatggag ccctttgagc ccctgctctg
      901 tgacttgtgg cctgggccag accctagagc aacggacatg tgatcaccct gcaccccgtc
      961 atgggggccc cttttgtgct ggtgatgcca ctcggaacca aatgtgtaac aaagccgtac
     1021 cttgccctgt aaacggggag tgggaggcct ggggaaaatg gagtgactgc agccggctga
     1081 gaatgtccat caactgtgaa ggaaccccag gccagcagtc acgttcaagg agctgtggcg
     1141 gccgcaaatt taatgggaag ccatgtgctg gaaaactcca ggatattcga cactgctata
     1201 acatccataa ctgtatcatg aaaggttcat ggtcacagtg gagtacctgg agtctgtgca
     1261 caccaccatg tagtcccaac gccacccgtg tccgccagcg cctctgcaca cctttgctcc
     1321 ccaagtaccc gcctacagtt tcaatggttg aaggtcaggg tgagaagaat gttaccttct
     1381 gggggactcc acggccactg tgtgaagcgc tacaggggca gaagctggtg gtggaagaga
     1441 aacggtcatg tctacatgtg cctgtctgca aagacccaga agagaagaaa ccctaaaatc
     1501 ccttgcttcc attctgaccc cctgactttc tagaccacaa taaaccagcc tttctagact
     1561 ctttctaaga ttctgtaatg acgaaggggg aacctgcccc caatattgga agtggggcaa
     1621 tagaattttc tagagc
//
