LOCUS       NM_009888               4365 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus complement component factor h (Cfh), mRNA.
ACCESSION   NM_009888 XM_916271 XM_924198
VERSION     NM_009888.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4365)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4365)
  AUTHORS   Qiu,C., Martin,B.K., Welsh,I.C., Daza,R.M., Le,T.M., Huang,X.,
            Nichols,E.K., Taylor,M.L., Fulton,O., O'Day,D.R., Gomes,A.R.,
            Ilcisin,S., Srivatsan,S., Deng,X., Disteche,C.M., Noble,W.S.,
            Hamazaki,N., Moens,C.B., Kimelman,D., Cao,J., Schier,A.F.,
            Spielmann,M., Murray,S.A., Trapnell,C. and Shendure,J.
  TITLE     A single-cell time-lapse of mouse prenatal development from
            gastrula to birth
  JOURNAL   Nature 626 (8001), 1084-1093 (2024)
   PUBMED   38355799
REFERENCE   3  (bases 1 to 4365)
  AUTHORS   Nielsen,M.K., Subhi,Y., Falk,M., Singh,A., Sorensen,T.L.,
            Nissen,M.H. and Faber,C.
  TITLE     Complement factor H Y402H polymorphism results in diminishing CD4+
            T cells and increasing C-reactive protein in plasma
  JOURNAL   Sci Rep 13 (1), 19414 (2023)
   PUBMED   37940659
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4365)
  AUTHORS   Kiss,M.G., Papac-Milicevic,N., Porsch,F., Tsiantoulas,D.,
            Hendrikx,T., Takaoka,M., Dinh,H.Q., Narzt,M.S., Goderle,L.,
            Ozsvar-Kozma,M., Schuster,M., Fortelny,N., Hladik,A., Knapp,S.,
            Gruber,F., Pickering,M.C., Bock,C., Swirski,F.K., Ley,K.,
            Zernecke,A., Cochain,C., Kemper,C., Mallat,Z. and Binder,C.J.
  TITLE     Cell-autonomous regulation of complement C3 by factor H limits
            macrophage efferocytosis and exacerbates atherosclerosis
  JOURNAL   Immunity 56 (8), 1809-1824 (2023)
   PUBMED   37499656
  REMARK    GeneRIF: Cell-autonomous regulation of complement C3 by factor H
            limits macrophage efferocytosis and exacerbates atherosclerosis.
REFERENCE   5  (bases 1 to 4365)
  AUTHORS   Grigsby,D., Klingeborn,M., Kelly,U., Chew,L.A., Asokan,A.,
            Devlin,G., Smith,S., Keyes,L., Timmers,A., Scaria,A. and Bowes
            Rickman,C.
  TITLE     AAV Gene Augmentation of Truncated Complement Factor H
            Differentially Rescues Ocular Complement Dysregulation in a Mouse
            Model
  JOURNAL   Invest Ophthalmol Vis Sci 64 (10), 25 (2023)
   PUBMED   37471073
REFERENCE   6  (bases 1 to 4365)
  AUTHORS   Morita,T., Kubota,H., Murata,K., Nozaki,M., Delarbre,C.,
            Willison,K., Satta,Y., Sakaizumi,M., Takahata,N., Gachelin,G. et
            al.
  TITLE     Evolution of the mouse t haplotype: recent and worldwide
            introgression to Mus musculus
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6851-6855 (1992)
   PUBMED   1495973
REFERENCE   7  (bases 1 to 4365)
  AUTHORS   Matsuda,Y., Harada,Y.N., Natsuume-Sakai,S., Lee,K., Shiomi,T. and
            Chapman,V.M.
  TITLE     Location of the mouse complement factor H gene (cfh) by FISH
            analysis and replication R-banding
  JOURNAL   Cytogenet Cell Genet 61 (4), 282-285 (1992)
   PUBMED   1486806
REFERENCE   8  (bases 1 to 4365)
  AUTHORS   Frankel,W.N., Lee,B.K., Stoye,J.P., Coffin,J.M. and Eicher,E.M.
  TITLE     Characterization of the endogenous nonecotropic murine leukemia
            viruses of NZB/B1NJ and SM/J inbred strains
  JOURNAL   Mamm Genome 2 (2), 110-122 (1992)
   PUBMED   1311971
REFERENCE   9  (bases 1 to 4365)
  AUTHORS   Vik,D.P., Munoz-Canoves,P., Kozono,H., Martin,L.G., Tack,B.F. and
            Chaplin,D.D.
  TITLE     Identification and sequence analysis of four complement factor
            H-related transcripts in mouse liver
  JOURNAL   J Biol Chem 265 (6), 3193-3201 (1990)
   PUBMED   1689298
REFERENCE   10 (bases 1 to 4365)
  AUTHORS   Wilcox,F.H., Hirschhorn,L., Taylor,B.A., Womack,J.E. and
            Roderick,T.H.
  TITLE     Genetic variation in alkaline phosphatase of the house mouse (Mus
            musculus) with emphasis on a manganese-requiring isozyme
  JOURNAL   Biochem Genet 17 (11-12), 1093-1107 (1979)
   PUBMED   540002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB661130.1 and BC066092.1.
            
            On Jun 23, 2006 this sequence version replaced NM_009888.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066092.1, SRR6116558.145818.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               BB661130.1         1-131
            132-4365            BC066092.1         1-4234
FEATURES             Location/Qualifiers
     source          1..4365
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 61.62 cM"
     gene            1..4365
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /note="complement component factor h"
                     /db_xref="GeneID:12628"
                     /db_xref="MGI:MGI:88385"
     exon            1..247
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..3894
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /EC_number="4.2.1.2"
                     /note="complement factor H related protein 3A4/5G4;
                     protein beta-1-H"
                     /codon_start=1
                     /product="complement factor H precursor"
                     /protein_id="NP_034018.2"
                     /db_xref="CCDS:CCDS48388.1"
                     /db_xref="GeneID:12628"
                     /db_xref="MGI:MGI:88385"
                     /translation="MVQHRFLLESVGPRKIQIMRLSARIIWLILWTVCAAEDCKGPPP
                     RENSEILSGSWSEQLYPEGTQATYKCRPGYRTLGTIVKVCKNGKWVASNPSRICRKKP
                     CGHPGDTPFGSFRLAVGSQFEFGAKVVYTCDDGYQLLGEIDYRECGADGWINDIPLCE
                     VVKCLPVTELENGRIVSGAAETDQEYYFGQVVRFECNSGFKIEGHKEIHCSENGLWSN
                     EKPRCVEILCTPPRVENGDGINVKPVYKENERYHYKCKHGYVPKERGDAVCTGSGWSS
                     QPFCEEKRCSPPYILNGIYTPHRIIHRSDDEIRYECNYGFYPVTGSTVSKCTPTGWIP
                     VPRCTLKPCEFPQFKYGRLYYEESLRPNFPVSIGNKYSYKCDNGFSPPSGYSWDYLRC
                     TAQGWEPEVPCVRKCVFHYVENGDSAYWEKVYVQGQSLKVQCYNGYSLQNGQDTMTCT
                     ENGWSPPPKCIRIKTCSASDIHIDNGFLSESSSIYALNRETSYRCKQGYVTNTGEISG
                     SITCLQNGWSPQPSCIKSCDMPVFENSITKNTRTWFKLNDKLDYECLVGFENEYKHTK
                     GSITCTYYGWSDTPSCYERECSVPTLDRKLVVSPRKEKYRVGDLLEFSCHSGHRVGPD
                     SVQCYHFGWSPGFPTCKGQVASCAPPLEILNGEINGAKKVEYSHGEVVKYDCKPRFLL
                     KGPNKIQCVDGNWTTLPVCIEEERTCGDIPELEHGSAKCSVPPYHHGDSVEFICEENF
                     TMIGHGSVSCISGKWTQLPKCVATDQLEKCRVLKSTGIEAIKPKLTEFTHNSTMDYKC
                     RDKQEYERSICINGKWDPEPNCTSKTSCPPPPQIPNTQVIETTVKYLDGEKLSVLCQD
                     NYLTQDSEEMVCKDGRWQSLPRCIEKIPCSQPPTIEHGSINLPRSSEERRDSIESSSH
                     EHGTTFSYVCDDGFRIPEENRITCYMGKWSTPPRCVGLPCGPPPSIPLGTVSLELESY
                     QHGEEVTYHCSTGFGIDGPAFIICEGGKWSDPPKCIKTDCDVLPTVKNAIIRGKSKKS
                     YRTGEQVTFRCQSPYQMNGSDTVTCVNSRWIGQPVCKDNSCVDPPHVPNATIVTRTKN
                     KYLHGDRVRYECNKPLELFGQVEVMCENGIWTEKPKCRDSTGKCGPPPPIDNGDITSL
                     SLPVYEPLSSVEYQCQKYYLLKGKKTITCRNGKWSEPPTCLHACVIPENIMESHNIIL
                     KWRHTEKIYSHSGEDIEFGCKYGYYKARDSPPFRTKCINGTINYPTCV"
     exon            248..433
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..539
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..616
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..808
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..979
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1153
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1348
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1525
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1708
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1885
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2059
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2242
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2422
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2599
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2776
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2986
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3160
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3337
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3514
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3697
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..4365
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4343..4348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /note="hexamer: AATAAA"
     polyA_site      4361
                     /gene="Cfh"
                     /gene_synonym="Mud-1; NOM; Sas-1; Sas1"
                     /note="major polyA site"
ORIGIN      
        1 ggtctactat tttagtttac tttgcagaag ttgctcatgg gcggagcaat cctgatttcc
       61 taaactgact ttcaacttcc ctttgaagca agtctttccc tgctgtgacc acagttcata
      121 gcagagagga actggatggt acagcacaga tttctcttgg agtcagttgg tcccagaaag
      181 atccaaatta tgagactgtc agcaagaatt atttggctta tattatggac tgtttgtgca
      241 gcagaagatt gtaaaggtcc tcctccaaga gaaaattcag aaattctctc aggctcgtgg
      301 tcagaacaac tatatccaga aggcacccag gctacctaca aatgccgccc tggataccga
      361 acacttggca ctattgtaaa agtatgcaag aatggaaaat gggtggcgtc taacccatcc
      421 aggatatgtc ggaaaaagcc ttgtgggcat cccggagaca caccctttgg gtcctttagg
      481 ctggcagttg gatctcaatt tgagtttggt gcaaaggttg tttatacctg tgatgatggg
      541 tatcaactat taggtgaaat tgattaccgt gaatgtggtg cagatgggtg gatcaatgat
      601 attccactat gtgaagttgt gaagtgtcta cctgtgacag aactcgagaa tggaagaatt
      661 gtgagtggtg cagcagaaac agaccaggaa tactattttg gacaggtggt gcggtttgaa
      721 tgcaattcag gcttcaagat tgaaggacat aaggaaattc attgctcaga aaatggcctt
      781 tggagcaatg aaaagccacg atgtgtggaa attctctgca caccaccgcg agtggaaaat
      841 ggagatggta taaatgtgaa accagtttac aaggagaatg aaagatacca ctataagtgt
      901 aagcatggtt atgtgcccaa agaaagaggg gatgccgtct gcacaggctc tggatggagt
      961 tctcagcctt tctgtgaaga aaagagatgc tcacctcctt atattctaaa tggtatctac
     1021 acacctcaca ggattataca cagaagtgat gatgaaatca gatatgaatg taattatggc
     1081 ttctatcctg taactggatc aactgtttca aagtgtacac ccactggctg gatccctgtt
     1141 ccaagatgta ccttgaaacc atgtgaattt ccacaattca aatatggacg tctgtattat
     1201 gaagagagcc tgagacccaa cttcccagta tctataggaa ataagtacag ctataagtgt
     1261 gacaacgggt tttcaccacc ttctgggtat tcctgggact accttcgttg cacagcacaa
     1321 gggtgggagc ctgaagtccc atgcgtcagg aaatgtgttt tccattatgt ggagaatgga
     1381 gactctgcat actgggaaaa agtatatgtg cagggtcagt ctttaaaagt ccagtgttac
     1441 aatggctata gtcttcaaaa tggtcaagac acaatgacat gtacagagaa tggctggtcc
     1501 cctcctccca aatgcatccg tatcaagaca tgttcagcat cagatataca cattgacaat
     1561 ggatttcttt ctgaatcttc ttctatatat gctctaaata gagaaacatc ctatagatgt
     1621 aagcagggat atgtgacaaa tactggagaa atatcaggat caataacttg ccttcaaaat
     1681 ggatggtcac ctcaaccctc atgcattaag tcttgtgata tgcctgtatt tgagaattct
     1741 ataactaaga atactaggac atggtttaag ctcaatgaca aattagacta tgaatgtctc
     1801 gttggatttg aaaatgaata taaacatacc aaaggctcta taacatgtac ttattatgga
     1861 tggtctgata caccctcatg ttatgaaaga gaatgcagtg ttcccactct agaccgaaaa
     1921 ctagtcgttt cccccagaaa agaaaaatac agagttggag atttgttgga attctcctgc
     1981 cattcaggac acagagttgg gccagattca gtgcaatgct accactttgg atggtctcct
     2041 ggtttcccta catgtaaagg tcaagtagca tcatgtgcac cacctcttga aattcttaat
     2101 ggggaaatta atggagcaaa aaaagttgaa tacagccatg gtgaagtggt gaaatatgat
     2161 tgcaaaccta gattcctact gaagggaccc aataaaatcc agtgtgttga tgggaattgg
     2221 acaaccttgc ctgtatgtat tgaggaggag agaacatgtg gagacattcc tgaacttgaa
     2281 catggctctg ccaagtgttc tgttcctccc taccaccatg gagattcagt ggagttcatt
     2341 tgtgaagaaa acttcacaat gattggacat gggtcagttt cttgcattag tggaaaatgg
     2401 acccagcttc ctaaatgtgt tgcaacagac caactggaga agtgtagagt gctgaagtca
     2461 actggcatag aagcaataaa accaaaattg actgaattta cgcataactc caccatggat
     2521 tacaaatgta gagacaagca ggagtacgaa cgctcaatct gtatcaatgg aaaatgggat
     2581 cctgaaccaa actgtacaag caaaacatcc tgccctcctc caccgcagat tccaaatacc
     2641 caagtgattg aaaccaccgt gaaatacttg gatggagaaa aattatctgt tctttgccaa
     2701 gacaattacc taactcagga ctcagaagaa atggtgtgca aagatggaag gtggcagtca
     2761 ttacctcgct gcattgaaaa aattccatgt tcccagcccc ctacaataga acatggatct
     2821 attaatttac ccagatcttc agaagaaagg agagattcca ttgagtccag cagtcatgaa
     2881 catggaacta cattcagcta tgtctgtgat gatggtttca ggatacctga agaaaatagg
     2941 ataacctgct acatgggaaa atggagcact ccacctcgct gtgttggact tccttgtgga
     3001 cctccacctt caattcctct tggtactgtt tctcttgagc tagagagtta ccaacatggg
     3061 gaagaggtta cataccattg ttctacaggc tttggaattg atggaccagc atttattata
     3121 tgcgaaggag gaaagtggtc tgacccacca aaatgcataa aaacggattg tgacgtttta
     3181 cccacagtta aaaatgccat aataagagga aagagcaaaa aatcatatag gacaggagaa
     3241 caagtgacat tcagatgtca atctccttat caaatgaatg gctcagacac tgtgacatgt
     3301 gttaatagtc ggtggattgg acagccagta tgcaaagata attcctgtgt ggatccacca
     3361 catgtgccaa atgctactat agtaacaagg accaagaata aatatctaca tggtgacaga
     3421 gtacgttatg aatgtaataa acctttggaa ctatttgggc aagtggaagt gatgtgtgaa
     3481 aatgggatat ggacagaaaa accaaagtgc cgagactcaa cagggaaatg tgggcctcct
     3541 ccacctattg acaatggaga catcacctcc ttgtcattac cagtatatga accattatca
     3601 tcagttgaat atcaatgcca gaagtattat ctccttaagg gaaagaagac aataacatgt
     3661 agaaatggaa agtggtctga gccaccaaca tgcttacatg catgtgtaat accagaaaac
     3721 attatggaat cacacaatat aattctcaaa tggagacaca ctgaaaagat ttattcccat
     3781 tcaggggagg atattgaatt tggatgtaaa tatggatatt ataaagcaag agattcaccg
     3841 ccatttcgta caaagtgcat taatggcacc atcaattatc ccacttgtgt ataaaatcat
     3901 aatacattta ttagttgatt ttattgttta gaaaggcaca tgcatgtgac taatatactt
     3961 tcaatttgca ttgaagtatt gtttaactca tgtcttctca taaatataaa catttttgtt
     4021 atatggtgat taatttgtaa ctttaaaaac tattgccaaa atgcaaaagc agtaattcaa
     4081 aactcctaat ctaaaatatg atatgtccaa ggacaaacta tttcaatcaa gaaagtagat
     4141 gtaagttctt caacatctgt ttctattcag aactttctca gattttcctg gatacctttt
     4201 gatgtaaggt cctgatttac agtggataaa ggatatattg actgattctt caaattaata
     4261 tgatttccca aagcatgtaa caaccaaact atcatatatt atatgactaa tgcatacaat
     4321 taattactat ataatacttt caaataaaag aatctaagaa acttc
//
