LOCUS       NM_007685               1038 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus cryptic, EGF-CFC family member 1 (Cfc1), transcript
            variant 1, mRNA.
ACCESSION   NM_007685
VERSION     NM_007685.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1038)
  AUTHORS   Shafiei,S. and Dufort,D.
  TITLE     Maternal Cripto is critical for proper development of the mouse
            placenta and the placental vasculature
  JOURNAL   Placenta 107, 13-23 (2021)
   PUBMED   33730615
  REMARK    GeneRIF: Maternal Cripto is critical for proper development of the
            mouse placenta and the placental vasculature.
REFERENCE   2  (bases 1 to 1038)
  AUTHORS   Aykul,S., Parenti,A., Chu,K.Y., Reske,J., Floer,M., Ralston,A. and
            Martinez-Hackert,E.
  TITLE     Biochemical and Cellular Analysis Reveals Ligand Binding
            Specificities, a Molecular Basis for Ligand Recognition, and
            Membrane Association-dependent Activities of Cripto-1 and Cryptic
  JOURNAL   J Biol Chem 292 (10), 4138-4151 (2017)
   PUBMED   28126904
REFERENCE   3  (bases 1 to 1038)
  AUTHORS   Santos,R., Kawauchi,S., Jacobs,R.E., Lopez-Burks,M.E., Choi,H.,
            Wikenheiser,J., Hallgrimsson,B., Jamniczky,H.A., Fraser,S.E.,
            Lander,A.D. and Calof,A.L.
  TITLE     Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals
            Multiple Determinants of Risk for Congenital Heart Defects
  JOURNAL   PLoS Biol 14 (9), e2000197 (2016)
   PUBMED   27606604
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1038)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   5  (bases 1 to 1038)
  AUTHORS   Shiratori,H., Yashiro,K., Iwai,N., Oki,S., Minegishi,K., Ikawa,Y.,
            Kanata,K. and Hamada,H.
  TITLE     Self-regulated left-right asymmetric expression of Pitx2c in the
            developing mouse limb
  JOURNAL   Dev Biol 395 (2), 331-341 (2014)
   PUBMED   25224222
REFERENCE   6  (bases 1 to 1038)
  AUTHORS   Colas,J.F. and Schoenwolf,G.C.
  TITLE     Subtractive hybridization identifies chick-cripto, a novel EGF-CFC
            ortholog expressed during gastrulation, neurulation and early
            cardiogenesis
  JOURNAL   Gene 255 (2), 205-217 (2000)
   PUBMED   11024280
REFERENCE   7  (bases 1 to 1038)
  AUTHORS   Gaio,U., Schweickert,A., Fischer,A., Garratt,A.N., Muller,T.,
            Ozcelik,C., Lankes,W., Strehle,M., Britsch,S., Blum,M. and
            Birchmeier,C.
  TITLE     A role of the cryptic gene in the correct establishment of the
            left-right axis
  JOURNAL   Curr Biol 9 (22), 1339-1342 (1999)
   PUBMED   10574770
REFERENCE   8  (bases 1 to 1038)
  AUTHORS   Yan,Y.T., Gritsman,K., Ding,J., Burdine,R.D., Corrales,J.D.,
            Price,S.M., Talbot,W.S., Schier,A.F. and Shen,M.M.
  TITLE     Conserved requirement for EGF-CFC genes in vertebrate left-right
            axis formation
  JOURNAL   Genes Dev 13 (19), 2527-2537 (1999)
   PUBMED   10521397
REFERENCE   9  (bases 1 to 1038)
  AUTHORS   Xu,C., Liguori,G., Adamson,E.D. and Persico,M.G.
  TITLE     Specific arrest of cardiogenesis in cultured embryonic stem cells
            lacking Cripto-1
  JOURNAL   Dev Biol 196 (2), 237-247 (1998)
   PUBMED   9576836
REFERENCE   10 (bases 1 to 1038)
  AUTHORS   Shen,M.M., Wang,H. and Leder,P.
  TITLE     A differential display strategy identifies Cryptic, a novel
            EGF-related gene expressed in the axial and lateral mesoderm during
            mouse gastrulation
  JOURNAL   Development 124 (2), 429-442 (1997)
   PUBMED   9053319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U57720.1.
            
            [WARNING] On Jul 28, 2024 this sequence was replaced by
            NM_007685.3.
            
            On Apr 6, 2007 this sequence version replaced NM_007685.1.
            
            Transcript Variant: This variant (1) represents the longer,
            protein-coding transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U57720.1, BC100705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1038              U57720.1           1-1038
FEATURES             Location/Qualifiers
     source          1..1038
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/Sv"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 13.34 cM"
     gene            1..1038
                     /gene="Cfc1"
                     /gene_synonym="b2b970Clo; cryptic"
                     /note="cryptic, EGF-CFC family member 1"
                     /db_xref="GeneID:12627"
                     /db_xref="MGI:MGI:109448"
     exon            1..308
                     /gene="Cfc1"
                     /gene_synonym="b2b970Clo; cryptic"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..864
                     /gene="Cfc1"
                     /gene_synonym="b2b970Clo; cryptic"
                     /note="cripto, FRL-1, cryptic family 1"
                     /codon_start=1
                     /product="cryptic protein precursor"
                     /protein_id="NP_031711.1"
                     /db_xref="CCDS:CCDS14869.1"
                     /db_xref="GeneID:12627"
                     /db_xref="MGI:MGI:109448"
                     /translation="MRANSPTQGISLKMHQARPLFLVTVALQLIGLGYSYQSEGDGAR
                     EVSNILSPVIPGTTLDRTLSNSSRKNDIPEGARLWDSLPDSSTLGESAVPVSRCCHNG
                     GTCVLGSFCVCPAYFTGRYCEHDQRRRDCGALGHGAWTLHSCRLCRCIFSALYCLPHQ
                     TFSHCDLKSFLSSGARGSRECSIPSLLLLVLCLLLQGVAGKG"
     exon            309..358
                     /gene="Cfc1"
                     /gene_synonym="b2b970Clo; cryptic"
                     /inference="alignment:Splign:2.1.0"
     exon            359..526
                     /gene="Cfc1"
                     /gene_synonym="b2b970Clo; cryptic"
                     /inference="alignment:Splign:2.1.0"
     exon            527..641
                     /gene="Cfc1"
                     /gene_synonym="b2b970Clo; cryptic"
                     /inference="alignment:Splign:2.1.0"
     exon            642..751
                     /gene="Cfc1"
                     /gene_synonym="b2b970Clo; cryptic"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1038
                     /gene="Cfc1"
                     /gene_synonym="b2b970Clo; cryptic"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggactgta tagggtcagc acttccagcc tggtggttca gagctcctga cctgagaggg
       61 cttcaacacc tggactccag gatcttcctt taaccctgct gtctctggtc caggcagagg
      121 gcagagacat cttcatcttg caagactgtg catcctgtaa cctgctatag tgattccaag
      181 acctggagta aagggtgcct ccggggctag gatatttgag tttcaacttc tgtggtcatc
      241 gatccccaag cacagatgag agcgaactca ccaacccagg gtatcagttt gaaaatgcat
      301 caagccaggc ctctgttttt ggtgactgtc gcgctgcagc tcatcggtct gggatacagt
      361 tatcagagcg aaggagatgg tgccagagaa gtcagcaata tcctctctcc agtgatcccc
      421 gggacgacac tggacagaac tctgagtaat tccagcagaa agaatgacat tccggagggg
      481 gcgcgcctat gggattccct tcctgactcc agcactttgg gagagagtgc agtccctgta
      541 tcccgctgtt gccacaatgg cggcacctgt gttctgggca gtttctgcgt gtgccctgcc
      601 tatttcactg gtcgctattg cgagcacgac cagaggcgca gagactgtgg tgccctaggg
      661 catggagctt ggaccctgca cagctgccgc ctatgcaggt gcatcttctc agccctgtac
      721 tgcctcccac accaaacgtt cagccactgt gacctgaaaa gcttcctttc ttcaggcgcc
      781 agaggatcaa gagaatgcag catcccaagc ctcctcctgc tggtgctctg cctcctcctg
      841 cagggtgtgg ctggtaaggg ctgaggctcc taagtgcgat gatagactct cctcctgagc
      901 tgtcaccctt gattacacca cagtgtgcca gcaagaaagc tgggtggtgg gcatctgact
      961 tggtgttgtg tcctgtaaat aacagattca ctggaatatg ctggattctc atgctgtaca
     1021 ataaagaggc ttaatggt
//
