LOCUS       NM_001409673            2066 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus complement component factor i (Cfi), transcript
            variant 3, mRNA.
ACCESSION   NM_001409673
VERSION     NM_001409673.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2066)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2066)
  AUTHORS   Song,H., Zhang,M., Li,X., Xu,F., Zhang,D., Zhu,X., Zhang,J.,
            Qin,W., Shi,S. and Wen,J.
  TITLE     Generation and Characterization of Mouse Models of C3
            Glomerulonephritis With CFI D288G and P467S Mutations
  JOURNAL   Front Physiol 12, 649801 (2021)
   PUBMED   34149444
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2066)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 2066)
  AUTHORS   Baudino,L., Sardini,A., Ruseva,M.M., Fossati-Jimack,L., Cook,H.T.,
            Scott,D., Simpson,E. and Botto,M.
  TITLE     C3 opsonization regulates endocytic handling of apoptotic cells
            resulting in enhanced T-cell responses to cargo-derived antigens
  JOURNAL   Proc Natl Acad Sci U S A 111 (4), 1503-1508 (2014)
   PUBMED   24474777
REFERENCE   5  (bases 1 to 2066)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2066)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   7  (bases 1 to 2066)
  AUTHORS   Nakao,M., Hisamatsu,S., Nakahara,M., Kato,Y., Smith,S.L. and
            Yano,T.
  TITLE     Molecular cloning of the complement regulatory factor I isotypes
            from the common carp (Cyprinus carpio)
  JOURNAL   Immunogenetics 54 (11), 801-806 (2003)
   PUBMED   12618913
REFERENCE   8  (bases 1 to 2066)
  AUTHORS   Schlaf,G., Rothermel,E., Oppermann,M., Schieferdecker,H.L.,
            Jungermann,K. and Gotze,O.
  TITLE     Rat complement factor I: molecular cloning, sequencing and
            expression in tissues and isolated cells
  JOURNAL   Immunology 98 (3), 464-474 (1999)
   PUBMED   10583609
REFERENCE   9  (bases 1 to 2066)
  AUTHORS   Yun,Y.S., Goldberger,G. and Minta,J.O.
  TITLE     Cloning and characterization of the non-catalytic heavy chain of
            mouse complement factor I gene: structure comparison with the human
            homologue
  JOURNAL   Biochem Mol Biol Int 47 (3), 493-500 (1999)
   PUBMED   10204086
REFERENCE   10 (bases 1 to 2066)
  AUTHORS   Minta,J.O., Wong,M.J., Kozak,C.A., Kunnath-Muglia,L.M. and
            Goldberger,G.
  TITLE     cDNA cloning, sequencing and chromosomal assignment of the gene for
            mouse complement factor I (C3b/C4b inactivator): identification of
            a species specific divergent segment in factor I
  JOURNAL   Mol Immunol 33 (1), 101-112 (1996)
   PUBMED   8604219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111097.10.
            
            Summary: This gene encodes a serine protease that plays an
            important role in the classical and alternative complement pathways
            where it cleaves C4b and C3b components of C3 and C5 convertases.
            The encoded preproprotein undergoes proteolytic processing to
            generate an active, disulfide-linked heterodimeric enzyme comprised
            of heavy and light chains. [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189682.112984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC111097.10        57558-57641         c
            85-364              AC111097.10        45589-45868         c
            365-518             AC111097.10        43577-43730         c
            519-700             AC111097.10        39283-39464         c
            701-814             AC111097.10        35956-36069         c
            815-925             AC111097.10        35601-35711         c
            926-961             AC111097.10        33184-33219         c
            962-988             AC111097.10        32432-32458         c
            989-1009            AC111097.10        32274-32294         c
            1010-1066           AC111097.10        29027-29083         c
            1067-1170           AC111097.10        26114-26217         c
            1171-1274           AC111097.10        25840-25943         c
            1275-1552           AC111097.10        21306-21583         c
            1553-1657           AC111097.10        20034-20138         c
            1658-2066           AC111097.10        19095-19503         c
FEATURES             Location/Qualifiers
     source          1..2066
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 59.21 cM"
     gene            1..2066
                     /gene="Cfi"
                     /note="complement component factor i"
                     /db_xref="GeneID:12630"
                     /db_xref="MGI:MGI:105937"
     exon            1..84
                     /gene="Cfi"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1875
                     /gene="Cfi"
                     /EC_number="3.4.21.45"
                     /note="isoform 3 preproprotein is encoded by transcript
                     variant 3; complement factor I; C3B/C4B inactivator"
                     /codon_start=1
                     /product="complement factor I isoform 3 preproprotein"
                     /protein_id="NP_001396602.1"
                     /db_xref="GeneID:12630"
                     /db_xref="MGI:MGI:105937"
                     /translation="MKLAHLSLFLLALHLSSSRSPSASDLPQEELVDQKCLLQKYTHR
                     SCNKVFCQPWQRCIEGTCICKLPYQCPRAGTPVCAMNGRSYPTYCHQKSFECLHPEIK
                     FSHNGTCAAEGKFNVSLIYGRTKTEGLVQVKLVDQDERMFICKNSWSMAEANVACVDL
                     GFPLGVRDIQGSFNISGNLHINDTECLHVHCRGVETSLAECAFTKRRTELSNGLAGVV
                     CYKQDADFPTSLSFQCVNGKHIPQEKACNGVNDCGDQSDELCCKGCRGNASLCKSGVC
                     IPDQYKCNGEVDCITGEDESRCEERKKGKGYKKENEDRQQNIPKGLARSAQGEAEIET
                     EETEMLTPGMDNERKRIKSLLPKLSCGVKRNTHTRRKRVIGGKPANVGDYPWQVAIKD
                     GQRITCGGIYIGGCWILTAAHCVRPSRAHSYQVWTALLDWLKPNSQLGIQTVKRVIVH
                     EKYNGATFQNDIALIEMKMHTGKKECELPNSVPACVPWSPYLFQPNDRCIISGWGRGK
                     DNQKVYSLRWGEVDLIGNCSQFYPDRYYEKEMQCAGTRDGSIDACKGDSGGPLVCEDI
                     NNVTYVWGIVSWGENCGKPEFPGVYTRVANYFDWISYHVGRSLVSQHNV"
     exon            85..364
                     /gene="Cfi"
                     /inference="alignment:Splign:2.1.0"
     exon            365..518
                     /gene="Cfi"
                     /inference="alignment:Splign:2.1.0"
     exon            519..700
                     /gene="Cfi"
                     /inference="alignment:Splign:2.1.0"
     exon            701..814
                     /gene="Cfi"
                     /inference="alignment:Splign:2.1.0"
     exon            815..925
                     /gene="Cfi"
                     /inference="alignment:Splign:2.1.0"
     exon            926..961
                     /gene="Cfi"
                     /inference="alignment:Splign:2.1.0"
     exon            962..988
                     /gene="Cfi"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1009
                     /gene="Cfi"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1066
                     /gene="Cfi"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1170
                     /gene="Cfi"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1274
                     /gene="Cfi"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1552
                     /gene="Cfi"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1657
                     /gene="Cfi"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..2066
                     /gene="Cfi"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2044..2049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfi"
                     /note="hexamer: AATAAA"
     polyA_site      2066
                     /gene="Cfi"
                     /note="major polyA site"
ORIGIN      
        1 ggagacttgg ccccgcactc ctccggcatg aagctcgctc atctcagtct ctttctcttg
       61 gctctccact tgagttcttc caggtccccg tcagcatcag atctgcctca ggaggagctg
      121 gtcgatcaga aatgcttact gcagaaatac acgcatcgct cctgtaacaa ggtcttctgc
      181 cagccgtggc agagatgtat cgaaggcacc tgtatctgca aactccccta ccagtgccca
      241 agggctggca ccccagtgtg tgccatgaat ggaaggagct acccgacata ctgtcaccag
      301 aagagtttcg aatgtcttca cccagagatc aagttttcac ataatggaac gtgcgcagct
      361 gaaggaaagt ttaatgtttc cttaatttat gggagaacaa aaacagaggg acttgttcaa
      421 gtcaaacttg tggaccaaga tgagagaatg ttcatatgta aaaacagctg gagcatggcg
      481 gaggccaacg tggcctgcgt cgaccttgga tttccactgg gtgttcgtga catacaagga
      541 agttttaata tatctggaaa tctccatata aacgacactg aatgcctgca tgtacattgc
      601 cggggagtag agaccagttt ggcggagtgt gcctttacga agaggagaac tgagttgtcc
      661 aatggcttgg cgggggtagt gtgttacaag caggatgcag atttcccaac gagtctgtcc
      721 ttccagtgtg tgaatgggaa gcacattcct caggagaaag cctgcaacgg tgtcaatgac
      781 tgtggagacc aaagcgatga gctgtgttgc aaaggttgcc gaggtaacgc ttccctttgt
      841 aagtcgggag tttgcattcc agaccaatac aagtgtaatg gtgaggtgga ctgcatcact
      901 ggtgaagatg agagccgttg tgaagagagg aagaaaggaa aaggttacaa gaaggagaat
      961 gaagaccgac agcagaacat tccaaaaggc cttgcacggt cagctcaagg agaagctgaa
     1021 attgaaactg aagaaacaga aatgttgact cctggtatgg acaatgaaag aaaacggata
     1081 aagtccttat tacctaaact ctcctgtgga gtcaaaagaa acactcacac tcgcaggaaa
     1141 cgagtgatcg gagggaagcc agcgaatgtg ggagactacc catggcaggt ggcaattaag
     1201 gatggccaaa gaatcacctg tggtggcatt tatatcggtg gctgttggat tctgactgct
     1261 gcgcactgtg tcagacccag tagagctcac agttaccaag tctggacggc tttattagac
     1321 tggctaaaac ctaactctca gttgggaatt caaacggtga agagagttat tgttcacgag
     1381 aaatataatg gagccacctt ccaaaatgac atagctttga ttgaaatgaa aatgcacacg
     1441 ggcaagaaag aatgtgaact ccccaattcc gtccctgcct gcgtcccgtg gtctccatat
     1501 ctgttccaac cgaatgacag atgtatcatc tctggatggg gtcgagggaa agataaccaa
     1561 aaagtctact cactcaggtg gggcgaagtt gatctaatag gcaactgctc tcagttttac
     1621 ccagatcgct actatgagaa agagatgcag tgcgcaggta cgcgtgatgg gtccattgat
     1681 gcctgcaaag gagactccgg aggccccttg gtctgtgagg atatcaacaa tgtcacttac
     1741 gtttggggca ttgtgagctg gggagaaaat tgtgggaagc ccgagttccc aggtgtttac
     1801 accagagtgg ccaattattt tgattggatt agctatcacg taggaaggtc tcttgtttct
     1861 caacacaatg tctgaagcta tgacctcctt ctttctacat ttattctttt aggagttaca
     1921 ttttaattga aatgaaactg tatagttagt tctcctcaga gctggcaaga agcaactcct
     1981 actggctagt cctaaagttt cttccaagtt tatgctgttt tagaattctg ccatataatc
     2041 tacaataaat attccggcta agcata
//
