LOCUS       NM_015780               1732 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus complement factor H-related 1 (Cfhr1), mRNA.
ACCESSION   NM_015780
VERSION     NM_015780.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1732)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1732)
  AUTHORS   Martin Merinero,H., Subias,M., Pereda,A., Gomez-Rubio,E., Juana
            Lopez,L., Fernandez,C., Goicoechea de Jorge,E.,
            Martin-Santamaria,S., Canada,F.J. and Rodriguez de Cordoba,S.
  TITLE     Molecular bases for the association of FHR-1 with atypical
            hemolytic uremic syndrome and other diseases
  JOURNAL   Blood 137 (25), 3484-3494 (2021)
   PUBMED   33651882
  REMARK    GeneRIF: Molecular bases for the association of FHR-1 with atypical
            hemolytic uremic syndrome and other diseases.
REFERENCE   3  (bases 1 to 1732)
  AUTHORS   Li,X., Hao,Z., Liu,X. and Li,W.
  TITLE     Deficiency of Mouse FHR-1 Homolog, FHR-E, Accelerates Sepsis, and
            Acute Kidney Injury Through Enhancing the LPS-Induced Alternative
            Complement Pathway
  JOURNAL   Front Immunol 11, 1123 (2020)
   PUBMED   32636836
  REMARK    GeneRIF: Deficiency of Mouse FHR-1 Homolog, FHR-E, Accelerates
            Sepsis, and Acute Kidney Injury Through Enhancing the LPS-Induced
            Alternative Complement Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1732)
  AUTHORS   Vik,D.P., Munoz-Canoves,P., Kozono,H., Martin,L.G., Tack,B.F. and
            Chaplin,D.D.
  TITLE     Identification and sequence analysis of four complement factor
            H-related transcripts in mouse liver
  JOURNAL   J Biol Chem 265 (6), 3193-3201 (1990)
   PUBMED   1689298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M29008.1, BC111870.1 and AI451168.1.
            
            On May 1, 2009 this sequence version replaced NM_015780.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M29008.1, BC111870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1251              M29008.1           1-1251
            1252-1579           BC111870.1         1235-1562
            1580-1732           AI451168.1         1-153               c
FEATURES             Location/Qualifiers
     source          1..1732
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 61.62 cM"
     gene            1..1732
                     /gene="Cfhr1"
                     /gene_synonym="Cfhl1; CFHRB"
                     /note="complement factor H-related 1"
                     /db_xref="GeneID:50702"
                     /db_xref="MGI:MGI:2138169"
     exon            1..137
                     /gene="Cfhr1"
                     /gene_synonym="Cfhl1; CFHRB"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1096
                     /gene="Cfhr1"
                     /gene_synonym="Cfhl1; CFHRB"
                     /note="complement component factor h-like 1; complement
                     factor H-related protein"
                     /codon_start=1
                     /product="complement factor H-related 1 precursor"
                     /protein_id="NP_056595.1"
                     /db_xref="CCDS:CCDS15337.1"
                     /db_xref="GeneID:50702"
                     /db_xref="MGI:MGI:2138169"
                     /translation="MGFCRLLLLAIVLLTSWFSTAKGEVSLCDFPKIRHGILYDEKKN
                     EPFSSVLSGKILYYSCEYNFASPSNSFWTRITCTESGWSPTPKCLRLCFFPFVENGNS
                     TSSGQTHVEGDIVQVVCNQGYSLQNNQSTITCAEEGWSITPKCISTNPTGKCGPPPPI
                     DNGDITSLSLPVYASLSSVEYQCQKYYLLKGNKTITCRNGKWSEPPTCIYPTGKCGPP
                     PPIDNGDITSLSLLEYEPLSSVEYQCQNYYVLKGKKTITCRNGKWSEPPTCLSACVIS
                     EAIMERHNILLRWRQSEKVYIQSGEDIEFGCKPRYKRAKGSLPFRTQCINGHINYPTC
                     MLNHNTFIH"
     exon            138..332
                     /gene="Cfhr1"
                     /gene_synonym="Cfhl1; CFHRB"
                     /inference="alignment:Splign:2.1.0"
     exon            333..509
                     /gene="Cfhr1"
                     /gene_synonym="Cfhl1; CFHRB"
                     /inference="alignment:Splign:2.1.0"
     exon            510..692
                     /gene="Cfhr1"
                     /gene_synonym="Cfhl1; CFHRB"
                     /inference="alignment:Splign:2.1.0"
     exon            693..875
                     /gene="Cfhr1"
                     /gene_synonym="Cfhl1; CFHRB"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1732
                     /gene="Cfhr1"
                     /gene_synonym="Cfhl1; CFHRB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagtttta acaacagggt tcccagaagc accaccagga ttggagtgct ctaggcttta
       61 gaagatgggg ttctgtcgcc tgttgctctt agctattgtt ctcctaacct catggttctc
      121 tactgccaaa ggtgaagtga gcctttgtga ttttccaaaa ataagacatg gaatactata
      181 tgatgaaaag aaaaatgagc ccttttcctc tgttcttagt gggaagattt tatactactc
      241 ctgtgaatat aattttgcat ctccatcaaa ttccttctgg actcgcatca cttgcacaga
      301 atcaggatgg tcaccaactc cgaagtgtct caggctatgc ttctttcctt ttgtggaaaa
      361 tggtaattct acatcttcag gtcaaaccca tgtagaaggt gacattgtac aagtggtctg
      421 caatcaaggc tacagccttc agaataatca gagcaccatc acctgtgctg aagagggctg
      481 gtccattacc cccaaatgca tttccaccaa tccaacaggg aaatgtgggc cccctccacc
      541 tattgacaat ggagacatca cctccttgtc gttaccagta tatgcatcat tatcatcagt
      601 tgaatatcag tgccagaagt attatctact taaaggaaat aagacaataa catgtagaaa
      661 tggaaagtgg tctgagccac caacctgtat atatccaaca gggaaatgtg ggccccctcc
      721 acctattgac aatggagaca tcacctcctt gtcattacta gaatatgaac cattatcatc
      781 agttgaatat cagtgccaga actattatgt acttaaggga aagaagacaa taacatgtag
      841 aaatggaaag tggtctgagc caccaacctg tttatctgca tgtgtaatat cagaagccat
      901 tatggaaaga cataacatac ttctcagatg gagacaaagc gaaaaggttt atattcagtc
      961 aggagaggat attgagtttg gatgtaaacc tagatataaa agagcaaaag gatcactgcc
     1021 atttcgtaca cagtgcatta atggtcacat caattatccc acttgtatgt taaatcacaa
     1081 tacgtttatt cattgatttt attgtttgta cgtttgggtt ttttatttgt ttggttgttt
     1141 gtttgcttgt ttttgttttt caagacaggg tttctctgtg tagccctgga actcactctg
     1201 tagatcacgc tggcctcaaa ctcagaaatc ggcctgactt ttcctcccaa gtgctgggat
     1261 taaaggcgtg caccaacact gcctgctgat tttattgctt agaaatgcac atgaatatta
     1321 ctgctacagt ttcaacttcc atttgaagta tcaactcatt tcttctcata aatataaact
     1381 ttttagttat atggtgatca atttgtaact ttaaagacaa ttgccaaaat gcaaaagcag
     1441 taatacaaaa ctcctaatcc aaaatatgat atgtccaagg acaaactatg tcaaacaaga
     1501 aaatttgatg taagtttttc agcattgttt ttctattcag aacttcctca gattttcctg
     1561 gatacctttt gatgtaacgt tttgatttat aatgaatgaa cgatatattg actcattctt
     1621 caaattagta ttatttctga atcatgtaac aaccaaacta tcatatatta tagtactaat
     1681 gcatataatt aaaaactatc taatactttc atatcaataa aaaaatctaa gg
//
