LOCUS       NM_023483               3285 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus cilia and flagella associated protein 68 (Cfap68),
            transcript variant 1, mRNA.
ACCESSION   NM_023483 XM_001002686
VERSION     NM_023483.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3285)
  AUTHORS   Nguyen,T.T.T., Tokuhiro,K., Shimada,K., Wang,H., Mashiko,D.,
            Tonai,S., Kiyozumi,D. and Ikawa,M.
  TITLE     Gene-deficient mouse model established by CRISPR/Cas9 system
            reveals 15 reproductive organ-enriched genes dispensable for male
            fertility
  JOURNAL   Front Cell Dev Biol 12, 1411162 (2024)
   PUBMED   38835510
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3285)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3285)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   4  (bases 1 to 3285)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3285)
  AUTHORS   Tabakoff,B., Saba,L., Kechris,K., Hu,W., Bhave,S.V., Finn,D.A.,
            Grahame,N.J. and Hoffman,P.L.
  TITLE     The genomic determinants of alcohol preference in mice
  JOURNAL   Mamm Genome 19 (5), 352-365 (2008)
   PUBMED   18563486
REFERENCE   6  (bases 1 to 3285)
  AUTHORS   Mulligan,M.K., Ponomarev,I., Hitzemann,R.J., Belknap,J.K.,
            Tabakoff,B., Harris,R.A., Crabbe,J.C., Blednov,Y.A., Grahame,N.J.,
            Phillips,T.J., Finn,D.A., Hoffman,P.L., Iyer,V.R., Koob,G.F. and
            Bergeson,S.E.
  TITLE     Toward understanding the genetics of alcohol drinking through
            transcriptome meta-analysis
  JOURNAL   Proc Natl Acad Sci U S A 103 (16), 6368-6373 (2006)
   PUBMED   16618939
REFERENCE   7  (bases 1 to 3285)
  AUTHORS   O'Brien,K.P., Tapia-Paez,I., Stahle-Backdahl,M., Kedra,D. and
            Dumanski,J.P.
  TITLE     Characterization of five novel human genes in the 11q13-q22 region
  JOURNAL   Biochem Biophys Res Commun 273 (1), 90-94 (2000)
   PUBMED   10873569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123614.6, AK043513.1, AK161835.1, BU609920.1 and BQ175429.1.
            
            On Mar 1, 2018 this sequence version replaced NM_023483.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043513.1, AK158460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC123614.6         113668-113699       c
            33-1814             AK043513.1         2-1783
            1815-2528           AK161835.1         391-1104
            2529-3089           BU609920.1         66-626
            3090-3285           BQ175429.1         1-196               c
FEATURES             Location/Qualifiers
     source          1..3285
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 27.75 cM"
     gene            1..3285
                     /gene="Cfap68"
                     /gene_synonym="1110032A03Rik; 4930500N06Rik; c11orf1"
                     /note="cilia and flagella associated protein 68"
                     /db_xref="GeneID:68721"
                     /db_xref="MGI:MGI:1915971"
     exon            1..327
                     /gene="Cfap68"
                     /gene_synonym="1110032A03Rik; 4930500N06Rik; c11orf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..786
                     /gene="Cfap68"
                     /gene_synonym="1110032A03Rik; 4930500N06Rik; c11orf1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0686 protein C11orf1 homolog"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 68
                     isoform 1"
                     /protein_id="NP_075972.2"
                     /db_xref="CCDS:CCDS23173.1"
                     /db_xref="GeneID:68721"
                     /db_xref="MGI:MGI:1915971"
                     /translation="MAVSCSLNHSTYLQRQNLVCYLRNPHYGSLIYADGHGEVWTDWN
                     DMSKFLQYGWRCTTNENSYSNRTLVGNWNQERYDLKNIVKPKPLPSQFGHAFETTYDA
                     NYSRKKPQSTHRFKREPHWFPGHQPELDPPHYKCTAKSTYMTNYSEPQPTHYSCCVYD
                     PSVSQS"
     exon            328..558
                     /gene="Cfap68"
                     /gene_synonym="1110032A03Rik; 4930500N06Rik; c11orf1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..625
                     /gene="Cfap68"
                     /gene_synonym="1110032A03Rik; 4930500N06Rik; c11orf1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..3268
                     /gene="Cfap68"
                     /gene_synonym="1110032A03Rik; 4930500N06Rik; c11orf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1284..1289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap68"
                     /gene_synonym="1110032A03Rik; 4930500N06Rik; c11orf1"
                     /note="hexamer: CATAAA"
     polyA_site      1304
                     /gene="Cfap68"
                     /gene_synonym="1110032A03Rik; 4930500N06Rik; c11orf1"
                     /note="major polyA site"
     regulatory      3246..3251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap68"
                     /gene_synonym="1110032A03Rik; 4930500N06Rik; c11orf1"
                     /note="hexamer: AATAAA"
     polyA_site      3268
                     /gene="Cfap68"
                     /gene_synonym="1110032A03Rik; 4930500N06Rik; c11orf1"
ORIGIN      
        1 ggcactaagt gatgacgcat caacagcttg ttaccaggat aaacatttgg agctactgct
       61 cgggagcttc gagcggggaa gtaaaatgga gctcttggcc ttgccccttc acctttgtgc
      121 gcctccaaag gctcgttttc ttttcagtac tcggacggcc caacacggac ggccctgagc
      181 gtcttcgcca ttcttgcttg aagcataact gtcactaact gaggggtgag acgagtcctg
      241 cgtattccag aggctcagga cgctgtaact gcaccatctc ctgacatggc tgtctcctgt
      301 tctctcaacc actcaacata tctccagaga caaaaccttg tctgttatct tagaaaccca
      361 cactatggca gccttattta tgctgatggt catggagaag tgtggacaga ctggaatgac
      421 atgtccaagt ttttacagta cggatggaga tgcaccacta atgagaactc ctattcgaac
      481 cgtaccctgg taggaaactg gaaccaggaa agatacgacc taaaaaatat tgtaaagcct
      541 aaacccttgc cttcccagtt tggacatgcc ttcgaaacaa catatgatgc aaactacagc
      601 aggaagaagc cacaatcaac acatagattt aaacgagagc ctcactggtt tcctggacat
      661 cagcctgagc tggatcctcc tcactacaaa tgcacagcga agtcaactta tatgactaac
      721 tactcagaac ctcagcccac tcattactcc tgctgtgtat atgatccaag cgtgagccag
      781 tcttagggcc cgggaatctg aagaagaaga agtagcttca tttttgtcta gagtagactg
      841 tagaaaggaa cacatgctaa gcagactcaa catcactctc aacatggctg ctgtctaaat
      901 aaagcacagc acaccaaaaa aaaatctcta tttgtttact ctaactgtcc tggtgagttt
      961 ttatcaactt cacacaaacc taaacatatc tgggaggagg ggattttaat tgagaaatta
     1021 tctccatacg attgccctgt aagcaagcct gtgatgggtg tattttcttg attaatgatt
     1081 gatgtaggag ggactatcca gcagggggca gtggcattgc tgggctggtg gtcctgggtg
     1141 ctataggaaa gcaggttaag caaagccaca gagaacaagc cagcaagcag cacttcttta
     1201 tggcctctaa ttcatctgca ttcagtttcc tgtcttgagt tcctgcccta actttcctgg
     1261 atgatggact taaaagctct aaacataaat gctttccttc ccaagttgcc cttagtcatg
     1321 gtgttttatc ccatcaatag aaacctaaga cagtatataa ctgccgtgtg tgtgtgtgtg
     1381 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtatg tgtgtgtgtg agtgaatgag
     1441 ggggaaagcc atgaatctga aaaggaacaa ggttatttga gaaggtttgt agggaggaaa
     1501 gggaagggag aaagattgta actatattct ctaatattaa acaattttta aaatagaatc
     1561 aaaccaaagg ttcacaaatg gtaggcaagt accctgaatc acaccccagc tctgagcttc
     1621 actcttagga acaggtgtgg tggtatatgc ctggctctcc agcatttaag aggctgacat
     1681 tgcaggagca aggccagcct gggctctcca ctgaaaccag gattgggcct gtggctcctc
     1741 catagagtat ttttttctag catgcttagg accctgagtt ggatccccag caccagaggg
     1801 caacagggag agagagaaaa ataaaaataa aaaataaata aaaattttaa aaaagcttag
     1861 gccgtgactt acaacatata gaacaatcag gaggctgagg caggagcata gcccggaatt
     1921 tgagacctgc ctatgggcta tatagtagac tacagagcat gatccagtct ccaaacaaaa
     1981 ccctatgtct cctagtcaaa cactcctctc cgctttctat cagtggcaaa tctgaaaagc
     2041 ccagcatagc ttacactttg cattcctgga gtcaaagagc attgttatgt tcttactgaa
     2101 tgacccctga tgagaggact atgaaggaaa cagcttccct aacagcacag aattctaagc
     2161 ataaagtaga cccacgaggt tagtggcatt tcttgggtac tacgtaccat cagtggtcta
     2221 ctgtccatgt gctttctctt ttgacttgat tctggaatac atctcagtaa tacactttca
     2281 tcttaatatc tctgtgtgtc ttcaaaaaaa aaaatgataa gggagagaca gccagttctg
     2341 aactcctcca cacagaggac caagaaaatc tgctgatcaa acaaagctaa gcatgctaaa
     2401 cctagcagct caaggaagaa caacttgcca cgggggcttg gtggcggttc aaaaagatgc
     2461 tgtagtaagc tactggtttg aggcacatcc agcaaagcag aagatggaaa gagaatcgtg
     2521 agtccttcag gtcagtgaat gtagggaggc agtggtctta cctgtgatac aggtaagcat
     2581 tgttagcatt ccttctaggc tccaccccac agttacctgg caacagccag gtatgcctgg
     2641 cttactataa aaggggctgt ttgcccctac tcactcttac tctcttaccc tcttgctttc
     2701 ttaccctctg tctttctttc cctgttcccc cccacccctg taactctatt ccatactata
     2761 tccgttgtgt ggctggtacc ttagtgggga aggatgtctc agcatgggcc cgcaaaggca
     2821 cacccttcca cctcaccata cctgctctat caaacatggc tctttttcat aaaacataac
     2881 aggcatcatt tcccctttcc tgtctaatgt atgaggacta ttgccagaag catctgtgcc
     2941 tgtaacttct ccttaaacag gatgtgaaag agctgctgtc atctccccag ccctagttag
     3001 tttatggaat ttgtagtgtt tatgatgtcg agtatgacta aatttcatgt cttttttttt
     3061 tttaactaag ttgtgtgggt tttttttttt tgttgttttt tgttcttttt tttctttatg
     3121 gatacctagt tctgatcact atttaaaaag gctgtaattt ctataatgtt gtttaaggca
     3181 attttatttt cgatctctgt gtgtgttggt ttgtaggttg tttttcttct attgcctttg
     3241 acaataataa agtaatactg gtctagtaaa aaaaaaaaaa aaaaa
//
