LOCUS       NM_008198               2449 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus complement factor B (Cfb), transcript variant 1, mRNA.
ACCESSION   NM_008198
VERSION     NM_008198.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2449)
  AUTHORS   Dolan,K., Liao,S.M., Crowley,M., Xiang,C., Adams,C.M., Brown,A.,
            Vo,N., Chen,A., Delgado,O., Buchanan,N., Guo,C. and Prasanna,G.
  TITLE     Complement Factor B Inhibition or Deletion Is Not Sufficient to
            Prevent Neurodegeneration in a Murine Model of Glaucoma
  JOURNAL   J Ocul Pharmacol Ther 40 (8), 524-535 (2024)
   PUBMED   38976487
  REMARK    GeneRIF: Complement Factor B Inhibition or Deletion Is Not
            Sufficient to Prevent Neurodegeneration in a Murine Model of
            Glaucoma.
REFERENCE   2  (bases 1 to 2449)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   3  (bases 1 to 2449)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2449)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 2449)
  AUTHORS   Brown,L.N., Barth,J.L., Jafri,S., Rumschlag,J.A., Jenkins,T.R.,
            Atkinson,C. and Lang,H.
  TITLE     Complement factor B is essential for the proper function of the
            peripheral auditory system
  JOURNAL   Front Neurol 14, 1214408 (2023)
   PUBMED   37560455
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2449)
  AUTHORS   Garnier,G., Ault,B., Kramer,M. and Colten,H.R.
  TITLE     cis and trans elements differ among mouse strains with high and low
            extrahepatic complement factor B gene expression
  JOURNAL   J Exp Med 175 (2), 471-479 (1992)
   PUBMED   1370685
REFERENCE   7  (bases 1 to 2449)
  AUTHORS   Lafuse,W.P., Lanning,D., Spies,T. and David,C.S.
  TITLE     PFGE mapping and RFLP analysis of the S/D region of the mouse H-2
            complex
  JOURNAL   Immunogenetics 36 (2), 110-116 (1992)
   PUBMED   1351875
REFERENCE   8  (bases 1 to 2449)
  AUTHORS   Ishikawa,N., Nonaka,M., Wetsel,R.A. and Colten,H.R.
  TITLE     Murine complement C2 and factor B genomic and cDNA cloning reveals
            different mechanisms for multiple transcripts of C2 and B
  JOURNAL   J Biol Chem 265 (31), 19040-19046 (1990)
   PUBMED   2229060
REFERENCE   9  (bases 1 to 2449)
  AUTHORS   Lafuse,W.P., Castle,L. and David,C.S.
  TITLE     Restriction fragment length polymorphism analysis of factor B and
            C2 genes in H-2 recombinant mouse strains
  JOURNAL   Immunogenetics 31 (4), 275-277 (1990)
   PUBMED   1970336
REFERENCE   10 (bases 1 to 2449)
  AUTHORS   Womack,J.E., Hawes,N.L., Soares,E.R. and Roderick,T.H.
  TITLE     Mitochondrial malate dehydrogenase (Mor-1) in the mouse: linkage to
            chromosome 5 markers
  JOURNAL   Biochem Genet 13 (9-10), 519-525 (1975)
   PUBMED   1203052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT573030.3.
            
            On Mar 23, 2022 this sequence version replaced NM_008198.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005451.1, M57890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               CT573030.3         224049-224213       c
            166-399             CT573030.3         223728-223961       c
            400-585             CT573030.3         223025-223210       c
            586-759             CT573030.3         222760-222933       c
            760-861             CT573030.3         222521-222622       c
            862-998             CT573030.3         222283-222419       c
            999-1137            CT573030.3         221933-222071       c
            1138-1269           CT573030.3         221439-221570       c
            1270-1371           CT573030.3         221227-221328       c
            1372-1509           CT573030.3         221006-221143       c
            1510-1607           CT573030.3         220495-220592       c
            1608-1725           CT573030.3         220034-220151       c
            1726-1879           CT573030.3         219665-219818       c
            1880-1956           CT573030.3         219489-219565       c
            1957-2057           CT573030.3         219216-219316       c
            2058-2190           CT573030.3         219001-219133       c
            2191-2240           CT573030.3         218877-218926       c
            2241-2449           CT573030.3         218371-218579       c
FEATURES             Location/Qualifiers
     source          1..2449
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.41 cM"
     gene            1..2449
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /note="complement factor B"
                     /db_xref="GeneID:14962"
                     /db_xref="MGI:MGI:105975"
     exon            1..165
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            166..399
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            400..585
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            586..759
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            760..861
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            862..998
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1137
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1269
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1371
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1509
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1607
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1725
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1879
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1956
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2057
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2190
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2240
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2449
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2428..2433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /note="hexamer: ATTAAA"
     polyA_site      2449
                     /gene="Cfb"
                     /gene_synonym="Bf; C2; Fb; H2-Bf"
                     /note="major polyA site"
ORIGIN      
        1 gtagccagat ccagcatttg ggtttcagtt tggacaggag gtcaaatagg cacccagagt
       61 gacctggaga gggctttggg ccactggact ctctggtgct ttccatgaca atggagagcc
      121 cccagctctg cctcgtcctc ttggtcttag gcttctcctc tggaggtgtg agcgcaactc
      181 cagtgcttga ggcccggccc caagtctcct gctctctgga gggagtagag atcaaaggcg
      241 gctcctttca acttctccaa ggcggtcagg ccctggagta cctatgtccc tctggcttct
      301 acccataccc cgtgcagact cgaacctgca gatccacagg ctcctggagc gacctgcaga
      361 cccgagacca aaagattgtc cagaaggcgg aatgcagagc aatacgctgc ccacgaccgc
      421 aggactttga aaatggggaa ttctggcccc ggtccccctt ctacaacctg agtgaccaga
      481 tttcttttca atgctatgat ggttacgttc tccggggctc tgctaatcgc acctgccaag
      541 agaatggccg gtgggatggg caaacagcaa tttgtgatga tggagctgga tactgtccca
      601 atcccggtat tcctattggg acaaggaagg tgggtagcca ataccgcctt gaagacattg
      661 ttacttacca ctgcagccgg ggacttgtcc tgcgtggctc ccagaagcga aagtgtcaag
      721 aaggtggctc atggagtggg acagagcctt cctgccaaga ttccttcatg tatgacagcc
      781 ctcaagaagt ggccgaagca ttcctatcct ccctgacaga gaccatcgaa ggagccgatg
      841 ctgaggatgg gcacagccca ggagaacagc agaagaggaa gattgtccta gacccctcgg
      901 gctccatgaa tatctacctg gtgctagatg gatcagacag catcggaagc agcaacttca
      961 caggggctaa gcggtgcctc accaacttga ttgagaaggt ggcgagttac ggggtgaggc
     1021 cacgatatgg tctcctgaca tatgctacag tccccaaagt gttggtcaga gtgtctgatg
     1081 agaggagtag cgatgccgac tgggtcacag agaagctcaa ccaaatcagt tatgaagacc
     1141 acaagctgaa gtcagggacc aacaccaaga gggctctcca ggctgtgtat agcatgatga
     1201 gctgggcagg ggatgccccg cctgaaggct ggaatagaac ccgccatgtc atcatcatta
     1261 tgactgatgg cttgcacaac atgggtggaa accctgtcac tgtcattcag gacatccgag
     1321 ccttgctgga catcggcagg gatcccaaaa atcccaggga ggattacctg gatgtgtatg
     1381 tgtttggggt cgggcctctg gtggactccg tgaacatcaa tgccttagct tccaaaaagg
     1441 acaatgagca tcatgtgttt aaagtcaagg atatggaaga cctggagaat gttttctacc
     1501 aaatgattga tgaaaccaaa tctctgagtc tctgtggcat ggtgtgggag cataaaaaag
     1561 gcaacgatta tcataagcaa ccatggcaag ccaagatctc agtcactcgc cctctgaaag
     1621 gacatgagac ctgtatgggg gccgtggtgt ctgagtactt cgtgctgaca gcagcgcact
     1681 gcttcatggt ggatgatcag aaacattcca tcaaggtcag cgtggggggt cagaggcggg
     1741 acctggagat tgaagaggtc ctgttccacc ccaaatacaa tattaatggg aaaaaggcag
     1801 aagggatccc tgagttctat gattatgatg tggccctagt caagctcaag aacaagctca
     1861 agtatggcca gactctcagg cccatctgtc tcccctgcac ggagggaacc acacgagcct
     1921 tgaggcttcc tcagacagcc acctgcaagc agcacaagga acagttgctc cctgtgaagg
     1981 atgtcaaagc tctgtttgta tctgagcaag ggaagagcct gactcggaag gaggtgtaca
     2041 tcaagaatgg ggacaagaaa gccagttgtg agagagatgc tacaaaggcc caaggctatg
     2101 agaaggtcaa agatgcctct gaggtggtca ctccacggtt cctctgcaca ggaggggtgg
     2161 atccctatgc tgaccccaac acatgcaaag gagattccgg gggccctctc attgttcaca
     2221 agagaagccg cttcattcaa gttggtgtga ttagctgggg agtagtagat gtctgcagag
     2281 accagaggcg gcaacagctg gtaccctctt atgcccggga cttccacatc aacctcttcc
     2341 aggtgctgcc ctggctaaag gacaagctca aagatgagga tttgggtttt ctataaagag
     2401 cttcctgcag ggagagtgtg aggacagatt aaagcagtta caataacaa
//
