LOCUS       NM_011801               3033 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Mus musculus craniofacial development protein 1 (Cfdp1), transcript
            variant 1, mRNA.
ACCESSION   NM_011801 XM_903475
VERSION     NM_011801.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3033)
  AUTHORS   Gopinathan,G., Xu,Q., Luan,X. and Diekwisch,T.G.H.
  TITLE     CFDP1 regulates the stability of pericentric heterochromatin
            thereby affecting RAN GTPase activity and mitotic spindle formation
  JOURNAL   PLoS Biol 22 (4), e3002574 (2024)
   PUBMED   38630655
  REMARK    GeneRIF: CFDP1 regulates the stability of pericentric
            heterochromatin thereby affecting RAN GTPase activity and mitotic
            spindle formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3033)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3033)
  AUTHORS   Iwashita,S., Suzuki,T., Kiriyama,Y., Dohmae,N., Ohoka,Y., Song,S.Y.
            and Nakashima,K.
  TITLE     Overcoming off-targets: assessing Western blot signals for
            Bcnt/Cfdp1, a tentative component of the chromatin remodeling
            complex
  JOURNAL   Biosci Rep 40 (6) (2020)
   PUBMED   32432658
  REMARK    GeneRIF: Overcoming off-targets: assessing Western blot signals for
            Bcnt/Cfdp1, a tentative component of the chromatin remodeling
            complex.
REFERENCE   4  (bases 1 to 3033)
  AUTHORS   Makeyev,A.V. and Bayarsaihan,D.
  TITLE     Molecular basis of Williams-Beuren syndrome: TFII-I regulated
            targets involved in craniofacial development
  JOURNAL   Cleft Palate Craniofac J 48 (1), 109-116 (2011)
   PUBMED   20500075
  REMARK    GeneRIF: Cfdp1 contains consensus TFII-I binding sites in the
            proximal promoters; the chromatin immunoprecipitation analysis
            showed that TFII-I transcription factors are recruited to these
            sites in vivo in Williams-Beuren syndrome.
REFERENCE   5  (bases 1 to 3033)
  AUTHORS   Luan,X., Ito,Y., Zhang,Y. and Diekwisch,T.G.
  TITLE     Characterization of the mouse CP27 promoter and NF-Y mediated gene
            regulation
  JOURNAL   Gene 460 (1-2), 8-19 (2010)
   PUBMED   20388536
  REMARK    GeneRIF: These results provide a basis for our understanding of the
            specific regulation of the cp27 gene in the NF-Y-mediated gene
            transcription network.
REFERENCE   6  (bases 1 to 3033)
  AUTHORS   Diekwisch,T.G. and Luan,X.
  TITLE     CP27 function is necessary for cell survival and differentiation
            during tooth morphogenesis in organ culture
  JOURNAL   Gene 287 (1-2), 141-147 (2002)
   PUBMED   11992732
REFERENCE   7  (bases 1 to 3033)
  AUTHORS   Iwashita,S.
  TITLE     [A novel type protein, Bcnt, that includes the region derived from
            a long interspersed nucleotide element]
  JOURNAL   Seikagaku 73 (12), 1435-1438 (2001)
   PUBMED   11831036
  REMARK    GeneRIF: includes the region derived from a long interspersed
            nucleotide
            Review article
REFERENCE   8  (bases 1 to 3033)
  AUTHORS   Iwashita,S., Itoh,T., Takeda,H., Sugimoto,Y., Takahashi,I.,
            Nobukuni,T., Sezaki,M., Masui,T. and Hashimoto,K.
  TITLE     Gene organization of bovine BCNT that contains a portion
            corresponding to an endonuclease domain derived from an RTE-1
            (Bov-B LINE), non-LTR retrotransposable element: duplication of an
            intramolecular repeat unit downstream of the truncated RTE-1
  JOURNAL   Gene 268 (1-2), 59-66 (2001)
   PUBMED   11368901
REFERENCE   9  (bases 1 to 3033)
  AUTHORS   Diekwisch,T.G., Marches,F., Williams,A. and Luan,X.
  TITLE     Cloning, gene expression, and characterization of CP27, a novel
            gene in mouse embryogenesis
  JOURNAL   Gene 235 (1-2), 19-30 (1999)
   PUBMED   10415329
REFERENCE   10 (bases 1 to 3033)
  AUTHORS   Takahashi,I., Nobukuni,T., Ohmori,H., Kobayashi,M., Tanaka,S.,
            Ohshima,K., Okada,N., Masui,T., Hashimoto,K. and Iwashita,S.
  TITLE     Existence of a bovine LINE repetitive insert that appears in the
            cDNA of bovine protein BCNT in ruminant, but not in human, genomes
  JOURNAL   Gene 211 (2), 387-394 (1998)
   PUBMED   9602175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127315.4.
            
            On Feb 6, 2019 this sequence version replaced NM_011801.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB010828.1, BC005589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AC127315.4         78395-78588
            195-312             AC127315.4         87521-87638
            313-520             AC127315.4         90742-90949
            521-648             AC127315.4         92247-92374
            649-768             AC127315.4         101743-101862
            769-927             AC127315.4         153323-153481
            928-3033            AC127315.4         163945-166050
FEATURES             Location/Qualifiers
     source          1..3033
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.98 cM"
     gene            1..3033
                     /gene="Cfdp1"
                     /gene_synonym="Bcnt; Bucentaur; Cfdp; cp27"
                     /note="craniofacial development protein 1"
                     /db_xref="GeneID:23837"
                     /db_xref="MGI:MGI:1344403"
     exon            1..194
                     /gene="Cfdp1"
                     /gene_synonym="Bcnt; Bucentaur; Cfdp; cp27"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1018
                     /gene="Cfdp1"
                     /gene_synonym="Bcnt; Bucentaur; Cfdp; cp27"
                     /note="isoform 1 is encoded by transcript variant 1; 27
                     kDa craniofacial protein"
                     /codon_start=1
                     /product="craniofacial development protein 1 isoform 1"
                     /protein_id="NP_035931.1"
                     /db_xref="CCDS:CCDS22680.1"
                     /db_xref="GeneID:23837"
                     /db_xref="MGI:MGI:1344403"
                     /translation="MEEFDSEDFSTSDEDEDYLPSGGEYSEDDVNELVKEDEVDGEEQ
                     AEKTKGKRRKAQGIPARKRKQSGLLLEEEEDGKEDSGGSSSEEDEEEQEGGLGSENAR
                     KKKEDELWASFLNDVGPKSKAAPGSQTKVAEETEEISSNKPLVKADELDKPRESEKVK
                     ITKVFDFAGEEVRVTKEVDAASKEAKSFLKQTEREKPQALVTSPATPLPAGSGIKRAS
                     GMSSLLGKIGAKKQKMSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLDR
                     VDHRQFEIERDLRLSKMKP"
     exon            195..312
                     /gene="Cfdp1"
                     /gene_synonym="Bcnt; Bucentaur; Cfdp; cp27"
                     /inference="alignment:Splign:2.1.0"
     exon            313..520
                     /gene="Cfdp1"
                     /gene_synonym="Bcnt; Bucentaur; Cfdp; cp27"
                     /inference="alignment:Splign:2.1.0"
     exon            521..648
                     /gene="Cfdp1"
                     /gene_synonym="Bcnt; Bucentaur; Cfdp; cp27"
                     /inference="alignment:Splign:2.1.0"
     exon            649..768
                     /gene="Cfdp1"
                     /gene_synonym="Bcnt; Bucentaur; Cfdp; cp27"
                     /inference="alignment:Splign:2.1.0"
     exon            769..927
                     /gene="Cfdp1"
                     /gene_synonym="Bcnt; Bucentaur; Cfdp; cp27"
                     /inference="alignment:Splign:2.1.0"
     exon            928..3033
                     /gene="Cfdp1"
                     /gene_synonym="Bcnt; Bucentaur; Cfdp; cp27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1205..1210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfdp1"
                     /gene_synonym="Bcnt; Bucentaur; Cfdp; cp27"
                     /note="hexamer: AATAAA"
     regulatory      1209..1214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfdp1"
                     /gene_synonym="Bcnt; Bucentaur; Cfdp; cp27"
                     /note="hexamer: AACAAA"
     polyA_site      1224
                     /gene="Cfdp1"
                     /gene_synonym="Bcnt; Bucentaur; Cfdp; cp27"
     polyA_site      1244
                     /gene="Cfdp1"
                     /gene_synonym="Bcnt; Bucentaur; Cfdp; cp27"
                     /note="major polyA site"
ORIGIN      
        1 atgtgcgctc gcctctaggg cggccctagc tgctggtcct gtacccctat ggtctcgccc
       61 tatatctagc ttcgctattt tggggcagtg gccgcagtcg tgtgggtagc aggccccaag
      121 tgacagcagc atggaggaat tcgactccga agacttctcc acatcggacg aggatgagga
      181 ctacttgccg tccggtggag agtacagtga agatgatgtc aatgaattag taaaggaaga
      241 tgaagtggac ggtgaagagc aggctgagaa aaccaaaggg aaaagaagga aggctcaggg
      301 cattccagcc aggaaaagga aacaaagtgg cctcttgtta gaagaagagg aagatggcaa
      361 ggaagactct ggaggtagta gcagtgaaga agatgaagag gagcaagaag gaggccttgg
      421 gtcagagaat gcaaggaaga agaaggaaga tgagttgtgg gccagcttcc ttaatgatgt
      481 aggaccaaag tcaaaagcag ccccaggttc acaaactaag gtagccgagg agactgaaga
      541 gattagttcg aataaaccgt tggtcaaagc agatgagctg gataagccta gagaatcaga
      601 aaaggtgaag attaccaagg tgtttgactt cgctggcgaa gaagtaaggg tgactaagga
      661 agtagatgct gcgtctaagg aagcgaagtc tttcctcaag caaacagaga gagaaaaacc
      721 gcaggctctt gtcacttcac cagcgacacc actccctgct gggtcaggga taaaaagagc
      781 aagtggtatg agcagcctct tagggaaaat tggagccaaa aaacagaaga tgagcaccct
      841 tgagaaatcc aaactggact gggagagctt caaggaagaa gaggggattg gtgaagaact
      901 ggccatccat aaccgaggga aagaagggta cattgagcgg aaagcttttc tggatcgagt
      961 ggaccacagg cagtttgaaa ttgagcgaga tctcaggctg agcaaaatga aaccttgaca
     1021 ttctgggaag gattcctagc agctgaatcc tattgacaat gtgagctcct ctgagtgtct
     1081 gtgaaatact tccagtgttc ctcatcatgt ttccagcaag tccctttttc tacgttgcag
     1141 tttgtttaat gtatgttaat ttcacctggc ttcattcatt ttccttttta aaatttgtct
     1201 tttaaataaa caaacagaac cctctgtgag gttggtgaga gtaagggtgc cgtgctcctt
     1261 ccctgtgctc tgcctctaag gctgaaggcc agcaggccca gccaccacat ctcagacctg
     1321 tctgtgatgg tcacaagcct ctttaaagtc agcctttcct ggagactcct cgggggcttc
     1381 ctggggtggc agctaacact gagtctctgg gcatttgttc tcaatgcatt cagctcctct
     1441 cttgtgtgag attcgtaagg tggggacatt gggataaatt aacgctaagt ggctttttgt
     1501 cttttcctat tcccctttct ccttaaaaaa acagtctact tcagatatat tttctacctc
     1561 agtagttctt caggttttgg tcaagggaca ttctttccag taatgctgca cacacctaga
     1621 atcccagtgc aaatggaaga ctggcaaaga actgctacaa atctgagggc agcctgggct
     1681 acatagctcc agaccagcct gggctggaga ctgagaaatg gggatgggga gtatataaag
     1741 acctcatgtt ctttctgctc cttaggagac ttccccactc agacttcctg cctaggaagc
     1801 gttgaacaca ttaaagtcca tcgcttgttc caagagcatg gggactgggg aaagtgggct
     1861 tcaaagacag cattctgttt cctgctcaga cccagctctg tggccttacc acagctttgt
     1921 tttctggcct gtggatggcg tgagtcacat cagtctttca gagggctgaa gtgagctgat
     1981 gccagcctaa ggccaaagaa cactaggtca cagtgggctt cctatctagg ccttgggtgt
     2041 gggggcagta tttgtagcaa ccaaaactga attggtgaca ccagatggct agcatctcat
     2101 tacccaaaaa ggaagtttac aagctacatt tgaactcctg gtctgttcac atccatctgc
     2161 aaaggacagt acaggggaca cagagcatac caagctggca ttgcggcaga tggtctcttc
     2221 tgagacttgg atgatgaagg aggtccttta accagaacca gccagaaccc cattgggata
     2281 ggacctccat gcctgtaaga caggggccca cttgtgttct gcctggcatg tcacctgctg
     2341 cactggcctg atgcttctca tgctgtgttg tggttgtgtg taccccagca tcccatctct
     2401 gcaaccatgg catcaatagc tcaagagcca actctgcctg tatatgtaga tgctcttcga
     2461 cccttaggat aaagggccat gcactcatgg taacttgggt tttcctctca gcaaaggcct
     2521 aagagattaa gaagtcagtg gatcagtgag acttgtctat gagtgtcagc cctgccagcc
     2581 ctcaaatagt cttttccatt ggtggcctgt tttcagtgtt cgtcacctct ctagaaaagg
     2641 ctgtctcttt ctcctgggtg tgtctattcc cagctgggca tatgtaaccc aggtgatact
     2701 ggttggactg acactcaggt acatgcacaa atccaaatgc atataccaat gtgtgttagc
     2761 atcagtaaga cgtaaagtgg ccccacagta gacctgggtc atcacaccgc tctggctgca
     2821 ggggaggctg caaacgtgtg catgtagtgt ttccctctcc tacactgaca gtcttttcta
     2881 aagctgtccc aggagagtca ggagtttgga gatgaaagca ggtggccgtg tttggtggtg
     2941 gctgagcctg ggagaggagt gtgcacagcc ttctgttctt cgaaacgtgg atatggactt
     3001 caatttttca taataaaaca ttttctaaag ttg
//
