LOCUS       NM_026789               4010 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cilia and flagella associated protein 57 (Cfap57),
            mRNA.
ACCESSION   NM_026789 XM_006503370
VERSION     NM_026789.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4010)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4010)
  AUTHORS   Ma,A., Zhou,J., Ali,H., Abbas,T., Ali,I., Muhammad,Z., Dil,S.,
            Chen,J., Huang,X., Ma,H., Zhao,D., Zhang,B., Zhang,Y., Shah,W.,
            Shah,B., Murtaza,G., Iqbal,F., Khan,M.A., Khan,A., Li,Q., Xu,B.,
            Wu,L., Zhang,H. and Shi,Q.
  TITLE     Loss-of-function mutations in CFAP57 cause multiple morphological
            abnormalities of the flagella in humans and mice
  JOURNAL   JCI Insight 8 (3), e166869 (2023)
   PUBMED   36752199
  REMARK    GeneRIF: Loss-of-function mutations in CFAP57 cause multiple
            morphological abnormalities of the flagella in humans and mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4010)
  AUTHORS   Rorick,N.K., Kinoshita,A., Weirather,J.L., Peyrard-Janvid,M., de
            Lima,R.L., Dunnwald,M., Shanske,A.L., Moretti-Ferreira,D.,
            Koillinen,H., Kere,J., Mansilla,M.A., Murray,J.C., Goudy,S.L. and
            Schutte,B.C.
  TITLE     Genomic strategy identifies a missense mutation in WD-repeat domain
            65 (WDR65) in an individual with Van der Woude syndrome
  JOURNAL   Am J Med Genet A 155A (6), 1314-1321 (2011)
   PUBMED   21574244
REFERENCE   4  (bases 1 to 4010)
  AUTHORS   Frankel,W.N., Yang,Y., Mahaffey,C.L., Beyer,B.J. and O'Brien,T.P.
  TITLE     Szt2, a novel gene for seizure threshold in mice
  JOURNAL   Genes Brain Behav 8 (5), 568-576 (2009)
   PUBMED   19624305
REFERENCE   5  (bases 1 to 4010)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: 1110020C03Rik is most abundantly expressed in tissues rich
            in highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   6  (bases 1 to 4010)
  AUTHORS   Miyamoto-Sato,E., Ishizaka,M., Horisawa,K., Tateyama,S.,
            Takashima,H., Fuse,S., Sue,K., Hirai,N., Masuoka,K. and Yanagawa,H.
  TITLE     Cell-free cotranslation and selection using in vitro virus for
            high-throughput analysis of protein-protein interactions and
            complexes
  JOURNAL   Genome Res 15 (5), 710-717 (2005)
   PUBMED   15867431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669952.8, BX321881.17 and BX842610.3.
            
            On or before Jun 24, 2019 this sequence version replaced
            XM_006503370.2, NM_026789.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849376
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AL669952.8         17271-17380         c
            111-272             AL669952.8         16844-17005         c
            273-589             AL669952.8         11302-11618         c
            590-873             AL669952.8         9519-9802           c
            874-1081            AL669952.8         7168-7375           c
            1082-1234           AL669952.8         3131-3283           c
            1235-1374           BX321881.17        33109-33248         c
            1375-1540           BX321881.17        32202-32367         c
            1541-1654           BX321881.17        31333-31446         c
            1655-1867           BX321881.17        28129-28341         c
            1868-2041           BX321881.17        25374-25547         c
            2042-2203           BX321881.17        21352-21513         c
            2204-2359           BX321881.17        17002-17157         c
            2360-2453           BX321881.17        15226-15319         c
            2454-2644           BX321881.17        14175-14365         c
            2645-2818           BX321881.17        13366-13539         c
            2819-2977           BX321881.17        11712-11870         c
            2978-3121           BX321881.17        8950-9093           c
            3122-3238           BX321881.17        4021-4137           c
            3239-3330           BX321881.17        2001-2092           c
            3331-3373           BX842610.3         51507-51549         c
            3374-3517           BX842610.3         51274-51417         c
            3518-3650           BX842610.3         43720-43852         c
            3651-4010           BX842610.3         36476-36835         c
FEATURES             Location/Qualifiers
     source          1..4010
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 54.84 cM"
     gene            1..4010
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /note="cilia and flagella associated protein 57"
                     /db_xref="GeneID:68625"
                     /db_xref="MGI:MGI:2686209"
     exon            1..110
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            111..272
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..3865
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /note="WD repeat-containing protein 65; WD repeat domain
                     65"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 57"
                     /protein_id="NP_081065.2"
                     /db_xref="CCDS:CCDS51286.1"
                     /db_xref="GeneID:68625"
                     /db_xref="MGI:MGI:2686209"
                     /translation="MSTVVAQALHVFGLRPHVTNNVFFFDEQIIIFPSGNHCVKYNID
                     QKWQKFIAGSDKSQGMLALAISPNRRYLAISETVQEKPAVTIYELSSIPCRKRKVLNN
                     FDFQVQKFTSMAFSPDSKYLLTQTSPPDSNLVYWLWEKQKVMAIIKADSQNNPIYQVS
                     ISSQDNSQVCITGSGVFKLLRFAEGTLKQINFQRGESSNYLAHAWVSEDRVIVGTDTG
                     KLFLFESGDQRWETSIMVKESTSSRSLEVIQESESLIEFPPLSSPVSSVERMDITTNT
                     QQQAMPQVFAIAAYSKGFACSAGPGRVLLFEKVEEKDFYRESREIRIPTDQQSNDPSQ
                     SDKQDVLCLCFSPSEETLIASTNKNQLYSITMSLTEISKGEAAHFEYLLYPLHSASIT
                     GLDTCIRKPLIATCSLDRSVRIWNYESNTLELYKEYQEEAYTVSLHPSGHYIVVGFAD
                     KLRLMNLLIDDIRPFKEYSVRGCKECSFSNGGHLFAAVNGNVIHIFTTTSLENINILK
                     GHTGKIRSLVWNLDDSKLVSAGTDGAVYEWNLSTGKRETECVLKSCSYNSVTTSPDAK
                     VIFAVGSDQTLKEISDSLILREIPAFDVIYTSITISHSGRMIFVGTSVGTIRAMKYPL
                     SLQKEYNEYQAHAGPVMKMLLTFDDQFLLTVGEDGCLFTWKVFDKDGRGIKREREVGF
                     AEEVLVTKTDMEEKAQIMLELKTRVEELKMENEYQLRLKDMNYTEKIKELTDKFIQEM
                     ESLKTKNQVLKTEKEKQDISHRERLEELVDKQTRELQDLECCNNQKLLLEYEKYQELQ
                     LKSQRMQEEYEKQLRDNDETKSQALEELTEFYEAKLQEKTGLLEEAQEDVRQQLREFE
                     ETKKQIEEDEDREIQDIKTKYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEERTN
                     DIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFK
                     FVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRA
                     TDQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEKIRGLFEKYVQRADMVE
                     IAGLNSDLQQEYARQREHLERNLATLKKKVIKEGELHRTDYVRIMQENVSLIKEINEL
                     RRELKLTRSQIYDLESALKVSKKTRSQEVPESVISKDVVGSTSTMRLNEQEETGRIIE
                     MQRLEIRRLRDQIQEQEQVPGFHTIAGVRLPSIVDSDVDFEVHTK"
     exon            273..589
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            590..873
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1081
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1234
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1374
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1540
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1654
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1867
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2041
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2203
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2359
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2453
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2644
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2818
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..2977
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3121
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3238
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3373
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3517
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..3650
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..4010
                     /gene="Cfap57"
                     /gene_synonym="1110020C03Rik; C130004B06Rik; Gm1363;
                     Wdr65"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctataggaa ctgctctagc gtttgggcgt gcccggattg cttcggatct ttaggaagag
       61 cacctactga tccctacgta gtctagtaac ccagagccgt gaagcaagag gtaccatgtc
      121 caccgtggta gctcaggcgc ttcatgtttt tggtcttcgg cctcacgtga ccaacaatgt
      181 cttcttcttc gatgaacaga tcattatatt tccttcagga aatcactgtg tgaagtacaa
      241 tatagatcag aaatggcaaa aattcattgc aggctcagac aagagtcagg gcatgctggc
      301 tttggccatc agtcccaatc ggcgatatct cgctatctcc gagactgtgc aagaaaaacc
      361 ggccgtcact atttatgaac tctcatccat cccttgccgg aagcgcaaag tcctgaataa
      421 ttttgatttc caagttcaaa agtttaccag catggctttt tctccagact ctaaatacct
      481 gctgacacag acgtcacctc cagactcaaa cctcgtctat tggctgtggg aaaagcagaa
      541 agtcatggcc attattaaag ctgatagtca aaacaacccc atctaccagg ttagcatcag
      601 ttcccaggat aatagtcaag tgtgtattac tggaagtggg gtatttaaac ttctccgctt
      661 tgctgaagga accctaaagc aaatcaattt ccagagggga gaatcttcaa actacctagc
      721 ccacgcctgg gtgtctgaag acagggtcat tgttggcact gacaccggca aactcttcct
      781 ctttgaatct ggagatcagc gctgggagac aagcataatg gtcaaggagt ctactagctc
      841 caggagcctg gaggtcattc aagagtcaga gagcctgata gagtttcccc cactcagctc
      901 cccggtctcc tccgttgaaa ggatggatat aaccactaac acccaacaac aggccatgcc
      961 ccaggtgttt gccatcgcag cctattcaaa gggatttgcc tgctctgcgg ggcctggaag
     1021 agtgctgctg tttgagaaag tggaagagaa ggacttttac cgggaaagca gggaaatccg
     1081 gatccccaca gaccaacaaa gcaatgaccc aagtcagtca gacaagcagg atgtcctgtg
     1141 cctgtgcttc agcccatcag aagaaaccct gatcgccagc accaacaaga accagctcta
     1201 ctccatcacc atgtccctga cggagatcag caagggagag gctgcccact tcgagtacct
     1261 gctgtaccca ttgcactcag catccatcac tggtctcgat acctgcatcc gaaaacccct
     1321 cattgccacc tgctctctgg atcgctccgt ccgcatctgg aattacgaat caaacacact
     1381 ggagctatat aaggaatacc aagaagaggc ctacacagtg agccttcacc cctctggaca
     1441 ctacattgtg gtagggtttg ctgacaaact gcgccttatg aatctgctca ttgatgacat
     1501 ccgtcctttc aaagaatatt ctgtcagagg gtgcaaagag tgctccttta gcaatggagg
     1561 tcacctgttt gctgcagtca acggaaatgt gattcacatc ttcaccacca cgagcctgga
     1621 gaacatcaat attttgaaag gccacacagg gaagatccgt tcactcgtgt ggaacttaga
     1681 tgacagcaaa ctggtttctg ctggaacaga tggtgctgtg tatgaatgga atctgtccac
     1741 agggaagaga gagacggagt gtgtgcttaa gtcctgtagc tacaactcgg tcaccacctc
     1801 ccctgatgcc aaagttatct ttgctgtcgg atcagaccag actctcaagg agatttcaga
     1861 ttctttgatc ctccgagaga taccagcatt tgacgtcatc tacacgtcca tcaccatctc
     1921 acattctggg cgcatgatat ttgtgggcac ttccgtgggg actatccgtg ccatgaagta
     1981 cccgctgtct ttgcagaaag aatacaatga gtaccaggct catgctggcc ctgtcatgaa
     2041 gatgctgctc acctttgacg accagttcct gctgacagtt ggtgaggatg gctgcctgtt
     2101 cacctggaag gtctttgata aggatggccg gggaatcaaa cgagagaggg aggtgggctt
     2161 tgctgaagag gtgctcgtga ctaagacaga catggaagag aaggctcaga ttatgctgga
     2221 gctgaagact cgtgtagagg aactgaagat ggagaatgag tatcagctcc ggctgaagga
     2281 catgaactac acggagaaga tcaaggagct gacggacaag ttcatccagg agatggaatc
     2341 cttaaagacg aagaaccagg tgttaaaaac agagaaagaa aaacaggaca tcagtcaccg
     2401 agagcgctta gaggaactcg tagacaaaca gacccgggag ctgcaagacc tggaatgctg
     2461 taacaaccag aagctgctcc ttgaatatga gaagtaccaa gagctgcagc tcaagtccca
     2521 gaggatgcag gaggagtacg aaaagcagct ccgggataac gatgagacga agagccaagc
     2581 cctggaggag ctgaccgagt tctatgaggc caaactccag gagaaaactg gccttctaga
     2641 ggaggcacag gaagatgtcc gacagcagct tcgggaattc gaggaaacca agaagcagat
     2701 tgaagaagat gaagacaggg agatccaaga catcaaaacc aagtacgaga ggaagcttag
     2761 ggatgagaag gagtctaacc ttcgactcaa gggagaaacg ggcatcatga ggaagaagtt
     2821 cagcagcctg cagaaggaga tcgaagagcg caccaacgac atcgagctcc tcaagtcgga
     2881 gcagatgaag ctgcagggca tcatcagatc cctggagaaa gacatccaag ggctcaagag
     2941 agagatccag gagagggacg agaccattca agacaaggag aagcgaattt atgatctgaa
     3001 gaagaagaac caagagctgg agaaattcaa gtttgtcctt gactacaaaa taaaggagct
     3061 gaagaagcaa atagaaccga gggagaacga gatcaaagtg atgaaagagc agatccagga
     3121 gatggaagcc gagctggagc gtttccataa acagaacacg caactggagc tgaacatcac
     3181 agaactgttg cagaaactgc gagctacgga tcaggagatg cgcaaggagc agcagaagga
     3241 acgggatctg gaagcgctgg tccgacgctt caagacagac cttcacaact gcgtggcgta
     3301 catccaggaa cccgggctgc tgaaggagaa gatccgtggc ctctttgaga agtacgtgca
     3361 gcgggcagac atggtggaga ttgcagggtt gaactcagac ctgcaacagg agtacgcccg
     3421 ccagcgggaa cacctggaga ggaaccttgc cacgctcaag aagaaagtga tcaaggaggg
     3481 tgagctgcat cgcaccgact atgtccgcat catgcaggaa aatgtctctc tgatcaaaga
     3541 aattaatgag ctccgcaggg agctgaagtt aacccgctcc caaatctatg accttgaatc
     3601 ggccctgaaa gtatccaaga agacgcgctc acaagaagtt ccagagtcag tgataagcaa
     3661 ggacgtagtc ggcagcacct ctactatgag gctgaacgaa caggaggaaa ccgggagaat
     3721 catcgagatg caacgtctgg aaatccgccg cctcagagac cagatccaag agcaggagca
     3781 ggtcccaggc ttccacacca ttgccggagt tcggcttcct tccatcgtcg actcagatgt
     3841 ggattttgaa gtgcacacca agtgacctcc ggtgagccat ttccagtcac agccagaagc
     3901 acgggaggca ccgggtgtct gtcacagagc cagactccta cccaagtccc accaacctct
     3961 ttcatcctgg gaaactggga gtagggtcag aataaaggtg tttgctcact
//
