LOCUS       NM_013459                942 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus complement factor D (Cfd), transcript variant 1, mRNA.
ACCESSION   NM_013459
VERSION     NM_013459.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 942)
  AUTHORS   McClure,J.J., McIlroy,G.D., Symons,R.A., Clark,S.M., Cunningham,I.,
            Han,W., Kania,K., Colella,F., Rochford,J.J., De Bari,C. and
            Roelofs,A.J.
  TITLE     Disentangling the detrimental effects of local from systemic
            adipose tissue dysfunction on articular cartilage in the knee
  JOURNAL   Osteoarthritis Cartilage 32 (12), 1552-1565 (2024)
   PUBMED   39103079
REFERENCE   2  (bases 1 to 942)
  AUTHORS   Ma,L., Gilani,A., Rubio-Navarro,A., Cortada,E., Li,A., Reilly,S.M.,
            Tang,L. and Lo,J.C.
  TITLE     Adipsin and adipocyte-derived C3aR1 regulate thermogenic fat in a
            sex-dependent fashion
  JOURNAL   JCI Insight 9 (11), e178925 (2024)
   PUBMED   38713526
  REMARK    GeneRIF: Adipsin and adipocyte-derived C3aR1 regulate thermogenic
            fat in a sex-dependent fashion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 942)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 942)
  AUTHORS   Jiang,M.Y., Man,W.R., Zhang,X.B., Zhang,X.H., Duan,Y., Lin,J.,
            Zhang,Y., Cao,Y., Wu,D.X., Shu,X.F., Xin,L., Wang,H., Zhang,X.,
            Li,C.Y., Gu,X.M., Zhang,X. and Sun,D.D.
  TITLE     Adipsin inhibits Irak2 mitochondrial translocation and improves
            fatty acid beta-oxidation to alleviate diabetic cardiomyopathy
  JOURNAL   Mil Med Res 10 (1), 63 (2023)
   PUBMED   38072993
  REMARK    GeneRIF: Adipsin inhibits Irak2 mitochondrial translocation and
            improves fatty acid beta-oxidation to alleviate diabetic
            cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 942)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 942)
  AUTHORS   White,R.T., Damm,D., Hancock,N., Rosen,B.S., Lowell,B.B., Usher,P.,
            Flier,J.S. and Spiegelman,B.M.
  TITLE     Human adipsin is identical to complement factor D and is expressed
            at high levels in adipose tissue
  JOURNAL   J Biol Chem 267 (13), 9210-9213 (1992)
   PUBMED   1374388
REFERENCE   7  (bases 1 to 942)
  AUTHORS   Johnson,R.S., Sheng,M., Greenberg,M.E., Kolodner,R.D.,
            Papaioannou,V.E. and Spiegelman,B.M.
  TITLE     Targeting of nonexpressed genes in embryonic stem cells via
            homologous recombination
  JOURNAL   Science 245 (4923), 1234-1236 (1989)
   PUBMED   2506639
REFERENCE   8  (bases 1 to 942)
  AUTHORS   Cook,K.S., Min,H.Y., Johnson,D., Chaplinsky,R.J., Flier,J.S.,
            Hunt,C.R. and Spiegelman,B.M.
  TITLE     Adipsin: a circulating serine protease homolog secreted by adipose
            tissue and sciatic nerve
  JOURNAL   Science 237 (4813), 402-405 (1987)
   PUBMED   3299705
REFERENCE   9  (bases 1 to 942)
  AUTHORS   Min,H.Y. and Spiegelman,B.M.
  TITLE     Adipsin, the adipocyte serine protease: gene structure and control
            of expression by tumor necrosis factor
  JOURNAL   Nucleic Acids Res 14 (22), 8879-8892 (1986)
   PUBMED   3024123
REFERENCE   10 (bases 1 to 942)
  AUTHORS   Phillips,M., Djian,P. and Green,H.
  TITLE     The nucleotide sequence of three genes participating in the adipose
            differentiation of 3T3 cells
  JOURNAL   J Biol Chem 261 (23), 10821-10827 (1986)
   PUBMED   3015943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC138778.1 and AA512566.1.
            
            On Jul 16, 2016 this sequence version replaced NM_013459.3.
            
            Summary: This gene encodes a serine protease that plays an
            important role in the alternative pathway of complement activation
            for pathogen recognition and elimination. The encoded preproprotein
            undergoes proteolytic processing to generate a mature, functional
            enzyme that in turn cleaves factor B in the complement pathway.
            This gene is expressed in adipocytes and the mature enzyme is
            secreted into the bloodstream. Mice lacking the encoded product
            cannot initiate alternative pathway of complement activation.
            [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138778.1, AK143817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-874               BC138778.1         1-874
            875-942             AA512566.1         165-232
FEATURES             Location/Qualifiers
     source          1..942
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..942
                     /gene="Cfd"
                     /gene_synonym="Adn; DF"
                     /note="complement factor D"
                     /db_xref="GeneID:11537"
                     /db_xref="MGI:MGI:87931"
     exon            1..128
                     /gene="Cfd"
                     /gene_synonym="Adn; DF"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..853
                     /gene="Cfd"
                     /gene_synonym="Adn; DF"
                     /EC_number="3.4.21.46"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; properdin factor D; C3 convertase activator; 28
                     kDa adipocyte protein; D component (adipsin) of
                     complement; complement factor D (adipsin)"
                     /codon_start=1
                     /product="complement factor D isoform 1 preproprotein"
                     /protein_id="NP_038487.1"
                     /db_xref="CCDS:CCDS23995.1"
                     /db_xref="GeneID:11537"
                     /db_xref="MGI:MGI:87931"
                     /translation="MHSSVYFVALVILGAAVCAAQPRGRILGGQEAAAHARPYMASVQ
                     VNGTHVCGGTLLDEQWVLSAAHCMDGVTDDDSVQVLLGAHSLSAPEPYKRWYDVQSVV
                     PHPGSRPDSLEDDLILFKLSQNASLGPHVRPLPLQYEDKEVEPGTLCDVAGWGVVTHA
                     GRRPDVLHQLRVSIMNRTTCNLRTYHDGVVTINMMCAESNRRDTCRGDSGSPLVCGDA
                     VEGVVTWGSRVCGNGKKPGVYTRVSSYRMWIENITNGNMTS"
     exon            129..285
                     /gene="Cfd"
                     /gene_synonym="Adn; DF"
                     /inference="alignment:Splign:2.1.0"
     exon            286..433
                     /gene="Cfd"
                     /gene_synonym="Adn; DF"
                     /inference="alignment:Splign:2.1.0"
     exon            434..691
                     /gene="Cfd"
                     /gene_synonym="Adn; DF"
                     /inference="alignment:Splign:2.1.0"
     exon            692..922
                     /gene="Cfd"
                     /gene_synonym="Adn; DF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      904..909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfd"
                     /gene_synonym="Adn; DF"
                     /note="hexamer: AATAAA"
     polyA_site      922
                     /gene="Cfd"
                     /gene_synonym="Adn; DF"
                     /note="major polyA site"
ORIGIN      
        1 aggggcagga ggtaagaggc aggagtccat aaaacagccc tgagagcctg ctgggtcagt
       61 gcctgctgtc agaatgcaca gctccgtgta cttcgtggct ctggtgatcc tgggagcggc
      121 tgtatgtgca gcacagcccc gaggccggat tctgggtggc caggaggccg cagcccatgc
      181 tcggccctac atggcttccg tgcaagtgaa cggcacacac gtgtgcggtg gcaccctgct
      241 ggacgagcag tgggtgctca gtgctgcaca ctgcatggat ggagtgacgg atgacgactc
      301 tgtgcaggtg ctcctgggtg cccactccct gtccgcccct gaaccctaca agcgatggta
      361 tgatgtgcag agtgtagtgc ctcacccggg cagccgacct gacagccttg aggacgacct
      421 cattcttttt aagctatccc agaatgcctc gttgggtccc cacgtgagac ccctaccctt
      481 gcaatacgag gacaaagaag tggaacccgg cacgctctgc gacgtggctg gttggggtgt
      541 ggtcacccat gcaggacgca ggcctgatgt cctgcatcaa ctcagagtgt caatcatgaa
      601 ccggacaacc tgcaatctgc gcacgtacca tgacggggta gtcaccatta acatgatgtg
      661 tgcagagagc aaccgcaggg acacttgcag gggagactcc ggcagccctc tagtgtgcgg
      721 ggatgcagtc gaaggtgtgg ttacgtgggg ctctcgcgtc tgtggcaatg gcaaaaagcc
      781 gggcgtctat acccgagtgt catcctaccg gatgtggatc gaaaacatca caaatggtaa
      841 catgacatcc tgaggggaca ccagagacac gtggctcagg gaaacaagag acacgtggct
      901 cacaataaat gcatgcatct gaaaaaaaaa aaaaaaaaaa aa
//
