LOCUS       NM_007688               2940 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cofilin 2, muscle (Cfl2), mRNA.
ACCESSION   NM_007688
VERSION     NM_007688.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2940)
  AUTHORS   Wang,K., Lin,Y., Shen,H., Yu,S. and Xu,J.
  TITLE     LncRNA TUG1 Exacerbates Myocardial Fibrosis in Diabetic
            Cardiomyopathy by Modulating the microRNA-145a-5p/Cfl2 Axis
  JOURNAL   J Cardiovasc Pharmacol 81 (3), 192-202 (2023)
   PUBMED   36450139
  REMARK    GeneRIF: LncRNA TUG1 Exacerbates Myocardial Fibrosis in Diabetic
            Cardiomyopathy by Modulating the microRNA-145a-5p/Cfl2 Axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2940)
  AUTHORS   Nguyen,M.T. and Lee,W.
  TITLE     Role of MiR-325-3p in the Regulation of CFL2 and Myogenic
            Differentiation of C2C12 Myoblasts
  JOURNAL   Cells 10 (10), 2725 (2021)
   PUBMED   34685705
  REMARK    GeneRIF: Role of MiR-325-3p in the Regulation of CFL2 and Myogenic
            Differentiation of C2C12 Myoblasts.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2940)
  AUTHORS   Nguyen,M.T., Min,K.H., Kim,D., Park,S.Y. and Lee,W.
  TITLE     CFL2 is an essential mediator for myogenic differentiation in C2C12
            myoblasts
  JOURNAL   Biochem Biophys Res Commun 533 (4), 710-716 (2020)
   PUBMED   33187645
  REMARK    GeneRIF: CFL2 is an essential mediator for myogenic differentiation
            in C2C12 myoblasts.
REFERENCE   4  (bases 1 to 2940)
  AUTHORS   Rosen,S.M., Joshi,M., Hitt,T., Beggs,A.H. and Agrawal,P.B.
  TITLE     Knockin mouse model of the human CFL2 p.A35T mutation results in a
            unique splicing defect and severe myopathy phenotype
  JOURNAL   Hum Mol Genet 29 (12), 1996-2003 (2020)
   PUBMED   32160286
  REMARK    GeneRIF: Knockin mouse model of the human CFL2 p.A35T mutation
            results in a unique splicing defect and severe myopathy phenotype.
REFERENCE   5  (bases 1 to 2940)
  AUTHORS   Tedeschi,A., Dupraz,S., Curcio,M., Laskowski,C.J., Schaffran,B.,
            Flynn,K.C., Santos,T.E., Stern,S., Hilton,B.J., Larson,M.J.E.,
            Gurniak,C.B., Witke,W. and Bradke,F.
  TITLE     ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in
            the Adult CNS
  JOURNAL   Neuron 103 (6), 1073-1085 (2019)
   PUBMED   31400829
  REMARK    GeneRIF: Actin depolymerizing factor (ADF)/cofilin controls actin
            turnover to sustain axon regeneration after spinal cord injury
            through its actin-severing activity. This pinpoints ADF/cofilin as
            a key regulator of axon growth competence, irrespective of
            developmental stage.
REFERENCE   6  (bases 1 to 2940)
  AUTHORS   Mohri,K., Takano-Ohmuro,H., Nakashima,H., Hayakawa,K., Endo,T.,
            Hanaoka,K. and Obinata,T.
  TITLE     Expression of cofilin isoforms during development of mouse striated
            muscles
  JOURNAL   J Muscle Res Cell Motil 21 (1), 49-57 (2000)
   PUBMED   10813634
REFERENCE   7  (bases 1 to 2940)
  AUTHORS   Takenaka,M., Imai,E., Kaneko,T., Ito,T., Moriyama,T., Yamauchi,A.,
            Hori,M., Kawamoto,S. and Okubo,K.
  TITLE     Isolation of genes identified in mouse renal proximal tubule by
            comparing different gene expression profiles
  JOURNAL   Kidney Int 53 (3), 562-572 (1998)
   PUBMED   9507200
REFERENCE   8  (bases 1 to 2940)
  AUTHORS   Gillett,G.T., Fox,M.F., Rowe,P.S., Casimir,C.M. and Povey,S.
  TITLE     Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13
            and muscle-type cofilin (CFL2) to chromosome 14
  JOURNAL   Ann Hum Genet 60 (3), 201-211 (1996)
   PUBMED   8800436
REFERENCE   9  (bases 1 to 2940)
  AUTHORS   Moon,A. and Drubin,D.G.
  TITLE     The ADF/cofilin proteins: stimulus-responsive modulators of actin
            dynamics
  JOURNAL   Mol Biol Cell 6 (11), 1423-1431 (1995)
   PUBMED   8589446
  REMARK    Review article
REFERENCE   10 (bases 1 to 2940)
  AUTHORS   Ono,S., Minami,N., Abe,H. and Obinata,T.
  TITLE     Characterization of a novel cofilin isoform that is predominantly
            expressed in mammalian skeletal muscle
  JOURNAL   J Biol Chem 269 (21), 15280-15286 (1994)
   PUBMED   8195165
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154732.3.
            
            On Mar 2, 2007 this sequence version replaced NM_007688.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L29468.1, AK004659.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC154732.3         99433-99566
            135-442             AC154732.3         100477-100784
            443-519             AC154732.3         100897-100973
            520-2940            AC154732.3         101073-103493
FEATURES             Location/Qualifiers
     source          1..2940
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 23.75 cM"
     gene            1..2940
                     /gene="Cfl2"
                     /note="cofilin 2, muscle"
                     /db_xref="GeneID:12632"
                     /db_xref="MGI:MGI:101763"
     exon            1..134
                     /gene="Cfl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..632
                     /gene="Cfl2"
                     /codon_start=1
                     /product="cofilin-2"
                     /protein_id="NP_031714.1"
                     /db_xref="CCDS:CCDS36448.1"
                     /db_xref="GeneID:12632"
                     /db_xref="MGI:MGI:101763"
                     /translation="MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDK
                     RQIIVEEAKQILVGDIGDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFI
                     FWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGSVVVS
                     LEGKPL"
     exon            135..442
                     /gene="Cfl2"
                     /inference="alignment:Splign:2.1.0"
     exon            443..519
                     /gene="Cfl2"
                     /inference="alignment:Splign:2.1.0"
     exon            520..2940
                     /gene="Cfl2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1441..1446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfl2"
                     /note="hexamer: AATAAA"
     polyA_site      1461
                     /gene="Cfl2"
                     /note="major polyA site"
ORIGIN      
        1 cgcccggctg cagctcccgg cgtgccctgc actctctgct gcccgccgcc gacccctcct
       61 tcttctcgtc ccagtgccac cgagccggag tccgagccac cgccgccgca gccacttcag
      121 ccgcgggcac tatggcatct ggagttacag tgaatgatga agtcatcaaa gtttttaatg
      181 atatgaaagt aagaaaatct tctacacagg aggagatcaa aaaaagaaag aaagcagttc
      241 tcttctgttt gagcgatgac aaaagacaaa taattgtaga ggaagccaag cagatcttgg
      301 tgggtgacat tggtgacact gtagaggacc cctacacatc ttttgtgaag ttgttgcctc
      361 tgaatgattg ccgatatgct ttgtacgatg ccacgtacga aacaaaagag tctaagaaag
      421 aagacctagt atttatattc tgggctcctg aaagtgcacc gttaaaaagc aagatgattt
      481 atgctagctc taaagatgcc attaaaaaga aatttacagg tattaaacat gagtggcaag
      541 taaatggctt ggacgatatt aaggaccgct cgacgctggg agagaaactg gggggcagtg
      601 ttgtagtttc ccttgaagga aagccactat aaaataatag ccaagtgcca tttgatctta
      661 aggggcttac acgtatctct ccagctcagt ccactggaat tgtattaggt tttgtttttt
      721 tttgtttatt cccttttcac tggtcccgtt cgtgaatgag tgaatataag aagcctgtca
      781 gtattgccat gagactgttt catatggtta cttttctgta ttcccaagga atgccttcct
      841 gtcttatttt agccaaaaca aactggttcc atgccttcct tgcagtgaac gttacaatgg
      901 atgtggttgt caatgtgaat agcttagagt actacaaagg gtaagctaac tgaatgcctt
      961 gaaaatatta tccactggtc ggtcatatgg gagacttgtt tcagtattat ttatagttgc
     1021 acttgattac cgttctctga ggcactggag ccttcataca cctcacctgc cttggcaagc
     1081 ctatttttgt gacctggcag cacagattta acactattcg ttaaaagcac ttttttttta
     1141 atgcgtttaa tcccttataa agaatgccaa ttaagtttta ttacctgtca tcaatttatc
     1201 ctagtatctc agtgttcatt cttcttgcct tcatattttt ttcaaagaaa cagctgtgct
     1261 aatgtctttg gtttcccgat gagtgtacac tactgtataa tttatgttta ccatatgagt
     1321 cttgaaacac tacagatatt ttgaatatca gtcatgatgg caatttctgt ataaaagagc
     1381 cttaaatgga acattgtttt gagatcaaac tccctaccct cacaaaagtg gccacgttgc
     1441 aataaaaatt gtggcagatt acagaatgtt gccttgtttt ccttggaaat tttgcaaatt
     1501 gttatgtgaa attttagggt aacggtgatt aagctctgca ctggtatttg gaattttttt
     1561 tcctttaatc tttggtttaa aaacatctta aaatcactta tatacaatca ttaaaagagt
     1621 ggtaatttta taaatgctta tttatgttat aaaatggaga tcagaaaaaa attctttttg
     1681 cactttggcc tatccagtat cttatttatt ctctagataa gctaggatat taatccagag
     1741 ttacattact gagaattgag tagtataagt aggatgtttt tattacttgg tcataatgaa
     1801 aataatttgt aaaatgtcat tcgaaggtta atgatgattg tgatgtttag gaatgtttgt
     1861 ctcagccaca gttccttcat agcttttcca aaatgaattg ggaaaaaaaa atcgtatagc
     1921 agtcttaaag cttagtaatg gaacttggct gtggcccaga gctttctcct tatagagaat
     1981 ttgatctgct ccgtgtgcgc tctctgctat tagccggagc tatttatggc aaacacatgc
     2041 ttttgtatct tgtcatagtc atccacagat ggcaaaactg gacttgattc tactggcatg
     2101 taagacaggc gtgctagtga gcagtcgtgt gtggctctgg actctgaccc cagagctctg
     2161 aagaatgctc ttatcagaag ataggaaatg aaaatatcct tttttaaaat atgtggaagt
     2221 aatttgggta taattagttt ttttctacct tttggaaagt tgtttttttg ttgttttttt
     2281 ttttttccca gatgagaaca ttaacatagt ggttaaatgt ctaggcttcc atttaaaact
     2341 acacaaatga cttgggatct ttttagcact aaggaatttg atttcagcct tccagctgtt
     2401 gctgtgagtt gttccagacc tttctgtggc tttttggtaa ggctgcttag aagcatgaga
     2461 agcatgagaa tggtaatgtg tgctaaacct atgtttaacc aatctttgca ccaaaggact
     2521 ttttcaccaa tttattttgt tattcttcca aatattaagt gatttctaaa aggtaaaggg
     2581 tgaccttttg tttttatatc taatttctca atttctttat atgcattttt agaataattt
     2641 gagagattaa atgctgcttg aaactattat actttgagtt ttagattggc caaatacatt
     2701 aatgtagtta aattcatctt taaagtacac atatgtgcct agagccaaaa aataataatg
     2761 atttaattta tgaccttatg ttgagactaa tttcacatct tattttgcag tcatttacag
     2821 tgaaacaatg ttccagctag ctttaaaagc tatacggtgc taattagtaa aatattgagg
     2881 gcaatatttt actgctagct tgcaaaatta taagtgtttt aaaaataaaa tacatgaaaa
//
