LOCUS       NM_028948               1876 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus cilia and flagella associated protein 53 (Cfap53),
            transcript variant 1, mRNA.
ACCESSION   NM_028948 XM_001001936 XM_001001947 XM_128864 XM_894960 XM_916810
            XM_924500
VERSION     NM_028948.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1876)
  AUTHORS   Lu,H., Twan,W.K., Ikawa,Y., Khare,V., Mukherjee,I., Schou,K.B.,
            Chua,K.X., Aqasha,A., Chakrabarti,S., Hamada,H. and Roy,S.
  TITLE     Localisation and function of key axonemal microtubule inner
            proteins and dynein docking complex members reveal extensive
            diversity among vertebrate motile cilia
  JOURNAL   Development 151 (14) (2024)
   PUBMED   39007638
REFERENCE   2  (bases 1 to 1876)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1876)
  AUTHORS   Ho,K.H., Candat,A., Scarpetta,V., Faucourt,M., Weill,S., Salio,C.,
            D'Este,E., Meschkat,M., Wurm,C.A., Kneussel,M., Janke,C.,
            Magiera,M.M., Genovesio,A., Meunier,A., Sassoe-Pognetto,M.,
            Brill,M.S., Spassky,N. and Patrizi,A.
  TITLE     Choroid plexuses carry nodal-like cilia that undergo axoneme
            regression from early adult stage
  JOURNAL   Dev Cell 58 (23), 2641-2651 (2023)
   PUBMED   37890489
REFERENCE   4  (bases 1 to 1876)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1876)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   6  (bases 1 to 1876)
  AUTHORS   Wu,B., Yu,X., Liu,C., Wang,L., Huang,T., Lu,G., Chen,Z.J., Li,W.
            and Liu,H.
  TITLE     Essential Role of CFAP53 in Sperm Flagellum Biogenesis
  JOURNAL   Front Cell Dev Biol 9, 676910 (2021)
   PUBMED   34124066
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1876)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8.. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1876)
  AUTHORS   Ide,T., Twan,W.K., Lu,H., Ikawa,Y., Lim,L.X., Henninger,N.,
            Nishimura,H., Takaoka,K., Narasimhan,V., Yan,X., Shiratori,H.,
            Roy,S. and Hamada,H.
  TITLE     CFAP53 regulates mammalian cilia-type motility patterns through
            differential localization and recruitment of axonemal dynein
            components
  JOURNAL   PLoS Genet 16 (12), e1009232 (2020)
   PUBMED   33347437
  REMARK    GeneRIF: CFAP53 regulates mammalian cilia-type motility patterns
            through differential localization and recruitment of axonemal
            dynein components.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1876)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1876)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN835862.1 and BC099500.1.
            
            On Oct 22, 2009 this sequence version replaced NM_028948.1.
            
            Transcript Variant: This variant (1) represents the shorter,
            protein-coding transcript.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is supported by available conservation data.
            The use of an alternative upstream start codon would result in a
            protein that is 86 aa longer.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099500.1, ERR3363658.427624.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                CN835862.1         11-92
            83-1876             BC099500.1         1-1794
FEATURES             Location/Qualifiers
     source          1..1876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 50.7 cM"
     gene            1..1876
                     /gene="Cfap53"
                     /gene_synonym="4933415I03Rik; Ccdc11"
                     /note="cilia and flagella associated protein 53"
                     /db_xref="GeneID:74453"
                     /db_xref="MGI:MGI:1921703"
     exon            1..167
                     /gene="Cfap53"
                     /gene_synonym="4933415I03Rik; Ccdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            168..397
                     /gene="Cfap53"
                     /gene_synonym="4933415I03Rik; Ccdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            398..571
                     /gene="Cfap53"
                     /gene_synonym="4933415I03Rik; Ccdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            572..875
                     /gene="Cfap53"
                     /gene_synonym="4933415I03Rik; Ccdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1094
                     /gene="Cfap53"
                     /gene_synonym="4933415I03Rik; Ccdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1311
                     /gene="Cfap53"
                     /gene_synonym="4933415I03Rik; Ccdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1414
                     /gene="Cfap53"
                     /gene_synonym="4933415I03Rik; Ccdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1876
                     /gene="Cfap53"
                     /gene_synonym="4933415I03Rik; Ccdc11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1713..1718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap53"
                     /gene_synonym="4933415I03Rik; Ccdc11"
                     /note="hexamer: GATAAA"
     polyA_site      1732
                     /gene="Cfap53"
                     /gene_synonym="4933415I03Rik; Ccdc11"
ORIGIN      
        1 ggggtgacgc accatggcaa ccagcactct gcgtctggga agtaaactcc accgtgcttt
       61 ctagtttcct gtcgccacca tcccaaagag acttgaagat gtacagccag cagtttggca
      121 ctgttccaag ggaatttaag ggccccactc ccaaagcggt gatcataaga gccaagcctc
      181 ccaaagctca gagagctgag caacatctaa aaagaatcca gcgcagctac cacaagtacc
      241 acactacttt ggcttccatc aagtcaaatg aggagaatcg cctgaaatgt gactggatcc
      301 agcgcaataa ccacaagacc tttgacagtc ttgtgcaagc gagagtccag gatgccatgc
      361 aaggctttgt catcaatact gaagagagac gcaataagct acgtgaactt ttggcatcag
      421 aagaaaacga gtatttttct gaaatgcaat tgaaaggaga aaccattgaa gagaaaaaag
      481 acaaaatgag agagagaacc aagttattaa gagagaagaa ggaaaaggag aggcaggagt
      541 ttgtagctga aaagttagac cagcagttca gggaacgctg tgaggagctc cgcactaaat
      601 tggccagcat ccacgagaaa aaggtggttg aggaacggaa tgcgcagata gaattcaaca
      661 aggagctgaa gaggcaaaag ctggtggaag agcacctgtt tgcgaggctt tgggaggaag
      721 acagattagc gaaggaaagg cgagaagccc aagaggagaa gagacagaga gagctggtac
      781 aaaatacacg cctgggtctg gatgctcagg tgaccagcat ccaggcacaa aggcaggggg
      841 cacgaaggat gaaggaagag gaggcccgca tcctggagca gaacaaagca cagatcaaac
      901 gagaggacga acaagaaaaa ctccagaagc agaagagaag acaggaaact aggagcagtt
      961 tgaaaaaagc tgtgcaggat aagatagagt ctatgcagcg ggagtacaga gaggacctgg
     1021 acttgaacat gaaactcgtg ggaagggccc ttcaagactt acaagatgag gcagataaga
     1081 agaagcagaa gagagaagaa atgggaagag agcagaagat atacaatgac tatctaatgc
     1141 agcgacgaga ggaagaaaaa gcccaggaga aagaactcaa cagactactg gaggacataa
     1201 aggcaaagaa gttggctgag aaggatcggg agctggcact ccaaagggcg gcaaggaagc
     1261 agctcatgaa tgaagtcatg aatacaagaa aactccaagt tcaagaaaga ttgcagcgaa
     1321 aactcagaga acaagaagaa cttgctctgc atgaacagcg tataagcgaa agcctgaagg
     1381 tgcttcacca ggaagacatg gaggactttg ccaggcgctg tgctttggct gaggagtata
     1441 ggaatcaact tcagatgcag attgcccacc agcagcaggc tcgagaagca gaaaaggaag
     1501 aggaacgcca ggaatttgaa gcagggttgg cagcaaacaa agcctgcctg gacaaaatac
     1561 agaggatcct ctctgagaat caagctctgt cccagaatgt ccaccccatg cgaaggggtt
     1621 accctgacaa gcctcctcta tagttttata taaatcaatg tatgttttct gggtctttca
     1681 atattttttt taactacacc ttttgactaa tggataaacg cttattctcc gagtttgtat
     1741 actttattag acataatttt cttccttcaa atgaatttgt tctttggata ctagttaaat
     1801 ctatattgct atagcaaaaa aaaaaaatct gacattgtca acttaaaaag aataaagatt
     1861 tattttagct tctggt
//
